Case Reports : Paroxysmal Supraventricular Tachycardia in an Infant with Hand, Foot, and Mouth Disease

( Peng Hu ),( Shu Hou ),( Peng Fei Du ),( Jia Bin Li ),( Ying Ye ) 대한피부과학회 2012 Annals of Dermatology Vol.24 No.2

An 11-month-old male infant was admitted to our hospital with fever, fussiness, poor feeding, vomiting, and tachypnea for two days prior. Physical examination revealed sporadic papules and vesicles occurring on his hands, feet, face, and perianal mucosa. Enterovirus 71 was identified from both throat swab and vesicle fluid using virus isolation techniques. The patient`s heart rate fluctuated in a very narrow range from 180~210/beats/min regardless of his physiologic state. An electrocardiogram showed P-waves buried within or occurring just after regular, narrow, QRS complexes. The patient was diagnosed as having hand, foot, and mouth disease in combination with paroxysmal supraventricular tachycardia (PSVT). The child recovered well with symptomatic treatment, including intravenous administration of acyclovir, glucocorticoids, immunoglobulin, adenosine, and sotalol. PSVT was terminated within 36 hours of hospitalization. The skin lesions became crusted on the third day, and then proceeded to heal spontaneously. Here we report on this unusual case and review the associated literature. (Ann Dermatol 24(2) 200∼202, 2012)

The Bioactive Effects of Chicoric Acid As a Functional Food Ingredient

Ye Peng,Quancai Sun,박연화 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.7

Chicoric acid, a hydroxycinnamic acid, has been reported to possess a variety of health benefits, including antivirus, antioxidant, anti-inflammation, obesity prevention, and neuroprotection effects. The purpose of this article is to summarize current knowledge of pharmacological and biological effects of chicoric acid. Since most studies to date on chicoric acid have limited their focus to cell cultures and animals, more human and mechanistic studies are therefore needed to further determine the beneficial effects of chicoric acid as a potential functional food ingredient.

siRNA-mediated Silencing of Notch-1 Enhances Docetaxel Induced Mitotic Arrest and Apoptosis in PCa Cells

Ye, Qi-Fa,Zhang, Yi-Chuan,Peng, Xiao-Qing,Long, Zhi,Ming, Ying-Zi,He, Le-Ye Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

Purpose: Notch is an important signaling pathway that regulates cell fate, stem cell maintenance and the initiation of differentiation in many tissues. It has been reported that activation of Notch-1 contributes to tumorigenesis. However, whether Notch signaling might have a role in chemoresistance of prostate cancer is unclear. This study aimed to investigate the effects of Notch-1 silencing on the sensitivity of prostate cancer cells to docetaxel treatment. Methods: siRNA against Notch-1 was transfected into PC-3 prostate cancer cells. Proliferation, apoptosis and cell cycle distribution were examined in the presence or absence of docetaxel by MTT and flow cytometry. Expression of $p21^{waf1/cip1}$ and Akt as well as activation of Akt in PC-3 cells were detected by Western blot and Real-time PCR. Results: Silencing of Notch-1 promoted docetaxel induced cell growth inhibition, apoptosis and cell cycle arrest in PC-3 cells. In addition, these effects were associated with increased $p21^{waf1/cip1}$ expression and decreased Akt expression and activation in PC-3 cells. Conclusion: Notch-1 promotes chemoresistance of prostate cancer and could be a potential therapeutic target.

An Analytical Solution for Analyzing the Sealing-efficiency of Compressed Air Energy Storage Caverns

Bin Ye,Zirui Cheng,Weimin Ye,Yicheng Peng 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.5

Compressed Air Energy Storage (CAES) is a commercial, utility-scale technology that is suitable for providing long-duration energy storage. Underground air storage caverns are an important part of CAES. In this paper, an analytical solution for calculating air leakage and energy loss within underground caverns were proposed. Using the proposed solution, the air leakage and energy loss under a typical CAES operation pressure were analyzed, and the influences of the permeability of the concrete lining and the lining thickness on the sealing efficiency of underground caverns were investigated. The results showed that under a typical CAES operation pressure, a concrete lining with a permeability of less than 6.36 × 10−18 m2 would result in an acceptable air leakage rate of less than 1%. Air leakage will increase linearly with increasing lining permeability. Increasing the thickness of the concrete lining could enhance the sealing efficiency of the storage cavern.

Research On Optimization In NC Bending Process Of Thin-walled Tube Based on Orthogonal Experiment

Ren Sheng-le,Wang Peng,Dai Ye 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.1

In the process of research and development of tube bending forming technology, the way of improving the forming quality and establishing the optimization of forming process parameters has become an important problem that should be solved quickly. This text simulated the process of bend forming with the way of finite element, combined with the effects of geometric and physical parameters on the forming quality of bending pipe, taking the important parameters which are measurements of the pipe wall thickness variation as test indexes, made the virtual orthogonal experiment and gained the laws of the bending angle, relative bending radius, relative wall thickness, thrust, pipe friction coefficient between mode have effects on the forming quality of wall thinning rate and wall thickening. Through the comprehensive analysis and additional test, obtained the optimal parameters values, improved the accuracy of simulation and the optimization results of orthogonal test, improved the quality of tube bending forming.

Spectral Image Reconstruction of Chinese Ink and Wash Painting Based on Self-training with Multispectral Imaging

Peng Xu,Jueqin Qiu,Haisong Xu,Zhengnan Ye 한국색채학회 2017 AIC 2017 Jeju Vol.2017 No.10

The Chinese ink and wash painting is a special type of Chinese classic paintings. In this study, the spectral image of the Chinese ink and wash painting was reconstructed with multispectral imaging based on a self-training method. By partitioning the multispectral images of the painting with k-means clustering algorithm, the training samples are directly selected from the painting itself to restrain the deterioration of the spectral estimation caused by the material inconsistence between the training samples and the object painting in the conventional spectral reconstruction technique. In each cluster, only one sample which owns minimum mean distance to all the other samples residing in the cluster is chosen as the training sample. The spectral image of a Chinese ink and wash painting was reconstructed with a filter wheel based multispectral camera, indicating that the recovered spectral reflectance of the Chinese ink and wash painting based on this self-training method is more accurate than that based on the commercial color target.

Synthesis of intermediate for lamellarin H

Ye-cheng You,Guang Yang,Ai-ling Wang,De-peng Li 한국물리학회 2005 Current Applied Physics Vol.5 No.5

Fabrication processing of a intermediate, 2,4,5-trimethoxy-a-chlor-acetophenone, was reported in details in this paper. The inter-mediate is the key substance for synthesis of lamellarin H and its derivatives by a simple synthesis route proposed recently. Lam-ellarin H has been shown to have antitumour activity (in particular, against human lung cancer) and anti-HIV properties. Theformed intermediate was identied by means of IR spectrum, HPLC, UV spectrum, H NMR and melting point measurement..

ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression

Ye Guiwen,Li Jinteng,Yu Wenhui,Xie Zhongyu,Zheng Guan,Liu Wenjie,Wang Shan,Cao Qian,Lin Jiajie,Su Zepeng,Li Dateng,Che Yunshu,Fan Shuai,Wang Peng,Wu Yanfeng,Shen Huiyong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Improving health and delaying aging is the focus of medical research. Previous studies have shown that mesenchymal stem cell (MSC) senescence is closely related to organic aging and the development of aging-related diseases such as osteoarthritis (OA). m6A is a common RNA modification that plays an important role in regulating cell biological functions, and ALKBH5 is one of the key m6A demethylases. However, the role of m6A and ALKBH5 in MSC senescence is still unclear. Here, we found that the m6A level was enhanced and ALKBH5 expression was decreased in aging MSCs induced by multiple replications, H2O2 stimulation or UV irradiation. Downregulation of ALKBH5 expression facilitated MSC senescence by enhancing the stability of CYP1B1 mRNA and inducing mitochondrial dysfunction. In addition, IGF2BP1 was identified as the m6A reader restraining the degradation of m6A-modified CYP1B1 mRNA. Furthermore, Alkbh5 knockout in MSCs aggravated spontaneous OA in mice, and overexpression of Alkbh5 improved the efficacy of MSCs in OA. Overall, this study revealed a novel mechanism of m6A in MSC senescence and identified promising targets to protect against aging and OA.

Effect of nano-carbon addition on color performance of polystyrene superstructure film

Ye-min ZHOU,Li-li Wang,Xiao-peng LI,Xiu-feng Wang,Hong-tao JIANG 한양대학교 세라믹연구소 2018 Journal of Ceramic Processing Research Vol.19 No.6

Polystyrene superstructure films show faint rainbow color, and this low color saturation limits its wide application. In thispaper, polystyrene superstructure films with single bright blue color were prepared by vertical deposition self-assemblymethod using polystyrene microspheres with average diameter of 310 ± 10 nm as raw material. Polystyrene superstructurefilms were modified by adding nano-carbon powder, and effect of the amount of nano-carbon powde on color performancewas studied. The results showed that without addition of nano-carbon powder, the superstructure films showed a faint rainbowcolor, while with addition of nano-carbon power, the superstructure films exhibited a single bright blue under the same naturallight source. Changing the amount of nano-carbon powder addition could adjust color saturation of the film. With increasingthe amount of nano-carbon powder addition from 0.008 wt% to 0.01 wt%, color saturation of the superstructure filmincreased gradually. Further increasing the amount of nano-carbon powder addition to 0.011wt%, color saturation of thesuperstructure film didn’t increase anymore and tended to get dark.

De novo malignancy after liver transplantation

Peng Ji Gao,Jie Gao,Zhao Li,Zhi Ping Hu,Ji Ye Zhu 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.88 No.4

Purpose: The aim of this study is to evaluate the incidence of de novo malignancy after liver transplantation (LT) and compare with those among the general Chinese population. Methods: A total of 466 patients who had a minimum follow-up time of 6 months were enrolled in the study. All data of medical records and follow up were retrospectively reviewed. Results: The incidence rate of de novo malignancy was 3.0% (14 in 466 patients). The median elapsed time from transplant to the diagnosis of de novo malignancy was 42 months (range, 6 to 106 months). The cumulative risk for development of de novo malignancy was 1.6%, 2.7%, and 8.2% at 3, 5 and 10 years after LT, respectively. The patients were all male. The types of de novo tumors included digestive system tumor (8 in 14), lung cancer (2 in 14), urologic neoplasm (2 in 14), and hematologic malignant tumor (2 in 14). Over a mean follow-up of 24 months after diagnosis of de novo malignancy, 7 patients (50.0%) died; the overall 5-year patient survival rate was 54.5%. The relative risk of malignancy following LT was 9.5 folds higher than the general Chinese population. Conclusion: The relative risk of malignancy following LT was much higher than the general Chinese population. Digestive system tumor is the most common type of de novo malignancy after LT in China.