Intrinsic memory characteristic of polycrystalline ZnTe film originating from Mott variable range hopping conduction

Wang Aoqiu,Cao Kun,Jie Wanqi,Xu Lingyan 한국물리학회 2022 Current Applied Physics Vol.39 No.-

The resistive switching characteristics of Au/ZnTe/ITO structure with polycrystalline ZnTe film as resistive switching layer is investigated. Macroscopically, 100 bipolar switching cycles under the direct current (dc) voltages were carried out and the conduction states can retain for several hours. Microscopically, reading and writing operations can be achieved on ZnTe film with Au top electrode replaced by conductive Atomic Force Microscopy (c-AFM) tip. The I–V characteristic in low resistance state (LRS) is linear in the whole range of voltage. The I–V characteristic in high resistance state (HRS) is linear in the low voltage while it obeys Schottky emission in the high voltage, and Schottky barrier height is symmetric in the positive and negative voltage. During linear I–V characteristic voltage range, the electrons transport between adjacent point defects via Mott variable range hopping. The higher hopping distance and higher activation energy in HRS contribute to the higher resistance value in HRS compared with LRS. Impedance spectroscopy in HRS and LRS both behave as a semicircle, which accords with the semiconductor-like characteristic of conductive point defects. Photoluminescence (PL) spectroscopy indicates the decisive role of deep level defects in conduction. This study confirms the intrinsic resistive switching characteristic of ZnTe film and provides a new choice for intrinsic nonoxides material in nonvolatile memory application.

Wideband Lamb wave analysis based on continuous wavelet transform

Shi, Lihua,Wang, Xinwei,Li, Gang,Zhang, Lingyan Techno-Press 2005 Smart Structures and Systems, An International Jou Vol.1 No.3

In Lamb wave detection of damages in smart structures, the excitation pulse is usually designed as a narrow band burst wave for the convenience of analysis and recognition. However, the wideband excitation can excite more modes in plate/shell structure and thus provides extra information for changes of the structure. This paper presents a method that can extract information in wideband Lamb wave signals. By transforming the detected signals into various sub-frequency band, the measured signal can be converted to its equivalences of narrow band excitations, therefore, the information in different frequency bands can be acquired from a single test and in the same time the complicity of wideband signal can be simplified. Some test results are provided to verify this method.

DPT (Data Process Tracking) Analysis of Biopharmaceutical Companies Based on fsQCA Method of ESG System: Aiming at Improving the ESG System MES-DPT & GMP-DPT and the ESG Quantitative Indicators of the Biopharmaceutical Industry

Gao Yu,Wang Lingyan,Qin Bingbing 한중경제문화학회 2023 한중경제문화연구 Vol.24 No.-

In recent years, safety recalls have occurred frequently in the biopharmaceutical industry, which affects the health of consumers. This article attempts to use the fsQCA method to draw a conclusion through the study of ESG and its quantification system, as well as the study of data samples related to MES and GMP processes, that is, MES-DPT has a positive impact on process safety management, and GMP-DPT has a positive impact on process safety. Management has a positive and positive impact, and ESG-DPT has a positive and positive impact on process safety management. Finally, this article puts forward suggestions for improving ESG-DPT, MES-DPT, GMP-DPT and the biomedical ESG-DPT model. Future research hopes to further study ESG -DPT model and ESG biomedical industry indicators.

Rehmannioside D mitigates disease progression in rats with experimental-induced diminished ovarian reserve via Forkhead Box O1/KLOTHO axis

Yan Liang,Huimin Wang,Jin Chen,Lingyan Chen,Xiaoyong Chen 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.2

This study aims to explore the impact of Rehmannioside D (RD) on ovarian functions of rats with diminished ovarian reserve (DOR) and its underlying mechanisms of action. A single injection of cyclophosphamide was performed to establish a DOR rat model, and fourteen days after the injection, the rats were intragastrically administrated with RD for two weeks. Rat estrus cycles were tested using vaginal smears. Ovarian tissues were histologically evaluated, the number of primordial, mature, and atretic follicles was calculated, and the apoptotic rate of granulosa cells. Follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) levels were determined by ELISA assays. Protein levels of Forkhead Box O1 (FOXO1), KLOTHO, Bcl-2, and Bax were investigated in ovarian tissues of DOR rats. The binding between FOXO1 and KLOTHO was verified by ChIP assay. High-dose administration of RD into DOR rats improved their estrus cycles, increased ovarian index, enhanced the number of primordial and mature follicles, reduced the number of atretic follicle number, and ovarian granulosa cell apoptosis in addition to inhibiting FSH and LH levels and upregulating E2 expression. FOXO1 and KLOTHO were significantly suppressed in DOR rats. FOXO1 knockdown partially suppressed the protective effects of RD on DOR rats, and KLOTHO overexpression could restore RD-induced blockade of DOR development despite knocking down FOXO1. FOXO1 antibody enriched KLOTHO promoter, and the binding between them was reduced in DOR group compared to that in sham group. RD improved ovarian functions in DOR rats and diminished granulosa cell apoptosis via the FOXO1/KLOTHO axis

Wideband Lamb wave analysis based on continuous wavelet transform

Lihua Shi,Xinwei Wang,Gang Li,Lingyan Zhang 국제구조공학회 2005 Smart Structures and Systems, An International Jou Vol.1 No.3

In Lamb wave detection of damages in smart structures, the excitation pulse is usually designed as a narrow band burst wave for the convenience of analysis and recognition. However, the wideband excitation can excite more modes in plate/shell structure and thus provides extra information for changes of the structure. This paper presents a method that can extract information in wideband Lamb wave signals. By transforming the detected signals into various sub-frequency band, the measured signal can be converted to its equivalences of narrow band excitations, therefore, the information in different frequency bands can be acquired from a single test and in the same time the complicity of wideband signal can be simplified. Some test results are provided to verify this method.

Synthesis and Biological Evaluation of 3-(1H-indol-3-yl)pyrazole- 5-carboxylic Acid Derivatives

Datong Zhang,Guangtian Wang,Chubing Tan,Weiren Xu,Yuan Pei,Lingyan Huo 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3

A series of novel compounds bearing a 3-(1H-indol-3-yl)pyrazole-5-carboxylic acid nucleus were synthesized. Analytical and spectral data confirmed the structures of the new compounds. The structures of the regioisomers in this series were determined by 1H-NMR spectra. The title compounds were evaluated for their endothelin-1 antagonist activities. In the in vitro functional assay, compounds 23, 24, 28 and 29 exhibited significant efficacy at the concentration of 1 μg/mL, and compounds 5b, 5c, 26 and 28 were as potent as the positive control bosentan at high concentration. In the experiment to assess prevention of endothelin-1-induced sudden death in mice, compound 5b showed comparable activity to bosentan, and 30 was more potent than bosentan. The final compounds were also screened for antibacterial activity against four Gram-positive and -negative bacteria. Some of the tested compounds showed weak antibacterial activity.

Insulin-positive ductal cells do not migrate into preexisting islets during pregnancy

Liu Qun,Jiang Yinan,Zhu Lingyan,Qian Jieqi,Wang Chaoban,Yang Tianlun,Prasadan Krishna,Gittes George K.,Xiao Xiangwei 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

The adult pancreatic ductal system was suggested to harbor facultative beta-cell progenitors similar to the embryonic pancreas, and the appearance of insulin-positive duct cells has been used as evidence for natural duct-to-beta-cell reprogramming. Nevertheless, the phenotype and fate of these insulin-positive cells in ducts have not been determined. Here, we used a cell-tagging dye, CFDA-SE, to permanently label pancreatic duct cells through an intraductal infusion technique. Representing a time when significant increases in beta-cell mass occur, pregnancy was later induced in these CFDA-SE-treated mice to assess the phenotype and fate of the insulin-positive cells in ducts. We found that a small portion of CFDA-SE-labeled duct cells became insulin-positive, but they were not fully functional beta-cells based on the in vitro glucose response and the expression levels of key beta-cell genes. Moreover, these insulin-positive cells in ducts expressed significantly lower levels of genes associated with extracellular matrix degradation and cell migration, which may thus prevent their budding and migration into preexisting islets. A similar conclusion was reached through analysis of the Gene Expression Omnibus database for both mice and humans. Together, our data suggest that the contribution of duct cells to normal beta-cells in adult islets is minimal at best.

magnetostratigraphy, 26Al-10Be, Yx02 borehole, tectonic evolution, Daxing Uplift, Beijing Sub-plain

Fubing He,Xiwei Xu,Fang Tian,Zhenhua Liu,Yueze Zhang,Lingyan Bai,Yubin Cui,Kai Wang,Wenzhi Niu,Jingbo Ni,Xiaoyong Liu,Mengmeng Cao 한국지질과학협의회 2024 Geosciences Journal Vol.28 No.2

The buried Daxing Uplift connects the Beijing Sag and Dachang Sag, which is the critical tectonic unit for understanding the structural evolution of the Beijing Sub-plain and its linkages to regional tectonics. This study combines paleomagnetic, 26Al-10Be isochron dates and sedimentary analyses from a new borehole (Yx02) in the northeastern Beijing Sub-plain to shed fresh light on regional tectonic processes and the sedimentary history since the Pliocene. The main findings are as follows: (1) the Daxing Uplift had formed three depositional episodes: alluvial-fan, lacustrine-delta, and alluvial-fan sedimentation since the Cenozoic; (2) The borehole records the Brunhes, Gauss normal chron, and the Matuyama, Gilbert reversed chron in the Daxing Uplift, the corresponding depths are 0–148.9 m, 148.9–315.0 m, 315.0–520.5 m and 520.5–650 m; (3) An important tectonic event started in ~4.3 Ma, disintegrated NE-trending basin and range terrain, reactivated the NW-trending Nankou-Sunhe fault, and formed Shunyi fault in Beijing Sub-plain. Sedimentation occurs exclusively in the Beijing Sag and the northeastern Daxing Uplift during ~4.3–1.77 Ma; (4) During ~1.77–1.07 Ma, a transition from an extension to a strike-slip occurred, and is described not only in a progressively higher increase of the overall deposition rate, but also in a decrease of the relative deposition disparity between sags and uplifts. Since then, the Beijing Sub-plain has been shaped, associated with an overall subsidence depression in the Bohai Bay Basin. This work enhances our understanding of the formation and evolution of the Beijing Sub-plain, the division of tectonic episodes, and the initiation time of the latest tectonic movement in the break-up region, North China Craton, since the Neogene.