급성 단순하부요로감염의 경험적 치료로써 레보플록사신 3일요법의 효과

이지열,이승주,이상돈,정희창,오봉렬,김세웅,최한용,조용현,윤문수 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.4

목적 : 급성 단순요로감염의 원인균에 대한 내성증가에 따른 경험적 1차치료의 선택에 대한 어려움으로 인하여 최근 미국의 Infectious Disease Society of America(IDSA)에서는 이에 대한 가이드라인을 제시하였다. IDSA의 가이드라인에 따르면 그 지역의 TMP-SMX에 대한 내성균주의 비율이 10-20% 이상일 때는 급성 단순요로감염의 경험적 1차치료제로 플루오로퀴놀론제를 선택하도록 하였다. 이에 저자들은 급성 단순하부요로감염 환자에 있어서 레보플록사신에 대한 임상적, 미생물학적 유효성 및 안전성을 알아보고자 하였다. 방법 : 시험은 전향적, 비맹검, 공개, 비비교, 다기관 임상시험으로 시행되었고 전국 5개 대학병원을 방문한 56명의 급성 단순하부요로감염 환자에게 레보플록사신 100㎎을 1일 3회, 3일간 경구 투여하여 1-3일 후에 추적 관찰하였다. 결과 : 평가가 가능하였던 53명의 환자 중 50명의 환자에서 치료 후 5-7일 후에 증상이 소실되었거나 호전되어 94%의 임상적 유효성을 보였으며, 51명의 환자에서 치료 후 1-3일 후에 원인균이 제거되어 96%의 미생물학적 유효성을 보였다. 약물 관련 이상반응은 2%의 환자에서 나타났으나 이로 인한 치료 중단 사례는 없었으며 심각한 생화학적 또는 혈액학적 이상반응은 나타나지 않았다. 결론 : 레보플록사신 100㎎ 1일 3회 3일 요법은 임상적, 미생물학적 유효성이 뒤어나며 안전한 치료요법으로 급성 단순하부요로감염의 경험적 1차 치료에 적합할 것으로 생각된다. Background : The increasing frequency of clinical failure of uncomplicated urinary tract infections (UTIs) may be due to emerging resistance to commonly prescribed antimicrobials. Infectious Diseases Society of America guidelines state that uncomplicated UTIs should be treated empirically with a fluoroquinolone, if the proportion of trimethoprim/sulfamethoxazole-resistant isolates in the community is >10%-20%. The clinical efficacy and safety of levofloxacin were assessed in patients with acute, uncomplicated lower urinary tract infection. Methods : The study was a multicenter, prospective, open label, non-comparative, non-blinded trial. Fifty-six patients with acute, uncomplicated symptomatic lower urinary tract infections from five university hospitals were treated with levofloxacin 100㎎ tid for 3 days and were followed up for 1 to 5 days. Results : Fifty-three of the 56 patients were evaluable. Ninety-four per cent of patients were symptomatically cured or improved by the fifth to seventh day after therapy started. Bacteriological eradication of initial pathogen was achieved by 1 to 3 days in 96%. Drug related adverse experiences were seen in 2% of patients. None necessitated cessation of therapy. No significant biochemical or hematological abnormalities occurred. Conclusion : These results demonstrate the clinical efficacy and safety of empirical 3-day levofloxacin for acute, uncomplicated urinary tract infections.

유기용제 취급근로자들의 요중대사물질과 말초임파구 자매염색분체교환 발현빈도에 관한 조사연구

김돈균,황인경,류철인,이수일,정갑열,이용환,이충렬,현원일,김석봉,전용덕 大韓産業醫學會 1990 대한직업환경의학회지 Vol.2 No.1

저자들은 유기용제 취급여성근로자 90명을 대상으로 1988년 7월부터 1989년 8월까지 말초혈액임파구에서의 자매염색분체교환의 발현빈도를 조사하고 이들의 업종, 근속연수, 요중마뇨산 농도등이 자매염색분체교환의 발현빈도에 미치는 영향을 조사하였으며 그 결과를 요약하면 다음과 같다. 1. 유기용제 취급근로자들의 말초혈액임파구에서의 자매염색분체교환의 발현빈도는 대조군에 비하여 유의하게 증가되었다. 2. 말초혈액임파구에서의 자매염색분체교환의 발현빈도가 가장 높은 업종은 프라스틱제품 제조업이었다. 3. 근속연수가 말초혈액임파구에서의 자매염색분체교환의 발현빈도에 미치는 영향은 현저하지 않았다. 4. 요중마뇨산농도와 말초혈액임파구에서의 자매염색분체교환의 발현빈도간에는 유의한 상관관계가 있었다. In order to know the possibility of utilizing the sister chromatid exchanges as an index which could evaluate the effect of organic solvents on the health in industrial workers, the authors studied the effects of the inductivity of sister chromatid exchanges in peripheral lymphocytes from 90 female workers expoxed to organic solvents and 20 non-exposed female workers. The results obtained were as follows : 1. The frequency of sister chromatid exchanges in peripheral lymphocytes from 90 female workers exposed to organic solvents was significantly increased in comparison with 20 control subject. 2. The frequency of sister chromatid exchanges was significantly increased in the workers who were employed in the manufacture of plastic materials than the other manufactures. 3. There were no significant differences in the frequency of sister chromatid exchanges by carriers of the exposed workers.

방사성 동위체 도입과 그 추적기술에 의한 수도계(水稻系) 활성상의 해명과 개선에 관한 연구(제3보) : 저인산성 무기 용성물질의 시용과 용수조절 효과에 대하여 Effects of Application of Fused Magnesium Low Level Phosphate and Control of Irrigation Water

이춘영,안학수,정희돈,김규원,노준정 한국농화학회 1973 Applied Biological Chemistry (Appl Biol Chem) Vol.16 No.1

1. Through out the entire stage of growth, the amount of nutrients, number of tillers and of spikes increased in the Simagcalin treated plot as compared with the control. The treated plot showed healthul growth at the later growing stage. On the other hand. management of irrigation water resulted in raised the grain straw ratio and retarded the culm height about 10%. 2. Application of Simagcalin greatly increased the content of phosphorus and magnesium at the harvesting time. The culm and sheath analyses are recommendable for the determination of magnesium deficiency. 3. The controled irrigation would effect root activity as the main factor, and Simagcalin might act as a secondary factor. 4. While the application of phosphorus may not affect the yield components, The basic elements in Simagcalin may enhance the uptake ov nutrients under heavy application of nitrogn.

용접공들의 면역능에 관한 연구

이수일,조봉수,김영욱,고광욱,조원근,김영실,강수용,황인경,조병만,김돈균 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.1

The authors examined human immunity indicators such as CD4, CD8, Natural Killer(NK) cell, IgG, IgA, and IgM, and heavy metals such as Pb, Cr, Cd to evaluate the health hazard of welders. We selected total 126 male subjects, 60 welders who had more than 5 year working history as an exposure group, and 66 office workers and medical college students as a control group. This immunity evaluation approach is the first newly designed study that has never been tried in past studies on welder's heath evaluation. And the results were as follows. 1. Total lymphocyte count of peripheral blood was significantly higher in welder group, 2,615±650 ea/㎕ compared with 2,368±681 ea/㎕ in control group(p>0.05). 2. The proportion of CD4, CD8, NK cell in welder group was 37.5±9.4%, 24.0±8.8%, and 21.0±9.5%, respectively, and 35.5±6.5%, 25.0±6.9%, and 19.6±8.8% in control group. CD4 and NK cell were slightly higher, and CD8 was slightly lower in welder group. but there was no statistical significance between two groups(p≥0.05). 3. IgG, IgA, and IgM in welder group were 15.9㎎/㎗, 2.7㎎/㎗ and 1.5㎎/㎗, respectively, and 15.6㎎/㎗, 2.9㎎/㎗ and 1.7㎎/㎗ in control group. There was no statistical significance between two groups(p≥0.05). 4. Blood lead, cadmium and chromium concentrations were 4.2±1.8㎍/㎗, 0.4±0.38㎍/㎗, 1.2±0.6㎍/㎗ in welder group and 3.2±1.7㎍/㎗, 0.44±0.29㎍/㎗, 1.1±0.6㎍/㎗ in control group, respectively, and these value were within normal ranges.

우리나라 파프리카 수출단지 및 선과장의 병해충 조사

김기돈,이시원,강은하,신용길,전재용,허노열,이흥식 충남대학교 농업과학연구소 2013 농업과학연구 Vol.40 No.2

The disease and insect were surveyed locally in greenhouse, fruit packing house and store house of 51 farms in 13 towns having purpose of paprika exportation. By analysis, various disease and insect were not only founded locally but more ones detected in farms having old facilities and no natural enemy. We found 15 pathogens such as Fusarium spp., Alternaria solani, Leveilluila taurica, PepMV (Pepino mosaic virus) and TMV (Tobacco mosaic virus) in greenhouse, Fusarium spp. in fruit packing house and Penicillium spp. in store house. We found 15 insects in greenhouse such as Bemisia tabaci, rialeurodes vaporariorum and Myzus persicae in greenhouse, Hylobitelus haroldi in fruit packing house. However, the problem quarantine disease and insect for importation and exportation were not detected in inspection time.

굴 養殖場 水域의 基礎生産 硏究

李秉暾,姜亨求,姜龍柱 동의대학교 기초과학연구소 1992 基礎科學硏究論文集 Vol.2 No.1

The primary production of phytoplankton in oyster farming bays were seasonally measured by ^14C method in Hansan-Koje Bay and Kamagyang Bay for one year period. In Hansan-Koje Bay, mean daily primary production was 0.52gC/㎡/day(0.22∼1.02gC/㎡/day), and it was relatively high in summer and low in winter. Annual primary production was estimated to be 189gC/㎡/yr. Mean chlorophyll α content was 1.70mg/㎥, and it was relatively high in summer. In Kamagyang Bay, mean daily primary production was 0.91gC/㎡/day(0.11∼3.61gC/㎡/day), and it was maximum in summer and minimum in fall. Annual primary production was estimated to be 334gC/㎡/yr. Mean chlorophyll α concentration was 2.34mg/㎥, and it was maximum in summer and relatively high in winter. Considering the water area of the two osyter farming bays, annual carbon production by phytoplankton were 9,450 ton in Hansan-Koje Bay and 37,000 ton in Kamagyang Bay. In general pattern of primary production in these bays, high production occurs in summer with increasing trend since spring.

카드뮴 첨가된 α형 산화철에 의한 일산화탄소의 촉매산화 반응연구

이성한,김용록,김돈,정원양,김규홍,최재시 연세대학교 자연과학연구소 1983 學術論文集 Vol.11 No.-

α형 산화철에 카드뮴을 4mol%, 8mol% 및 12mol%로 각각 첨가시켜 외성영역의 특성을 갖는 산화물들을 제조하였다. 이 산화물들을 촉매로한 일산화탄소의 산화반응 속도론적 연구를 통하여 본산화물의 결함구조, CO 산화반응에 대한 촉매성 및 불순물 첨가효과등을 조사하였다. 또한 450℃에서 O_2 및 CO를 여러압력으로 도입시켜 Cd-doped α-Fe_2O_3의 전기전도도를 측정하고 이를 반응속도론적 데이타와 결부시켜 본산화물상에서 CO 의 산화반응 메카니즘과 율속단계를 제안하였다. 반응온도범위 350~460℃에서 산출된 활성화에너지는 10.1~11.3kcal.mol^-1이었다. CO_2흡착에 의한 CO산화반응의 억제효과는 본실험의 반응온도 영역인 350~460℃에서는 나타나지 않았으며 CO 산화반응의 전반응속도 차수는 1.5차로서 일산화탄소에 대해서는 1차, 산소에 대해서는 0.5차임이 밝혀졌다. 반응속도론적 데이타와 전기전도도 데이타에 의해 본촉매의 활성은 카드뮴도프로 인해 생성된 산소공위(Vo"-2e^-)에 기인한 것이었다. 카드뮴의 첨가량이 증가할수록 반응속도는 증가하였으나 12mol% 이상의 카드뮴이 첨가된 산화철상에서는 반응속도가 크게 증가하지 않는 것으로 나타났다. CO와 O_2는 근본적으로 화학흡착하며 CO의 흡착자리는 격자산소(O^-2_(latt))와 기흡착원산소 (O^-_(ads)), 그리고 O_2의 흡착자리는 산소공위(Vo"-2e^-)로 밝혀졌다. The α-Ferric oxide containing 4, 8, and 12mol% with cadmium were prepared. The oxidation rates of carbon monoxide in the presence of these oxide systems were measured to investigate the defect structure, the catalytic activity for the oxidation of carbon monoxide, and the impurity effect. The conductivity was also measured at 450℃ under the various pressures of oxygen and carbon monoxide. From the agreement between the kinetic and conductivity data, the oxidation mechanism of carbon monoxide and the rate determining step on this oxide catalyst were suggested. In the temperature range from 350 to 460℃, the calculated activation energy for the CO oxidation over Cd-doped α-Fe_2O_3 systems were 10.1∼11.3kcal·mol^-1. The inhibition by an adsorbed CO_2 during the CO oxidation was not observed in the above temperature range. The overall reaction order for the CO oxidation is 1.5; the first order with respect to CO and the one-half order with respect to O_2. The catalytic activity of this oxide system is due to oxygen vacancies induced by Cd-doping. The oxidation rates increase with increasing the amount of dopant and above 12mol%, however, don't highly increased. CO and O_2 are essentially chemisorbed as ions and the adsorption sites for CO are the lattice oxygens (O^2-_(latt)) and prechemisorbed oxygens (O^-_(ads)), the adsorption site for O_2 is the oxygen vacancies (Vo¨-2e^-).

加里, 燐酸 및 石灰 施用量의 差異가 大豆의 生育 및 收量에 미치는 影響

李因敦,安容泰,林炳琦 서울여자대학교 1979 서울여자대학논문집 Vol.- No.8

In order to investigate the effects of P, K, and Ca fertilization on the growth and yield of late sown soybean, cultivar Clark # 36 was examined with 9 different fertilization levels by the randomized block design replicated 4 times under the field and pot conditions, and following results were obtained. 1. Growth in field and pot conditions a. The highest stem and canopy were observed at the level of 4 to 8㎏/10a for the P, and K fertilization under the condition of lime application. b. The stem and canopy were higher in the field condition than in the pot condition. c. The P, K fertilization of 4 to 8㎏/10a was effective for the branch growth under the condition of Ca application. d. The P, K and Ca fertilization did not affect the number of brancesh, diameter of stem, and number of nodes on main stem. e. The longer branch, the thicker stem, the more number of branches and nodes on main stem were observed in the pot trial than in the field trial. 2. Dry matter production in field condition a. The leaf to stem ratio was not affected by the P, K, and Ca fertilization. b. D.M. wt. was increased in accodance with increasing the fertilization level of P, K under the condition of lime application. c. SLA and LAI were increased by the increase of the P, and K fertilization level under liming condition. d. CGR, RGR and NAR were increased in accordance with increasing the P, K, level up to 8㎏/10 a under the liming condition. e. The amounts of N, P, and K absorbed during the growing period were also increased due to increase of the P, K level up to 4 to 8㎏/10a a under the condition of lime fertilization. 3. Yield and yield components in field and pot trial a. The stem wt. was increased by the increasing of P, K level up to 8 ㎏/10a under the condition of liming. b. The pod weight and grain weight were increased by the increasing of P, K fertilization level up to 4 to 8㎏/10a with liming. c. The effect of P, K on the stem grain percentage couldn't be recognized. The stem grain percentage was higher in the pot trial than in the field trial. d. The pod number per plant was increased in accordance with increasing of the P, K fertilization level with liming. The more pod number per plant was obtained from the pot trial compared with the field trial. e. The number of ovules per pod was not affected by the fertilization. The more ovules per pod was obtained from the pot culture compared with the field culture. f. The grain number per plant was increased by the P, and K fertilization of 4 to 8㎏/10a with liming. The more grain number per plant was obtained from the pot condition compared with the field condition. g. The ripend seed percentage was highest at 4 to 8㎏/10a of the P, and K fertilization level. It was higher in the pot condition than in the field condition. h. The 100 grain weight was also increased by the P, and K fertilization of 4 to 8㎏/10a. It was heavier in the field condition than in the pot condition. i. There was a tendency that soybean plants need an ample supply of balanced nutrient elements (not single element only) for the yield increase.

비뇨기과 입원환자에서 진통이 미치는 Nabumetone(Unimetone^(�))의 임상적 효과

이홍우,김세웅,이광돈,조용현,윤문수 최신의학사 1994 最新醫學 Vol.37 No.6

직업성 청력손실과 이에 미치는 제인자들의 영향에 관한 조사 연구

이용환,김돈균 부산의대 1991 부산의대잡지 - 부산대학교 의과대학 Vol.31 No.2