임용 후보자 선정 경쟁시험에 대한 초등 특수교사의 인식 및 개선 요구

정평강,김유리 이화여자대학교 교과교육연구소 2017 교과교육학연구 Vol.21 No.4

본 연구의 목적은 초등 특수교사를 선발하는 임용시험에 대한 초등 특수교사의 인식 및 요구를 알아보고, 이를 토대로 초등 특수교사 임용제도가 역량 있는 특수교사를 선발하는 타당한 절차로 정착되는 데 필요한 기초 자료를 제공하는 데 있다. 이를 위해 임용시험을 통해 국·공립학교에 배치되어 근무하고 있는 초등 특수교사 9명을 대상으로 개별 심층면담을 실시하였으며, 면담자료는 연속적 비교분석법을 이용하여 분석되었다. 분석 결과 임용시험의 타당성, 개선요구라는 대주제 2개가 도출되었으며 대주제별로 하위주제 3개씩 총 6개의 하위주제가 드러났다. 연구결과를 바탕으로 초등 특수교사 임용시험을 개선하기 위한 시사점이 논의되었으며, 이와 함께 후속연구를 위한 제언이 제시되었다. 초등 특수교사의 관점에서 바라본 초등 임용시험에 대한 더 깊은 이해는 앞으로 임용시험 문항의 내용이나 절차, 제도를 개선하는 데 중요한 기초 자료를 제공할 것으로 사료된다 The purpose of the present study was to explore the perceptions of elementary special education teachers on the national teacher exam. In-depth interviews were conducted with each of the 9 elementary special teachers and the interview data were analyzed using the constant comparative method. Two main themes and 6 sub-themes emerged from the data analysis. Based on the findings, practical implications on how to improve the national teacher exam are discussed and future areas for research are suggested. A better understanding of the teacher exam based on perspectives of elementary special teachers seems to provide essential basic information that assists the improvement of its process and systems.

미니 임플란트 직경에 따른 피로파절강도의 비교 연구

허유리,손미경,김희중,최한철,정재헌 大韓齒科補綴學會 2012 대한치과보철학회지 Vol.50 No.3

Purpose: This study was conducted to obtain difference in fracture strength according to the diameter of one-body O-ring-type of mini implant fixture, to determine the resistance of mini implant to masticatory pressure, and to examine whether overdenture using O-ring type mini implant is clinically usable to maxillary and mandibular edentulous patients. Materials and methods: For this study, 13 mm long one body O-ring-type mini implants of different diameters (2.0 mm, 2.5 mm and 3.0 mm) (Dentis, Daegu, Korea) were prepared, 5 for each diameter. The sample was placed at 30 from the horizontal surface on the universal testing machine, and off-axis loading was applied until permanent deformation occurred and the load was taken as maximum compressive strength. The mean value of the 5 samples was calculated, and the compressive strength of implant fixture was compared according to diameter. In addition, we prepared 3 samples for each diameter, and applied loading equal to 80%, 60% and 40% of the compressive strength until fracture occurred. Then, we measured the cycle number on fracture and analyzed fatigue fracture for each diameter. Additionally, we measured the cycle number on fracture that occurred when a load of 43 N, which is the average masticatory force of complete denture, was applied. The difference on compressive strength between each group was tested statistically using one-way ANOVA test. Results: Compressive strength according to the diameter of mini implant was 101.5 ± 14.6 N, 149 ± 6.1 N and 276.0 ± 13.4 N, respectively, for diameters 2.0 mm, 2.5 mm and 3.0 mm. In the results of fatigue fracture test at 43 N, fracture did not occur until 2×106 cycles at diameter 2.0 mm, and until 5×106 cycles at 2.5 mm and 3.0 mm. Conclusion: Compressive strength increased significantly with increasing diameter of mini implant. In the results of fatigue fracture test conducted under the average masticatory force of complete denture, fracture did not occur at any of the three diameters. All of the three diameters are usable for supporting overdenture in maxillary and mandibular edentulous patients, but considering that the highest masticatory force of complete denture is 157 N, caution should be used in case diameter 2.0 mm or 2.5 mm is used. 연구 목적: 일체형의 o-ring type 미니 임플란트 고정체의 직경에 따른 파절강도의 차이를 비교하고자 한다. 연구 재료 및 방법: 길이 13 mm의 one body o-ring type의 미니 임플란트(Dentis, Daegu, Korea)를 직경2.0, 2.5, 3.0 mm 각각 5개씩 준비하였다. Instron universal testing machine 에 수직면에서 30도 각도로 샘플을 위치시키고 off-axis loading을 가하여 영구변형이 일어난 하중 값을 파절강도로 하고 5개의 시편의 평균을 구하여 각 직경에 따른 임플란트의 고정체의 파절강도를 비교하였다. 또한, 각 직경마다 3개의 시편을 준비하고 동적하중 피로 시험기를 이용하여, 파절이 발생할 때까지 파절강도의 80%, 60%, 40%의 loading 을 가하여 파절되는 cycle수를 측정하여 각 직경의 피로 파절을 분석하였다. 추가적으로 총의치의 평균 저작력인 43 N의 하중을 가하여 파절되는 cycle 수를 측정하였다. 각 군간의 차이를 검증하기 위해서 일원분산분석(one-way ANOVA test)을 시행하였고, 통계처리는 SPSS ver.12 (SPSS Inc. Chicago, IL, USA) 을 이용하여 실시하였다. 결과: 직경 3.0 mm 의 미니 임플란트는 평균 276.0 ± 13.4 N의 압축력을 받았을 때 영구 변형이 일어났고 직경 2.5 mm 미니 임플란트가 149.0 ± 6.1 N, 2.0 mm 미니 임플란트가 101.5 ± 14.6 N일 때 영구 변형이 일어났다. 각 군간의 파절강도에는 유의한 차이가 있었다(P<.001). 총의치의 평균 저작력 하중에서 실시한 피로 파절 실험 결과, 세직경 모두 5×106 cycle까지 파절이 일어나지 않았다. 결론: 미니 임플란트의 정적 하중 하에서 최대 압축강도는 직경이 증가할수록 유의적으로 증가하였다. 최대 압축강도는 세 직경 모두 총의치의 평균 저작력 보다는 크나 최대 교합력보다는 직경 3.0 mm에서만 크게 나타났다. 총의치의 평균 저작력 하중에서 실시한 피로 파절 실험 결과, 세 직경 모두 파절이 일어나지 않았다.

가변적층쾌속조형시스템에 대한 연구

정동원,한유리,고형훈 제주대학교 공과대학 첨단기술연구소 2005 尖端技術硏究所論文集 Vol.16 No.1

Today, product a model is diversified according to consumer various request, and product development period and beginning period and cost saving are urgently required. High speed modeling system can serve to reduce expense and time. That is required in product development that product arrived from design to prototype production to cope effectively with a market's request. In this paper, studied to supplement problems to use VLM-ST to solve problem of modeling time of long hours, high price's device induction and preservation etc. that is problem of that do existent rapid prototyping system.

운동에 의한 뇌 활성과 인지기능에 대한 고찰

김경애,정유진,안나리,장혁기 서울여자대학교 자연과학연구소 2013 자연과학연구논문집 Vol.25 No.-

We reviewed literatures on human brain activity on exercise. It was proved that exercise activate brain function through various equipments. Among methods to evaluate brain activation, there are Electroencephalography (EEG), Magnetoencephalography (MEG), transcranial doppler sonography (TCD), Magnetic resonance imaging (MRI), Near Infrared Spectroscopy (NIRS) methods. There were different characteries in each measurement methods to demonstrate exercise effects. NIRS is a spectroscopic method that uses the near infrared region of the electromagnetic spectrum. According to using brain scanning equipments involved NIRS, moderate exercise increased frontal lobe (specially prefrontal cortex) and improves cognitive performance. This review will be discussed about brain activation and cognitive functions.

Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells

Jung, Yu Ri,Kim, Eun Ju,Choi, Hyeong Jwa,Park, Jung-Jin,Kim, Hak-Su,Lee, Yoon-Jin,Park, Myung-Jin,Lee, Minyoung American Society for Pharmacology and Experimental 2015 Molecular pharmacology Vol.88 No.4

<P>Cancer therapies attempt to destroy the entire tumor, but this tends to require toxic compounds and high doses of radiation. Recently, considerable attention has focused on therapy-induced senescence (TIS), which can be induced in cancer cells by low doses of therapeutic drugs or radiation and provides a barrier to tumor development. However, the molecular mechanisms governing TIS remain elusive. Special attention has been paid to the potential chemopreventive effect of aspirin against human colorectal cancer. In this study, we investigated the effects of aspirin on TIS of human colorectal carcinoma (CRC) cells and show that it occurs via sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK), two key regulators of cellular metabolism. Aspirin increased the senescence of CRC cells, increased the protein levels of SIRT1, phospho-AMPK (T172), and phospho-acetyl CoA carboxylase (S79), and reduced the cellular level of ATP. Small-interfering RNA–mediated downregulation or pharmacological inhibition of SIRT1 or AMPK significantly attenuated the aspirin-induced cellular senescence in CRC cells. In contrast, treatment with a SIRT1 agonist or an AMP analog induced cellular senescence. Remarkably, SIRT1 knockdown abrogated the aspirin-induced activation of AMPK, and vice versa. During the progression of aspirin-induced cellular senescence in CRC cells, SIRT1 showed increased deacetylase activity at a relatively early time point but was characterized by decreased activity with increased cytoplasmic localization at a later time point. Collectively, these novel findings suggest that aspirin could provide anticancer effects by inducing senescence in human CRC cells through the reciprocal regulation of SIRT1-AMPK pathways.</P>

Identification of time-dependent biomarkers by EndoTox Array in cells exposed to nonylphenol

Yu Ri An,So-Yeon Yu,Seung Jun Kim,Jung-Mi Ha,Jong-Phil Youn,Jun-Sub Kim,Moon-Ju Oh,Jung-Hwa Oh,류재천,Seok Joo Yoon,Jaehoon Jo,황승용 대한독성 유전단백체 학회 2011 Molecular & cellular toxicology Vol.7 No.4

Nonylphenol (NP) is considered an endocrine disruptor due to its weak ability to mimic estrogen and in turn disrupt the natural balance of hormones in affected organisms. NP is reported to cause negative health effects in humans, such as hormone abnormalities and inhibition of growth and reproduction. In the present study, we developed a molecular tool for the evaluation of endocrine toxicity in mouse. To identify gene regulation effects of NP, we estimated gene expression in mouse Sertoli (TM4) and germ cell (GC)lines after exposure to NP. We measured the IC30 value of NP, then exposed the cells to that concentration for 3 hr and 24 hr and used EndoTox Array. The EndoTox Array was manufactured to monitor the endotoxicity of environmental chemicals. This array contains 1306genes that are influenced in reproductive toxicity or by EDCs. In the expression pattern analysis, 28 genes related to the reproductive process, cell proliferation,and nervous system development were progressively changed over time in NP-exposed cells. The study of gene interaction will increase our understanding of the time-dependent molecular mechanisms of NP.

New-onset of palmoplantar pustulosis while on adalimumab treatment for ankylosing spondylitis

( Yu Na Lee ),( Ho Jung Jung ),( Yu Ri Kim ),( Jae Wook Jung ),( Hyun Jung Park ),( Hyung Jin Hahn ),( Young Ji Hwang ),( Ji Young Kim ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.1

Inhibitory Effect of 1-O-Hexyl-2,3,5-Trimethylhydroquinone on Dimethylnitrosamine-induced Liver Fibrosis in Male SD Rats

Jung, Yu-Ri,Lee, Young-Jung,Lee, Nam-Jin,Lin, Chun-Mai,Moon, Jun-Hawn,Chai, Hee-Yul,Kang, Jong-Koo Korean Society of ToxicologyKorea Environmental Mu 2010 Toxicological Research Vol.27 No.3

Hepatic fibrosis represents the main complication of most chronic liver disorders and, regardless of its etiology, is characterized by excessive deposition of extracellular matrix components. In this study, we examined that 1-O-Hexyl-2,3,5-Trimethylhydroquinone (HTHQ), a potent anti-oxidative agent, could prevent experimental hepatic fibrosis induced by dimethylnitrosamine (DMN) in male SD rats. Except for vehicle control group, other groups were induced hepatic fibrosis by intraperitoneal injection with DMN (10 mg/ml/kg) on 3 consecutive days weekly for 4 weeks. During the same 4 weeks, control and DMN groups were given vehicle and HTHQ 50, 100 and 200 groups were orally administered HTHQ (50, 100, 200 mg/kg respectively). In HTHQ 100 and 200 groups, relative liver weight and serum chemistry level improved significantly. HTHQ reduced hydroxyproline (p < 0.05) and malondialdehyde (p < 0.05) level in the liver. Histopathological examination of H&E, Masson's trichrome stain showed the reduced fibrotic septa in HTHQ 100 and 200 groups. HTHQ administration showed reduced mRNA level of PDGF (Platelet-derived growth factor), $\alpha$-SMA ($\alpha$-smooth muscle actin) and TGF-$\beta$ (transforming growth factor-$\beta$) than DMN-induced hepetic fibrosis animals in the liver tissue. In this study, we showed that HTHQ improves against DMN-induced liver fibrosis in male SD rats.

Inhibitory Effect of 1-O-Hexyl-2,3,5-Trimethylhydroquinone on Dimethylnitrosamine-induced Liver Fibrosis in Male SD Rats

Yu-Ri Jung,Young-Jung Lee,Nam-Jin Lee,Chun-Mai Lin,Jun-Hawn Moon,Hee-Yul Chai,Jong-Koo Kang 한국독성학회 2010 Toxicological Research Vol.26 No.3

Hepatic fibrosis represents the main complication of most chronic liver disorders and, regardless of its etiology, is characterized by excessive deposition of extracellular matrix components. In this study, we examined that 1-O-Hexyl-2,3,5-Trimethylhydroquinone (HTHQ), a potent anti-oxidative agent, could prevent experimental hepatic fibrosis induced by dimethylnitrosamine (DMN) in male SD rats. Except for vehicle control group, other groups were induced hepatic fibrosis by intraperitoneal injection with DMN (10 ㎎/㎖/㎏) on 3 consecutive days weekly for 4 weeks. During the same 4 weeks, control and DMN groups were given vehicle and HTHQ 50, 100 and 200 groups were orally administered HTHQ (50, 100, 200 ㎎/㎏ respectively). In HTHQ 100 and 200 groups, relative liver weight and serum chemistry level improved significantly. HTHQ reduced hydroxyproline (p<0.05) and malondialdehyde (p<0.05) level in the liver. Histopathological examination of H&E, Masson’s trichrome stain showed the reduced fibrotic septa in HTHQ 100 and 200 groups. HTHQ administration showed reduced mRNA level of PDGF (Plateletderived growth factor), α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β) than DMN-induced hepetic fibrosis animals in the liver tissue. In this study, we showed that HTHQ improves against DMN-induced liver fibrosis in male SD rats.

Is the adefovir plus entecavir combination therapy superior than adefovir plus lamivudine in patients with antiviral resistant chronic hepatitis B?

( Yu Ri Cho ),( Dong Hyeon Lee ),( Jeong Hoon Lee ),( Su Jong Yu ),( Jung Hwan Yoon ),( Hyo Suk Lee ),( Yoon Jun Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1

Background: Antiviral resistance is a major challenge for the treatments that are currently available for hepatitis B virus. However, the efficacy of adefovir (ADV) and entecavir (ETV) combination therapy in patients who developed antiviral resistance was not fully evaluated. In this study, we aimed to evaluate the efficacy of ADV and ETV combination therapy as compared to the efficacy of LAM and ADV in patients with antiviral resistant chronic hepatitis B (CHB). Methods: Antiviral resistance was defined as follows: persistently detectable HBV DNA after 36 weeks after LAM or ADV therapy ; virological breakthrough with previous LAM or ADV therapy ; or documented LAM or ADV-resistant mutations. We assessed 90 patients with antiviral resistant CHB. Of these, 27 patients were treated with a combination of ADV+ETV and 63 patients were treated with a combination of LAM+ADV. The virological and biochemical parameters were compared between the two groups at 3, 6, 9 and 12 months, respectively. Results: Treatment with a combination of ADV+ETV resulted significant difference in virological response compared to that in the LAM+ADV group through 12 months (p=0.001). At 12 months, the HBV DNA declined more in the ADV+ETV group than that in the LAM+ADV group (-4.52±1.956 vs. -2.65±1.723 log10IU/ml; p=0.001). The rate of a virological non-response, which is defined as <1 log10IU/ml reduction in HBV DNA concentration at 3 months was significantly greater in the LAM+ADV group than that in the ADV+ETV group (26.78% vs. 7.40%, p=0.022). Also, the rate of a virological complete response at 12 months was greater in the ADV+ETV group than that in the LAM+ADV group (73.68% vs. 31.48%, p=0.005). In the multivariate analysis, parameters related to a virological response at Month 12 were the baseline HBV DNA level [OR, 0.403 ; p=0.004] and virological non-response at Month 3 [OR, 0.102 ; p=0.028]. Conclusion: In patients with antiviral resistant CHB, the response to ADV+ETV was significantly superior compared to that of the LAM+ADV group for suppressing HBV DNA through 12 months. The result indicates that ADV+ETV should be used in the patients antiviral resistant CHB, especially in the area where tenofovir is not available.