Effect of Country Distance on E-commerce Export: Focusing on the Moderating Effect of Entrepreneurship

Yi Chen Wang,Tae Hee Lee,Moon Gyu Bae,Keon Hee Lee 한국무역학회 2021 Journal of Korea trade Vol.25 No.4

Purpose - This study examines the role of e-commerce resulting from technological innovation as a new approach toward internationalization. We study the relationship between e-commerce export and country distance, measured in CAGE distance, which has hindered traditional internationalization. As a control variable, entrepreneurship was introduced to check the moderating effect on the relationship between country distance and e-commerce export. Design/methodology - Based on empirical analysis, e-commerce exports from the Republic of Korea to 96 countries were used as dependent variables. First, hierarchical regression analysis was conducted to test the hypothesis about each country s distance, measured by CAGE distance, and each dimension of CAGE, on e-commerce exports. Next, the hypothesis was tested through the interaction term to examine the moderating effect of entrepreneurship. Findings - The analysis showed that the hypothesis, which postulated e-commerce exports as affected negatively by the country s distance, was supported but not that all CAGE dimensions affected it. Specifically, geographical distance and economic distance have negative effects, but cultural distance and administrative distance did not affect e-commerce exports. Thus, in contrast to the expectation that distance restrictions in e-commerce would not exist, this study confirmed that distance still matters to internationalization and that entrepreneurship can mitigate the adverse effects. Originality/value - Through these results, when export firms try to enter new markets and start internationalization through e-commerce, the entrepreneurship of the importing country should be considered.

5-Lipoxygenase mediates RANKL-induced osteoclast formation via the cysteinyl leukotriene receptor 1.

Lee, Jung-Min,Park, Hyojung,Noh, A Long Sae Mi,Kang, Ju-Hee,Chen, Ling,Zheng, Ting,Lee, Juhyun,Ji, Sun-Young,Jang, Chang-Young,Shin, Chan Soo,Ha, Hyunil,Lee, Zang Hee,Park, Hea-Young,Lee, Dong-Seok,Yi American Association of Immunologists 2012 Journal of Immunology Vol. No.

<P>5-Lipoxygenase (5-LO) catalyzes the formation of two major groups of leukotrienes, leukotriene B4 and cysteinyl leukotrienes (CysLTs), and it has been implicated as a promising drug target to treat various inflammatory diseases. However, its role in osteoclastogenesis has not been investigated. In this study, we used mouse bone marrow-derived macrophages (BMMs) to show that 5-LO inhibitor suppresses RANKL-induced osteoclast formation. Inhibition of 5-LO was associated with impaired activation of multiple signaling events downstream of RANK, including ERK and p38 phosphorylation, and IκB degradation, followed by a decrease in NFATc1 expression. Ectopic overexpression of a constitutively active form of NFATc1 partly rescued the antiosteoclastogenic effect of 5-LO inhibitor. The knockdown of 5-LO in BMMs also resulted in a significant reduction in RANKL-induced osteoclast formation, accompanied by decreased expression of NFATc1. Similar effects were shown with CysLT receptor (CysLTR)1/2 antagonist and small RNA for CysLTR1 in BMMs, indicating the involvement of CysLT and CysLTR1 in 5-LO-mediated osteoclastogenesis. Finally, 5-LO inhibitor suppressed LPS-induced osteoclast formation and bone loss in the in vivo mouse experiments, suggesting a potential therapeutic strategy for treating diseases involving bone destruction. Taken together, the results of this study demonstrate that 5-LO is a key mediator of RANKL-induced osteoclast formation and possibly a novel therapeutic target for bone-resorption diseases.</P>

Enhanced Performance of Solution‐Processed TESPE‐ADT Thin‐Film Transistors

Chen, Liang‐,Hsiang,Hu, Tarng‐,Shiang,Huang, Peng‐,Yi,Kim, Choongik,Yang, Ching‐,Hao,Wang, Juin‐,Jie,Yan, Jing‐,Yi,Ho, Jia‐,Chong,Lee, Cheng‐,Chung,Chen WILEY‐VCH Verlag 2013 Chemphyschem Vol.14 No.12

<P><B>Abstract</B></P><P>A solution‐processed anthradithiophene derivative, 5,11‐bis(4‐triethylsilylphenylethynyl)anthradithiophene (TESPE‐ADT), is studied for use as the semiconducting material in thin‐film transistors (TFTs). To enhance the electrical performance of the devices, two different kinds of solution processing (spin‐coating and drop‐casting) on various gate dielectrics as well as additional post‐treatment are employed on thin films of TESPE‐ADT, and <I>p</I>‐channel OTFT transport with hole mobilities as high as ∼0.12 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP> are achieved. The film morphologies and formed microstructures of the semiconductor films are characterized in terms of film processing conditions and are correlated with variations in device performance.</P>

Scalar Dyon Production In Near Extremal Kerr-Newman Black Holes

Chen, Chiang-Mei,Kim, Sang Pyo,Sun, Jia-Rui,Tang, Fu-Yi,Gwak, B.,Kang, G.,Kim, C.,Kim, H.-C.,Lee, C.-H.,Lee, J.,Lee, S.,Lee, W. EDP Sciences 2018 The European Physical Journal Conferences Vol.168 No.-

<P>The pair production of charged scalar dyons is analytically studied in near-extremal Kerr-Newman (KN) dyonic black holes. The pair production rate and its thermal interpretation are given. Moreover, the absorption cross section ratio has been compared with the two-point function of the conformal field theories (CFTs) holographically dual to the near horizon geometry, namely warped AdS3, of the near extremal Kerr-Newman black holes to verify the threefold dyonic KN/CFTs correspondence.</P>

HOW DOES BRAND-SPECIFIC LEADERSHIP INFLUENCE ON EMPLOYEE-BASED BRAND EQUITY?

Yi-Hsuan Lee,Chan Hsiao,Hsin-Yi Chan,I-Chen Lee 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07

Brand equity (BE) previously focused on consumers’ perceptions under brand marketing stimuli, they often used financial performance indicators for evaluating brand value (Aaker,1996;Keller,1993). However the primary stakeholders of a service brand are employees (Brexendorf & Kernstock,2007).Thus, the enhancement of employee- based BE could be an important topic for in-depth investigation in the fields of brand and internal marketing. Morhart (2009) was the first to introduce the concepts of brand-specific transformational leadership (TFL) and brand-specific transactional leadership (TRL) based on employees’ brand-building behavior. Theory asserts that leaders should endeavor to influence employees through the internalization of brand values and a brand-based role (Morehart,2001) . In the process of brand internalization, leaders with brand experience and brand knowledge should also uphold and constantly reaffirm brand values because they're more capable than ordinary leaders to clearly convey brand values (Hoffman,1999). For this reason, brand-specific leadership based on employee brand-building behaviors is the focus of this study. This study adopts hierarchical linear modeling for individual and organizational-level analyses. This research to investigate (1)whether TFL and TRL have directly affect employee-based individual-level BE.(2)whether TFL and TRL have indirectly affect employee-based BE as an individual-level mediator.(3)how managers use brand-specific leadership to elicit employees’ perceived brand value congruence for improved employee-based BE.

Apple Polyphenol Suppresses Indomethacin-Induced Gastric Damage in Experimental Animals by Lowering Oxidative Stress Status and Modulating the MAPK Signaling Pathway

Yi-Chen Lee,Chun-Wen Cheng,Huei-Jane Lee,Huei-Chuien Chu 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.11

Indomethacin is a nonsteroid anti-inflammatory drug (NSAID) that is used to alleviate pain and inflammation in clinical medicine. Previous studies indicated that NSAIDs can cause gastrointestinal mucosal complications, and it is associated with mucosal lipid peroxidation and oxidative damage. Based on the evidences, decreasing oxidative stress may be an ideal therapeutic strategy for preventing gastrointestinal ulcer. Apple (Rosaceae Malus sp.) is one of the most commonly consumed fruits worldwide. The abundant polyphenolic constituents have received increasing attention for decades. In both in vivo and in vitro studies, the reports showed that apple polyphenol (AP) seems to provide an indirect antioxidant protection by activating cellular antioxidant enzymes to defend against oxidative stress. To address this issue and develop AP into a healthy improvement supplement, we studied the effect and potential mechanisms of AP in indomethacin-treated animal. The results showed AP can decelerate the gastric lesion, significantly suppress lipid peroxidation, increase the level of glutathione and the activity of catalase, and regulate the MAPK signaling proteins. These findings imply that AP protects the gastric mucosa from indomethacin-caused lesions and the protection is at least partially attributable to its antioxidative properties. This alternative medical function of AP may be a safe and effective intervention for preventing indomethacin-induced gastric complications.

Porous Two-Dimensional Monolayer Metal–Organic Framework Material and Its Use for the Size-Selective Separation of Nanoparticles

Jiang, Yi,Ryu, Gyeong Hee,Joo, Se Hun,Chen, Xiong,Lee, Sun Hwa,Chen, Xianjue,Huang, Ming,Wu, Xiaozhong,Luo, Da,Huang, Yuan,Lee, Jeong Hyeon,Wang, Bin,Zhang, Xu,Kwak, Sang Kyu,Lee, Zonghoon,Ruoff, Rodn American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.33

<P>Rational bottorritup construction of two-dimensional (2D) covalent or nonCovalent organic materials with precise structural control at the: atomic or molecular level remains a challenge. The design and synthesis of metal organic frameworks (MOFS) based on new building blocks is of great significance in achieving new types of 2D monolayer MOF films. Here, we demonstrate that a complexation between copper(II) ions and tri(beta-diketone) ligands yields a novel 2D MOF siyucture, either-inthe form of a powder.or.as a monolayer filth. It has been Characterized by Fourier transform infrared, Raman, ultraviolet-visible, X-ray photoelectron, and electron paramagnetic-resonance spectroscopies. Selected area electron diffraction and powder X-ray diffraction results show that the MOF is Crystalline and has a hexagonal structure. A MOF-based membrane has been prepared by vacuum filtration of an aqueous dispersion of the MOF powder onto a porous Anodisc filter having pore-size 0.02 mu m. The porous MOF membrane filters gold nanOparticies with a cutoff of similar to 2.4 nm.</P>

Morphological Responses of Grapevine Root to Copper Stress Given Different Calcium Nutritional Levels

Pei-Yi Chen,Kai-Wei Juang,Bo-Ching Chen,Yung-I Lee 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Enhancement of Aggregation-Induced Emission in Dye-Encapsulating Polymeric Micelles for Bioimaging

Wu, Wen-Chung,Chen, Ching-Yi,Tian, Yanqing,Jang, Sei-Hum,Hong, Yuning,Liu, Yang,Hu, Rongrong,Tang, Ben Zhong,Lee, Yi-Ting,Chen, Chin-Ti,Chen, Wen-Chang,Jen, Alex K.-Y. WILEY-VCH Verlag 2010 Advanced Functional Materials Vol.20 No.9

<P>Three amphiphilic block copolymers are employed to form polymeric micelles and function as nanocarriers to disperse hydrophobic aggregation-induced emission (AIE) dyes, 1,1,2,3,4,5-hexaphenylsilole (HPS) and/or bis(4-(N-(1-naphthyl) phenylamino)-phenyl)fumaronitrile (NPAFN), into aqueous solution for biological studies. Compared to their virtually non-emissive properties in organic solutions, the fluorescence intensity of these AIE dyes has increased significantly due to the spatial confinement that restricts intramolecular rotation of these dyes and their better compatibility in the hydrophobic core of polymeric micelles. The effect of the chemical structure of micelle cores on the photophysical properties of AIE dyes are investigated, and the fluorescence resonance energy transfer (FRET) from the green-emitting donor (HPS) to the red-emitting acceptor (NPAFN) is explored by co-encapsulating this FRET pair in the same micelle core. The highest fluorescence quantum yield (∼62%) could be achieved by encapsulating HPS aggregates in the micelles. Efficient energy transfer (>99%) and high amplification of emission (as high as 8 times) from the NPAFN acceptor could also be achieved by spatially confining the HPS/NPAFN FRET pair in the hydrophobic core of polymeric micelles. These micelles could be successfully internalized into the RAW 264.7 cells to demonstrate high-quality fluorescent images and cell viability due to improved quantum yield and reduced cytotoxicity.</P> <B>Graphic Abstract</B> <P>Highly efficient fluorescence probes are achieved through the encapsulation of aggregation-induced emission molecules, 1,1,2,3,4,5-hexaphenylsilole (HPS) and/or bis(4-(N-(1-naphthyl) phenylamino)-phenyl)fumaronitrile (NPAFN) in the core of polymeric micelles. Bright fluorescence cell images are shown with tunable colors of green directly from HPS aggregates and red through efficient fluorescence resonance energy transfer (FRET) from HPS aggregates to NPAFN aggregates. <img src='wiley_img_2010/1616301X-2010-20-9-ADFM200902043-content.gif' alt='wiley_img_2010/1616301X-2010-20-9-ADFM200902043-content'> </P>

The tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells

Chun-Yu Liu,Tzu-Ting Huang,Pei-Yi Chu,Chun-Teng Huang,Chia-Han Lee,Wan-Lun Wang,Ka-Yi Lau,Wen-Chun Tsai,Tzu-I Chao,Jung-Chen Su,Ming-Huang Chen,Chung-Wai Shiau,Ling-Ming Tseng,Kuen-Feng Chen 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

Triple-negative breast cancer (TNBC) remains difficult to treat and urgently needs new therapeutic options. Nintedanib, a multikinase inhibitor, has exhibited efficacy in early clinical trials for HER2-negative breast cancer. In this study, we examined a new molecular mechanism of nintedanib in TNBC. The results demonstrated that nintedanib enhanced TNBC cell apoptosis, which was accompanied by a reduction of p-STAT3 and its downstream proteins. STAT3 overexpression suppressed nintedanib-mediated apoptosis and further increased the activity of purified SHP-1 protein. Moreover, treatment with either a specific inhibitor of SHP-1 or SHP-1-targeted siRNA reduced the apoptotic effects of nintedanib, which validates the role of SHP-1 in nintedanib-mediated apoptosis. Furthermore, nintedanib-induced apoptosis was attenuated in TNBC cells expressing SHP-1 mutants with constantly open conformations, suggesting that the autoinhibitory mechanism of SHP-1 attenuated the effects of nintedanib. Importantly, nintedanib significantly inhibited tumor growth via the SHP-1/p-STAT3 pathway. Clinically, SHP-1 levels were downregulated, whereas p-STAT3 was upregulated in tumor tissues, and SHP-1 transcripts were associated with improved disease-free survival in TNBC patients. Our findings revealed that nintedanib induces TNBC apoptosis by acting as a SHP-1 agonist, suggesting that targeting STAT3 by enhancing SHP-1 expression could be a viable therapeutic strategy against TNBC.