http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
지능박약 환자에서 Carbamazepine에 의해 발생한 골연화증 1예
김성훈,김동선,안유헌,최낙원,이창범,박용수,최웅환,김태화,김희수,백상현 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.2
Anticonvusant therapy with any of several agents, especially phenytoin, phenobarbital, and primidone causes disturbances in bone mineral metabolism. Anticonvulsants stimulate the hepatic microsomal mixed-oxidase enzymes and hence increase the rate of clearance of vitamin D and its metabolism. The severity of clinical manifestations in any given individual appears to be a function of the combined effects of variety of factors including drug type and total drug dose, dietary vitamin D intake, sunlight exposure, and physical activity level. We report a case of osteomalacia associated with long term carbamazepine therapy in a 21-year-old male with less exposure to sunlight(J Kor Soc Endocrinol 15:286?290, 2000).
Kim, Young-Beom,Kim, Yoon Sik,Kim, Woong Bin,Shen, Feng-Yan,Lee, Seung Won,Chung, Hyun Joo,Kim, Jeong Sook,Han, Hee Chul,Colwell, Christopher S.,Kim, Yang In American Heart Association, Inc. 2013 Circulation research Vol.113 No.12
<P><B><U>Rationale:</U></B></P><P>Increased arginine-vasopressin (AVP) secretion is a key physiological response to hyperosmotic stress and may be part of the mechanism by which high-salt diets induce or exacerbate hypertension.</P><P><B><U>Objective:</U></B></P><P>Using deoxycorticosterone acetate-salt hypertension model rats, we sought to test the hypothesis that changes in GABA<SUB>A</SUB> receptor–mediated inhibition in AVP-secreting magnocellular neurons contribute to the generation of Na<SUP>+</SUP>-dependent hypertension.</P><P><B><U>Methods and Results:</U></B></P><P>In vitro gramicidin-perforated recordings in the paraventricular and supraoptic nuclei revealed that the GABAergic inhibition in AVP-secreting neurons was converted into excitation in this model, because of the depolarization of GABA equilibrium potential. Meanwhile, in vivo extracellular recordings in the supraoptic nuclei showed that the GABAergic baroreflexive inhibition of magnocellular neurons was transformed to excitation, so that baroreceptor activation may increase AVP release. The depolarizing GABA equilibrium potential shift in AVP-secreting neurons occurred progressively over weeks of deoxycorticosterone acetate-salt treatment along with gradual increases in plasma AVP and blood pressure. Furthermore, the shift was associated with changes in chloride transporter expression and partially reversed by bumetanide (Na<SUP>+</SUP>-K<SUP>+</SUP>-2Cl<SUP>–</SUP> cotransporter inhibitor). Intracerebroventricular bumetanide administration during deoxycorticosterone acetate-salt treatment hindered the development of hypertension and rise in plasma AVP level. Muscimol (GABA<SUB>A</SUB> agonist) microinjection into the supraoptic nuclei in hypertensive rats increased blood pressure, which was prevented by previous intravenous V1a AVP antagonist injection.</P><P><B><U>Conclusions:</U></B></P><P>We conclude that the inhibitory-to-excitatory switch of GABA<SUB>A</SUB> receptor–mediated transmission in AVP neurons contributes to the generation of Na<SUP>+</SUP>-dependent hypertension by increasing AVP release. We speculate that normalizing the GABA equilibrium potential may have some utility in treating Na<SUP>+</SUP>-dependent hypertension.</P>
Woong-Beom Kim,Young-Seop Park,Jong-Hwa Park,Seung-Jae Hyun 대한척추신경외과학회 2015 Neurospine Vol.12 No.3
A 54-year-old female with neurofibromatosis type 1 presented with progressing truncal shift owing to spinal deformity. On plain radiograph, the Cobb angle was 54 degree in coronal plane. Radiological examinations showed severe dystrophic change with dysplastic pedicles, bony scalloping, neural foraminal widening from dural ectasia. The patient underwent deformity correction and reconstruction surgery from the T9 to the pelvis using multiple iliac screws and Wisconsin interspinous segmental instrumentation by wiring due to maximize fixation points. The postoperative course was uneventful. One-year follow-up radiographs showed a successful curve correction with solid fusion. We report a case of pedicle dysplasia and dystrophic change treated by posterior segmental spinal instrumentation and fusion with help of multiple iliac screws and modified Wisconsin interspinous segmental wiring.
Kim, Hyo Song,Koom, Woong Sub,Baek, Song-Ee,Kim, Hyoung-Il,Jung, Minkyu,Beom, Seung-Hoon,Kang, Beodeul,Kim, Hyunki,Chang, Jee Suk,Choi, Yoon Young,Son, Taeil,Cheong, Jae-Ho,Noh, Sung Hoon,Kim, Eun Hye Elsevier Science Publishers 2019 Radiotherapy and oncology Vol.140 No.-
<P><B>Abstract</B></P> <P><B>Background and purpose</B></P> <P>To evaluate the safety and efficacy of preoperative chemotherapy (CTx) followed by chemoradiotherapy (CCRT) for high-risk gastric cancer (GC).</P> <P><B>Methods and materials</B></P> <P>The inclusion criteria were as follows: (1) Borrmann type 4; (2) large Borrmann type 3 (≥8 cm); (3) single bulky (≥3 cm × 1) or multiple lymph nodes (≥1.5 cm × 3). Patients received two 21-day courses of induction CTx of TS-1 (35 mg/m<SUP>2</SUP>, p.o, twice daily on days 1–14), docetaxel (30 mg/m<SUP>2</SUP>, i.v., days 1 and 8), and cisplatin (30 mg/m<SUP>2</SUP>, i.v., days 1 and 8) followed by CCRT (two courses of TS-1 and cisplatin in combination with 45 Gy radiation).</P> <P><B>Results</B></P> <P>Forty-two patients were enrolled between March 2014 and February 2016, and 39 of these completed sequential CTx and CCRT. Among the 33 patients who underwent R0 resection, the pathologic response rate was 39.4% [no residual carcinoma (<I>n</I> = 5, 15.2%), with 1–10% residual carcinoma (<I>n</I> = 8, 24.2%)]. Overall, 4 patients (12.1%) were pathologic stage 0, 7 (21.2%) were stage I, 10 (30.3%) were stage II, and 12 (36.4%) were stage III. The overall survival rate at 3 years was 77.9% for stages 0 and I, 66.8% for stages II–III, and 33.3% for unresectable cases (<I>P</I> = 0.001). Toxicity was mild to moderate with grade 4 neutropenia (<I>n</I> = 1) and neutropenic fever (<I>n</I> = 1) as the most prominent side-effects.</P> <P><B>Conclusions</B></P> <P>Sequential CTx and CCRT prior to surgery are feasible and effective for high-risk GC.</P> <P>Trial registration number: NCT02495493.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A complex preoperative staging was adopted for high-risk GC. </LI> <LI> We adopted an intensive, weekly-split, triplet regimen with favorable toxicities. </LI> <LI> Induction chemotherapy and chemoradiotherapy indicate a promising outcome. </LI> </UL> </P>
Systematic Lymphadenectomy for Survival in Epithelial Ovarian Cancer : A Meta-Analysis
Kim, Hee Seung,Ju, Woong,Jee, Byung Chul,Kim, Yong Beom,Park, Noh Hyun,Song, Yong Sang,Kim, Seung Cheol,Kang, Soon-Beom,Kim, Jae Weon BMJ 2010 International journal of gynecological cancer Vol.20 No.4
<P>BACKGROUND: The role of systematic lymphadenectomy (SL) remains unclear for improving overall survival (OS) in epithelial ovarian cancer (EOC). To evaluate the role of SL in EOC, we performed a meta-analysis for comparing the efficacy for OS between SL and unsystematic lymphadenectomy (USL). METHODS: After the extensive literature search between January 1995 and December 2008, we analyzed 9 studies (2 randomized controlled trials [RCTs] and 7 observational studies) with 21,919 patients with EOC who underwent staging laparotomy including SL or USL. RESULTS: Although SL was a favorable factor for OS compared with USL (hazard ratio [HR], 0.72; 95% confidence interval [CI], 0.68-0.76), the efficacy of SL on increased OS could not be determined in all-stage and early-stage EOC owing to the lack of RCTs and the deviation of weight by large-scale observational studies, whereas SL improved OS in advanced-stage EOC (HR, 0.70; 95% CI, 0.67-0.75). Moreover, SL increased OS in patients with all-stage disease who underwent optimal debulking surgery (HR, 0.84; 95% CI, 0.69-0.99), whereas it could not improve OS statistically in early-stage and advanced-stage diseases. However, SL showed increased OS with marginal significance in advanced-stage EOC patients treated with optimal debulking surgery (HR, 0.82; 95% CI, 0.66-1.02). CONCLUSIONS: These findings suggest the possibility that SL can improve OS in advanced-stage EOC. However, the efficacy of SL on OS is still unknown because of the lack of RCTs, which requires more relevant studies for investigating the role of SL in EOC.</P>
Wine drinking and epithelial ovarian cancer risk: a meta-analysis.
Kim, Hee Seung,Kim, Jae Weon,Shouten, Leo J,Larsson, Susanna C,Chung, Hyun Hoon,Kim, Yong Beom,Ju, Woong,Park, Noh Hyun,Song, Yong Sang,Kim, Seung Cheol,Kang, Soon-Beom Korean society of gynecologic oncology and colposc 2010 Journal of Gynecologic Oncology Vol.21 No.2
<P>Wine has been the focus in the prevention of epithelial ovarian cancer (EOC) development because resveratrol abundant in wine has anti-carcinogenic properties. However, epidemiologic results have been heterogenous in the chemopreventive effect of wine on the development of EOC. Thus, we performed a meta-analysis for comparing EOC risk between wine and never drinkers using previous related studies.</P>
Phosphatidylcholine and bipolar radiofrequency for treatment of localized fat deposits
Kim, In Su,Hyun, Moo Yeol,Park, Kui Young,Kim, Chan Woong,Kim, Beom Joon,Kim, Myeung Nam Informa Healthcare USA on behalf of Informa UK Ltd 2014 The Journal of dermatological treatment Vol.25 No.4
<P>Bipolar radiofrequency (RF) is capable of delivering higher energy fluencies direct to the dermis through a needle electrode. This produces heat when the tissue electrical resistance converts the electric current to thermal energy in the tissue. A 38-year-old man visited our clinic for reduction of submental fat deposit, but otherwise in overall good health. After deciding to perform phosphatidylcholine (PPC) injections subcutaneously, we concerned about edema and swelling of injection site lasted several weeks. We wanted to shorten the period of edema and swelling, and we decided to add bipolar RF treatment. After 1 week of PPC injection combined with RF treatment, overall volume of jowl was decreased and edema and swelling on the PPC injected site markedly subsided. This reduction of fat deposit lasts longer than 1 year. Follow-up for 1 year demonstrated that the cosmetic results were well maintained.</P>
Orbital-driven Double Nodal-line States in a Room-temperature van der Waals Ferromagnet Fe₃GaTe₂
Beom Tak Kang,Mijin Lim,Junho Seo,Jun Young Choi,Sun Kyu Park,C. J. Won,Sang-Wook Cheong,Youn Jung Jo,Woun Kang,Jae Young Kim,Han Woong Yeom,Kyoo Kim,Hyun-Woo Lee,Jun Sung Kim 한국자기학회 2024 한국자기학회 학술연구발표회 논문개요집 Vol.34 No.1
Long-Term Follow-Up Results of Anterior Cervical Inter-Body Fusion with Stand-Alone Cages
Kim, Woong-Beom,Hyun, Seung-Jae,Choi, Hoyong,Kim, Ki-Jeong,Jahng, Tae-Ahn,Kim, Hyun-Jib The Korean Neurosurgical Society 2016 Journal of Korean neurosurgical society Vol.59 No.4
Objective : The purpose of this study was to evaluate long-term follow-up radiologic/clinical outcomes of patients who underwent anterior cervical discectomy and inter-body fusion (ACDF) with stand-alone cages (SAC) in a single academic institution. Methods : Total 99 patients who underwent ACDF with SAC between February 2004 and December 2012 were evaluated retrospectively. A total of 131 segments were enrolled in this study. Basic demographic information, radiographic [segmental subsidence rate, fusion rate, C2-7 global angle, and segmental angle changes)/clinical outcomes (by Odom's criteria and visual analog score (VAS)] and complications were evaluated to determine the long-term outcomes. Results : The majority were males (55 vs. 44) with average age of 53.2. Mean follow-up period was 62.9 months. The segmental subsidence rate was 53.4% and fusion rate was 73.3%. In the subsidence group, anterior intervertebral height (AIH) had more tendency of subsiding than middle or posterior intervertebral height (p=0.01). The segmental angle led kyphotic change related to the subsidence of the AIH. Adjacent segmental disease was occurred in 18 (18.2%) patients. Total 6 (6%) reoperations were performed at the index level. There was no statistical significance between clinical and radiological outcomes. But, overall long-term clinical outcome by Odom's criteria was unsatisfactory (64.64%). The neck and arm VAS score were increased by over time. Conclusion : Long-term outcomes of ACDF with SAC group were acceptable but not satisfactory. For optimal decision making, more additional comparative long-term outcome data is needed between ACDF with SAC and ACDF with plating.
Kim, Seung Up,Choi, Gi Hong,Han, Woong Kyu,Kim, Beom Kyung,Park, Jun Yong,Kim, Do Young,Choi, Jin Sub,Yang, Seung Choul,Choi, Eun Hee,Ahn, Sang Hoon,Han, Kwang-Hyub,Chon, Chae Yoon Blackwell Publishing Ltd 2010 Liver International Vol.30 No.2
<P>Abstract</P><P>Aims</P><P>To identify the normal range of liver stiffness (LS) values by recruiting healthy living liver and kidney donors in South Korea.</P><P>Methods</P><P>Liver stiffness measurement (LSM) was performed in 69 healthy living liver and kidney donors who were admitted for transplantation. None of the subjects suffered from diabetes mellitus, hypertension, hepatitis B virus infection, hepatitis C virus infection, heart dysfunction, liver dysfunction or metabolic syndrome.</P><P>Results</P><P>LSM failure rate was 2.7%. Among 12 liver donors (17.4%) with available liver histology, eight showed normal liver histology and four showed liver steatosis of <5% of the hepatocytes. The mean age of our study population was 38.9 ± 11.9 years (35 men and 34 women), with a mean LS value of 4.6 ± 0.5 kPa (range 3.3–5.6 kPa). LS values were not significantly different between men (4.6 ± 0.6 kPa) and women (4.5 ± 0.5 kPa, <I>P</I>=0.636), nor were they significantly different according to age (<I>P</I>=0.851). Using the fifth and 95th percentiles, we determined the normal range of LS values to be 3.9–5.3 kPa.</P><P>Conclusions</P><P>We identified the normal range of LS values and found that LS values were not significantly influenced by age and gender.</P>