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      • 沖庵金淨의 <濟州風土錄> 硏究

        조정윤(Jo, Jeong-yun) 충남대학교 충청문화연구소 2018 충청문화연구 Vol.21 No.-

        본고는 沖庵 金淨(1486~1521)이 제주 유배 중에 지은 <濟州風土錄>의 내용 및 문체적 특징을 검토하여 김정 문학의 일면모를 밝혀보고자 한 것이다. 김정은 탁월한 文才를 바탕으로 22세 되던 해 文科別試에서 장원급제하여 환로에 들어섰다. 순창군수 재직 시 朴祥과 함께 廢妃愼氏의 복위를 청하는 상소를 올렸다가 유배되기도 하였지만, 다시 復官되어 中宗의 두터운 신임을 받아 빠르게 승진하며 도학적 이상 정치의 실현을 위해 소격서의 革罷, 鄕約의 간행, 현량과 실시 등 여러 개혁 정치를 시도하였다. 그러나 신진 사림들의 정치 개혁 시행 및 僞勳削除 요구 등에 위기의식을 느낀 훈구공신들이 일으킨 己卯士禍에 휘말려 錦山및 珍島를 거쳐 제주도로 유배되었다가 1521년 10월 제주에서 賜死되었다. 궁행실천의 도학적 학문자세를 지녔던 김정은 유배객이 되어서도 濟州民을 위해 풍속을 교화하고자 노력하였으며, 제주 유배시기 작품에는 좌절과 고독, 슬픔의 감정 등이 나타나기도 하지만, 자연의 섭리를 이해하고 천명에 순응하고자 하는 모습이 나타난다. 이러한 실천적 학문성향과 작품 경향은 <제주풍토록>에서도 발견된다. <제주풍토록>은 제주의 이색적 풍토에 대해 비평적인 소개로, 미개한 풍속에 대한 실천적 도학자의 교화와 개혁의 시각이 담겨있다. 김정은 제주의 기후와 풍속, 지리, 산물 등, 제주의 환경과 사회상을 상세하게 기록하면서 그 원인과 개선점에 대해서도 지적하였다. 또한 제주도의 지리적 환경 및 謫所의 주변을 서술한 부분에서는 유배자의 고독과 비애의 감정을 드러내기도 하지만 원망이나 불평이 아닌 천명에 순응하는 달관의 경지를 보여주어 비장미를 표출하였다. 한편, 김정의 산문은 ‘西漢風’을 추구하였던 것으로 평가받았다. <제주풍토록> 역시 제주의 물산을 나열적으로 서술하고, 내용의 범위와 규모가 넓은 면에서 <子虛賦>와 비견된다. 수록내용이 풍부하면서도 세부적인 수식이나 자잘한 묘사를 생략하고 축약적인 4자구를 多用하고 있으며 虛字와 典故의 사용이 적어서 호방하면서도 간결한 효과를 보여준다. 곧 <제주풍토록>은 김정의 ‘修己治人’의 학문적 경향에 의해 저술된 것으로, 제주 환경에 대한 敍事와 유배생활의 정서에 대한 抒情이 조화를 이룬 작품이다. This thesis is designed to examine the contents and the characteristic of the style of Record of Jeju Customs (濟州風土錄) that Chuangam Kim Jeong wrote during his Jeju exile, and to reveal an aspect of Kim Jeong"s literature. Kim Jeong won the first place in the special civil service examination and entered government service on the basis of his excellent literary talent when he was 22 years old. While holding the office of Sunchang county governor, Kim jeong filed an appeal to ask the restoration of Ms Shin, a retired queen with Park Sang and was exiled, but was restored to his office and then was promoted with the deep confidence of Jungjong tried to perform various political reformations for the realization of the ideal politics of Confucianism, such as the reformation of Sokyeokseo (昭格署), the publication of Hyangyak (鄕約), and the establishment of Hyunlyang department (賢良科), etc. But Kim Jeong was swept away by the Literati Purge raised by the meritorious elite threaten by the political reformation and enforcement of the Neo-Confucian Literati, the requirement of the deletion of the memorial service, etc. and was exiled to Eunsan, Jindo, and Jeju Island, poisoned into death October, 1521. Although Kim Jeong who had a Confucian attitude to practice in person was an exile, he tried to educate the residents of Jeju Island regarding their customs. Even though the works during the Jeju exile show such emotions as desperation, solitude, sorrow, he tried to understand the providence of nature and to conform to Heaven"s will. Such tendency of practical studies and works is found even in Record of Jeju Customs (濟州風土錄). Record of Jeju Customs (濟州風土錄) is a critical introduction of Jeju"s exotic customs, containing the viewpoint of a practical Confucian"s educating and reforming uncivilized customs. Kim Jeong recorded Jeju"s environment and society such as its climate, customs, geometry, products, etc. in detail, pointing out the cause and improvement. In addition, although he shows an exile"s solitude and sorrow in the part describing the geological environment and the place of exile, he shows not resentment or complaint, but a far-sighted view conforming to Heaven"s will. Meanwhile, Kim Jeong"s prose was estimated as pursuing ‘Seohanpung’ (西漢風). Record of Jeju Customs (濟州風土錄) also describes Jeju"s products, similar to Jaheobu (子虛賦) in that the range and scale of the contents are wide. The recorded contents are rich, detailed modification or petty description are omitted, a number of abbreviated four-letter phrases are used, Huhja (虛字) and reference episodes are rare, which show a broad and brief effect. Thus Record of Jeju Customs (濟州風土錄) was written by Kim Jeong"s cultivating himself and ruling other people, harmonious between the description of Jeju"s environment and the sentiment of his exile life.

      • 간세포암종에 대한 간동맥 화학색전술 후 발생한 급성호흡곤란증후군

        조윤원,이정미,최자윤,유동훈,차라리,오혜원,김홍준,민현주,김현진,정운태,이옥재,하창윤,이선영 이화여자대학교 의과학연구소 2013 EMJ (Ewha medical journal) Vol.36 No.1

        Transcatheter arterial chemoembolization (TACE) has become an effective alternative treatment strategy for patients with inoperable hepatocellular carcinoma (HCC). Although TACE is relatively safe, acute respiratory distress syndrome associated with pulmonary lipiodol embolism is a rare and potentially fatal complication. We report a rare case of acute respiratory distress syndrome after TACE for inoperable HCC. A 75-year-old man, with huge HCC in right lobe, was treated by TACE for the first time. Seven hours after uneventful TACE procedure, he felt dyspneic and his oxygen saturation recorded by pulse oximetry (SpO2) fell to 80% despite of applying non-rebreathing mask. He underwent mechanical ventilation with a protective ventilatory strategy. We experienced a case of acute respiratory distress syndrome after TACE for HCC.

      • HL-60 세포주를 이용한 결핵균항원의 세포성면역반응의 분석

        박정규,강윤중,김운옥,임재현,송창화,조은경,김화중 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

        Most persons who become infected with M. tuberculosis mount a protective immune response and remain clinically well, the only evidence of infection being development of a positive tuberculin skin test. Five to 10% develop tuberculosis disease within the first 2 years after infection (primary tuberculosis) or thereafter (reactivation tuberculosis). Acquired resistance against tuberculosis paradigmatically rests on cell-mediated immunity, with the major factors being mononuclear phagocytes and T Lymphocytes. While the former cells act as the principal effectors, the latter ones serve as the predominant inducers of protection. The usefulness of the single dose of BCG routinely given in childhood in many developing countries in preventing far more commonly occurring tuberculosis in adults is in doubt. An effective and safe vaccine against tuberculosis is sorely needed. A subunit vaccine are capable of inducing protective immunity and could have substantial advantages over BCG or other whole-bacterium vaccines. The human promyelocytic cell line HL-60 adopted characteristic macrophage-like properties, including adherence and CD14 expression after a period of continuous culture at high ambient CO_(2) concentration. When HL-60 cells were cultured with 1,25-dihydroxyvitamin D_(3) for 4 days, the cells acquired the activity to potentiate T cell proliferation by the 30 kDa or 38 kDa antigen of Mycobacterium tuberculosis H37Rv Therefore, vitamin D-treated HL-60 cells showed the function of the antigen presenting cells.

      • KCI등재

        Cone-beam CT를 이용한 안면비대칭자에서 이부편위에 따른 치성보상의 양상분석

        박수병,박정희,정연화,조봉혜,김용일 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.5

        Objective: The purpose of this study was to evaluate the correlation between menton deviation and dental compensation in facial asymmetry. Methods: Tooth axis and distance of first molar and canine to the reference plane were investigated by cone-beam computerized tomography. The subjects consisted of 50 patients with asymmetric mandibles (male 21, female 29, mean age 24.3 years). Control groups were also assessed (male 11, female 9, mean age 25.6 years). Nine measurements (5 linear measurements and 4 angular measurements) were measured in order to evaluate the correlation between menton deviation and the linear and angular difference of first molar and canine in the deviated and none-deviated sides using the defined MPR images. The differences between deviated and non-deviated side, according to menton deviation, were statistically analyzed using stepwise multiple regression analysis. Results: From the result, Menton deviation was negatively correlated with mandibular first molar's angular measurement (Δ∠LM6-Mn plane (dev.-ndev.)) and positively with maxillary fist molar's angular measurement (Δ∠UM6-FH plane (dev.-ndev.)) (p < 0.01). Two angular measurements (Δ∠ LM6-Mn plane (dev.-ndev.), Δ∠UM6-FH plane (dev.-ndev.)) explained the variability in menton deviation with a significant r² value of 0.589. Conclusions: This study suggests that the tooth axis of upper and lower first molars leans towards the deviated side of Menton when there is mandibular asymmetry with Menton deviation. 본 연구는 Cone-beam CT의 MPR이미지상에서 하악골 평면에 대한 하악 제1대구치와 견치의 편위측과 비편위측의 높이와 각도차이 그리고 FH 평면에 대한 상악 제1대구치와 견치의 편위측과 비편위측의 높이와 각도차이를 계측함으로써 안면비대칭자에서 이부편위에 따른 편위측과 비편위측의 제1대구치와 견치의 높이와 협설측 경사도를 CBCT를 이용하여 분석하고 그 관련성을 알아보는 데 있다. 연구대상은 하악골의 이부편위를 동반한 안면비대칭 환자 50명(여자 29명, 남자 21명, 평균나이 24세 4개월)으로 하였다. 대조군으로 평균나이 25세 7개월인 20명(남자 11명, 여자 9명)을 분석하였다. 결과는 이부편위에 대해 FH 평면에 대한 상악 제1대구치의 편위측과 비편위측의 길이 및 각도 차이(편위측 - 비편위측)는 대조군에 대해 통계적으로 유의한 차이가 존재하였다 (p < 0.01). 비대칭군에서 상악 제1대구치 각도는 편위측이 비편위측보다 평균 8.62 ± 5.95˚ 컸다 (p < 0.01). 상악 견치의 경우에도 편위측과 비편위측의 각도차이가 평균 4.48 ± 5.05˚로 통계적으로 유의한 차이가 존재하였다 (p < 0.01). 하악골 평면에 대한 하악 제1대구치의 수직 길이와 각도는 편위측과 비편위측에서 통계적으로 유의할 만한 차이가 존재하였다 (p < 0.01). 각도의 차이는 평균 -11.92 ± 5.79˚로 나타났다. 이부편위에 대한 상하악 제1대구치와 견치의 수직거리 및 각도의 Pearson 상관분석 및 회귀분석 결과, FH 평면에 대한 상악 제1대구치의 편위측과 비편위측의 각도차이(Δ∠ UM6-FH plane (dev.-ndev.))는 통계적으로 유의한 양의 상관관계를 나타내었고, 하악골 평면에 대한 하악 제1대구치의 편위측과 비편위측의 각도차이(Δ∠LM6-Mn plane (dev.-ndev.))는 통계적으로 유의한 음의 상관관계를 나타내었다. 이상의 결과에서 이부편위를 동반한 하악골 비대칭이 존재하는 경우, 이부가 편위되는 방향으로 상하악 제1대구치의 치아장축의 각도가 변화되는 것으로 나타났다.

      • SCIESCOPUSKCI등재
      • The clinical classification of hand eczema

        ( Jeong Won Jo ),( Chang Il Kwon ),( Young Bin Shin ),( Hae Bong Jeong ),( Yun Sun Moon ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

        Background: Hand eczema is one of the most common dermatological disorders. Although it is a general term referring to eczematous dermatitis of the hands, it actually covers a wide range of diseases. However, classification of hand eczema is controversial even now. Objectives: In this study, we attempts to classify subdiagnoses of hand eczema into 6 types with respect to medical history and morphology. Methods: This study was conducted from 2015-2017 and we investigated the distribution of gender, age, clinical features and duration of disease for all patients. Sixty patients were included from dermatology clinics in our hospital outpatients. The patients were classified into one of the six diagnostic subgroups with standard photographs as reference. Results: Out of 60 cases, the mean duration time was 2.9 years and patients showed symptoms such as erythema, vesicle, fissure, scaling and edema. Thirty three patient (55%) were classified as irritant contact dermatitis, 9 (15%) as atopic hand eczema, 5 (8.3%) as allergic contact dermatitis, 5 (8.3%) as protein contact dermatitis/contact urticaria, 3 (5%) as hyperkeratotic endogenous eczema, 2 (3.4%) as vesicular endogenous eczema and 3 (5%) was not classified in any category. Conclusion: This study shows that hand eczema can be classified into various categories. Therefore, we expect to be able to provide appropriate treatment for each lesion through classification of hand eczema.

      • P191 The clinicopathologic study of multiple dermatofibroma

        ( Jeong Won Jo ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

        <div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Dermatofibromas are common, benign, painless dermal nodules. Although cases of solitary dermatofibromas are common, multiple dermatofibromas are rare and there is no explainable theory in healthy people. Objectives: This study was conducted to obtain better understanding of the clinicopathologic features of multiple dermatofibroma. Methods: This is a retrospective study of multiple dermatofibroma pathologically diagnosed at our hospital over a 12-year period (2004~2015). Clinicopathologic features of 22 patients, 108 lesions were evaluated. The sex, age, number of lesions, site, symptoms and histopathological finding are included. Results: Of the 22 patients, sixteen (72.7%) were female and six (27.3%) were male. mean age was 39.1(±11.5) years old. The number of lesions ranged 2 to 20 and the mean was 4.9. The most common predilection sites were lower extremities (42.6%). All cases treated by excisional biopsy. According to the histopathological finding, the most common histological subtype was fibrocollagenous (66.7%). Most of the cases were extended dermis (62.5%) layer. Mitotic activity was not definite in majority of cases. The major infiltrated inflammatory cells were lymphocyte (75.2%). Conclusion: Multiple and solitary dermatofibroma have clinical and pathological consistency except for numbers of lesions.

      • P064 The effect of excess caffeine exposure on human umbilical vein endothelial cells and head and neck squamous cell carcinoma

        ( Jeong Won Jo ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

        <div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Caffeine intake and consumption of coffee were estimated from food frequency questionnaires results these are increasing. Caffeine may repair skin damage induced by excessive exposure to ultraviolet light. In previous report of the associations between coffee consumption and incidence of these skin cancers, the result that the consumption of neither caffeinated nor decaffeinated coffee was associated with basal cell carcinoma and squamous cell carcinoma (SCC). Objectives: In this study, our aim is to describe the mechanisms of the anti-angiogenic effect of caffeine in human umbilical vein endothelial cells (HUVECs) and head and neck squamous cell carcinoma (HNSCC). Methods: Matrigel assays were used to investigate the effect of caffeine on angiogenesis at cell migration and wound healing and proliferation assays using HUVECs and HNSCC. Results: Caffeine was found to inhibit blood vessel formation dose-dependently and to inhibit the proliferation of HUVECs time- and dose-dependently. The apoptosis examination was used by western blotting and immunofluorescence staining. Conclusion: Caffeine was found to inhibit blood vessel formation dose-dependently and to inhibit the proliferation of HUVECs on the same manners. There is no satisfactory enhancement and/or inhibition on proliferation of HNSCC.

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