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Chemical Constituents of the Morinda tomentosa Leaves and their α-Glucosidase Inhibitory Activity
Vu, Huong Giang,Ninh, Khac Ban,Nguyen, Xuan Nhiem,Phan, Van Kiem,Chau Van, Minh,Hoang, Le Tuan Anh,Pham, Hai Yen,Bui, Huu Tai,Nguyen, Xuan Cuong,Nguyen, Hoai Nam,Kim, Seung Hyun,Kwon, Young-In,Kim, Yo Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.5
Service Migration over Edge Computing Infrastructure
Xuan-Tuong Vu,Minh-Ngoc Tran,Young-Han Kim 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.2
Multi-access Edge Computing (MEC) is a new promising technique, which provides lowlatency services to end-users. However, due to the limited resource of the edge node and the mobility of users, deploying applications at the edge does not guarantee continuous service for mobile users. User mobility leads to services are disrupted frequently and delayed response since users leave the initial serving edge nodes. In this paper, first, we discuss delivering container orchestration to the edge with an example open-source project and present a solution to integrating service transfer function to the edge platform, which enables transparent service continuity across the Orchestrated Edge computing networks.
Cytotoxic Oleane-type Triterpene Saponins from Glochidion eriocarpum
Nguyen Xuan Nhiem,김영호,Vu Kim Thu,Phan Van Kiem,Chau Van Minh,Bui Huu Tai,TRANHONG QUANG,Nguyen Xuan Cuong,Pham Hai Yen,Hye-Jin Boo,강정일,강희경 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.1
The anticancer activity of ten compounds from the aerial parts of Glochidion eriocarpum were evaluated on two human cancer cell lines, HL-60 and HCT-116. Compounds 1-4 displayed highly potent cytotoxic activity on the HCT-116 cancer cell line with IC50 values ranging of 0.41~1.16 μM. Compounds 1-4 significantly inhibited the HL-60 cell line with IC50 values ranging of 4.51~6.33 μM. These results suggested that the benzoyl group at the C-22 position in oleane-type triterpene saponins was essential for cytotoxicity towards tumor cells. Moreover, compounds 2 and 3 showed more potent cytotoxicity than compounds 1 and 4 against HL-60 and HCT-116 cells. With respect to the mechanism underlying cytotoxicity, compounds 1-4 increased chromatin condensation, a typical apoptotic characteristic in HL-60 and HCT-116 cells. In the mechanism of apoptosis induction, compounds 1-4 reduced Bcl-2expression, whereas the expression of Bax was increased compared to controls in HCT-116 cells. In addition, compounds 1-4 decreased the level of procaspase-3. The cleavage of poly (ADP-ribose) poly merase (PARP), a vital substrate of effector caspase, was observed in HCT-116 cells. Furthermore, the induction of apoptosis was also accompanied by an activation of extracellular signal-regulated kinase (ERK) and p38 kinase in HCT-116 cells. These findings provide evidence demonstrating that the pro-apoptotic effects of compounds 1-4 are mediated through the activation of ERK and p38 in HCT-116 cells.
Inhibitory Activity of Plantago major L. on Angiotensin I-converting Enzyme
Nguyen Xuan Nhiem,김영호,Bui Huu Tai,Phan Van Kiem,Chau Van Minh,Nguyen Xuan Cuong,Nguyen Huu Tung,Vu Kim Thu,Trinh Nam Trung,Hoang Le Tuan Anh,조성훈,장해동,권영인 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3
Eight compounds were isolated from methanol extract of Plantago major L. leaves and investigated for their ability to inhibit angiotensin I-converting enzyme activity. Among them, compound 1 showed the most potent inhibition with rate of 28.06 ± 0.21% at a concentration of 100 μM. Compounds 2 and 8 exhibited weak activities. These results suggest that compound 1 might contribute to the ability of P. major to inhibit the activity of angiotensin I- converting enzyme.
Triterpenoids from aerial parts of Glochidion eriocarpum.
Thu, Vu Kim,Kiem, Phan Van,Yen, Pham Hai,Nhiem, Nguyen Xuan,Tung, Nguyen Huu,Cuong, Nguyen Xuan,Minh, Chau Van,Huong, Hoang Thanh,Lau, Trinh Van,Thuan, Ngo Thi,Kim, Young Ho Natural Product Communications 2010 Natural product communications Vol.5 No.3
<P>From the aerial parts of Glochidion eriocarpum, a new triterpene, glochieriol (1), three new triterpenoid saponins, glochieriosides C - E (2 - 4), together with four known triterpenes (glochidonol, glochidiol, lupeol, and 3-epi-lupeol) were isolated by using combined chromatographic separations. The structures of the new compounds were elucidated on the basis of spectroscopic data, including FTICR-MS, 1D and 2D NMR.</P>
( Dien Minh Vu ),( Binh Hoa Pham ),( Duc Pham Xuan ),( Dung Nguyen Dinh ),( Vinh Nguyen Duy ) 한국공업화학회 2023 공업화학 Vol.34 No.3
Fuel cells are one of the renewable energy sources that have sparked a lot of scientific attention for solving problems related to the energy crisis and environmental pollution. One of the most crucial subjects concerning the utilization of fuel cells is modeling. Therefore, an analytical steady-state and dynamic fuel cell model was described in this study. The parameter for the identification process was investigated, and the MATLAB/Simulink implementation was demonstrated. A 15-W proton exchange membrane fuel cell was used to apply the suggested modeling methodology. Comparing experimental and simulation findings indicated that the model error was constrained to 3%. This study showed that temperature and humidity affect fuel cell performance.
Hoang Vu Dao,Xuan Dinh To,Hoai Vu Anh Truong,Tri-Cuong Do,Cong Minh Ho,Tri Dung Dang,안경관 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.8 No.4
Fuel cell hybrid electric construction equipment (FCHECE) is known as a promising solution to achieve the goal of energy saving and environment protection. Energy management strategy is a key technology of FCHECE, which splits the energy fl ow between power sources. This paper presents a novel optimal energy management strategy for a hybrid electric-powered hydraulic excavator system to enhance power performance, power sources lifespan, and fuel economy. As for the proposed powertrain configuration, fuel cell serves as a primary energy source, and supercapacitor and battery are considered as energy storages. The integration of supercapacitor and battery in fuel cell vehicle has advantages of improving power performance and storing the regenerative energy for future usage. An energy management strategy based on fuzzy logic control and a rule-based algorithm is proposed to effectively distribute the power between the three sources and reuse the regenerative energy. Furthermore, the parameters of the fuzzy logic system are optimized using the combination of a backtracking search algorithm which provides a good direction to the global optimal region and sequential dynamic programming as a local search method to fi ne-tune the optimal solution in order to reduce the hydrogen consumption and prolong the lifetime of the power sources. Simulation results show that the proposed energy management strategy enhances the vehicle performance, improves fuel economy of the FCHECE by 10.919%, increase battery and supercapacitor charge-sustaining capability as well as efficiency of the fuel cell system.
Discovery of cycloartane-<i>type</i> triterpene saponins from <i>Mussaenda glabra</i>
Thu, Vu Kim,Bach, Nguyen Xuan,Anh, Luu The,Trang, Do Thi,Nhiem, Nguyen Xuan,Tai, Bui Huu,Van Kiem, Phan,Van Minh, Chau,Park, SeonJu,Seo, Yohan,Namkung, Wan,Kim, Seung Hyun Elsevier 2019 PHYTOCHEMISTRY LETTERS Vol.33 No.-
<P><B>Abstract</B></P> <P>Five new cycloartane saponins, mussaglaosides A–E (<B>1</B>–<B>5</B>) together with five known saponins, mussaendoside O, mussaendoside, G mussaendoside U, mussaendoside P, and mussaendoside Q (<B>6</B>–<B>10</B>) were isolated from the leaves of <I>Mussaenda glabra.</I> Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, and MS data. All compounds were evaluated for ANO1 inhibitory activity using calcium-activated chloride channel and YFP expressing HT29 cells. Among the tested compounds, compound <B>6</B> strongly inhibited chloride channel activity with IC<SUB>50</SUB> value of 22.0 ± 1.7 μM without any cytotoxicity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Five new cycloartane saponins, mussaglaosides A–E (<B>1</B>–<B>5</B>) were isolated from <I>Mussaenda glabra</I>. </LI> <LI> The structures were successfully determined by spectroscopic evidence. </LI> <LI> Compound <B>6</B> strongly inhibited chloride channel activity (IC<SUB>50</SUB> value of 22.0 ± 1.7 μM). </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Dinh, To Xuan,Thuy, Le Khac,Tien, Nguyen Thanh,Dang, Tri Dung,Ho, Cong Minh,Truong, Hoai Vu Anh,Dao, Hoang Vu,Do, Tri Cuong,Ahn, Kyoung Kwan The Korean Society for Fluid Power and Constructio 2019 드라이브·컨트롤 Vol.16 No.2
Fuel cell hybrid electric vehicle is an attractive solution to reduce pollutants, such as noise and carbon dioxide emission. This study presents an approach for energy management and control algorithm based on energetic macroscopic representation for a fuel cell hybrid electric vehicle that is powered by proton exchange membrane fuel cell, battery and supercapacitor. First, the detailed model of the fuel cell hybrid electric vehicle, including fuel cell, battery, supercapacitor, DC-DC converters and powertrain system, are built on the energetic macroscopic representation. Next, the power management strategy was applied to manage the energy among the three power sources. Moreover, the control scheme that was based on back-stepping sliding mode control and inversed-model control techniques were deduced. Simulation tests that used a worldwide harmonized light vehicle test procedure standard driving cycle showed the effectiveness of the proposed control method.
Nhiem, Nguyen Xuan,Kiem, Phan Van,Minh, Chau Van,Tai, Bui Huu,Cuong, Nguyen Xuan,Thu, Vu Kim,Anh, Hoang Le Tuan,Jo, Sung-Hoon,Jang, Hae-Dong,Kwon, Young-In,Kim, Young Ho The Pharmaceutical Society of Japan 2010 Chemical & pharmaceutical bulletin Vol.58 No.10
<P>One new monoterpenoid glycoside, myresculoside (<B>1</B>), and eleven known compounds, were isolated from methanol extract of <I>Myrica esculenta</I> leaves by repeated column chromatography. The effects of these compounds on angiotensin I-converting enzyme (ACE) inhibition were investigated. Compounds <B>3</B> and <B>4</B> showed the most potent ACE inhibition with rates of 29.97% and 25.63% at concentration of 100 μ<SMALL>M</SMALL>, respectively. Compounds <B>5</B>, <B>6</B>, and <B>11</B> showed weak activity with inhibitory rates of 0.07—1.41% at concentration of 100 μ<SMALL>M</SMALL>.</P>