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Output SNR Analysis of the LPP-Hough Transform
Xiumei Li,Guoqing Yang,Guangchun Gao 한국전자통신연구원 2013 ETRI Journal Vol.35 No.1
Recently, a new method called the local polynomial periodogram-Hough transform (LHT) was proposed for linear frequency modulated (LFM) signal detection. In this letter, a closed-form expression of the output signal-to-noise ratio is derived for the LHT, showing that the method exhibits a threshold effect for LFM signal detection. Comparisons with the pseudo-Wigner-Hough transform (PWHT) show that the threshold of the LHT is lower (better) than that of the PWHT.
Lu Liu,Xiumei Zhang,Dianrong Sun,Tianxiang Gao,Na Song 한국해양과학기술원 2019 Ocean science journal Vol.54 No.2
The population genetic studies of marine fishes usually show complex patterns of genetic differentiation which were influenced by both historical process and contemporary gene flow. Genetic structure of eight different populations for eastern keelback mullet, Liza affinis, collected from the coast along eastern and southern China, was examined using six microsatellite loci. We found strong genetic similarities among most of the samples except the Dongguan population and most microsatellite variation was found within populations. All loci were characterized by high genetic variability with expected heterozygosities ranging from 0.871 to 0.928. The Bayesian cluster analysis of the microsatellite data detected four genetic groups with no relation to geographic areas. The bottleneck results also showed no significant values. Based on these data we postulated that complex marine currents and larval dispersal shaped the genetic structured of studied populations. The present study illustrated the importance of understanding the biological significance of genetic differentiation when using molecular data in identifying units for management and protection.
IL28B Is Associated with Outcomes of Chronic HBV Infection
Xiaodong Shi,Junqi Niu,Xiumei Chi,Yu Pan,Yanhang Gao,Wanyu Li,Chen Yang,Jin Zhong,Damo Xu,Manna Zhang,Gerald Minuk,Jing Jiang 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.3
Purpose: The role of IL28B gene variants and expression in hepatitis B virus (HBV) infections are not well understood. Here, we evaluated whether IL28B gene expression and rs12979860 variations are associated with HBV outcomes. Materialsand Methods: IL28B genetic variations (rs12979860) were genotyped by pyrosequencingof DNA samples from 137 individuals with chronic HBV infection [50 inactive carriers (IC), 34 chronic hepatitis B (CHB), 27 cirrhosis, 26 hepatocellular carcinoma (HCC)], and 19 healthy controls. IL28A/B mRNA expression in peripheralblood mononuclear cells was determined by qRT-PCR, and serum IL28B proteinwas measured by ELISA. Results: Patients with IL28B C/C genotype had greater IL28A/B mRNA expression and higher IL28B protein levels than C/T patients. Within the various disease stages, compared to IC and healthy controls, IL28B expression was reduced in the CHB, cirrhosis, and HCC cohorts (CHB vs. IC, p=0.02; cirrhosis vs. IC, p=0.01; HCC vs. IC, p=0.001; CHB vs. controls, p<0.01; cirrhosis vs. controls, p<0.01; HCC vs. controls, p<0.01). When stratified with respect to serum HBV markers in the IC and CHB cohorts, IL28B mRNA and protein levels were higher in HBeAg-positive than negative individuals (p=0.01). Logistic regression analysis revealed that factors associated with high IL28B proteinlevels were C/C versus C/T genotype [p=0.016, odds ratio (OR)=0.25, 95% confidence interval (CI)=0.08‒0.78], high alanine aminotransferase values (p<0.001, OR=8.02, 95% CI=2.64‒24.4), and the IC stage of HBV infection (p<0.001). Conclusion: Our data suggest that IL28B genetic variations may play an important role in long-term development of disease in chronic HBV infections.
정시연,장민선,최상호,오세량,우홍화,Yan Zhu,Xiumei Gao,Xiaoying Wang,Baojin Zhang,임다솔,이준영,김소담,송윤선 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.5
Phytoestrogen (PE) has received considerableattention due to the physiological significance of itsestrogenicity. Flemingia strobilifera (FS) has been used asa folk medicine in Asia for the treatment of inflammation,cancer, and infection; however, the estrogenic effects andchemical components of FS have not yet been reported. Weaimed to uncover the estrogenic properties and PEs derivedfrom FS using phytochemical and pharmacological evaluation. PEs from FS extract (FSE) were analyzed by NMR,HPLC, and MS. To evaluate estrogenic activity, FSE andits compounds were evaluated by in vitro and in vivoassays, including human estrogen receptor alpha (hERa)binding, estrogen response element (ERE)-luciferasereporter assays, and uterotrophic assays. FSE and itscompounds 1–5 showed binding affinities for hERa andactivated ERE transcription in MCF-7 cells. Additionally,FSE and compounds 1–5 induced MCF-7 cell proliferationand trefoil factor 1 (pS2) expression. In immature femalerats, significant increases in uterine weight and pS2 genewere observed in FSE-treated groups. We identifiedestrogenic activities of FSE and its bioactive compounds,suggesting their possible roles as PEs via ERs. PEs derivedfrom FSE are promising candidates for ER-targeted therapyfor post-menopausal symptoms.
Eucommia ulmoides Bark Protects Against Renal Injury in Cadmium-Challenged Rats
Erwei Liu,Lifeng Han,Jialong Wang,Wei He,Haihua Shang,Xiumei Gao,Tao Wang 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.3
Eucommia ulmoides Oliver is a perennial woody plant distributed widely in China. To characterize some major compounds in E. ulmoides bark extract, six compounds were identified via high-performance liquid chromatography qualitative analysis. E. ulmoides bark extract protects against cadmium-induced oxidative damage in rat kidneys. Two compounds of E. ulmoides bark extract, geniposide and genipin, which were identified both in serum and in kidney tissue, showed inhibitory effects on nitric oxide production. This study provides biological evidence supporting the usefulness of E. ulmoides bark against cadmium-induced toxic oxidative stress in rat kidney tissue.
Chunxiao Li,Lu Chen,Min Song,Zhirui Fang,Lusha Zhang,Joel Wake Coffie,Liyuan Zhang,Lulu Ma,Qianyi Wang,Wenjie Yang,Leyu Fang,Shaoxia Wang,Xiumei Gao,Hong Wang 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.8
Acute myocardial infarction (AMI) resultsin irreversible cardiac cell damage or death because ofdecreased blood fl ow to the heart. Apoptosis plays an importantrole in the process of tissue damage after myocardialinfarction (MI), which has pathological and therapeuticimplications. Ferulic acid (FA) is a phenolic acid endowedwith strong antioxidative and cytoprotective activities. Thepresent study aimed to investigate whether FA protectscardiomyocytes from apoptosis by regulating autophagy,which is a cellular self-digestion process, and one of thefi rst lines of defense against oxidative stress. Apoptosis wasinduced by TNF-α (10 ng/mL) and cycloheximide (CHX,5 μg/mL) in rat H9c2 cardiomyocytes. FA-inhibited TNF-α/CHX-induced apoptosis was determined by the quantifi cationof TUNEL-positive cells, and the eff ect was associatedwith decreased ROS production and inhibited caspase3activation. FA treatment enhanced autophagy and increasedautophagy-associated protein expression, leading to an inhibitionof mTOR signaling. When co-treated with 3-methyladenine(3-MA), an autophagy inhibitor, the anti-apoptoticeff ect of FA was attenuated. In an in vivo mouse MI model,FA treatment decreased the apoptotic cell number, reducedinfarct size, and improved cardiac performance, as determinedby histological and echocardiographic assessments. Taken collectively, these results suggest that FA could protectcardiomyocytes from apoptosis by enhancing autophagy.
Jingyu Ni,Zhihao Liu,Miaomiao Jiang,Lan Li,Jie Deng,Xiaodan Wang,Jing Su,Yan Zhu,Feng He,Jingyuan Mao,Xiumei Gao,Guanwei Fan 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.2
Background: Ginsenoside Rg3 is one of the main active ingredients in ginseng. Here, we aimed to confirm its protective effect on the heart function in transverse aortic coarctation (TAC)-induced heart failure mice and explore the potential molecular mechanisms involved. Methods: The effects of ginsenoside Rg3 on heart and mitochondrial function were investigated by treating TAC-induced heart failure in mice. The mechanism of ginsenoside Rg3 for improving heart and mitochondrial function in mice with heart failure was predicted through integrative analysis of the proteome and plasma metabolome. Glucose uptake and myocardial insulin sensitivity were evaluated using micro-positron emission tomography. The effect of ginsenoside Rg3 on myocardial insulin sensitivity was clarified by combining in vivo animal experiments and in vitro cell experiments. Results: Treatment of TAC-induced mouse models with ginsenoside Rg3 significantly improved heart function and protected mitochondrial structure and function. Fusion of metabolomics, proteomics, and targeted metabolomics data showed that Rg3 regulated the glycolysis process, and Rg3 not only regulated glucose uptake but also improve myocardial insulin resistance. The molecular mechanism of ginsenoside Rg3 regulation of glucose metabolism was determined by exploring the interaction pathways of AMPK, insulin resistance, and glucose metabolism. The effect of ginsenoside Rg3 on the promotion of glucose uptake in IR-H9c2 cells by AMPK activation was dependent on the insulin signaling pathway. Conclusions: Ginsenoside Rg3 modulates glucose metabolism and significantly ameliorates insulin resistance through activation of the AMPK pathway.