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Song, Joon Young,Noh, Ji Yun,Lee, Jacob,Woo, Heung Jeong,Lee, Jin Soo,Wie, Seong-Heon,Kim, Young Keun,Jeong, Hye Won,Kim, Shin Woo,Lee, Sun Hee,Park, Kyung-Hwa,Kang, Seong Hui,Kee, Sae Yoon,Kim, Tae H KOREAN ACADEMY OF MEDICAL SCIENCE 2018 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.33 No.7
<P>Since 2013, the Hospital-based Influenza Morbidity and Mortality (HIMM) surveillance system began a H7N9 influenza surveillance scheme for returning travelers in addition to pre-existing emergency room (ER)-based influenza-like illness (ILI) surveillance and severe acute respiratory infection (SARI) surveillance. Although limited to eastern China, avian A/H7N9 influenza virus is considered to have the highest pandemic potential among currently circulating influenza viruses. During the study period between October 1st, 2013 and April 30th, 2016, 11 cases presented with ILI within seven days of travel return. These patients visited China, Hong Kong, or neighboring Southeast Asian countries, but none of them visited a livestock market. Seasonal influenza virus (54.5%, 6 among 11) was the most common cause of ILI among returning travelers, and avian A/H7N9 influenza virus was not detected during the study period.</P>
Kwon, Sun Sang,Yi, Jaeseok,Lee, Won Woo,Shin, Jae Hyeok,Kim, Su Han,Cho, Seunghee H.,Nam, SungWoo,Park, Won Il American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.1
<P>We have studied the role of defects in electrolyte-gated graphene mesh (GM) field-effect transistors (FETs) by introducing engineered edge defects in graphene (Gr) channels. Compared with Gr-FETs, GM-FETs were characterized as having large increments of Dirac point shift (similar to 30-100 mV/pH) that even sometimes exceeded the Nernst limit (59 mV/pH) by means of electrostatic gating of H+ ions. This feature was attributed to the defect-mediated chemisorptions of H+ ions to the graphene edge, as supported by Raman measurements and observed cycling characteristics of the GM FETs. Although the H+ ion binding to the defects increased the device response to pH change, this binding was found to be irreversible. However, the irreversible component showed relatively fast decay, almost disappearing after 5 cycles of exposure to solutions of decreasing pH value from 8.25 to 6.55. Similar behavior could be found in the Gr-FET, but the irreversible component of the response was much smaller. Finally, after complete passivation of the defects, both Gr-FETs and GM-FETs exhibited only reversible response to pH change, with similar magnitude in the range of 68 mV/pH.</P>
Song, G.H.,Yoon, J.H.,Shin, K.S.,Kim, H.S.,Sun, C.,Huang, R.F.,Wen, L.S. 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-
The nucleation and nucleus shape of diamond films on silicon (100) has been investigated by varying the negative bias value applied to substrate during Hot Filament Chemical Vapor Deposition (HFCVD). Results showed that the nucleation density increased, peaked and then decreased with increase of the applied bias value. it seemed that there was an optimum bias value. The nucleation of diamond film by HFCVD is a competitive process of deposition and etchings (sputtered) due to the particles impinging on the substrate. The magnitude of the energy, quantity of the particles and the ratio of carbon to hydrogen in reactive gas plasma controlled the competitive process and determined which process was primary. The deposition rate and the nucleation density gradually increased reaching to a maximum with the increment of the energy of the adatoms. With further increment of the energy of the adatoms, however, the deposition process was suppressed by strengthened particle impact on the substrate and the etching or sputtering became the primary process. Experimental results also showed the nucleus crystal shape of diamond films sequentially changed from cubic to dodecahedron, and then to irregular shape with the increment of the bias value. The change of the nucleus crystal shape of diamond films with substrate bias is thought to be related to the each process of the H+ ion with different kinetic energy, as well as the process of the diffusion and migration of the adatoms.
맹선재,김기석,신동혁,금동화 대한금속재료학회(대한금속학회) 1990 대한금속·재료학회지 Vol.28 No.8
The microstructural aspects of the superplastic behavior in 7475 Al alloy are investigated. After superplastic tests, several specimens revealed large zones free of dispersoid particles-occasionally as large as 5㎛ across. Typical micrograph depicting dispersoid-free zones (DFZ) after 100% tensile strain showed DFZ at grain boundaries lying primarily normal to the tensile stress direction. This result emphasizes the importance of diffusional flow in explaining superplastic deformation of the fine-grained 7475 A1 alloy especially at low elongations, The dissolution and growth processes of dispersoid occured at high elongations and these processes can be responsible for the formation of the dispersoid-free zone.
Kwak, H.B.,Sun, H.M.,Ha, H.,Kim, H.N.,Lee, J.H.,Kim, H.H.,Shin, H.I.,Lee, Z.H. North-Holland ; Elsevier Science Ltd 2008 european journal of pharmacology Vol.601 No.1
Tanshinone IIA isolated from Danshen is widely used in Oriental medicine. However, the action of tanshinone IIA in inflammatory bone-resorptive diseases remains unknown. Here we examined the effect of tanshinone IIA in inflammation-mediated osteoclastic bone resorption. Tanshinone IIA inhibited osteoclast differentiation in cocultures of bone marrow cells and calvarial osteoblasts. Tanshinone IIA regulated the expression of receptor activator of NF-κB ligand and osteoprotegerin in osteoblasts treated with lipopolysaccharide (LPS). Also, tanshinone IIA inhibited prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) synthesis by inhibiting Cyclooxygenase-2 (COX-2) expression induced by LPS. Furthermore, tanshinone IIA greatly suppressed bone loss in the mouse models of bone loss. Our findings suggest that tanshinone IIA inhibits osteoclast formation by inhibiting COX-2/PGE<SUB>2</SUB> signaling and by suppressing bone erosion in vivo. These results suggest that tanshinone IIA may be of therapeutic value as an anti-bone-resorptive drug in the treatment of bone-related disease.
Polyphosphoinositides Are Derived from Ether-linked Inositol Glycerophospholipids in Rat Brain
Shin, Sun-H.,Kim, Jong-S.,Kim, Hak-R.,Lim, Jin-K.,Choi, Byung-K.,Yeo, Young-K. Korean Society for Biochemistry and Molecular Biol 2005 Journal of biochemistry and molecular biology Vol.38 No.3
Membrane inositol glycerophospholipid (IGP) is metabolized to phosphatidylinositol-4-phosphate (PIP), phosphatidylinositol-4, 5-bisphosphate ($PIP_2$), and inositol triphosphate ($IP_3$) in signaling transduction. This study was carried out to determine the subclasses of IGP involved in signaling pathway. The acyl chain moieties of the phospholipids are easily modulated by dietary fatty acids. We analyzed acyl chain composition of IGP 3-subclasses, PIP and $PIP_2$ from rat brain after feeding sunflower seed oil enriched with linoleic acid or fish oil high in eicosapentaenoic acid and docosahexaenoic acid. Long chain polyunsaturated fatty acids (LCPUFA) as eicosapentaenoic acid and docosahexaenoic acid were not incorporated into ether-linked IGP (alkenylacylglycerophosphoinositol and alkylacyl-glycerophosphoinositol), PIP and $PIP_2$, while diacyl-glycerophosphoinositol (GPI) contained high LCPUFA. These results suggest that PIP might be phosphorylated from only the ether-linked IGP (alkenylacyl- and alkylacyl species) but not from diacyl subclass for signals to intracellular responses in the plasma membrane of rat brain.
Hassan, Ahmed H.E.,Choi, Eunwoo,Yoon, Yoon Mi,Lee, Kun Won,Yoo, Sung Yeun,Cho, Min Chang,Yang, Ji Seul,Kim, Hye In,Hong, Joo Young,Shin, Ji-Sun,Chung, Kyung-Sook,Lee, Jeong-Hun,Lee, Kyung-Tae,Lee, Yon Elsevier 2019 European journal of medicinal chemistry Vol.161 No.-
<P><B>Abstract</B></P> <P>Cancer still represents a major global health problem. All currently available anticancer agents have disadvantages like resistance or side effects. Therefore, introduction of novel anticancer agents is needed. Intrigued by the high success rate for natural products-based drug discovery, we designed and synthesized antiproliferative chemical entities as hybrids of two natural products; 3,5,4′-trimethoxystilbene and 5,6,7-trimethoxyflavone. To probe the spectrum of the synthesized compounds, <I>in vitro</I> evaluation was conducted against nine panels representing major cancer diseases. The results revealed the hybrid analogs <B>4f</B>, <B>4h</B>, <B>4k</B> and <B>4q</B> as promising broad-spectrum anticancer lead compounds eliciting high growth inhibition of several cell lines representing multiple cancers diseases. Evaluation of the promising lead compounds against normal human cell lines suggested a selective cytotoxic effect on cancer cells. Mechanistic investigation of the cytotoxic activity of compound <B>4f</B> in human cervical cancer HeLa cells showed that it triggers cell death through induction of apoptosis. As a whole, this study presents the natural products hybrid analogs <B>4f</B>, <B>4h</B>, <B>4k</B> and <B>4q</B> as potential lead compounds for further development of novel anticancer therapeutics.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Design, synthesis and <I>in vitro</I> antiproliferative evaluation of 3,5,4′-trimethoxystilbene-5,6,7-trimethoxyflavone hybrids. </LI> <LI> Compounds <B>4f</B>, <B>4h</B>, <B>4k</B> and <B>4q</B> elicited promising broad spectrum antiproliferative activity. </LI> <LI> Compounds <B>4f</B>, <B>4h</B>, <B>4k</B> and <B>4q</B> were more selective to human cancer cells rather than normal human cells. </LI> <LI> Compound <B>4f</B> triggered cell death via induction of apoptosis in HeLa cells. </LI> <LI> Compounds <B>4f</B>, <B>4h</B>, <B>4k</B> and <B>4q</B> might be potential leads for development of natural-products based anticancer agents. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>