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Sang Jun Song,Cheol Hee Park,Jong Whan Lee,Hyun Woo Lee,Kang Il Kim,Dae Kyung Bae 대한정형외과학회 2023 Clinics in Orthopedic Surgery Vol.15 No.3
In the article entitled “Infection and instability increasing the risk of patella baja and pseudo-patella baja after revision total knee arthroplasty” the name of one of the authors was incorrectly presented: Kand Il Kim should read Kang Il Kim.
신재호,Sung-Jin Park,Hyun-Jin Cho,Geumhee Gwak,Byung-Noe Bae,Ki Whan Kim,Hong-Yong Kim2,Kyeongmee Park,Sehwan Han 한국유방암학회 2009 Journal of breast cancer Vol.12 No.1
Purpose: Human epidermal growth factor receptor-2 (HER-2)/neu amplification affects the cell proliferation through the modulation of multiple G1 cell cycle regulators in breast tumor cells. We performed this study to investigate whether retinoblastoma protein (pRB) and p27Kip1 were differently expressed according to the HER2 amplification status in human breast cancer. Methods: HER2 amplification was assayed by fluorescence in situ hybridization and the expression of cell cycle regulators were assayed by immunohistochemistry on 153 consecutive invasive breast cancers. The proliferative activity of breast cancer was analyzed according to the HER2 amplification and cell cycle protein expression status. Results: HER2 amplification was observed in 39 (25.5%) of 153 breast cancers. In the HER2 amplified breast cancers, the pRB expression was significantly increased (p=0.011) whereas there was no significant relationship between HER2 amplification and p27Kip1 expression. There was an inverse correlation between pRB expression and Ki-67 labeling index in the HER2 amplified breast cancers (p=0.036). In contrast, Ki67 labeling index was significantly decreased as p27Kip1 expression increased in HER2 non-amplified breast cancers (p=0.028). In HER2 non-amplified breast cancers, we could not observe any association between the pRB expression and Ki67 labeling index. Conclusion: The proliferation of the breast cancers was associated with pRB expression in HER2 amplified tumors whereas it was associated with p27Kip1 expression in HER2 non-amplified tumors. The results of the current study indicate that the cell proliferative activity of the breast cancer is under different growth signal pathways according to HER2 amplification status.
A Morphological Study on Changes of Fat Bodies in Pieris rapae L. during Metamorphosis.
Kim, Chang-Whan,Kim, Woo-Kab,Yang, He-Young,Han, Sung-Sik 한국곤충학회 1977 Korean journal of entomology Vol.7 No.1
배추흰나비의 변태과정에 따른 지방체의 미세구조와 그 변화양상을 형태학적으로 연구하였다. 1. Glycogen은 5령 유충 40시간 이후부터 밀도가 증가하여 용화 직전에 최대치를 나타내었다. 2. Golgi체 영역에서 단백질 과립의 응숙과 성장, mitochondria의 autophagic vacuole 형성에 기원을 둔 단백질 결정의 형성 등은 용화직전의 핵주위에서 이루어졌다. 3. 핵막 소실시기에는 핵막 영역에 120nm의 전자밀도가 높은 과립이 출현하였다. 4. Golgi체는 전과정에서 거의 관찰되지 않았고, mitochondria는 유충, 용 시기에는 rod혹은 filament형이며, microtubule은 유충의 전 과정에서 잘 나타났고 폭은 240$\AA$이었다. The developmental changes and the fine structures in fat body in Pieris rapae L. were observed with the aid of light and electron microscopes. 1. In 40 hr's 5th instar larvae the glycogen begans to be accumulated and its concentration reached maximum just before pupation. 2. The accumulation of the potein granules occured arround the nucleus just before pupation. 3. In some cases fat cells lost their nuclear envel opes and the dense granules(120nm in diameter) were detected arround the region of the original nuclear envelopes. 4. Golgi complexes were not identified in all stages and the mitochondria appeared as rods or filaments in larvae and pupae, and as globles in adults. 5. The microtubules(240${\AA}$ in width) were relatively well developed in all stages.
Transport alternating current losses of BSCCO and YBCO tapes
Kim, Seog-Whan,Joo, Jin-Hong,Song, Kyu Jeong,Park, Chan,Ko, Rock-Kil,Ha, Hong-Soo,Kim, Ho-Sup,Moon, Seung-Hyun,Yoo, Sang-Im,Ryu, Kyungwoo IEEE 2005 IEEE transactions on applied superconductivity Vol.15 No.2
After the discovery of HTS (High Temperature Superconductor), many types of HTS conductors have been developed. Several BSCCO tapes fabricated by PIT (Powder In Tube) method became commercially available, and the transport current loss characteristics of BSCCO tapes have been investigated by many research groups. The transport current loss characteristics of YBCO tapes, however, are not well studied. This is because measuring transport current requires tape samples over a certain length (15 cm for our own system). Many groups are currently focusing their effort on manufacturing long YBCO tape conductors, and new world records of length and current carrying capability are replacing the old ones in an increasingly fast rate. This paper deals with transport current losses of commercially available BSCCO tapes and YBCO tapes made at Korea Electrotechnology Research Institute (KERI) of Korea. YBCO tapes show relatively high transport current losses. This can be explained by the fact that the YBCO tape does not consist of filaments. Measurement results of the tapes are presented with analyses and discussions.
Sung Jun Jung,Jeong Sook Choi,Jiyeon Kwak,Jun Kim,Jong Whan Kim,Sang Jeong Kim 대한생리학회-대한약리학회 2003 The Korean Journal of Physiology & Pharmacology Vol.7 No.2
The glutamate receptors (GluRs) are key receptors for modulatory synaptic events in the central nervous system. It has been reported that glutamate increases the intracellular Ca<SUP>2</SUP> concentration ([Ca<SUP>2</SUP>]<SUB>i</SUB>) and induces cytotoxicity. In the present study, we investigated whether the glutamate-induced [Ca<SUP>2</SUP>]<SUB>i</SUB> increase was associated with the activation of ionotropic (iGluR) and metabotropic GluRs (mGluR) in substantia gelatinosa neurons, using spinal cord slice of juvenile rats (10∼21 day). [Ca<SUP>2</SUP>]<SUB>i</SUB> was measured using conventional imaging techniques, which was combined with whole-cell patch clamp recording by incorporating fura-2 in the patch pipette. At physiological concentration of extracellular Ca<SUP>2</SUP>, the inward current and [Ca<SUP>2</SUP>]<SUB>i</SUB> increase were induced by membrane depolarization and application of glutamate. Dose-response relationship with glutamate was observed in both Ca<SUP>2</SUP> signal and inward current. The glutamate-induced [Ca<SUP>2</SUP>]<SUB>i</SUB> increase at holding potential of 70 mV was blocked by CNQX, an AMPA receptor blocker, but not by AP-5, a NMDA receptor blocker. The glutamate-induced [Ca<SUP>2</SUP>]<SUB>i</SUB> increase in Ca<SUP>2</SUP> free condition was not affected by iGluR blockers. A selective mGluR (group I) agonist, RS-3,5-dihydroxyphenylglycine (DHPG), induced [Ca<SUP>2</SUP>]<SUB>i</SUB> increase at holding potential of 70 mV in SG neurons. These findings suggest that the glutamate-induced [Ca<SUP>2</SUP>]<SUB>i</SUB> increase is associated with AMPA-sensitive iGluR and group I mGluR in SG neurons of rats.
Diniconazole 처리가 일일초와 샐비어의 생장 및 개화에 미치는 영향
Sung-Hwan Choi(최성환),Jum-Soon Kang(강점순),Young-Whan Choi(최영환),Yong-Jae Lee(이용재),Young-Hoon Park(박영훈),Mi-Ra Kim(김미라),Beung-Gu Son(손병구),Hyeun-Kyeung Kim(김현경),Hong-Yul Kim(김홍열),Wook Oh(오욱),Hak-Bo Sim(심학보) 한국생명과학회 2011 생명과학회지 Vol.21 No.7
따라서 본 실험에서는 생장 억제에 효과 있는 기존의 생장억제제인 스미세븐은 고가의 생장억제제이므로 이을 대신할 수 있으며 지금까지는 주로 살균제로 사용되고 있는 빈나리의 농도별 처리가 일일초과 샐비어의 생장 및 개화에 미치는 영향에 대해서 조사하였다. 일일초와 샐비어 모두 빈나리처리에 의해서 생장이 억제되었다. 두 식물체 모두 빈나리 100 ㎎/ℓ 처리가 스미세븐 5 ㎎/ℓ보다 높은 생장억제효과를 나타내었다. 빈나리 처리에 의해서 두 식물체 모두 엽장은 감소하였으나 엽폭은 큰 변화가 없었다. 그 결과 엽형이 둥굴어지는 현상이 나타났다. 개화소요일수는 일일초과 샐비어 모두 대조구에 비해 빈나리 처리시 증가하였다. 일일초의 꽃수는 빈나리 400 ㎎/ℓ 처리를 제외하고 대조구와 큰 차이가 없었다. 샐비어의 경우 빈나리 100, 200 ㎎/ℓ 처리에 의해서 소화수가 증가하였다. This study was conducted to investigate the effects of uniconazole (Sumiseven), an existing expensive growth retardant, and diniconazole (Binnari), used as a cheap germicide, on the growth and flowering of Vinca major and Salvia splendis for the possibility of substitution for expensive growth retardants. The growths of V. major and S. splendis were retarded by Binnari treatment. The effect of Binnari 100 ㎎/ℓ treatment was higher than that of Sumiseven 5 ㎎/ℓ treatment in both plants. The length of leaves was remarkably retarded by Binnari treatment, however, the width of leaves was only slightly retarded, giving the leaf a round shape. The number of days to flowering was increased by Binnari treatment in both in V. major and S. splendis. The number of days to flowering in V. major showed no significant difference compared to the control except by treatemtn with Binnari 400 ㎎/ℓ. The number of florets of S. splendis increased with treatment with Binnari 100 and 200 ㎎/ℓ.
Preclinical development of a humanized neutralizing antibody targeting HGF
Kim, Hyori,Hong, Sung Hee,Kim, Jung Yong,Kim, In-Chull,Park, Young-Whan,Lee, Song-Jae,Song, Seong-Won,Kim, Jung Ju,Park, Gunwoo,Kim, Tae Min,Kim, Yun-Hee,Park, Jong Bae,Chung, Junho,Kim, In-Hoo Nature Publishing Group 2017 Experimental and molecular medicine Vol.49 No.3
<P>Hepatocyte growth factor (HGF) and its receptor, cMET, play critical roles in cell proliferation, angiogenesis and invasion in a wide variety of cancers. We therefore examined the anti-tumor activity of the humanized monoclonal anti-HGF antibody, YYB-101, in nude mice bearing human glioblastoma xenografts as a single agent or in combination with temozolomide. HGF neutralization, The extracellular signal-related kinases 1 and 2 (ERK1/2) phosphorylation, and HGF-induced scattering were assessed in HGF-expressing cell lines treated with YYB-101. To support clinical development, we also evaluated the preclinical pharmacokinetics and toxicokinetics in cynomolgus monkeys, and human and cynomolgus monkey tissue was stained with YYB-101 to test tissue cross-reactivity. We found that YYB-101 inhibited cMET activation <I>in vitro</I> and suppressed tumor growth in the orthotopic mouse model of human glioblastoma. Combination treatment with YYB-101 and temozolomide decreased tumor growth and increased overall survival compared with the effects of either agent alone. Five cancer-related genes (TMEM119, FST, RSPO3, ROS1 and NBL1) were overexpressed in YYB-101-treated mice that showed tumor regrowth. In the tissue cross-reactivity assay, critical cross-reactivity was not observed. The terminal elimination half-life was 21.7 days. Taken together, the <I>in vitro</I> and <I>in vivo</I> data demonstrated the anti-tumor efficacy of YYB-101, which appeared to be mediated by blocking the HGF/cMET interaction. The preclinical pharmacokinetics, toxicokinetics and tissue cross-reactivity data support the clinical development of YYB-101 for advanced cancer.</P>