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Chung, Hyewon,Yu, Kyung-Sang,Hong, Kyung Taek,Choi, Jung Yoon,Hong, Che Ry,Kang, Hyoung Jin,Park, Kyung Duk,Shin, Hee Young,Lee, SeungHwan Raven Press 2017 Therapeutic drug monitoring Vol.39 No.3
<P>Busulfan is a cytotoxic agent used in preconditioning for hematopoietic stem cell transplantation. Therapeutic drug monitoring of busulfan is necessary owing to its narrow therapeutic range. Patients undergoing preconditioning are susceptible to infection and might require coadministration of antibiotics. We present a case study of a 3-year-old girl with precursor T-cell acute lymphoblastic leukemia who received intravenous busulfan before hematopoietic stem cell transplantation. Metronidazole was coadministered before the third dose of busulfan because of Clostridium difficile infection. The daily pharmacokinetic analysis revealed that the clearance reduced to 57% of that before the coadministration. Although the underlying mechanism is unclear, a significant pharmacokinetic interaction was observed between busulfan and metronidazole, underscoring the importance of therapeutic drug monitoring.</P>
Chung-Che Chou,Gee‑Jin Yu,Kung‑Juin Wang,Wei‑Tze Chang,Chiun‑Lin Wu,Charlene Chin‑Jie Zhao,Chun‑Yao Yang,Ming‑Ti Chou 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.9
This paper presents a study to investigate the feasibility of using robotic welding technologies to weld the continuity plate and the column flange plate during manufacturing steel built-up box columns in buildings. Specimens designed to emulate the key components in the steel beam-to-column moment connections for Special moment frame were fabricated and welded using a proposed automated procedure that performs multi-layer, multi-pass welding for thick steel plates. Effects of controlling parameters on robotic welding results that includes the manner of bead stacking, wire feed speed, travel speed, working angle, arc voltage, the path of the welding pass, and the methods to start and finish welding passes were investigated. The quality of the welded products was assessed by visual inspection and ultrasonic testing (UT). Further mechanical tests including tensile tests, bending tests, and cyclic loading tests were carried out on selected welded products that passed the UT examination. The test results indicated that the robotic welds showed no visible damage or cracks, met requirements specified in the AWS specification, and exhibited satisfactory strength and ductility.
Kun-Che Ho,Cheng-Chung Lin,F. Selin Bagci,Shun-Chung Wang,Yi-Hua Liu,Yu-Shan Cheng 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
In this study, three swarm intelligence (SI)-based maximum power point tracking (MPPT) techniques for photovoltaic generation systems (PGSs) operating under partially shaded conditions (PSCs) are investigated. The compared methods include particle swarm optimization (PSO), firefly algorithm (FA) and cuckoo search (CS). Simulated results for 252 different shading patterns will be provided and some conclusion will be made. This study presents reference information for scholars planning to carry out research in this field.
Hou Ming-Feng,Ou-Yang Fu,Li Chung-Liang,Chen Fang-Ming,Chuang Chieh-Han,Kan Jung-Yu,Wu Cheng-Che,Shih Shen-Liang,Shiau Jun-Ping,Kao Li-Chun,Kao Chieh-Ni,Lee Yi-Chen,Moi Sin-Hua,Yeh Yao-Tsung,Cheng Chi 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
In Western countries, breast cancer tends to occur in older postmenopausal women. However, in Asian countries, the proportion of younger premenopausal breast cancer patients is increasing. Increasing evidence suggests that the gut microbiota plays a critical role in breast cancer. However, studies on the gut microbiota in the context of breast cancer have mainly focused on postmenopausal breast cancer. Little is known about the gut microbiota in the context of premenopausal breast cancer. This study aimed to comprehensively explore the gut microbial profiles, diagnostic value, and functional pathways in premenopausal breast cancer patients. Here, we analyzed 267 breast cancer patients with different menopausal statuses and age-matched female controls. The α-diversity was significantly reduced in premenopausal breast cancer patients, and the β-diversity differed significantly between breast cancer patients and controls. By performing multiple analyses and classification, 14 microbial markers were identified in the different menopausal statuses of breast cancer. Bacteroides fragilis was specifically found in young women of premenopausal statuses and Klebsiella pneumoniae in older women of postmenopausal statuses. In addition, menopausal-specific microbial markers could exhibit excellent discriminatory ability in distinguishing breast cancer patients from controls. Finally, the functional pathways differed between breast cancer patients and controls. Our findings provide the first evidence that the gut microbiota in premenopausal breast cancer patients differs from that in postmenopausal breast cancer patients and shed light on menopausal-specific microbial markers for diagnosis and investigation, ultimately providing a noninvasive approach for breast cancer detection and a novel strategy for preventing premenopausal breast cancer.
A longitudinal analysis with CA-125 to predict overall survival in patients with ovarian cancer
An Jen Chiang,Jiabin Chen,Yu-Che Chung,Huan-Jung Huang,Wen Shiung Liou,Chung Chang 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.1
Objective: The objective of this study was to explore the association of longitudinal CA-125 measurements with overall survival (OS) time by developing a flexible model for patient-specific CA-125 profiles, and to provide a simple and reliable prediction of OS. Methods: A retrospective study was performed on 275 patients with ovarian cancer who underwent at least one cycle of primary chemotherapy in our institute. Serial measurements of patients’ CA-125 levels were performed at different frequencies according to their clinical plans. A statistical model coupling the Cox proportional hazards and the mixed-effects models was applied to determine the association of OS with patient-specific longitudinal CA-125 values. Stage and residual tumor size were additional variables included in the analysis. Results: A total of 1,601 values of CA-125 were included. Longitudinal CA-125 levels, stage, and the residual tumor size were all significantly associated with OS. A patient-specific survival probability could be calculated. Validation showed that, in average, 85.4% patients were correctly predicted to have a high or low risk of death at a given time point. Comparison with a traditional model using CA-125 half-life and time to reach CA-125 nadir showed that the longitudinal CA-125 model had an improved predicative value. Conclusion: Longitudinal CA-125 values, measured from the diagnosis of ovarian cancer to the completion of primary chemotherapy, could be used to reliably predict OS after adjusting for the stage and residual tumor disease. This model could be potentially useful in clinical counseling of patients with ovarian cancer.
과학기술지식정보서비스의 보건의료 분야 연구· 개발과제: 분포와 연구비용 비중 분석
고영곤 ( Younggon Goh ),정태영 ( Taeyoung Jung ),정혜주 ( Haejoo Chung ),차선화 ( Xianhua Che ),유사라 ( Sarah Yu ),조민진 ( Minjin Jo ),차수진 ( Sujin Cha ),문다슬 ( Daseul Moon ),서지영 ( Jiyoung Suh ),조규진 ( Kujin Cho ) 한국보건행정학회 2015 보건행정학회지 Vol.25 No.2
With the growth of aging population in Korea, a better care of chronic and other degenerative illnesses is urgently needed. Evidences suggest that this can be achieved through incorporating a wide range of care options, expanding beyond medical interventions. The aim of this study is to analyze the distribution of publically funded research to understand if the Korean research and development funding system matches various approaches and purposes to successfully tackle the chronic care needs of an aging society. We complied the list of funded projects to be analyzed by searching the National Technical Information Service database with key words such as aging society/senescence, chronic diseases, disability, and health promotion. Most projects were based on the biomedical approach with the purpose of establishing the etiology and clinical (treatment) interventions. Health promotion projects showed a distinctive distribution with more percentage of projects based on psycho-behavioral approaches while research on chronic diseases predominantly biomedical. It would be necessary to diversify publically-funded research projects to develop effective and efficient care technologies for the future.