Changing prevalence of upper gastrointestinal disease in 28 893 Koreans from 1995 to 2005

Kim, Jin Il,Kim, Sang Gyun,Kim, Nayoung,Kim, Jae Gyu,Shin, Sung Jae,Kim, Sang Woo,Kim, Hyun Soo,Sung, Jae Kyu,Yang, Chang Heon,Shim, Ki-Nam,Park, Seun Ja,Park, Joon Yong,Baik, Gwang Ho,Lee, Sang Woo,P Lippincott Williams Wilkins, Inc. 2009 European journal of gastroenterology & hepatology Vol.21 No.7

OBJECTIVES: Changes in the pattern of gastrointestinal diseases in a population tend to be influenced by changes in diet and lifestyle. Shifts in gastrointestinal disease from 1995 to 2005 in Korea were evaluated, retrospectively. METHODS: Seventeen nationwide medical centers participated in this study. The cross-sectional review of endoscopic findings in 28 893 patients included 8441 patients from 1995, 10 350 patients from 2000, and 10 102 patients from 2005. RESULTS: The prevalence of reflux esophagitis increased from 1.8% in 1995 to 5.9% in 2000 and 9.1% in 2005 (P<0.001, the P value was only for the comparison between 1995 and 2005, the followings were as same). The prevalence of peptic ulcer diseases was 18.0% in 1995, 19.1% in 2000, and 20.2% in 2005 (P<0.001). Although no significant differences were noted in duodenal ulcers (8.4, 8.7, and 8.2%, P=0.449), gastric ulcers showed an increasing trend (9.6, 10.5, and 12.0%, P<0.001). The prevalence of gastric cancer increased from 3.4% in 1995 to 4.5% in 2000 (P<0.001), but then decreased to 2.4% in 2005 (P<0.001). The incidence of advanced gastric cancer was 2.5, 3.2, and 1.3%, respectively (P<0.001), and that of early gastric cancer remained constant with rates of 0.8%, 1.3, and 1.1%, respectively (P=0.056). CONCLUSION: The cross-sectional review of data collected in 1995, 2000, and 2005 showed an increase in reflux esophagitis and peptic ulcer diseases. Meanwhile, the prevalence of gastric cancer increased until 2000, but decreased in 2005.

Activity of Green Tea Polyphenol Epigallocatechin-3-gallate Against Ovarian Carcinoma Cell Lines

Yong Wook Kim,Su Mi Bae,Sung Eun Namkoong,Sei Jun Han,Sang Hee Kim,Yong-Wan Kim,Joon Mo Lee,Byoung Rai Lee,Young Joo Lee,Woong Shick Ahn,Insu P. Lee,Chong Kook Kim 대한암학회 2004 Cancer Research and Treatment Vol.36 No.5

Purpose: A constituent of green tea, (-)-epigallocatechin-3-gallate (EGCG), is known to possess anti-cancer properties. In this study, the time-course of the anticancer effects of EGCG on human ovarian cancer cells were investigated to provide insights into the molecular-level understanding of the growth suppression mechanism involved in EGCG-mediated apoptosis and cell cycle arrest. Materials and Methods: Three human ovarian cancer cell lines (p53 negative, SKOV-3 cells; mutant type p53, OVCAR-3 cells; and wild type p53, PA-1 cells) were used. The effect of EGCG treatment was studied via a cell count assay, cell cycle analysis, FACS, Western blot and macroarray assay. Results: EGCG exerts a significant role in suppressing ovarian cancer cell growth, showed dose dependent growth inhibitory effects in each cell line and induced apoptosis and cell cycle arrest. The cell cycle was arrested at the G1 phase by EGCG in SKOV-3 and OVCAR-3 cells.In contrast, the cell cycle was arrested in the G1/S phase in PA-1 cells. EGCG differentially regulated the expression of genes and proteins (Bax, p21, Retinoblastoma, cyclin D1, CDK4 and Bcl-XL) more than 2 fold, showing a possible gene regulatory role for EGCG. The continual expression in p21WAF1 suggests that EGCG acts in the same way with p53 proteins to facilitate apoptosis after EGCG treatment. Bax, PCNA and Bcl-X are also important in EGCG-mediated apoptosis. In contrast, CDK4 and Rb are not important in ovarian cancer cell growth inhibition. Conclusion: EGCG can inhibit ovarian cancer cell growth through the induction of apoptosis and cell cycle arrest, as well as in the regulation of cell cycle related proteins. Therefore, EGCG-mediated apoptosis could be applied to an advanced strategy in the development of a potential drug against ovarian cancer. (Cancer Res Treat. 2004;36:315-323)

아미노산 수액의 신속한 정맥내 주사 후 담낭 수축에 관한 연구

김미영,김영수,최원,장재남,김명식,김인한,신용운,권계숙,이돈행,오윤주,김형길,이재수,김범수,조현근 대한소화기학회 1999 대한소화기학회지 Vol.33 No.1

Background/Aims: Gallbladder (GB) sludges and/or gallstones frequently develop due to hypomotility of GB after long-term total parenteral nutrition, abdominal surgery, bone marrow transplantatation, AIDS infection, trauma. The purpose of this study is to promote GB contraction and emptying with the rapid intravenous infusion of aminoacids and then, to determine the most effective dosage and infusion rate. Methods: After infusion of aminoacids, the volume of GB was measured serially using ultrasonography before infusion and immediately (0 min), 15 min, 30 min, 45 min and 60 min after infusion. The subjects of this study were 28 healthy male volunteers aged from 23 to 26. For control group (n=4), 250 cc of normal saline was infused for 30 min. For group A (n=8), 250 cc of aminoacids solution was infused for 30 min (21.2 g, 0.7 g/min). For group B (n=8), 250 cc of aminoacids solution was infused for 10 min (21.2 g, 2.1 g/mn). For group C (n=8), 125 cc of aminoacids solution was infused for 5 min (10.6 g, 2.1 g/min). Results: The volume of GB was significantly decreased with the lapse of time in A, B, C groups and the most significant change occurred at 45 min after infusion (p=0.0001). These groups showed significant volume change com pared to control group (p=0.0029). At 15 min after infusion, significant GB contraction occurred in group B, C compared to control group (p=0.0030). Only B group showed significant GB contraction at 45 min after infusion (p=0.0041). Conclusions: It is concluded that the intermittent rapid intravenous minoacids infusion may be useful to prevent GB sludges in the high risk groups. (Kor J Gastroenterol 1999;33:90 - 96)

Pharmacodynamic Effect of Cilostazol Plus Standard Clopidogrel Versus Double-Dose Clopidogrel in Patients With Type 2 Diabetes Undergoing Percutaneous Coronary Intervention

Jeong, Young-Hoon,Tantry, Udaya S.,Park, Yongwhi,Kwon, Tae Jung,Park, Jeong Rang,Hwang, Seok-Jae,Bliden, Kevin P.,Koh, Eun-Ha,Kwak, Choong Hwan,Hwang, Jin-Yong,Kim, Sunjoo,Gurbel, Paul A. American Diabetes Association 2012 Diabetes care Vol.35 No.11

<P><B>OBJECTIVE</B></P><P>To determine the effect of adding cilostazol (100 mg b.i.d.) to standard-dose clopidogrel (75 mg/d) (TRIPLE) compared with double-dose clopidogrel (150 mg/d) (DOUBLE) and the influence of the cytochrome P450 (<I>CYP2C19*2/*3</I>, <I>CYP3A5*3)</I>and ATP-binding cassette subfamily B1(<I>ABCB1 C3435T</I>) genetic polymorphisms in type 2 diabetes (T2DM) patients.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>T2DM patients were treated with TRIPLE (<I>n</I> = 41) or DOUBLE (<I>n</I> = 39) after percutaneous coronary intervention. Conventional aggregometry and VerifyNow were performed at baseline and at 30 days. The primary end point was absolute change in 20-μM ADP-induced maximal platelet aggregation (ΔMPA<SUB>20</SUB>) between baseline and switching values.</P><P><B>RESULTS</B></P><P>TRIPLE versus DOUBLE showed greater ΔMPA<SUB>20</SUB> (22.9 ± 11.6 vs.12.7 ± 15.5%; difference, 10.2% [95% CI 4.2–16.3]; <I>P</I> < 0.001). Carriage of one (β coefficient, −5.4%; <I>P</I> = 0.162) and two <I>CYP2C19</I> loss-of-function allele(s) (−8.3%; <I>P</I> = 0.007) were associated with lower ΔMPA<SUB>20</SUB> in DOUBLE–treated patients, but not in TRIPLE-treated patients.</P><P><B>CONCLUSIONS</B></P><P>Among T2DM patients, adding cilostazol achieves greater platelet inhibition compared with clopidogrel (150 mg/d), which is not influenced by genetic polymorphisms.</P>

Circulating TNF receptors predict cardiovascular disease in patients with chronic kidney disease

Bae, Eunjin,Cha, Ran-Hui,Kim, Yong C.,An, Jung N.,Kim, Dong K.,Yoo, Kyung D.,Lee, Su M.,Kim, Myoung-Hee,Park, Jung T.,Kang, Shin-Wook,Park, Jae Y.,Lim, Chun S.,Kim, Yon S.,Yang, Seung H.,Lee, Jung P. Williams & Wilkins Co 2017 Medicine Vol.96 No.19

<P>We prospectively recruited 984 patients with CKD from 11 centers between 2006 and 2012. The levels of cTNFR1 and cTNFR2 were determined by performing an enzyme-linked immunosorbent assay. During the mean follow-up period of 4 years, 36 patients experienced a CVD event. The median serum concentrations of cTNFR1 and cTNFR2 were 2703.4 (225.6-13,057.7) and 5661.0 (634.9-30,599.6) pg/mL, respectively, and the cTNFR1 level was closely correlated with the cTNFR2 level (r=0.86, P < .0001). The urinary protein-to-creatinine ratio (UPCR) and estimated glomerular filtration rate (eGFR) were significantly correlated with the cTNFR2 level (r=0.21 for UPCR, r=-0.67 for eGFR; P<.001 for all). Similar correlations were observed for serum cTNFR1 (r=0.21 for UPCR, r=-0.75 for eGFR; P < .001 for all). In the Cox proportional hazard analyses, cTNFR1 (hazard ratio [HR] 2.506, 95% confidence interval [CI] 1.186-5.295, P=.016) and cTNFR2 (HR4.156, 95% CI 1.913-9.030, P < .001) predictedCVDrisk even after adjustment for clinical covariates, such as UPCR, eGFR, and high-sensitivity C-reactive protein. cTNFR1 and 2 are associated with CVD and other risk factors in CKD, independently of eGFR and UPCR. Furthermore, cTNFRs could be relevant predictors of CVD in CKD patients.</P>

Preparation of Photocathodic p-CuFeO₂ Nanocolumnar Film by Reactive Ballistic Deposition

Yong Ho Lee(이용호),P.V.R.K Ramacharyulu(P.V.R.K. 라마차류루),Pil Gun Oh(오필건),Chang Woo Kim(김창우) 한국태양에너지학회 2021 한국태양에너지학회 학술대회논문집 Vol.2021 No.11

Crystal structure of pre-activated arrestin p44

Kim, Yong Ju,Hofmann, Klaus Peter,Ernst, Oliver P.,Scheerer, Patrick,Choe, Hui-Woog,Sommer, Martha E. Nature Publishing Group, a division of Macmillan P 2013 Nature Vol.497 No.7447

Arrestins interact with G-protein-coupled receptors (GPCRs) to block interaction with G proteins and initiate G-protein-independent signalling. Arrestins have a bi-lobed structure that is stabilized by a long carboxy-terminal tail (C-tail), and displacement of the C-tail by receptor-attached phosphates activates arrestins for binding active GPCRs. Structures of the inactive state of arrestin are available, but it is not known how C-tail displacement activates arrestin for receptor coupling. Here we present a 3.0 Å crystal structure of the bovine arrestin-1 splice variant p44, in which the activation step is mimicked by C-tail truncation. The structure of this pre-activated arrestin is profoundly different from the basal state and gives insight into the activation mechanism. p44 displays breakage of the central polar core and other interlobe hydrogen-bond networks, leading to a ∼21° rotation of the two lobes as compared to basal arrestin-1. Rearrangements in key receptor-binding loops in the central crest region include the finger loop, loop 139 (refs 8, 10, 11) and the sequence Asp 296–Asn 305 (or gate loop), here identified as controlling the polar core. We verified the role of these conformational alterations in arrestin activation and receptor binding by site-directed fluorescence spectroscopy. The data indicate a mechanism for arrestin activation in which C-tail displacement releases critical central-crest loops from restricted to extended receptor-interacting conformations. In parallel, increased flexibility between the two lobes facilitates a proper fitting of arrestin to the active receptor surface. Our results provide a snapshot of an arrestin ready to bind the active receptor, and give an insight into the role of naturally occurring truncated arrestins in the visual system.

복직근에 발생한 원발성 복부 방선균증 1 예

김미영,김영수,박상준,신용운,권계숙,이돈행,민효영,조현근,김대혁,김준미,김범수,최 원 대한소화기학회 1999 대한소화기학회지 Vol.33 No.6

Actinomycosis is a chronic granulomatous and suppurative disease caused by Actinomyces species. As a pathogen, it can cause fistulas or sinuses, and may form a mass. Sulfur granules in the lesion, sinu walls or discharge are characteristics of actinomycosis. The most common location of abdominal actinomycosis is the appendix or ileocecal region of the intestine. In addition, actinomycosis has been found in the rectum, the sigmoid and the transverse colon as well as the liver, the pancreas and th pelvis. However, primary rectus abdominis actinomycosis is a rare form of actinomycosis. We repor a case of primary rectus abdominis actinomycosis presenting an abdominal mass in a 60-year-old man whose chief complaint is fever.

십이지장궤양 환자에서 혈액형 및 흡연과 Helicobacter pylori 감염과의 상관 관계

김영수,최원,김영배,김명식,신용운,권계숙,이돈행,조현근,김범수,장재남 대한소화기학회 1999 대한소화기학회지 Vol.32 No.6

Background/Aims: Helicobacter pylori (H. pylori) infects over half of world' s population and is associated with peptic ulcer disease. The age, sex, blood type O and smoking history are also known as the risk factors causing duodenal ulcer. The purpose of this study was to evaluate the relationship between these risk factors and histology of gastritis associated with H. pylori. Methods: The study population consisted of 53 patients with endoscopically confirmed duodenal ulcer. The history of smoking was confirmed and ABO blood type was determined by slide agglutination. Two biopsy specimens were taken from the antrum during gastroscopy and were processed with routine H-E and alcian yellow-toluidine blue stain for grading of histologic finding and H. pylori colonization. The parameters (H. pylori colonization, neutrophil infiltration and the severity of chronic gastritis) tha could be assessed in a semi- quantitative fashion were graded on a scale ranging from 0 through 5 Results: H. pylori infection was identified in 92% (49/53) of patients with duodenal ulcer. However the scoring of H. pylori gastritis was not different statistically according to age, sex, blood type and smoking. Chronic gastritis of smoker was significantly severer than that of non-smoker (p$lt;0.05) Conclusions: We suggest that H. pylori infection is not correlated with age, sex, blood type and smoking in causing duodenal ulcer.

Hydrogen Absorption in Ti45Zr38-xNi17+x Quasicrystals and Measurements of the Equilibrium Vapor Pressure

Kim Jae Yong,Gibbons, P . C .,Kelton, K . F . 대한금속재료학회(대한금속학회) 1999 METALS AND MATERIALS International Vol.5 No.6

To evaluate their technological usefulness and to probe the local structure of the quasicrystal, p-c-T curves were measured for as-quenched Ti_(45)Zr_(38)Ni_(17) and Ti_(45)Zr_(30)Ni_(25) quasicrystal ribbons at 350℃ with a computer-controlled apparatus. For both quasicrystals, the p-c-T curves do not exhibit a clear pressure plateau. Instead, the equilibrium vapor pressure remains low ($lt; 5 torn) below H/M ◎1; it increases sharply for increasing H/M. Such p-c-T curves may reflect structural features of the quasicrystal. Due to the formation of the crystal hydride phase during the p-c-T measurements, however, the site energy distribution in the quasicrystals could not be obtained. Instead, qualitative conclusions are presented. For Ti_(45)Zr_(38)Ni_(17) quasicrystals, estimates of the site energy distribution for hydrogen suggest a prominent site located between -0.2 eV and -0.15 eV with a possible broad, weakly binding second peak at higher energy. The site energy locations for hydrogen for Ti_(45)Zr_(30)Ni_(25) quasicrystals are similar. The Ti_(45)Zr_(38)Ni_(17) quasicrystals desorb most of the absorbed hydrogen at 650℃ in one hour by continuous pumping without phase transformation, and do not become powder after three cycles.