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Eucommia ulmoides Bark Protects Against Renal Injury in Cadmium-Challenged Rats
Erwei Liu,Lifeng Han,Jialong Wang,Wei He,Haihua Shang,Xiumei Gao,Tao Wang 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.3
Eucommia ulmoides Oliver is a perennial woody plant distributed widely in China. To characterize some major compounds in E. ulmoides bark extract, six compounds were identified via high-performance liquid chromatography qualitative analysis. E. ulmoides bark extract protects against cadmium-induced oxidative damage in rat kidneys. Two compounds of E. ulmoides bark extract, geniposide and genipin, which were identified both in serum and in kidney tissue, showed inhibitory effects on nitric oxide production. This study provides biological evidence supporting the usefulness of E. ulmoides bark against cadmium-induced toxic oxidative stress in rat kidney tissue.
Zhizhu Decoction Promotes Gastric Emptying and Protects the Gastric Mucosa
Wei He,Yi Zhang,Xinrui Wang,Lingling Guo,Lifeng Han,Erwei Liu,Tao Wang 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.4
The aim of this study was to evaluate the effects of the Zhizhu decoction on gastric emptying and gastric mucosal protection. The Zhizhu decoction is composed of Aurantii fructus and Atractylodes macrocephala Rhizoma. Results showed that oral administration of the Zhizhu decoction accelerated gastric emptying in mouse and protected gastric mucosa from ethanol-induced ulcers in rat. Our investigations demonstrated that the Zhizhu decoction accelerated gastric emptying, at least in part, by activating the muscarinic and 5-HT3 receptors. The gastroprotective effect is involved in its antioxidant effects and increased vascular endothelial growth factor expression.