http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
유능수,남윤수,이정완,이명재 강원대학교 산업기술연구소 2005 産業技術硏究 Vol.25 No.B
Two methods, the bin averaging method and least square method, are often used in calibrating wind turbine test sites. The objective of this work was to determine a better method to predict the wind speed at wind turbine installing point. The calibration was done at the test site on a complex terrain located in Daegwallyeong, Korea. It was performed for two different cases based on the IEC 61400-12 power performance measurement standard. The wind speeds averaged for 10 minutes ranged between 4 m/s and 16 m/s. The wind-direction bins of each meteorological mast were 10 degrees apart, and only the bins having data measured for more than 24 hours were employed for the test site calibration. For both cases, the two methods were found to yield almost same results which estimated real wind speed very closely.
Engineered iron oxide nanoparticles to improve regenerative effects of mesenchymal stem cells
Wan Su Yun,Susmita Aryal,Ye Ji Ahn,서영준,Jaehong Key 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.2
Mesenchymal stem cells (MSCs) based therapies are a major fi eld of regenerative medicine. However, the success of MSCtherapy relies on the effi ciency of its delivery and retention, diff erentiation, and secreting paracrine factors at the targetsites. Recent studies show that superparamagnetic iron oxide nanoparticles (SPIONs) modulate the regenerative eff ects ofMSCs. After interacting with the cell membrane of MSCs, SPIONs can enter the cells via the endocytic pathway. The physicochemicalproperties of nanoparticles, including size, surface charge (zeta-potential), and surface ligand, infl uence theirinteractions with MSC, such as cellular uptake, cytotoxicity, homing factors, and regenerative related factors (VEGF, TGF-β1). Therefore, in-depth knowledge of the physicochemical properties of SPIONs might be a promising lead in regenerativeand anti-infl ammation research using SPIONs mediated MSCs. In this review, recent research on SPIONs with MSCs andthe various designs of SPIONs are examined and summarized.
Wan Su Yun,Wonseok Yang,심만규,Sukyung Song,최지웅,김정래,Jinseong Kim,Yujeong Moon,조성훈,Dong-Kwon Lim,Kwangmeyung Kim 한국생체재료학회 2024 생체재료학회지 Vol.28 No.00
Photothermal therapy (PTT) at mild temperatures ranging from 44 to 45 °C holds tremendous promise as a strategy for inducing potent immunogenic cell death (ICD) within tumor tissues, which can reverse the immunosuppressive tumor microenvironment (ITM) into an immune-responsive milieu. However, accurately and precisely controlling the tumor temperature remains a formidable challenge. Here, we report the precision photothermal immunotherapy by using silica-coated gold nanorods (AuNR@SiO2), and investigating the optimal administration routes and treatment protocols, which enabled to achieve the sustained and controlled mild heating within the tumor tissues. First, the highest photothermal performance of AuNR@SiO2 with 20-nm silica shell thickness than 5 or 40 nm was confirmed in vitro and in vivo. Then, the optimal conditions for precision immunotherapy were further investigated to produce mild temperature (44 to 45 °C) accurately in tumor tissues. The optimal conditions with AuNR@SiO2 result in a distinct cell death with high early/late apoptosis and low necrosis, leading to very efficient ICD compared to lower or higher temperatures. In colon tumor-bearing mice, intratumorally injected AuNR@SiO2 efficiently promotes a mild temperature within the tumor tissues by local irradiation of near-infrared (NIR) laser. This mild PTT substantially increases the population of mature dendritic cells (DCs) and cytotoxic T cells (CTLs) within tumor tissues, ultimately reversing the ITM into an immune-responsive milieu. Furthermore, we found that the combination mild PTT with AuNR@SiO2 and anti-PD-L1 therapy could lead to the 100% complete regression of primary tumors and immunological memory to prevent tumor recurrence. Collectively, this study demonstrates that AuNR@SiO2 with a robust methodology capable of continuously inducing mild temperature accurately within the ITM holds promise as an approach to achieve the precision photothermal immunotherapy.
Yun, Wan Su,Choi, Jin Sil,Ju, Hyun Mi,Kim, Min Hee,Choi, Seong Jin,Oh, Eun Seol,Seo, Young Joon,Key, Jaehong MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.5
<P>Intranasal delivery of mesenchymal stem cells (MSCs) to the olfactory bulb is a promising approach for treating olfactory injury. Additionally, using the homing phenomenon of MSCs may be clinically applicable for developing therapeutic cell carriers. Herein, using superparamagnetic iron oxide nanoparticles (SPIONs) and a permanent magnet, we demonstrated an enhanced homing effect in an olfactory model. Superparamagnetic iron oxide nanoparticles with rhodamine B (IRBs) had a diameter of 5.22 ± 0.9 nm and ζ-potential of +15.2 ± 0.3 mV. IRB concentration of 15 µg/mL was injected with SPIONs into MSCs, as cell viability significantly decreased when 20 μg/mL was used (<I>p</I> ≤ 0.005) compared to in controls. The cells exhibited magnetic attraction in vitro. SPIONs also stimulated CXCR4 (C-X-C chemokine receptor type 4) expression and CXCR4-SDF-1 (Stromal cell-derived factor 1) signaling in MSCs. After injecting magnetized MSCs, these cells were detected in the damaged olfactory bulb one week after injury on one side, and there was a significant increase compared to when non-magnetized MSCs were injected. Our results suggest that SPIONs-labeled MSCs migrated to injured olfactory tissue through guidance with a permanent magnet, resulting in better homing effects of MSCs in vivo, and that iron oxide nanoparticles can be used for internalization, various biological applications, and regenerative studies.</P>
Virus Isolation from the First Patient with SARS-CoV-2 in Korea
Wan Beom Park,권낙중,Su Jin Choi,강창경,Pyoeng Gyun Choe,Jin Yong Kim,Jiyoung Yun,Gir-Won Lee,성문우,Nam Joong Kim,서정선,Myoung-don Oh 대한의학회 2020 Journal of Korean medical science Vol.35 No.7
Novel coronavirus (SARS-CoV-2) is found to cause a large outbreak started from Wuhan since December 2019 in China and SARS-CoV-2 infections have been reported with epidemiological linkage to China in 25 countries until now. We isolated SARS-CoV-2 from the oropharyngeal sample obtained from the patient with the first laboratory-confirmed SARS- CoV-2 infection in Korea. Cytopathic effects of SARS-CoV-2 in the Vero cell cultures were confluent 3 days after the first blind passage of the sample. Coronavirus was confirmed with spherical particle having a fringe reminiscent of crown on transmission electron microscopy. Phylogenetic analyses of whole genome sequences showed that it clustered with other SARS- CoV-2 reported from Wuhan.