DNA Repair Gene Polymorphisms Do Not Predict Response to Radiotherapy-Based Multimodality Treatment of Patients with Rectal Cancer: a Meta-analysis

Guo, Cheng-Xian,Yang, Guo-Ping,Pei, Qi,Yin, Ji-Ye,Tan, Hong-Yi,Yuan, Hong Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

Background: A number of association studies have been carried out to investigate the relationship between genetic polymorphisms in DNA repair genes and response to radiotherapy-based multimodality treatment of patients with rectal cancer. However, their conclusions were inconsistent. The objective of the present study was to assess the role of DNA repair gene genetic polymorphisms in predicting genetic biomarkers of the response in rectal cancer patients treated with neoadjuvant chemoradiation. Materials and Methods: Studies were retrieved by searching the PubMed database, Cochrane Library, Embase, and ISI Web of Knowledge. We conducted a meta-analysis to evaluate the association between genetic polymorphisms and the response in rectal cancer treated with neoadjuvant chemoradiation by checking odds ratios (ORs) and 95% confidence intervals (CIs). Results: Data were extracted from 5 clinical studies for this meta-analysis. The results showed that XRCC1 RS25487, XRCC1 RS179978, XRCC3 RS861539, ERCC1 RS11615 and ERCC2 RS13181 were not associated with the response in the radiotherapy-based multimodality treatment of patients with rectal cancer (p>0.05). Conclusions: This study shows that DNA repair gene common genetic polymorphisms are not significantly correlated with the radiotherapy-based multimodality treatment in rectal cancer patients.

How to organically integrate moral education and art curriculum in schools

Guo Qi 동방문화대학원대학교 문화예술콘텐츠연구소 2021 문화와예술연구 Vol.17 No.-

“도덕교육은 학생과 가깝고 직업과 가까우며 사회와 가까운 실천을 중시해야 한다.” 그래서 직업학교의 도덕교육은 학생의 인지능력과 전공특징에 따라 과감하게 혁신적인 교육 디자인을 하고, 예술교육의 내용과 형식을 차용해야 한다. 그 형상성으로 도덕교육을 그 모습을 생생하고 생동감 있게 만들어야 한다. 학생들의 감정적 공감을 불러일으키고 교육 효과를 향상시키며 학생의 종합적인 자질을 향상시켜야 한다. 그러므로 도덕교육은 그 과목의 기본적 문제를 핵심으로 삼고 학생들이 관련 지식을 배우는 것부터 시작함으로써 삶에 뿌리를 두어야 한다. 학생들이 삶을 관찰하고, 삶을 느끼고, 삶을 경험하는 과정에서 긍정적인 삶의 태도를 형성하여 도덕교육의 ‘지식, 감정, 의도, 믿음, 그리고 실천’의 통합을 실현할 수 있도록 해야 한다. "Moral education should be close to students, to the profession, and to the Society and pay attention to the practice". Therefore, according to the cognitive ability and professional characteristics of students, the moral education in vocational schools should boldly innovate teaching design, and use its figure to make moral education vividly and lively depending on the content and form of art education. It can inspire students with emotional resonance, improve teaching effects and enhance the comprehensive quality of students. Therefore, the moral education shall be rooted in life, by taking the basic problems of the subject as the core, and starting with students learning relevant knowledges. So that students can form a positive attitude towards life in the process of observing life, feeling life and experiencing life, so as to realize the unity of "knowledge, emotion, intention, faith and practice" of moral education.

Effect of Hot-forging on NiTi Shape Memory Alloy Fibers Reinforced Mg Alloy Composite

Guo Qi,Li Gang,Tang Renjian,Yan Biao 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1

The composite used in this paper was prepared by hot-pressing ball-milled Mg alloy powders, in which NiTi shape memory alloy fibers in a row were sandwiched. The microstructure and property were examined. It is shown that the composite consisted of a homogenous matrix with uniformly distributed NiTi shape memory alloy fibers, recrystallization took place in the Mg alloy matrix which was subjected to plastic deformation an adequate bonding formed between the matrix and fibers; the density and tensile strength of the composite increased after the hot-forging; the hot-forging process is capable of improving properties of the composite.

Fatigue performance and life prediction methods research on steel tube-welded hollow spherical joint

Qi Guo,Ying Xing,Honggang Lei,Jingfeng Jiao,Qingwei Chen 국제구조공학회 2020 Steel and Composite Structures, An International J Vol.36 No.1

The grid structures with welded hollow spherical joint (WHSJ) have gained increasing popularity for use in industrial buildings with suspended cranes, and usually welded with steel tube (ST). The fatigue performance of steel tube-welded hollow spherical joint (ST-WHSJ) is however not yet well characterized, and there is little research on fatigue life prediction methods of ST-WHSJ. In this study, based on previous fatigue tests, three series of specimen fatigue data with different design parameters and stress ratios were compared, and two fatigue failure modes were revealed: failure at the weld toe of the ST and the WHSJ respectively. Then, S–N curves of nominal stress were uniformed. Furthermore, a finite element model (FEM) was validated by static test, and was introduced to assess fatigue behavior with the hot spot stress method (HSSM) and the effective notch stress method (ENSM). Both methods could provide conservative predictions, and these two methods had similar results. However, ENSM, especially when using von Mises stress, had a better fit for the series with a non- positive stress ratio. After including the welding residual stress and mean stress, analyses with the local stress method (LSM) and the critical distance method (CDM, including point method and line method) were carried out. It could be seen that the point method of CDM led to more accurate predictions than LSM, and was recommended for series with positive stress ratios.

Characterization and Expression Profile Analysis of a New cDNA Encoding Taxadiene Synthase from Taxus media

Guo Yin Kai,Ling Xia Zhao,Lei Zhang,Zhu Gang Li,Bin Hui Guo,Dong Li Zhao,Xiao Fen Sun,Zhi Qi Miao,Ke Xuan Tang 한국생활환경학회 2005 BMB Reports Vol.38 No.6

Invasiveness evaluation of fireweed (Crassocephalum crepidioides) based on its seed germination features

Guo Qi Chen,Shui Liang Guo,Qiu Sheng Huang 한국잡초학회 2009 Weed Biology and Management Vol.9 No.2

Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice

Guo, Qi,Shen, Zhiyang,Yu, Hongxia,Lu, Gaofeng,Yu, Yong,Liu, Xia,Zheng, Pengyuan The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1

Acetaminophen (APAP) overdose is one of the most common causes of acute liver failure. The study aimed to investigate the protective effect of carnosic acid (CA) on APAP-induced acute hepatotoxicity and its underlying mechanism in mice. To induce hepatotoxicity, APAP solution (400 mg/kg) was administered into mice by intraperitoneal injection. Histological analysis revealed that CA treatment significantly ameliorated APAP-induced hepatic necrosis. The levels of both alanine aminotransferase (ALT) and aspartate transaminase (AST) in serum were reduced by CA treatment. Moreover, CA treatment significantly inhibited APAP-induced hepatocytes necrosis and lactate dehydrogenase (LDH) releasing. Western blot analysis showed that CA abrogated APAP-induced cleaved caspase-3, Bax and phosphorylated JNK protein expression. Further results showed that CA treatment markedly inhibited APAP-induced pro-inflammatory cytokines TNF-${\alpha}$, IL-$1{\beta}$, IL-6 and MCP-1 mRNA expression and the levels of phosphorylated $I{\kappa}B{\alpha}$ and p65 protein in the liver. In addition, CA treatment reduced APAP- induced hepatic malondialdehyde (MDA) contents and reactive oxygen species (ROS) accumulation. Conversely, hepatic glutathione (GSH) level was increased by administration of CA in APAP-treated mice. Mechanistically, CA facilitated Nrf2 translocation into nuclear through blocking the interaction between Nrf2 and Keap1, which, in turn, upregulated anti-oxidant genes mRNA expression. Taken together, our results indicate that CA facilitates Nrf2 nuclear translocation, causing induction of Nrf2-dependent genes, which contributes to protection from acetaminophen hepatotoxicity.

Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice

Qi Guo,Zhiyang Shen,Hongxia Yu,Gaofeng Lu,Yong Yu,Xia Liu,Pengyuan Zheng 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1

Acetaminophen (APAP) overdose is one of the most common causes of acute liver failure. The study aimed to investigate the protective effect of carnosic acid (CA) on APAP-induced acute hepatotoxicity and its underlying mechanism in mice. To induce hepatotoxicity, APAP solution (400 mg/kg) was administered into mice by intraperitoneal injection. Histological analysis revealed that CA treatment significantly ameliorated APAP-induced hepatic necrosis. The levels of both alanine aminotransferase (ALT) and aspartate transaminase (AST) in serum were reduced by CA treatment. Moreover, CA treatment significantly inhibited APAP-induced hepatocytes necrosis and lactate dehydrogenase (LDH) releasing. Western blot analysis showed that CA abrogated APAP-induced cleaved caspase-3, Bax and phosphorylated JNK protein expression. Further results showed that CA treatment markedly inhibited APAP-induced pro-inflammatory cytokines TNF-a, IL-1b, IL-6 and MCP-1 mRNA expression and the levels of phosphorylated IkBa and p65 protein in the liver. In addition, CA treatment reduced APAP- induced hepatic malondialdehyde (MDA) contents and reactive oxygen species (ROS) accumulation. Conversely, hepatic glutathione (GSH) level was increased by administration of CA in APAP-treated mice. Mechanistically, CA facilitated Nrf2 translocation into nuclear through blocking the interaction between Nrf2 and Keap1, which, in turn, upregulated anti-oxidant genes mRNA expression. Taken together, our results indicate that CA facilitates Nrf2 nuclear translocation, causing induction of Nrf2-dependent genes, which contributes to protection from acetaminophen hepatotoxicity.

Curcumol Induces Apoptosis in SPC-A-1 Human Lung Adenocarcinoma Cells and Displays Anti-neoplastic Effects in Tumor Bearing Mice

Tang, Qi-Ling,Guo, Ji-Quan,Wang, Qi-You,Lin, Hai-Shu,Yang, Zhou-Ping,Peng, Tong,Pan, Xue-Diao,Liu, Bing,Wang, Su-Jun,Zang, Lin-Quan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

Curcumol is a sesquiterpene originally isolated from curcuma rhizomes, a component of herbal remedies commonly used in oriental medicine. Its beneficial pharmacological activities have attract significant interest recently. In this study, anti-cancer activity of curcumol was examined with both in vitro and in vivo models. It was found that curcumol exhibited time- and concentration-dependent anti-proliferative effects in SPC-A-1 human lung adenocarcinoma cells with cell cycle arrest in the G0/G1 phase while apoptosis-induction was also confirmed with flow cytometry and morphological analyses. Interestingly, curcumol did not display growth inhibition in MRC-5 human embryonic lung fibroblasts, suggesting the anti-proliferative effects of curcumol were specific to cancer cells. Anti-neoplastic effects of curcumol were also confirmed in tumor bearing mice. Curcumol (60 mg/ kg daily) significantly reduced tumor size without causing notable toxicity. In conclusion, curcumol appears a favorable anti-cancer candidate for further development.

Roles of E-Cadherin (CDH1) Genetic Variations in Cancer Risk: a Meta-analysis

Deng, Qi-Wen,He, Bang-Shun,Pan, Yu-Qin,Sun, Hui-Ling,Xu, Ye-Qiong,Gao, Tian-Yi,Li, Rui,Song, Guo-Qi,Wang, Shu-Kui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

E-Cadherin (CDH1) genetic variations may be involved in invasion and metastasis of various cancers by altering gene transcriptional activity of epithelial cells. However, published studies on the association of CDH1 gene polymorphisms and cancer risk remain contradictory, owing to differences in living habits and genetic backgrounds. To derive a more better and comprehensive conclusion, the present meta-analysis was performed including 57 eligible studies of the association between polymorphisms of CDH1 gene promoter -160 C>A, -347 G>GA and 3'-UTR +54 C>T and cancer risk. Results showed that these three polymorphisms of CDH1 were significantly associated with cancer risk. For -160 C>A polymorphism, -160A allele carriers (CA and CA+AA) had an increased risk of cancer compared with the homozygotes (CC), and the similar result was discovered for the -160A allele in the overall analyses. In the subgroup analyses, obvious elevated risk was found with -160A allele carriers (AA, CA, CA+AA and A allele) for prostate cancer, while a decreased colorectal cancer risk was shown with the AA genotype. For the -347 G>GA polymorphism, the GAGA genotype was associated with increased cancer risk in the overall analysis with homozygous and recessive models. In addition, results of subgroup analysis indicated that the elevated risks were observed in colorectal cancer and Asian descendants. For +54 C>T polymorphism, a decreased risk of cancer was found in heterozygous, dominant and allele models. Moreover, +54T allele carriers (CT, CT+TT genotype and T allele) showed a potential protective factor in gastric cancer and Asian descendants.