Simulation and Experimental Studies of Speed Sensorless Control of Permanent Magnet Synchronous Motors for Mine Electric Locomotive Drive

Yudong Li,Yujun Zhang,Tianyu Zhang 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.1

Excessive Daytime Sleepiness and Insomnia Symptoms in Adolescents With Major Depressive Disorder: Prevalence, Clinical Correlates, and the Relationship With Psychiatric Medications Use

Yudong Shi,Wei Li,Changhao Chen,Xiaoping Yuan,Yingying Yang,Song Wang,Zhiwei Liu,Feng Geng,Jiawei Wang,Xiangfen Luo,Xiangwang Wen,Lei Xia,Huanzhong Liu 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.11

Objective Excessive daytime sleepiness (EDS) and insomnia symptoms are common in patients with major depressive disorder (MDD), which might lead to a poor prognosis and an increased risk of depression relapse. The current study aimed to investigate the prevalence, and sociodemographic and clinical correlates of EDS and insomnia symptoms among adolescents with MDD.Methods The sample of this cross-sectional study included 297 adolescents (mean age=15.26 years; range=12–18 years; 218 females) with MDD recruited from three general and four psychiatric hospitals in five cities (Hefei, Bengbu, Fuyang, Suzhou, and Ma’anshan) in Anhui Province, China between January and August, 2021. EDS and insomnia symptoms, and clinical severity of depressive symptoms were assessed using Epworth sleepiness scale, Insomnia Severity Index, and Clinical Global Impression-Severity.Results The prevalence of EDS and insomnia symptoms in adolescents with MDD was 39.7% and 38.0%, respectively. Binary logistic regression analyses showed that EDS symptoms were significantly associated with higher body mass index (odds ratio [OR]=1.097, 95% confidence interval [CI]=1.027–1.172), more severe depressive symptoms (OR=1.313, 95% CI=1.028–1.679), and selective serotonin reuptake inhibitors use (OR=2.078, 95% CI=1.199–3.601). And insomnia symptoms were positively associated with female sex (OR=1.955, 95% CI=1.052–3.633), suicide attempts (OR=1.765, 95% CI=1.037–3.005), more severe depressive symptoms (OR=2.031, 95% CI=1.523–2.709), and negatively associated with antipsychotics use (OR=0.433, 95% CI=0.196–0.952).Conclusion EDS and insomnia symptoms are common among adolescents with MDD. Considering their negative effects on the clinical prognosis, regular screening and clinical managements should be developed for this patient population.

Study on the interventional path planning method of bronchoscope catheter

Yudong Bao,Xu LI,Wen Wei,Hejun Liu,Shengqian Qu 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.5

This paper presents a scientific approach to catheter intervention path planning. Firstly, it gives a three-dimensional reconstruction of bronchi using Mimics software based on CT image data. It also measures and analyzes geometric morphological data of the 3D model, which includes diameter, cross-sectional area, node spacing, and curvature at different locations. Secondly, starting from the bending structure of the catheter, Adams simulation experiments and with and without constraints of the serpentine bending structure were conducted. Comparison and analysis of the experimental results of the above three experiments to obtain the quantitative relationship of the bending angle. This study established a simple control device for interventional examination, verified the effect of the method on linear motion of the device, and provided some theoretical basis for future research to realize an automatic machine for human tracheal intervention.

Application of galactinol to tomato enhances tolerance to cold and heat stresses

Liu Yudong,Zhang Li,Ma Jian,Meng Sida,Pang Chunpeng,Zhao Xiaomeng,Zhang Huidong,Wang Shou,Xu Tao,He Yi,Liu Yufeng,Qi Mingfang 한국원예학회 2022 Horticulture, Environment, and Biotechnology Vol.63 No.3

Galactinol, a galactosyl donor, is the key substrate in raffinose family oligosaccharide (RFO) biosynthesis pathways. Many studies proved that galactinol also regulates some defense-related genes to be transcribed as a sugar signal under biotic and abiotic stresses. There are four galactinol synthase (SlGolS) genes in tomato. In this study, SlGolS1, SlGolS2, and SlGolS4 responded to cold stress, especially SlGolS1 stems treated for 12 h and SlGolS4 stems treated for 24 h. Under heat stress, the expression levels of SlGolS1, SlGolS2, and SlGolS3, especially SlGolS1 and SlGolS2, increased in leaves, roots, and stems. When expressed in E. coli cells, SlGolS2 and SlGolS4 enhanced cold tolerance, whereas SlGolS1 and SlGolS3 improved heat tolerance. These results suggested that SlGolS family members played different roles in tolerance to cold and heat stresses. In addition, the application of galactinol or galactinol + α-galactosidase inhibitor (DGJ) improved the cold and heat tolerances of tomato plants, whereas the single application of DGJ had no effect. Interestingly, the applications of DGJ, galactinol, and galactinol + DGJ also affected the expression levels of SlRS, SlSTS, and SlAGAL under cold and heat stresses. These findings indicated that galactinol was involved in the biosynthesis pathways of RFOs as a galactosyl donor and regulated the expression levels of RFO biosynthesis and breakdown-related genes as a sugar signal under cold and heat stresses.

Research on Cold-Formed Steel Stiffened-Web Built-up I-Section Columns with Complex Edge Stiffeners

Zhuangnan Zhang,Yudong Li,Chungang Wang,Yikai Hao,Jianqiao Song,Qinglin Guo 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.1

A series of double-limbs built-up I-section simply supported specimens subjected to compression were examined. The test columns contained 18 concentric compression columns and 12 eccentric compression columns with three section forms respectively. The infl uence of web stiff eners on buckling mode, ultimate bearing capacity and interaction between limbs were studied. It was shown that stiff eners in web eff ectively decreased the element width-to-thickness ratio and increased the bearing capacity of built-up I-section columns. But when larger eccentricity made the moment control the failure of eccentric compression specimens, the bearing capacity of the specimens was not improved obviously by web stiff eners. Distortional buckling could replace local buckling to control the failure modes of columns. Compared with double-limbs channel steel built-up open-sections with complex edge stiff eners under the same steel quantity and eccentricity, the load carrying capacity of double limb Σ-shaped channel built-up sections increased from 4.4% to 20.3%. While for double limb channel with V-type web stiff ener sections, the increment was from 2.2% to 17.4%. Furthermore, parametric study of 90 Σ-shaped built-up section members was investigated to obtain the optimization proportion of the web sub-element and relationship of carrying capacity between single Σ-shaped section and double limb Σ-shaped I-section. Finally, the ultimate load-carrying capacity of built-up columns subjected to axial compression were calculated by two kinds of direct strength method formulas, which were compared with the tests values. The results showed that the method considered the interaction between distortional buckling and fl exural buckling could obtain conservative results.

Piezo2: A Candidate Biomarker for Visceral Hypersensitivity in Irritable Bowel Syndrome?

( Tao Bai ),( Ying Li ),( Jing Xia ),( Yudong Jiang ),( Lei Zhang ),( Huan Wang ),( Wei Qian ),( Jun Song ),( Xiaohua Hou ) 대한소화기기능성질환·운동학회 2017 Journal of Neurogastroenterology and Motility (JNM Vol.23 No.3

Background/Aims Currently, there exists no biomarker for visceral hypersensitivity in irritable bowel syndrome (IBS). Piezo proteins have been proven to play an important role in the mechanical stimulation to induce visceral pain in other tissues and may also be a biomarker candidate. The aim of this study was to test the expressions of Piezo1 and Piezo2 proteins in the intestinal epithelial cells from different intestinal segments and to explore the correlation between Piezo proteins expression and visceral pain threshold. Methods Post-infectious IBS was induced in mice via a Trichinella spiralis infection. Visceral sensitivity was measured with abdominal withdrawal reflex to colorectal distention. Inflammation in the small intestine and colon was scored with H&E staining. Expression location of Piezo proteins was confirmed by immunohistochemistry. Abundance of Piezo proteins were measured with real-time reverse transcriptase polymerase chain reaction. Results Piezo1 and Piezo2 proteins were expressed in the intestinal epithelial cells. The expression levels of Piezo1 and Piezo2 were abundant in the colon than the small intestine (P < 0.001 for Piezo1, P = 0.003 for Piezo2). Expression of Piezo2 in the colon significantly correlated to the visceral sensitivity (r = -0.718, P = 0.001) rather than the mucosal inflammation. Conclusion Piezo2 is a candidate biomarker for visceral hypersensitivity in IBS. (J Neurogastroenterol Motil 2017;23:453-463)

Analysis of the Interference Effects in CMOS Image Sensors Caused by Strong Electromagnetic Pulses

Yang Zhikang,Wen Lin,Li Yudong,Zhou Dong,Wang Xin,Ding Rui,Zhong Meiqing,Meng Cui,Fang Wenxiao,Guo Qi 한국전자파학회 2024 Journal of Electromagnetic Engineering and Science Vol.24 No.2

With the electromagnetic environment becoming increasingly complex, it is crucial to address the risk posed by electromagnetic pulse, which critically impairs the performance and reliability of electronic systems based on complementary metal oxide semiconductor (CMOS) image sensors. In this context, research on the failure types of CMOS image sensors in a high-power electromagnetic environment, caused by strong electromagnetic pulses and the rapid evaluation method of interference immunity, has garnered significant interest. This paper conducts electromagnetic pulse simulation experiments on CMOS image sensors to first study their failure types, such as image abnormalities and functional interruption, and then identify the corresponding failure criteria. Furthermore, this study builds on the small sample test evaluation method to investigate the interference threshold of functional interruptions in CMOS image sensors by calculating the failure probability at different field strengths. The obtained data were combined with the Weibull distribution function for fitting, the results of which found the interference threshold to be at 40.4 kV/m. The findings of this study provide a basis for evaluating the survivability of CMOS image sensors and their associated reinforcement technology in high-power electromagnetic environments.

Modelling and Prediction of Stress Relaxation for Thermal Bonded Nonwoven Geotextiles

Shiyuan Sun,Xiaoping Gao,Chunhong Fu,Yudong Zhou,Xiaoying Wei,Jiaxin Li,Yiping Qiu 한국섬유공학회 2020 Fibers and polymers Vol.21 No.7

Stress relaxation experiments were performed on three types of thermal bonded nonwoven geotextiles in this studyto model and predict their stress relaxation behaviors. Four mechanical models, including the standard linear solid mechanicsmodel, Eyring’s model, the modified two-Maxwell-unit model and the modified three-Maxwell-unit model were used topredict stress values for 600 h based on 3 and 90 h experimental relaxation data. Results indicated that Eyring’s model and themodified three-Maxwell-unit model fitted the experimental results better than the other two. Estimation using modified three-Maxwell-unit model seemed to construct an upper bound while that using Eyring’s model form a lower bound for thecorresponding experimental data. In addition, predicted curves were much closer to the experimental curve when equationsof the two models were built with the 90 h experimental data than those data of 3 h. Thus, the prediction capability of the twomodels can be substantially improved by employing the data with longer time. In summary, the combination of the modifiedthree-Maxwell-unit model and Eyring’s model can well forcast the range of actual stress during stress relaxation experimentswith the longer term experimental data.

Combined Let-7a and H19 Signature: A Prognostic Index of Progression-Free Survival in Primary Breast Cancer Patients

Qiannan Guo,Runyao Wen,Bin Shao,Yudong Li,Xin Jin,Heran Deng,Jiannan Wu,Fengxi Su,Fengyan Yu 한국유방암학회 2018 Journal of breast cancer Vol.21 No.2

Purpose: The long non-coding RNA H19, a conservatively imprinted gene, acts as a molecular sponge for the let-7 family, which has been identified as a set of tumor suppressors. However, the combined prognostic value of H19 and let-7a signature in breast cancer patients remains unclear. Methods: In this research we assessed the prognostic value of the combined H19 and let-7a signature in breast cancer patients by retrospectively reviewing that data of 79 patients who underwent neoadjuvant chemotherapy; we also investigated the expression and function of H19 in breast cancer cell lines in vitro. Survival data were calculated using the Kaplan-Meier method and compared using the log-rank test. Univariate and multivariate survival analyses were conducted using the Cox proportional hazards regression method. As determined using X-tile, the optimal cutoff value for the risk score to assess progression-free survival (PFS) based on the combined signature was –0.1. Results: Patients with an overall positive treatment response had higher let-7a and lower H19 levels. In addition, let-7a expression was negatively correlated with H19 expression. Patients with a risk score of >–0.1 had shorter overall survival and PFS. In vitro data showed that chemoresistant cell lines exhibit higher H19 and lower let-7a levels and knockdown H19 restores paclitaxel sensitivity. Conclusion: Our results suggest that the combined let-7a and H19 signature is a novel prognostic factor for breast cancer patients treated with neoadjuvant chemotherapy.

Rheinic acid ameliorates radiation‑induced acute enteritis in rats through PPAR‑γ/NF‑κB

Haixia Sha,Yu Gu,Weixing Shen,Li Zhang,Fei Qian,Yudong Zhao,Haixiao Li,Ting Zhang,Weimin Lu 한국유전학회 2019 Genes & Genomics Vol.41 No.8

Background Acute radiation enteritis (ARE), a common complication of intestinal caused by abdominal and pelvic radiation therapy. Rheinic acid is a major active ingredient derived from Rhubarb. Rhubarb could suppress inflammation, tumor, fibrosis oxidative damage. However, RA as the main active component and extract monomer of Rhubarb, the pharmacological activity and the underlying molecular mechanism on various diseases has not yet been revealed. Objective To determine the potential role of rheinic acid (RA) in ameliorating inflammation of rats with acute radiation enteritis (ARE), and explore the underlying mechanism. Methods ARE rat model was established by irradiated with single-dose 10 Gy X-rays at a rate of 0.62 Gy/min to the abdomen. The rats were executed after orally administered with Rheinic acid 7 days and used in the subsequent experiments. Body weight, fecal characteristics and bloody of rats were used to assess the disease activity index. Histological analysis of the jejunum and colon were evaluated using H&E staining. The pro-inflammatory cytokines levels were measured by immunohistochemistry and ELISA. The levels of nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) were also determined. The mRNA and protein expression were examined by real-time polymerase chain reaction (qRT-PCR) and western blot, respectively. Results Rheinic acid promoted intestinal functional recovery, and ameliorated intestinal damage and bloody stool in ARE rats. Rheinic acid strongly decreased the levels of tumor necrosis factor-α, interleukin-1, interleukin-6, NO, and MDA, whereas increased levels of anti-oxidants, SOD and GSH. Moreover, the expression of apoptosis-related proteins, cleaved caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP), were decreased with RA treatment. Further study indicated that PPAR-γ was activated and thereby NF-κB and p38 MAPK signaling pathway were suppressed after rheinic acid treatment. Conclusion Rheinic acid could ameliorate acute radiation enteritis and the underlying molecular mechanism is, at least partially, through PPAR-γ/NF-κB and p38 MAPK/JNK pathways.