Effects of near-fault loading and lateral bracing on the behavior of RBS moment connections

Qi-Song “Kent” Yu,Chia-Ming Uang 국제구조공학회 2001 Steel and Composite Structures, An International J Vol.1 No.1

An experimental study was conducted to evaluate the effects of loading sequence and lateral bracing on the behavior of reduced beam section (RBS) steel moment frame connections. Four full-scale moment connections were cyclically tested-two with a standard loading history and the other two with a near-fault loading history. All specimens reached at least 0.03 radian of plastic rotation without brittle fracture of the beam flange groove welds. Two specimens tested with the nearfault loading protocol reached at least 0.05 radian of plastic rotation, and both experienced smaller buckling amplitudes at comparable drift levels. Energy dissipation capacities were insensitive to the types of loading protocol used. Adding a lateral bracing near the RBS region produced a higher plastic rotation; the strength degradation and buckling amplitude were reduced. A non-linear finite element analysis of a one-and-a-half-bay beam-column subassembly was also conducted to study the system restraint effect. The study showed that the axial restraint of the beam could significantly reduce the strength degradation and buckling amplitude at higher deformation levels.

Value of Porous Titanium Alloy Plates for Chest Wall Reconstruction after Resection of Chest Wall Tumors

Qi, Yu,Li, Xin,Zhao, Song,Han, Yong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11

Objective: To explore the value of porous titanium alloy plates for chest wall reconstruction after resection of chest wall tumors. Materials and Methods: A total of 8 patients with chest wall tumors admitted in our hospital from Jan. 2006 to Jan. 2009 were selected and underwent tumor resection, then chest wall repair and reconstruction with porous titanium alloy plates for massive chest wall defects. Results: All patients completed surgery successfully with tumor resection-induced chest wall defects being $6.5{\times}7cm{\sim}12{\times}15.5$ cm in size. Two weeks after chest wall reconstruction, only 1 patient had subcutaneous fluidify which healed itself after pressure bandaging following fluid drainage. Postoperative pathological reports showed 2 patients with costicartilage tumors, 1 with squamous cell carcinoma of lung, 1 with lung adeno-carcinoma, 1 with malignant lymphoma of chest wall, 2 with chest wall metastasis of breast cancers and 1 with chest wall neurofibrosarcoma. All patients had more than 2~5 years of follow-up, during which time 1 patient with breast cancer had surgical treatment due to local recurrence after 7 months and none had chest wall reconstruction associated complications. The mean survival time of patients with malignant tumors was ($37.3{\pm}5.67$) months. Conclusions: Porous titanium alloy plates are safe and effective in the chest wall reconstruction after resection of chest tumors.

Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice

Qi Guo,Zhiyang Shen,Hongxia Yu,Gaofeng Lu,Yong Yu,Xia Liu,Pengyuan Zheng 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1

Acetaminophen (APAP) overdose is one of the most common causes of acute liver failure. The study aimed to investigate the protective effect of carnosic acid (CA) on APAP-induced acute hepatotoxicity and its underlying mechanism in mice. To induce hepatotoxicity, APAP solution (400 mg/kg) was administered into mice by intraperitoneal injection. Histological analysis revealed that CA treatment significantly ameliorated APAP-induced hepatic necrosis. The levels of both alanine aminotransferase (ALT) and aspartate transaminase (AST) in serum were reduced by CA treatment. Moreover, CA treatment significantly inhibited APAP-induced hepatocytes necrosis and lactate dehydrogenase (LDH) releasing. Western blot analysis showed that CA abrogated APAP-induced cleaved caspase-3, Bax and phosphorylated JNK protein expression. Further results showed that CA treatment markedly inhibited APAP-induced pro-inflammatory cytokines TNF-a, IL-1b, IL-6 and MCP-1 mRNA expression and the levels of phosphorylated IkBa and p65 protein in the liver. In addition, CA treatment reduced APAP- induced hepatic malondialdehyde (MDA) contents and reactive oxygen species (ROS) accumulation. Conversely, hepatic glutathione (GSH) level was increased by administration of CA in APAP-treated mice. Mechanistically, CA facilitated Nrf2 translocation into nuclear through blocking the interaction between Nrf2 and Keap1, which, in turn, upregulated anti-oxidant genes mRNA expression. Taken together, our results indicate that CA facilitates Nrf2 nuclear translocation, causing induction of Nrf2-dependent genes, which contributes to protection from acetaminophen hepatotoxicity.

Genetic variations in the bitter taste receptor gene TAS2R38 are related to cigarette smoking behavior in Han Chinese smokers

Qi Fei-Yan,Zhu Zhou-Hai,Li Meng,Guan Ying,Peng Qi-Yuan,Lu She-Ming,Liu Zhi-Hua,Wang Ming-Feng,Miao Ming-Ming,Chen Zhang-Yu,Li Xue-Mei,Bai Jie,Yao Jian-Hua 한국유전학회 2022 Genes & Genomics Vol.44 No.11

Background: Smoking behavior is influenced by multiple genes, including the bitter taste gene TAS2R38. It has been reported that the correlation between TAS2R38 and smoking behavior has ethnicity-based differences. However, the TAS2R38 status in Chinese smokers is still unclear. Objective: This study aims to investigate the possible relationship between genetic variations in TAS2R38 (A49P, V262A and I296V) and smoking behaviors in the Han Chinese population. Methods: The haplotype analyses were performed and smoking behavior questionnaire was completed by 1271 individuals. Genetic association analyses for smoking behavior were analyzed using chi-square test. Further, for investigating the molecular mechanism of TAS2R38 variants effect on smoking behavior, we conducted TAS2R38-PAV and TAS2R38-AVI expression plasmids and tested the cellular calcium assay by cigarette smoke compounds stimulus in HEK293. Results: Significant associations of genetic variants within TAS2R38 were identified with smoking behavior. We found a higher PAV/PAV frequency than AVI/AVI in moderate and high nicotine dependence (FTND ≥ 4; X2 = 4.611, 1 df, p = 0.032) and strong cigarette smoke flavor intensity preference (X2 = 4.5383, 1 df, p = 0.033) in participants. Furthermore, in the in vitro cellular calcium assay, total particle matter (TPM), N-formylnornicotine and cotinine, existing in cigarette smoke, activated TAS2R38-PAV but not TAS2R38-AVI-transfected cells. Conclusion: Our data highlights that genetic variations in TAS2R38 are related to smoking behavior, especially nicotine dependence and cigarette smoke flavor intensity preference. Our findings may encourage further consideration of the taste process to identify individuals susceptible to nicotine dependence, particularly Han Chinese smokers.

TERT rs2736098 Polymorphism and Cancer Risk: Results of a Meta-analysis

Qi, Hao-Yu,Zou, Peng,Zhao, Lin,Zhu, Jue,Gu, Ai-Hua Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

Objective: Several studies have demonstrated associations between the TERT rs2736098 single nucleotide polymorphisms (SNPs) and susceptibility to cancer development. However, there are conflicting results. A systematic meta-analysis was therefore performed to establish the cancer risk associated with the polymorphism. Methods: In this meta-analysis, a total of 6 case-control studies, including 5,567 cases and 6,191 controls, were included. Crude odds ratios with 95% confidence intervals were used to assess the strength of associations in several genetic models. Results: Our results showed no association reaching the level of statistical significance for overall risk. Interestingly, in the stratified analyses (subdivided by ethnicity), significantly increased risks were found in the Asian subgroup which indicates the TERT rs2736098 polymorphism may have controversial involvement in cancer susceptibility. Conclusions: Overall, this meta-analysis indicates that the TERT rs2736098 polymorphism may have little involvement in cancer susceptibility.

Antioxidant Effect of Grapevine Leaf Extract on the Oxidative Stress Induced by a High-fat Diet in Rats

Qi-Ming Yu,임은지,최수경,서정숙 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.3

This study was conducted to investigate theeffect of grapevine leaf extract (GLE) on the oxidativestress of rats fed a high-fat diet. Rats were divided into sixgroups: a normal diet with 0% (NC), 1.0% (NG1.0), and1.5% GLE (NG1.5); and a high-fat diet with 0% (HFC),1.0% (HFG1.0), and 1.5% GLE (HFG1.5). Treatment withGLE to the high-fat diet reduced lipid peroxide concentrationsin plasma and liver compared to those of HFC rats. Totalglutathione and GSH/GSSG of the groups with GLE werehigher than those of untreated groups. Hepatic glutathioneperoxidase, glutathione-S-transferase, and glutathionereductase activities along with catalase and glutathioneperoxidase activities in erythrocytes increased after GLEtreatment to high-fat diet compared with HFC rats. Hepaticretinol and tocopherol increased in HFG1.5 groupcompared to those of HFC group. These results indicatethat GLE can protect against oxidative stress induced by ahigh-fat diet in rats.

Elevated Circulating CD19⁺ Lymphocytes Predict Survival Advantage in Patients with Gastric Cancer

Yu, Qi-Ming,Yu, Chuan-Ding,Ling, Zhi-Qiang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Background: Circulating lymphocyte subsets reflect the immunological status and might therefore be a prognostic indicator in cancer patients. Our aim was to evaluate the clinical significance of circulating lymphocyte subset in gastric cancer (GC) cases. Methods: A retrospective study on a prevalent cohort of 846 GC patients hospitalized at Hospital from Aug 2006 to Jul 2010 was conducted. We calculated the patient's disease free survival (DFS) after first hospital admission, and hazard ratios (HR) from the Cox proportional hazards model. Results: Our findings indicated a significantly decreased percentage of CD3+, and CD8+ cells, a significantly increased proportion of $CD4^+$, $CD19^+$, $CD44^+$, $CD25^+$, NK cells, and an increased $CD4^+/CD8^+$ ratio in GC patients as compared with healthy controls (all P < 0.05). Alteration of lymphocyte subsets was positively correlated with sex, age, smoking, tumor stage and distant metastasis of GC patients (all P<0.05). Follow-up analysis indicated significantly higher DFS for patients with high circulating $CD19^+$ lymphocytes compared to those with low $CD19^+$ lymphocytes (P=0.037), with $CD19^+$ showing an important cutoff of $7.91{\pm}2.98%$ Conclusion: Circulating lymphocyte subsets in GC patients are significantly changed, and elevated CD19+ cells may predict a favorable survival.

Recent advances of bioactive proteins/polypeptides in the treatment of breast cancer

Qi-Zhang Li,Ze-Rong Zhou,Cui-Yu Hu,Xian-Bin Li,Yu-Zhou Chang,Yan Liu,Yu-Liang Wang,Xuan-Wei Zhou 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.3

Proteins do not only serve as nutrients to fulfill the demand for food, but also are used as a source of bioactive proteins/polypeptides for regulating physical functions and promoting physical health. Female breast cancer has the highest incidence in the world and is a serious threat to women’s health. Bioactive proteins/polypeptides exert strong anti-tumor effects and exhibit inhibition of multiple breast cancer cells. This review discussed the suppressing effects of bioactive proteins/polypeptides on breast cancer in vitro and in vivo, and their mechanisms of migration and invasion inhibition, apoptosis induction, and cell cycle arrest. This may contribute to providing a basis for the development of bioactive proteins/polypeptides for the treatment of breast cancer.

Two-sided Matching Decision under Multi-granularity Uncertain Linguistic Environment

Qi Yue,Yongshan Peng,Bingwen Yu,Yu Hong,Quan Xiao 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.11

With respect to the two-sided matching problem, where the agents’ preferences are in the format of multi-granularity uncertain linguistic terms, a matching method is proposed. Some basic concepts and definitions on uncertain linguistic term and 2-tuple are firstly given. Based on this, the two-sided matching problem with multi-granularity uncertain linguistic terms is described. Then, multi-granularity uncertain linguistic term matrixes are transformed into multi-granularity 2-tuple matrixes. Furthermore, a multi-objective optimization model is developed by using the extended 2-tuple weighted average. By using the normalization method and the linear weighted method twice, the multi-objective optimization model can be converted into a single-objective optimization model. By solving the model, the matching alternative can be obtained. Example of matching demand and supply in agricultural knowledge illustrates the feasibility and effectiveness of this method.

Impression of Busan

Qi Yu Zhe 한국콘텐츠학회 2022 ICCC International Digital Design Invitation Exhib Vol.2022 No.07