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( Ji Seok Kim ),( Chan Hee Nam ),( Ji Yeon Yoo1 ),( Hyun Jung Kim ),( Se Kyoo Jeong ),( Sung Ku Ahn ),( Seung Phil Hong ) 한국피부장벽학회 2014 한국피부장벽학회지 Vol.16 No.2
Purpose: There are researches indicating that in human skin, the cannabinoid receptors exist, which take a part of endocannabinoid system. Nonetheless, the possible association of cannabinoid receptors with the pathogenesis of psoriasis has not yet been fully elucidated. Through this research, we tried to document the association between cannabinoid system, epidermal differentiation and psoriasis. Methods: Using human keratinocyte (KC), the expression of cannabinoid receptor-1 (CB1R) and -2 (CB2R) was analyzed according to the degree of differentiation. Also we examined for changes in differentiation marker of KC after application of CBR agonist. In addition, murine model applied with imiquimod to induce psoriasis symptoms was used to evaluate the effect of topical CBR agonist on inflammation and skin barrier function. Results: Compared to normal human skin, CBR expression was reduced in epidermis of psoriasis skin. Western blotting revealed the expression of both CB1R and CB2R in undifferentiated KC. The expression level of CB1R increased as the differentiation progressed in KC as with involucrin, K1 and K10. On the other hand, there was no change of CB2R in the process of differentiation. Furthermore, CB1R agonist partly increased expression of proteins associated with epidermal differentiation. Through this we could speculate that the CB system may be associated with proteins related to epidermal differentiation. Moreover, inflammation and barrier function in murine models with psoriasis symptoms were improved after 3 days-application of topical CB1R agonist. Conclusion: Cannabinoid receptors in human skin might be related to the differentiation of KC, and since its activation could improve skin barrier condition in murine psoriasis model, it can be expected to be a new therapeutic target for treatment of psoriasis.
Signed-DLMS 적응 알고리즘 이용한 무선 중계 간섭 제거기
유태훈(Tae-Hoon Yoo),우대호(Dae-Ho Woo),김주완(Dae-Ho Woo),하성희(Sung-Hee Ha),반지훈(Ji-Hun Van),이종현(Jong-Hyun Lee) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.7
In this paper, we study the signed- DLMS adaptive algorithm of wireless repeater for solving shadow region due to propagation between base station and mobile station. The the signed-DLMS algorithm reduces interference signals from multipath and solves the oscillation problem of repeater by estimation and cancellation. To efficiently reject interference signal. the signed-DLMS adaptive algorithm is applied. The computational complexities of the signed-DLMS are reduced verse standard LMS algorithm. Wireless ICS repeater based on signed-DLMS reduces the cost and is able to increase channel capacities.
A case of Ramsay Hunt syndrome diagnosed after kidney transplantation
( Yoo Min Park ),( Da Rae Kim ),( Ji Yoon Park ),( Seul Ki Kim ),( Se Yun Kim ),( Jin Sug Kim ),( Yu Ho Lee ),( Yang Gyun Kim ),( Kyung Hwan Jeong ),( Ju Young Moon ),( Sang Ho Lee ),( Chun Gyoo Ihm ) 대한신장학회 2015 Kidney Research and Clinical Practice Vol.34 No.4
We report the first case of Ramsay Hunt syndrome (RHS) diagnosed after kidney transplantation in Korea. RHS is a disease caused by latent varicella-zoster characterized to involve geniculate ganglion of the seventh cranial nerve. Patients who have undergone kidney transplantation can be easily affected by viral infections because of their immune-compromised status. A 35-year-old man with hypertensive end-stage renal disease underwent kidney transplantation. Two months after surgery, the recipient was diagnosed with RHS and treated with antivirals and steroids. However, after using the antiviral agents for the recommended duration, facial paralysis occurred as a new presentation and he required further treatment. Otalgia and periauricular vesicles improved, but the facial palsy remained.
Daclatasvir and Asunaprevir for Chronic Hepatitis C Virus Genotype 1b Infection: Real Life Data
( Ji Hoon Kim ),( Yang Jae Yoo ),( Young-sun Lee ),( Sang Jun Suh ),( Young Kul Jung ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Kwan Soo Byun ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: We evaluated the real life efficacy and safety in Korean patients with genotype 1b HCV infection who were treated with daclatasvir and asunaprevir Methods: 410 patients with chronic HCV genotype 1b infection received RAS (resistance associated substitution) examination from July 2015 to September 2016 in three medical centers of Korea university. Among them, 241 patients received daclatasvir and asunaprevir and we analyzed the efficacy and safety in 150 patients who SVR (sustained virologic response) could be attained. HCV RNA at baseline, 4, 12, 24 weeks and SVR (post treatment 12 or 24 weeks) were assayed with laboratory tests. Lower limit of HCV RNA quantification was 20 IU/ml. Significant adverse events were defined as more than grade 3 according to CTCAE v4.0. Results: Among 410 patients, RAS were detected in 20.2% (83/410); L31(2.4%), Y93(16.6%) and both (1.2%). In 150 further analysis patients, mean age was 5.3 years, 107 (71.3%) patients were treatment naïve, and 45(30%) patients had liver cirrhosis (LC). All daclatasvir and asunaprevir treated patients did not have RAS except four (all Y93). Overall SVR rate was 90.7%(136/150). Among 146 patients with no RAS, 133(91.1%) showed SVR. In 4 RAS positive patients, 3 showed SVR. SVR rate according to presence of LC or not were 92.4% and 86.7%. SVR rate according to experience of interferon (IFN) or not were 90.7% in both. SVR rate according to presence of LC-/IFN-, LC-/IFN+, LC+/IFN- and LC+/IFN + were 94.5%, 87.5%, 82.4%, 100%. There was no statistically significant difference but a trend of lower SVR in LC+/IFN- than LC-/IFN- (p=0.07). Any adverse event occurred in 47.3% of patients. One patient showed ALT increase more than 5 upper normal limit and discontinued medication and then ALT increase recovered. Conclusions: In real-life data, daclatasvir and asunaprevir showed good efficacy in consistent with previous clinical studies.
Clinical Safety and Efficiency of the H-Port for Treatment of Leptomeningeal Metastasis
Sung-Min Jang,Ho-Shin Gwak,Ji-Woong Kwon,Sang Hoon Shin,Heon Yoo The Korean Neurosurgical Society 2024 Journal of Korean neurosurgical society Vol.67 No.4
Objective : To evaluate the usefulness of a cranial implantable chemoport, the H-port, as an alternative to the Ommaya reservoir for intraventricular chemotherapy/cerebrospinal fluid (CSF) access in patients with leptomeningeal metastasis (LM). Methods : One hundred fifty-two consecutive patients with a diagnosis of LM and who underwent H-port installation between 2015 and 2021 were evaluated. Adverse events associated with installation and intraventricular chemotherapy, and the rate of increased intracranial pressure (ICP) control via the port were evaluated for safety and efficacy. These indices were compared with published data of Ommaya (n=89), from our institution. Results : Time-to-install and installation-related complications of intracranial hemorrhage (n=2) and catheter malposition (n=5) were not significantly different between the two groups. Intraventricular chemotherapy-related complications of CSF leakage occurred more frequently in the Ommaya than in the H-port group (13/89 vs. 3/152, respectively, p<0.001). Intracranial hemorrhage during chemotherapy occurred only in the Ommaya group (n=4). The CSF infection rate was not statistically different between groups (14/152 vs. 12/89, respectively). The ICP control rate according to reservoir type revealed a significantly higher ICP control rate with the H-port (40/67), compared with the Ommaya result (12/58, p<0.001). Analyzing the ICP control rate based on the CSF drainage method, continuous extraventricular drainage (implemented only with the H-port), found a significantly higher ICP control rate than with intermittent CSF drainage (33/40 vs. 6/56, respectively, p<0.0001). Conclusion : The H-port for intraventricular chemotherapy in patients with LM was superior for ICP control; it had equal or lower complication rates than the Ommaya reservoir.
Yoo, Young-Lin,Han, Doo-Hee,Hong, Ji-Seok,Sung, Hong-Gye Elsevier 2017 INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER - Vol.112 No.-
<P><B>Abstract</B></P> <P>A three-dimensional large eddy simulation (LES) is conducted to investigate the breakup and atomization of a liquid jet into a cross turbulent flow for several variants of a liquid-gas momentum flux ratio by varying the liquid injection velocity and cross flow temperature. The spray-field dynamics are treated using a combined Eulerian-Lagrangian approach in which the gas phase is discretized using a density-based, finite-volume approach. A Kelvin-Helmholtz and Rayleigh-Taylor (KH-RT) hybrid wave breakup model is implemented to simulate the liquid column and droplet breakup process. While the KH model is applied to the liquid column breakup (primary breakup), the RT model is implemented to the breakup of the small droplets (secondary breakup). The detail flow structures of the counter-rotating vortex pair (CVP) and vortex interaction behind the injector are observed. The spray penetration depth in the crossflow compares well with the experimental data and similar to empirical equations. The Sauter mean diameter (SMD) distribution is analyzed along the flow downstream representing somewhat different, and an analytical correlation model is proposed to pre-evaluate the SMD in the flowfield.</P> <P><B>Highlights</B></P> <P> <UL> <LI> An LES of the breakup and atomization of a liquid jet in crossflow was performed. </LI> <LI> The penetration depth and SMD distribution for the various conditions were analyzed. </LI> <LI> SMD distribution correlation equations were developed and evaluated. </LI> </UL> </P>
Sang-Soep Nahm,Ji Eun Yoo,Louise C. Abbott 한국실험동물학회 2010 Laboratory Animal Research Vol.26 No.3
The leaner mouse carries a mutation in the gene encoding the α1A subunit of P/Q-type calcium channels. Leaner mice exhibit extensive cerebellar granule and Purkinje cell loss that results in cerebellar dysfunction. A previous study suggested that a small population of leaner Purkinje cells undergo apoptosis, however the cell death mode of the rest of degenerating Purkinje cells has not been identified. In order to investigate the mechanisms underlying leaner Purkinje cell death, gene arrays that contain 243 cell death related genes were carried out. To increase the chance of detecting Purkinje cell specific genes, laser capture microdissection was employed to obtain Purkinje cell enriched samples. The gene array analysis revealed several potential genes that are involved in autophagic cell death pathway including cathepsin D, a key lysosomal protease that triggers autophagic degradation. Further analysis on LC3, which is a hallmark for autophagic cell death showed that leaner Purkinje cells are degenerating via autophagic process. The present study provides evidence that calcium channel defects trigger different modes of neurodegeneration in the cerebellum.