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인체혈장 중 에탐부톨의 HPLC 분석법의 검증 및 단일용량 투여에 의한 약물동태 연구
곽혜선,박경호,최준식,송진아,성민경,장정옥,이화정 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.2
An HPLC method was employed for the determination of ethambutol in human plasma. After addition of internal standard (IS, octylamine, 2 μg/mL) and alkalinization of the plasma with 5 M sodium hydroxide, the drug and IS were extracted into the mixture of chloroform and diethyl ether (40:60, v/v). Following a 15-min vortex-mixing and a 10-min centrifugation, the organic phase was spiked with 100 pL of phenylethylisocyanate (2000 μg/mL) for chemical derivatization, mixed for 5 min and evaporated to dryness under a stream of nitrogen. The residue was reconstituted with 100 μL of mobile phase and 20 pL was injected into Cl8 column with a mobile phase consisting of methanol:water (70:30, v/v). The samples were detected utilizing an ultraviolet detector at 200 nm. The method was specific and validated with a limit of 0.15 μg/mL. Infra- and inter-day precision and accuracy were acceptable for all quality control samples including the lower limit of quantification. The applicability of this method was demonstrated by analysis of human plasma after oral administration of a single 1200-mg dose to 20 healthy subjects. From the plasma ethambutol concentration vs. time curves, the mean AUC was 9.61 ± 1.64 μg hr/mL. and Cmax of 2.68 μg/mL reached 2.73 hr after administration. The mean biological half-life of ethambutol was 3.46 ± 1.21 hr. Based on the results, this simple and validated assay could readily be used in any pharmacokinetic studies using humans.
Park, Seol-Hoon,Ryu, Jin-Sook,Oh, Seung-Jun,Park, Seung-Il,Kim, Yong-Hee,Jung, Hoon-Yong,Lee, Gin-Hyug,Song, Ho-Jun,Kim, Jong-Hoon,Song, Ho-Young,Cho, Kyoung-Ja,Kim, Sung-Bae The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.1
Purpose : The aim of this study was to determine whether $^{18}F$-fluorothymidine (FLT) PET is feasible for the early prediction of tumor response to induction chemotherapy followed by concurrent chemoradiotherapy in patients with esophageal cancer. Methods : This study was prospectively performed as a collateral study of "randomized phase II study of preoperative concurrent chemoradiotherapy with or without induction chemotherapy with S-1/oxaliplatin in patients with resectable esophageal cancer". $^{18}F$-FLT positron emission tomography (PET) images were obtained before and after two cycles of induction chemotherapy, and the percent change of maximum standardized uptake value (SUVmax) was calculated. All patients underwent esophagography, gastrofiberoscopy, endoscopic ultrasonography (EUS), computed tomography (CT) and $^{18}F$-fluorodeoxyglucose (FDG) PET at baseline and 3-4 weeks after completion of concurrent chemoradiotherapy. Final tumor response was determined by both clinical and pathologic tumor responses after surgery. Results : The 13 patients for induction chemotherapy group were enrolled until interim analysis. In a primary tumor visual analysis, the tumor detection rates of baseline $^{18}F$-FLT and $^{18}F$-FDG PET were 85% and 100%, respectively. The tumor uptakes on $^{18}F$-FLT PET were lower than those of $^{18}F$-FDG PET. Among nine patients who completed second $^{18}F$-FLT PET, eight patients were responders and one patient was a non-responder in the assessment of final tumor response. The percent change of SUVmax in responders ranged from 41.2% to 79.2% (median 57.1%), whereas it was 10.2% in one non-responder. Conclusion : The percent change of tumor uptake in $^{18}F$-FLT PET after induction chemotherapy might be feasible for early prediction of tumor response after induction chemotherapy and concurrent chemoradiotherapy in patients with esophageal cancer.
Polyester에 대한 Methacrylic acid 의 방사선에 의한 Graft Copolymerization.
박용성,이진국,안원재 서울산업대학교 1977 논문집 Vol.10 No.1
The grafting of methacrylic acid to polyester fiber with high dose rate of electromagneic radiation techniques has been studied. The polyester fiber which had been impregnated by the monomer mixture solution was made constant to pickup % and allowed to mutual dosage under the air. The apparent graft %, conversion %, and graft efficiency were improved as the dose rate increase. The graft polymerization reaction was greatly affected by the variation of the concentration of swelling agents and solvent.
문자와 이미지의 상호 침윤 -단테의 사랑을 그린 로세티의 그림들-
박상진 ( Park Sang Gin ) 한국이탈리아어문학회(구 한국이어이문학회) 2013 이탈리아어문학 Vol.0 No.38
Dante Gabriel Rossetti is one of the main interpreters of Dante, both in literature and the visual arts; he translated Dante`s Vita nuova (as well as poetry by Dante`s contemporaries) into English and revived Dante`s literary world in his paintings. His interpretations were unique as his technique of painting. This is because he had no opportunity to have formal training in fine art. In fact, he was criticized for his technical immaturity in drawing and perspective which, ironically, led him to express his vision with more originality. However, more importantly, his originality needs to be traced to his absorption in Dante`s literary world, which, with its inexhaustible inspiration, had produced many, diverse adaptations. The relationship with Dante was crucial in order for Rossetti to establish his own way of expressing himself. This is because for Rossetti conveying symbols and meanings was much more serious than technique. In particular, we need to note that the originality of Rossetti`s vision did indeed derive from his contemplation of Dante`s literature; here the vision can be understood as that which Dante pursues in his pilgrimage toward salvation. This vision allows them to see the eternal value and truth beyond the superficial perception of things. This paper aims to read closely the paintings that Rossetti based on Dante and thereby show that his interpretations are indispensable for understanding the aesthetic value of Dante`s literature. As poet and painter, Rossetti created the so-called two-fold work of art in the way in which he includes Dante`s linguistic text in the frame of his paintings or writes it into the paintings directly. By this means he seems to have strived to show the reciprocal effect of saturation between word and image. His paintings are realistic in that they faithfully represent Dante`s world, in which Dante`s contemporary realities are inexorably related, and, at the same time, fantastic in that they always display symbolic and allegorical signification. He can be evaluated as a translator of Dante; here what translation means is something not only literary but also cultural insofar as, through his capacity of creative alteration, he promoted the alternative development of the language and culture to which he belonged.
Analysis of the Fatigue Stress on Welded Joints of the U-Rib in an Orthotropic Steel Deck
Hong, Sung Nam,Park, Jon Gin,Park, Sun Kyu,Choi, Jin Woong Trans Tech Publications, Ltd. 2014 Advanced materials research Vol.891 No.-
<P>With the improvement in the quality of steel materials, the issue of fatigue cracking has become more important for steel bridges than the failure of the material itself. In this study, the Pelikan-Esslinger method was used to determine the fatigue stress of an orthotropic steel deck. A parametric study was then conducted with the steel deck components as the parameters. Based on the results, the effect of the diverse components of the steel deck on the fatigue stress was analyzed.</P>
( Eo Gin Lee ),( Dong Joo Hyun ),( Jae Yang Park ),( Kyu Young Seo ),( Sang Eun Lee ),( Hee Jung Lee ),( Moon Soo Yoon ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Postherpetic neuralgia (PHN) is the most common complication of herpes zoster (HZ). Recently, there was an open label pilot study which showed that gabapentin administered in acute herpes zoster was effective in reducing the incidence of PHN. However, high-dose gabapentin may cause adverse effects in older patients. Objectives: A prospective study was performed to evaluate the efficacy of treatment with low-dose gabapentin plus valacyclovir for the management of acute pain and the prevention of PHN in patients with acute HZ. Methods: From March, 2012 to July, 2013, 64 patients (age, ≥50 years) who presented with HZ within 3 days of rash onset with moderate to severe pain (≥4 on the 10-point Likert scale) were recruited. The patients received 1000 mg of valacyclovir 3 times a day for 7 days plus gabapentin at an initial dose of 300mg/d, titrated up to a maximum of 900 mg/d. The severity of pain, quality-of-life measures (determined by the Dermatology Life Quality Index, DLQI), and adverse events were assessed at recruitment and 1, 3, 5, 8, and 12 weeks later. Results: Among the total of 64 patients (mean age, 63.4 years), the overall incidence of zoster pain (≥4 on the Likert scale) at 3 months was 3.13%. The DLQI improved significantly at 3 months and patients experienced minimal adverse events from the medication. Conclusion: The combination of low-dose gabapentin and valacyclovir administered acutely in patients with HZ is well-tolerated and reduces the incidence of PHN.
( Eo Gin Lee ),( Dong Joo Hyun ),( Jae Yang Park ),( Kyu Young Seo ),( Sang Eun Lee ),( Hee Jung Lee ),( Moon Soo Yoon ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Microneedle fractional radiofrequency (RF) induces deep dermal heating and leaves the epidermis less affected, which showed therapeutic effects for wrinkle, pore and various scars. Sublative fractional RF induces not only superficial fractional ablation of upper epidermis but also upper dermal remodeling, which had been reported to show improvement of skin aging. Objectives: We evaluated efficacy and safety of combined microneedle fractional RF and sublative fractional RF for acne scars in Asian skin. Methods: 20 patients (mean age 23.65±2.94, skin phototype III-IV) received three consecutive combined microneedle fractional RF and sublative fractional RF at 4-week intervals over 12 weeks. Investigator`s global assessment and complications were assessed up to 2 months after last treatment by standardized photographs. Subjective improvement and pain score were also assessed. Results: Follow-up results revealed that 4 patients had clinical improvement of 76% to 100%, 10 had improvements of 51% to 75%, 6 had improvements of 26% to 50%. The mean duration of post-therapy crusting or scaling was 5.21 days and post-therapy erythema lasted 2.52 days. Conclusion: We suggest that combined microneedle fractional RF and sublative fractional RF may provide a new treatment algorithm for acne scars in Asians. The limitations are the small number of patients.
( Eo Gin Lee ),( Dong Joo Hyun ),( Jae Yang Park ),( Kyu Young Seo ),( Sang Eun Lee ),( Hee Jung Lee ),( Moon Soo Yoon ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Presently, only few tests have been published for evaluating the efficacy of skin cleansers, and they are neither standardized nor widely-accepted. Objectives: We developed a new in-vivo test method for the semi-quantitative evaluation of the efficacy of cleansing products and evaluated its validity and reliability. Methods: Five different skin cleansers were tested on the forearms of 25 healthy volunteers according to the washing procedure using standard dirt. We evaluated the residual amount of standard dirt on the cyanoacrylate skin surface stripping sample using a dermoscopy and an image analysis program. We also graded the cleansing power through a pattern analysis of dermoscopic images. For the comparison regarding the validity, we obtained data according to other preexisting methods using a Chromameter, Mexameter and Glossymeter. Results: The cleansing efficacy of five skin cleansers which was assessed by our new method showed significant correlations with the results from other preexisting methods using a Chromameter and Mexameter (Pearson correlation coefficient 0.826 and 0.738, respectively, P<0.001). This new method also showed a high internal consistency reliability (Cronbach`s alpha=0.997). Conclusion: We presented a new in-vivo method for assessing the cleansing efficacy of skin cleansers which was shown to be reliable and valid. Further studies are required to establish a standardized method to objectify cleansing effectiveness of skin cleansers.