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김이슬 ( Yi-seul Kim ),김슬기 ( Seul-gi Kim ),임순연 ( Soon-ryun Lim ),조수정 ( Su-jung Cho ) 한국치위생학회 2023 한국치위생학회지 Vol.23 No.6
Objectives: This study aimed to analyze research literature, created over the past 10 years, on occupational stress among domestic dental hygienists and identify the major factors affecting occupational stress. Methods: Of the 192 articles found through literature searches, 26 were selected for the analysis after reviewing titles, abstracts, and full texts. General characteristics of each study, measurement tools employed, and data related to pertinent factors were systematically analyzed. Results: Seven instruments were utilized to measure job stress. Among the variables exhibiting positive correlation with occupational stress, turnover intention was the most prevalent, while variables showing negative correlation were predominantly associated with job satisfaction. Factors influencing occupational stress included emotional labor, workload, organizational social capital, and experiencing verbal abuse. Conclusions: With regard to the most influential factors, “emotional labor” and “turnover intention” had the greatest impacts on job stress and occupational stress, respectively. Based on the findings of this study, follow-up research needs to be conducted to suggest ways to prevent, manage, and reduce occupational stress among dental hygienists
Cho, Kwang-Hyun,Lee, Seul-Yi,Joo, Kayoung,Rhie, Duck-Joo The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.5
It is known that top-down associative inputs terminate on distal apical dendrites in layer 1 while bottom-up sensory inputs terminate on perisomatic dendrites of layer 2/3 pyramidal neurons (L2/3 PyNs) in primary sensory cortex. Since studies on synaptic transmission in layer 1 are sparse, we investigated the basic properties and cholinergic modulation of synaptic transmission in layer 1 and compared them to those in perisomatic dendrites of L2/3 PyNs of rat primary visual cortex. Using extracellular stimulations of layer 1 and layer 4, we evoked excitatory postsynaptic current/potential in synapses in distal apical dendrites (L1-EPSC/L1-EPSP) and those in perisomatic dendrites (L4-EPSC/L4-EPSP), respectively. Kinetics of L1-EPSC was slower than that of L4-EPSC. L1-EPSC showed presynaptic depression while L4-EPSC was facilitating. In contrast, inhibitory postsynaptic currents showed similar paired-pulse ratio between layer 1 and layer 4 stimulations with depression only at 100 Hz. Cholinergic stimulation induced presynaptic depression by activating muscarinic receptors in excitatory and inhibitory synapses to similar extents in both inputs. However, nicotinic stimulation enhanced excitatory synaptic transmission by ~20% in L4-EPSC. Rectification index of AMPA receptors and AMPA/NMDA ratio were similar between synapses in distal apical and perisomatic dendrites. These results provide basic properties and cholinergic modulation of synaptic transmission between distal apical and perisomatic dendrites in L2/3 PyNs of the visual cortex, which might be important for controlling information processing balance depending on attentional state.
Seul-Yi Lee,Tuan Anh Vuong,Xianlan Wen,Hyeon-Ju Jeong,Hyun-Kyung So,Ilmin Kwon,Jong-Sun Kang,Hana Cho 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
The sodium leak channel NALCN is a key player in establishing the resting membrane potential (RMP) in neurons andtransduces changes in extracellular Ca2+ concentration ([Ca2+]e) into increased neuronal excitability as thedownstream effector of calcium-sensing receptor (CaSR). Gain-of-function mutations in the human NALCN gene causeencephalopathy and severe intellectual disability. Thus, understanding the regulatory mechanisms of NALCN isimportant for both basic and translational research. This study reveals a novel mechanism for NALCN regulation byarginine methylation. Hippocampal dentate granule cells in protein arginine methyltransferase 7 (PRMT7)-deficientmice display a depolarization of the RMP, decreased threshold currents, and increased excitability compared to wildtypeneurons. Electrophysiological studies combined with molecular analysis indicate that enhanced NALCN activitiescontribute to hyperexcitability in PRMT7−/− neurons. PRMT7 depletion in HEK293T cells increases NALCN activity byshifting the dose-response curve of NALCN inhibition by [Ca2+]e without affecting NALCN protein levels. In vitromethylation studies show that PRMT7 methylates a highly conserved Arg1653 of the NALCN gene located in thecarboxy-terminal region that is implicated in CaSR-mediated regulation. A kinase-specific phosphorylation siteprediction program shows that the adjacent Ser1652 is a potential phosphorylation site. Consistently, our data fromsite-specific mutants and PKC inhibitors suggest that Arg1653 methylation might modulate Ser1652 phosphorylationmediated by CaSR/PKC-delta, leading to [Ca2+]e-mediated NALCN suppression. Collectively, these data suggest thatPRMT7 deficiency decreases NALCN methylation at Arg1653, which, in turn, decreases CaSR/PKC-mediated Ser1652phosphorylation, lifting NALCN inhibition, thereby enhancing neuronal excitability. Thus, PRMT7-mediated NALCNinhibition provides a potential target for the development of therapeutic tools for neurological diseases.
Yi Seul Choi,Jeong‐Kwon Choi,김종우,Kyung Tae Min,권영도,장문주,So Young Chong,오도연,Yoon Kyung Cho,Seung Ho Hong,김남근 한국유전학회 2011 Genes & Genomics Vol.33 No.2
Angiogenesis plays a pivotal role in the development of colon cancer during the promotion and metastasis of tumor growth. Vascular endothelial growth factor (VEGF) is known to be a potent angiogenic factor. This hospital‐based case‐control study was carried out to decide where there existed an association between the VEGF ‐1154G>A polymorphism and the susceptibility to colon cancer. DNA samples taken from 278 colon cancer patients and 226 healthy controls were studied using with real‐time PCR for VEGF ‐1154G>A polymorphism. Genotype frequencies of the VEGF ‐1154G>A polymorphism were significantly different between patient and control groups (adjusted OR=2.735, 95% CI=1.243‐6.015 for AA vs. GG genotype). In addition, upon stratification by gender and age, the frequencies of the A allele‐bearing genotypes significantly increased the risk for development of colon cancer in men and patients younger than 55 years (in men, adjusted OR=3.375,95% CI=1.062‐10.717, and in <55 years, adjusted OR=4.908,95% CI=1.294‐18.617). Also, upon stratification of patients with proximal and distal colon cancer individually, the association only showed these significant patterns in distal colon cancer. This study provides evidence that VEGF ‐1154G>A polymorphism, at least in Koreans, might be associated with risks of the colon cancer, particularly in males.
Effect of microporosity on nitrogen-doped microporous carbons for electrode of supercapacitor
Cho, Eun-A,Lee, Seul-Yi,Park, Soo-Jin 한국탄소학회 2014 Carbon Letters Vol.15 No.3
Nitrogen-doped microporous carbons were prepared using a polyvinylidene fluoridemelamine mixture. The electrochemical performance of the nitrogen-doped microporous carbons after being subjected to different carbonization conditions was investigated. The nitrogen to carbon ratio and specificsurface area decreased with an increase in the carbon-ization temperature. However, the maximum specificcapacitance of 208 F/g was obtained at a carbonization temperature of 800ºC because it produced the highest microporosity.
Post-translational modification of OCT4 in breast cancer tumorigenesis
Cho, Yunhee,Kang, Hyeok Gu,Kim, Seok-Jun,Lee, Seul,Jee, Sujin,Ahn, Sung Gwe,Kang, Min Jueng,Song, Joon Seon,Chung, Joon-Yong,Yi, Eugene C.,Chun, Kyung-Hee Nature Publishing Group 2018 CELL DEATH AND DIFFERENTIATION Vol. No.
<P>Recurrence and drug resistance of breast cancer are still the main reasons for breast cancer-associated deaths. Cancer stem cell (CSC) model has been proposed as a hypothesis for the lethality of breast cancer. Molecular mechanisms underlying CSC maintenance are still unclear. In this study, we generated mammospheres derived from breast cancer MDA-MB231 cells and MCF7 cells to enrich CSCs and performed DNA microarray analysis. We found that the expression of carboxy terminus of HSP70-interacting protein (CHIP) E3 ubiquitin ligase was significantly downregulated in breast CSCs. CHIP depletion increased mammosphere formation, whereas CHIP overexpression reversed this effect. We identified interactomes by mass spectrometry and detected CHIP directly interacted with OCT4, a stemness factor. CHIP overexpression decreased OCT4 stability through proteasomal degradation. CHIP induced OCT4 ubiquitination, whereas H260Q, a catalytic CHIP mutant, did not. Interestingly, we determined that OCT4 was ubiquitinated at lysine 284, and CHIP overexpression did not degrade K284R mutant OCT4. CHIP overexpression decreased the proliferation and side population of breast cancer cells, but these were not occurred in K284R mutant OCT4 overexpressed cells. Only 1000 cells showing CHIP depletion or OCT4 overexpression sufficiently generated breast tumors and lung metastases in xenografted mice. Ubiquitination-defective mutant of OCT4(K284R) overexpressed cells drastically generated tumor burdens in mice. Patients with breast cancer who showed low CHIP expression had poor survival probability. Taken together, we suggest that CHIP-induced OCT4 ubiquitination is important in breast CSCs. Regulation of CHIP expression and OCT4 protein stability is a considerable approach for breast cancer therapy.</P>
Seul-Yi Lee,Tuan Anh Vuong,Hyun-Kyung So,Hyun-Ji Kim,Yoo Bin Kim,Jong-Sun Kang,Ilmin Kwon,Hana Cho 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
HCN channels regulate excitability and rhythmicity in the hippocampal CA1 pyramidal cells. Perturbation in the HCN channel current (Ih) is associated with neuropsychiatric disorders, such as autism spectrum disorders. Recently, protein arginine methyltransferase 7 (PRMT7) was shown to be highly expressed in the hippocampus, including the CA1 region. However, the physiological function of PRMT7 in the CA1 neurons and the relationship to psychiatric disorders are unclear. Here we showed that PRMT7 knockout (KO) mice exhibit hyperactivity and deficits in social interaction. The firing frequency of the CA1 neurons in the PRMT7 KO mice was significantly higher than that in the wild-type (WT) mice. Compared with the WT CA1 neurons, the PRMT7 KO CA1 neurons showed a more hyperpolarized resting potential and a higher input resistance, which were occluded by the Ih-current inhibitor ZD7288; these findings were consistent with the decreased Ih and suggested the contribution of Ih-channel dysfunction to the PRMT7 KO phenotypes. The HCN1 protein level was decreased in the CA1 region of the PRMT7 KO mice in conjunction with a decrease in the expression of Shank3, which encodes a core scaffolding protein for HCN channel proteins. A brief application of the PRMT7 inhibitor DS437 did not reproduce the phenotype of the PRMT7 KO neurons, further indicating that PRMT7 regulates Ih by controlling the channel number rather than the open probability. Moreover, shRNA-mediated PRMT7 suppression reduced both the mRNA and protein levels of SHANK3, implying that PRMT7 deficiency might be responsible for the decrease in the HCN protein levels by altering Shank3 expression. These findings reveal a key role for PRMT7 in the regulation of HCN channel density in the CA1 pyramidal cells that may be amenable to pharmacological intervention for neuropsychiatric disorders.