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Park, Sunny,Hyun, Yang Jin,Kim, Yu Ran,Lee, Ju Hyun,Ryu, Sunae,Kim, Jeong Mi,Oh, Woo-Yong,Na, Han Sung,Lee, Jong Gu,Seo, Doo Won,Hwang, In Yeong,Park, Zewon,Jang, In-Jin,Oh, Jaeseong,Choi, Seung Eun The Korean Academy of Medical Sciences 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.5
<P>The aim of this study was to examine the effects of <I>CYP2C19*2</I> and <I>*3</I> genetic polymorphisms on omeprazole pharmacokinetic (PK) and pharmacodynamic (PD) responses. Twenty-four healthy Korean volunteers were enrolled and given 20 mg omeprazole orally once daily for 8 days. The genotypes of <I>CYP2C19</I> single nucleotide polymorphisms (SNPs) (<I>*2</I>, <I>*3</I>, and <I>*17</I>) were screened. The plasma concentrations of omeprazole, omeprazole sulfone, and 5-hydroxy (5-OH) omeprazole were determined by liquid chromatography with tandem mass spectrometry (LC-MS/MS). The noncompartmental method was used for the determination of PK parameters. Change of mean pH and proportion (%) of time of gastric pH above 4.0 were estimated. The poor metabolizer (PM) group had the lowest metabolic ratio and exhibited the highest area under the curve (AUC) for omeprazole among the <I>CYP2C19</I> phenotype groups. The PM group showed the greatest change of mean pH and the highest % time of gastric pH above 4.0. The relationship between AUC of omeprazole and % time of gastric pH above 4.0 was confirmed. The study demonstrates that <I>CYP2C19*2</I> and <I>*3</I> influence the PKs and PDs of omeprazole in Korean healthy volunteers. Clinical trial registry at the U.S. National Institutes of Health (https://clinicaltrials.gov), number NCT02299687.</P>
Effects of Kimchi on human health : A protocol of systematic review of controlled clinical trials
Kim, Myung-Sunny,Yang, Hye Jeong,Kim, Soon-Hee,Lee, Hye Won,Lee, Myeong Soo Williams & Wilkins Co 2018 Medicine Vol.97 No.13
<P><B>Abstract</B></P><P><B>Background:</B></P><P>Kimchi, a traditional, fermented Korean food that is consumed daily, has been recognized as a health food due to its beneficial effects on human health. The aim of this overview is to critically evaluate all clinical trials of the use of Kimchi in the treatment of any condition or symptom.</P><P><B>Methods and analysis:</B></P><P>Eight databases will be searched from inception until March 2018. We will include all prospective trials, including randomized controlled trials (RCTs), non-RCTs, and uncontrolled trials. The methodological quality of the trials will be assessed using Cochrane risk of bias (ROB) assessment tool and ROB in nonrandomized studies-I for RCTs and non-RCTs, respectively.</P><P><B>Ethics and dissemination:</B></P><P>Ethical approval will not be required, given that this protocol is for a systematic review. The full systematic review will be published in a peer-reviewed journal. The review will also be disseminated electronically and in print. Updates of the review will be conducted to inform and guide health care practice and policy.</P><P><B>Trial registration number:</B></P><P>PROSPERO 2018 CRD42018087375</P>
의료기관 종별 의무기록 중요서식 항목별 작성 실태 및 의무기록 완결점검표 분석
서순원,김광환,황용화,강선희,강진경,조우현,홍준현,부유경,이현실 한국의료QA학회 2002 한국의료질향상학회지 Vol.9 No.2
Background : This study is to suggest the standardized format of the clinical sheets and the standardized items of every clinical sheet. The standardization of the medical records will increase the faithfulness of the contents in them and it will contribute to construct the good health information system. Method : From Jan. 1st. 2001 to March 31st 2001, we gathered as many paper clinical sheets as possible by every class of institutions to review the faithfulness of the clinical contents in them. Clinical sheets of 9 tertiary care hospitals, 6 general hospitals and 56 clinics were gathered. Two experienced medical record administrators reviewed them. The review focus was to check whether the items recommend by the hospital standardization review criteria and hospital service evaluation organization were appeared in the clinical sheets and whether the contents of every item were written. Results : Tertiary care hospitals ; In case of administrative data, the contents were filled well if the items were fixed. The clinical data like C.C, history, physical examiniation were filled well, but if the items were not fixed, some items were omitted. The result is that more items are to be filled if they are fixed. General hospitals Administrative data were filled more than 50%. Final diagnosis was filled about 66.7%. But other clinical data were not filled well and not many clinical related items were appeared in the sheets. In the legal point of view, the reason for visiting hosptals or the right diagnosis, patient condition at discharge could not be confirmed well. In surgery cases, surgical procedures could not be confirmed well as many surgical related information(surgery time, fluids and blood, number of sponges, biopsy, etc) were omitted. Clinics : More than 70% administrative data were filled and fixed as items. Among the clinical related data, laboratory result was the most credible data. But without the right diagnosis, drug orders were given and doctors’ written signatures were not appeared over 96.4%. So the clinical sheets cannot be used as a legal document. Conclusion : There was a tendency that the contents were filled well if the items were fixed in the documents, We also suggest a clinical check list to review the completeness and faithfulness of the clinical sheets. If many hospitals use the suggested clinical check list and in they make the necessary items fixed in the clinical sheets, the quality of the medical record will increase dramatically.
최춘환,Joo-Won Yoon,연규환,김영섭,유시용,석순자,Sunny Kang,김영호 한국생약학회 2012 Natural Product Sciences Vol.18 No.4
Mushrooms have a long history of use in traditional medicine, and hundreds of novel constituents in mushrooms with miraculous biological properties have been identified recently. Although diverse effects for medicinal use of mushrooms such as anticancer activity are proven, their reversal activities of drug resistance in cancer cells was rarely reported so far. In the search for novel medicinal use of mushrooms, we tested the multidrug resistance (MDR) reversal activities of diverse mushrooms collected from Korea. Among, the mushroom extracts tested, Cantharellus cibarius (M02) and Russula emetica (M12) revealed MDR reversal activities of paclitaxel in the P-glycoprotein (Pgp)-positive HCT15 and MES-SA/dX5 cancer cells, but not in the Pgp-negative A549 and MES-SA cancer cells. In addition, these mushrooms also enhanced the cytotoxicity of doxorubicin, another well-kwown Pgp-associated anticancer drug against MES-SA/DX5 cells, but not against MES-SA cells. Meanwhile, the cytotoxicity of cisplatin, a well-known Pgp-non-associated anticancer drug, was not affected by the mushrooms all the cells tested. From these results, we suspected that some ingredients of M02 and M12 have Pgp-associated MDR reversal activities.
Chemoprevention of Scutellaria bardata on human cancer cells and tumorigenesis in skin cancer
Suh, Seok-Jong,Yoon, Jong-Won,Lee, Tae-Kyun,Jin, Un-Ho,Kim, Sun-Lim,Kim, Myung-Sunny,Kwon, Dae Young,Lee, Young-Choon,Kim, Cheorl-Ho Heyden & Son 2007 Phytotherapy research Vol.21 No.2
<P>Scutellaria barbata D. Don (Lamiaceae) (SB) is a perennial herb, which is natively distributed throughout Korea and southern China. This herb is known in traditional Chinese medicine as Ban-Zhi-Lian and in traditional Korean medicine as Banjiryun. SB has been used as an antiinflammatory and antitumor agent. The SB showed strong growth-inhibitory activity and cancer chemopreventive activity in assays representing three major stages of carcinogenesis. The SB was found to act as an antimutagen; it mediated antiinflammatory effects; inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity). In addition, SB inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. On the other hand, an inhibitory effect of SB on the growth of gynecological cancer cell lines such as HeLa cell and human ovary cancer (HOC) was shown. When HOC cells were treated with SB, the expression of cyclooxygenase-2 was inhibited. These data suggest that SB merits investigation as a potential cancer chemopreventive agent in humans, especially in gynecological cancers. Copyright © 2006 John Wiley & Sons, Ltd.</P>