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Liquid‐Crystalline Blue Phase Laser with Widely Tunable Wavelength (Adv. Mater. 21/2013)
Hur, Sung‐,Taek,Lee, Bo Ram,Gim, Min‐,Jun,Park, Kyung‐,Won,Song, Myoung Hoon,Choi, Suk‐,Won WILEY‐VCH Verlag 2013 ADVANCED MATERIALS Vol.25 No.21
<P>A liquid‐crystalline blue‐phase laser with a tunable photonic bandgap (PBG) of over 150 nm and a wide temperature range is demonstrated by Myoung Hoon Song and Suk‐Won Choi on p. 3002. A lasing peak shift of more than 100 nm is realized due to the large PBG shift of the liquid‐crystalline blue phase. The shift in the lasing wavelength was reversible during repeated temperature changes over the entire stability range of the liquid‐crystalline cubic blue phase. </P>
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( Won Suk Choi ),( Ji Hyeon Baek ),( Yu Bin Seo ),( Sae Yoon Kee ),( Hye Won Jeong ),( Hee Young Lee ),( Byung Wook Eun ),( Eun Ju Choo ),( Ja Cob Lee ),( Young Keun Kim ),( Joon Young Song ),( Seong 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.1
TGFBR2 frameshift mutation in gastric tumors with microsatellite instability
Song, Jae-Hwi,Lee, Hwa-Sung,Yoon, Jung-Hwan,Kang, Young-Hwi,Nam, Suk-Woo,Lee, Jung-Young,Park, Won-Sang The Korean Society of Toxicogenomics and Toxicopro 2010 Molecular & cellular toxicology Vol.6 No.3
Microsatellite instability (MSI) is a form of genetic instability present in virtually all tumors from patients with hereditary nonpolyposis colon cancer and a subset of various sporadic tumors, including colorectal and gastric cancers. Transforming growth factor-beta receptor 2 (TGFBR2) mutations in MSI-positive cancer cell lines may partially inactivate TGF-$\beta$-induced growth inhibition. The aim of this study was to investigate whether MSI and TGFBR2 gene mutations contribute to the progression from gastric adenoma to cancer in multi step gastric carcinogenesis. MSIs were analyzed using 5 micro satellite markers and a frame shift mutation in poly(A)10 within the TGFBR2 gene in 50 gastric adenomas and 88 gastric cancer specimens. One (2.0%) of 50 gastric adenomas and 22 (25.0%) of 88 gastric cancers were MSI-positive. TGFBR2 frame shift mutations were found in 9 gastric cancers, but not in adenoma. All cases with the TGFBR2 frameshift mutation showed high-frequency MSIs. These results suggest that MSIs may occur in the development of gastric cancers, but not in adenomas less than 2 cm, and the TGFBR2 gene may be a target of genomic instability in MSI gastric carcinogenesis.
Genetic and epigenetic analysis of the <i>EPHB2</i> gene in gastric cancers
SONG, JAE HWI,KIM, CHANG JAE,CHO, YONG GU,KWAK, HYUN JUNG,NAM, SUK WOO,YOO, NAM JIN,LEE, JUNG YOUNG,PARK, WON SANG Wiley-Blackwell Munksgaard 2007 APMIS Vol. No.
<P>EPHB2 is a member of the Eph receptor tyrosine kinase family and a direct transcriptional target of &bgr;-catenin/TCF. EPHB2 plays an important role in maintaining the correct positioning of the proliferative compartment in the crypt-villous axis. A loss of EPHB2 expression has been observed in human tumors, particularly in colonic adenomas and carcinomas. A search was made for mutations at the A9 tract in exon 17, an allelic loss at the <I>EPHB2</I> gene locus, and promoter hypermethylation of the <I>EPHB2</I> gene in 81 sporadic gastric cancers in order to determine if genetic or epigenetic alterations of the <I>EPHB2</I> gene are involved in the development and/or progression of gastric cancer. Unexpectedly, no frameshift mutation was found and there was a low frequency (20.8%) of allelic loss. In addition, promoter hypermethylation was detected in only one gastric cancer tissue sample. Therefore, genetic or epigenetic alterations of the <I>EPHB2</I> gene might be an uncommon event in the development or progression of gastric cancers.</P>
( Won Jai Jung ),( Byung Hoon Park ),( Kyung Soo Chung ),( Song Yee Kim ),( Eun Young Kim ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Se Kyu Kim ),( Joon Chang ),( Moo Suk Park ) 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-
Background: Plasma glucagon in sepsis has scarcely studied. We tried to identify whether glucagon levels were associated with disease severity and mortality in patients with severe sepsis or septic shock. Methods: We evaluated patients with severe sepsis or septic shock admitted to ICU of the university-affiliated hospital in Korea. Plasma levels of glucagon were measured in a total 112 patients (57 survivors and 55 non-survivors) with severe sepsis or septic shock. Results: Compared with the survivors, patients who died in 28 days had significantly higher levels of glucagon on day 0 (admission day), 1, 3, and 7. Glucagon levels were correlated with severity scores (SOFA and APACHE-II). Multivariate analysis identified glucagon levels, presence of septic shock as independent predictors of the overall 28-day mortality rate. Receiver operating characteristic analysis showed that the area under curve of glucagon levels to predict 28-day survival was 0.63 (95% CI=0.52-0.73; P=0.021) as similar as APACHE II. Conclusions: Glucagon levels are related to poor prognosis in patients with severe sepsis.Background: Plasma glucagon in sepsis has scarcely studied. We tried to identify whether glucagon levels were associated with disease severity and mortality in patients with severe sepsis or septic shock. Methods: We evaluated patients with severe sepsis or septic shock admitted to ICU of the university-affiliated hospital in Korea. Plasma levels of glucagon were measured in a total 112 patients (57 survivors and 55 non-survivors) with severe sepsis or septic shock. Results: Compared with the survivors, patients who died in 28 days had significantly higher levels of glucagon on day 0 (admission day), 1, 3, and 7. Glucagon levels were correlated with severity scores (SOFA and APACHE-II). Multivariate analysis identified glucagon levels, presence of septic shock as independent predictors of the overall 28-day mortality rate. Receiver operating characteristic analysis showed that the area under curve of glucagon levels to predict 28-day survival was 0.63 (95% CI=0.52-0.73; P=0.021) as similar as APACHE II. Conclusions: Glucagon levels are related to poor prognosis in patients with severe sepsis.Background: Plasma glucagon in sepsis has scarcely studied. We tried to identify whether glucagon levels were associated with disease severity and mortality in patients with severe sepsis or septic shock. Methods: We evaluated patients with severe sepsis or septic shock admitted to ICU of the university-affiliated hospital in Korea. Plasma levels of glucagon were measured in a total 112 patients (57 survivors and 55 non-survivors) with severe sepsis or septic shock. Results: Compared with the survivors, patients who died in 28 days had significantly higher levels of glucagon on day 0 (admission day), 1, 3, and 7. Glucagon levels were correlated with severity scores (SOFA and APACHE-II). Multivariate analysis identified glucagon levels, presence of septic shock as independent predictors of the overall 28-day mortality rate. Receiver operating characteristic analysis showed that the area under curve of glucagon levels to predict 28-day survival was 0.63 (95% CI=0.52-0.73; P=0.021) as similar as APACHE II. Conclusions: Glucagon levels are related to poor prognosis in patients with severe sepsis.
Song, Hun-Suk,Jeon, Jong-Min,Kim, Hyun-Joong,Bhatia, Shashi Kant,Sathiyanarayanan, Ganesan,Kim, Junyoung,Won Hong, Ju,Gi Hong, Yoon,Young Choi, Kwon,Kim, Yun-Gon,Kim, Wooseong,Yang, Yung-Hun Elsevier 2017 Bioresource technology Vol.245 No.2
<P><B>Abstract</B></P> <P>To reduce the furfural toxicity for biochemical production in <I>E. coli</I>, a new strategy was successfully applied by supplying NAD(P)H through the nicotine amide salvage pathway. To alleviate the toxicity, nicotinamide salvage pathway genes were overexpressed in recombinant, isobutanol-producing <I>E. coli</I>. Gene expression of <I>pncB</I> and <I>nadE</I> respectively showed increased tolerance to furfural among these pathways. The combined expression of <I>pncB</I> and <I>nadE</I> was the most effective in increasing the tolerance of the cells to toxic aldehydes. By comparing <I>noxE</I>- and <I>fdh</I>-harbouring strains, the form of NADH, rather than NAD<SUP>+</SUP>, was the major effector of furfural tolerance. Overall, this study is the application of the salvage pathway to isobutanol production in the presence of furfural, and this system seems to be applicable to alleviate furfural toxicity in the production of other biochemical.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The increased gene expression of <I>pncB</I> and <I>nadE</I> reduced the toxicity of furfural. </LI> <LI> Overexpression of <I>pncB</I> and <I>nadE</I> also reduced inhibitory effect of vanillin, 4-hydroxybenzaldehyde. </LI> <LI> NADH is more important than NAD<SUP>+</SUP> in increasing the tolerance to furfural. </LI> <LI> NAD<SUP>+</SUP> salvage pathway genes is applicable to isobutanol production in the presence of furfural. </LI> </UL> </P>
Salvage of Infected Breast Implants
Song, Joon Ho,Kim, Young Seok,Jung, Bok Ki,Lee, Dong Won,Song, Seung Yong,Roh, Tai Suk,Lew, Dae Hyun Korean Society of Plastic and Reconstructive Surge 2017 Archives of Plastic Surgery Vol.44 No.6
Background Implant-based breast reconstruction is being performed more frequently, and implants are associated with an increased risk of infection. We reviewed the clinical features of cases of implant infection and investigated the risk factors for breast device salvage failure. Methods We retrospectively analyzed 771 patients who underwent implant-based breast reconstruction between January 2010 and December 2016. Age, body mass index, chemotherapy history, radiation exposure, and smoking history were assessed as potential risk factors for postoperative infection. We also evaluated the presence and onset of infection symptoms, wound culture pathogens, and other complications, including seroma, hematoma, and mastectomy skin necrosis. Additionally, we examined the mastectomy type, the use of acellular dermal matrix, the presence of an underlying disease such as hypertension or diabetes, and axillary node dissection. Results The total infection rate was 4.99% (58 of 1,163 cases) and the total salvage rate was 58.6% (34 of 58). The postoperative duration to closed suction drain removal was significantly different between the cellulitis and implant removal groups. Staphylococcus aureus infection was most frequently found, with methicillin resistance in 37.5% of the cases of explantation. Explantation after infection was performed more often in patients who had undergone 2-stage expander/implant reconstruction than in those who had undergone direct-to-implant reconstruction. Conclusions Preventing infection is essential in implant-based breast reconstruction. The high salvage rate argues against early implant removal. However, when infection is due to methicillin-resistant S. aureus and the patient's clinical symptoms do not improve, surgeons should consider implant removal.