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Effect of TiC Content on Oxidation Behavior of Sintered WC-TiC-TaC Alloys
Tanaka Hiroki,Mouri Shigeki,Nakahara Kenji,Sano Hideaki,Zheng Guo Bin,Uchiyama Yasuo 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
The effect of TiC content on oxidation behavior of the sintered WC-TiC-TaC alloys with 2 mass% TaC and different TiC amounts of 3-45 mass% was investigated through oxidation tests in air at 973K. As a result of the tests, it was revealed that with increasing TiC content in the alloys, mass changes caused by oxidation and thickness of the scale decreased. Thus, it is considered that the main component of the scales changed gradually from to with increasing TiC content in the alloys, and oxygen diffusion through the scale to the alloys was inhibited gradually.
Effect of thin LiF layers in multi-layered PVCz polymer LEDs
Hiroki Yoshihara,Yousuke Tanaka,Suiko Tanaka,Masahiko Kitagawa,Hiroyuki Kusano,Hiroshi Kobayashi 한국물리학회 2005 Current Applied Physics Vol.5 No.1
We have investigated in detail the dependence of the electroluminescent characteristics on the thin LiF layer inserted under theelectrode layer of multi-layered PVCz polymer light emitting diode (PLED). Clear dependency has been obtained and reduction inthe operating voltage, improvement in luminance and the luminous and current eciencies have been realized with the optimizationof the thickness. The eect of thin LiF layer has been analyzed by using the current voltage dependence at low voltage regions andthe current is supposed to be carried considered LiF layer by tunnel injection between the PVCz layer and the electrode layer
Hiroki Tanaka,Shimpei Matsusaki,Youichirou Baba,Yoshiaki Isono,Tomohiro Sase,Hiroshi Okano,Tomonori Saito,Katsumi Mukai,Tetsuya Murata,Hiroki Taoka 대한소화기내시경학회 2018 Clinical Endoscopy Vol.51 No.2
Background/Aims: It is sometimes difficult to distinguish between malignant and benign biliary strictures using imaging studiesalone, and pathological diagnosis is necessary. The aim of this study was to determine the usefulness of endoscopic transpapillary tissuesampling and factors predictive of diagnostic accuracy. Methods: From April 2008 to December 2014, 136 patients underwent endoscopic transpapillary tissue sampling for malignantbiliary strictures. The cytological and histological findings were reported as negative, suspicious, or positive. Suspicious and positivefindings were defined as pathologically positive. Results: The sensitivity was 65.0% for forceps biopsy, 49.5% for brush cytology, 46.2% for bile aspiration cytology, and 21.9% forendoscopic nasobiliary drainage cytology. The combination of these procedures improved the sensitivity (72.8%). Endoscopictranspapillary tissue sampling was more sensitive for lesions of biliary origin (91.4%) than for extrabiliary lesions (66.3%). In surgicalcases, the sensitivity for tumors with an infiltrative growth pattern (53.3%) was significantly lower than for a tumor with an expandingor intermediate growth pattern (87.5%). Conclusions: Combining procedures can improve diagnostic accuracy. It may be possible to predict the sensitivity of endoscopictranspapillary tissue sampling by evaluating the etiology and tumor growth pattern using preoperative imaging studies.
Foxf2 represses bone formation via Wnt2b/β-catenin signaling
Tanaka Tomoyuki,Takahashi Akira,Kobayashi Yutaka,Saito Masanori,Xiaolong Sun,Jingquan Chen,Ito Yoshiaki,Kato Tsuyoshi,Ochi Hiroki,Sato Shingo,Yoshii Toshitaka,Okawa Atsushi,Carlsson Peter,Inose Hiroyu 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Differentiation of mesenchymal stem cells (MSCs) into osteoblasts is a critical process for proper skeletal development and acquisition/maintenance of bone mass. However, since this regulatory mechanism has not yet been fully elucidated, the treatment of severe osteoporosis and fractures is a challenge. Here, through a comprehensive analysis of gene expression during the differentiation of MSCs into osteoblasts, we show that the forkhead transcription factor Foxf2 is a crucial regulator of this process. Foxf2 expression transiently increased during MSC osteoblastic differentiation. Overexpression of Foxf2 in MSCs inhibited osteoblastic differentiation, and conversely, knockdown of Foxf2 expression promoted this process. Osteoprogenitor-specific Foxf2 knockout mice developed a high bone mass phenotype due to increased bone formation. RNA-seq analysis and molecular experiments revealed that Foxf2 regulation of bone formation is mediated by Wnt2b. Knockdown of Foxf2 in mouse femurs enhanced bone regeneration in vivo. FOXF2 expression was correlated with hip bone mineral density in postmenopausal women with low bone mass. Finally, inhibition of FOXF2 promoted osteoblastic differentiation of human MSCs. This study uncovers a critical role of Foxf2 in the differentiation of MSCs into osteoblasts and provides insight into the pathogenesis associated with bone-related diseases such as osteoporosis and nonunion after fracture
Hiroki Higashihara,Yusuke Ono,Kaisyu Tanaka,Kosuke Tomotake,Noriyuki Tomiyama 소화기인터벤션의학회 2021 International journal of gastrointestinal interven Vol.10 No.4
Conventional transarterial chemoembolization (TACE) using ethiodized oil and gelatin sponge (GS) particles is a standard treatment for unresectable BCLC-B stage hepatocellular carcinoma (HCC). Ethiodized oil can cause temporary embolic micro-interactions in tumor sinuses, portal veins, hepatic venous sinuses, and arteries as a temporary embolic material for the microvasculature. Using GS particles as an added embolic material, strong ischemic effects can be achieved not only in HCC, but also in the surrounding liver parenchyma. In recent years, various technical innovations in TACE using ethiodized oil have been made in Japan to improve the outcomes of TACE, such as a device for emulsifying ethiodized oil and water-soluble anticancer drugs, the use of intraoperative embolization guidance software to plan embolization during TACE, and the introduction of various microcatheters. This report examines some of the technical innovations that have been adopted to improve TACE outcomes.
Hiroki Higashihara,Yusuke Ono,Kaisyu Tanaka,Kosuke Tomotake,Noriyuki Tomiyama 소화기인터벤션의학회 2021 Gastrointestinal Intervention Vol.10 No.4
Conventional transarterial chemoembolization (TACE) using ethiodized oil and gelatin sponge (GS) particles is a standard treatment for unresectable BCLC-B stage hepatocellular carcinoma (HCC). Ethiodized oil can cause temporary embolic micro-interactions in tumor sinuses, portal veins, hepatic venous sinuses, and arteries as a temporary embolic material for the microvasculature. Using GS particles as an added embolic material, strong ischemic effects can be achieved not only in HCC, but also in the surrounding liver parenchyma. In recent years, various technical innovations in TACE using ethiodized oil have been made in Japan to improve the outcomes of TACE, such as a device for emulsifying ethiodized oil and water-soluble anticancer drugs, the use of intraoperative embolization guidance software to plan embolization during TACE, and the introduction of various microcatheters. This report examines some of the technical innovations that have been adopted to improve TACE outcomes.