On Some Matrix Transformations Involving Prime Numbers

Srinivasan, V . K . 호남수학회 1985 호남수학학술지 Vol.7 No.1

The object of this note is to discuss the relationship between some matrix transformations that naturally occur involving prime numbers in the theory of Summability.

The Effect of 1-Furan-2-yl-3-pyridine-2-yl-propenone on Pharmacokinetic Parameters of Warfarin

Srinivasan Shanmugam,이응석,정태천,용철순,최한곤,우종수,유봉규 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7

1-Furan-2-yl-3-pyridine-2-yl-propenone (FPP-3) is an investigatory drug which has a dual inhibitory action on cyclooxygenase (COX) and 5-lipoxygenase (5-LOX). We examined its effect on the pharmacokinetics of warfarin. Three consecutive days of pretreatment with 17 mg/kg of FPP-3 had no significant effect on the pharmacokinetic parameters of warfarin when orally administered to rats. A higher dosage of FPP-3 however, did cause significant changes in the pharmacokinetic parameters of wafarin. The cytochrome P450 activity test demonstrated that the metabolism of R-warfarin was significantly inhibited by FPP-3 while there was little or no inhibition of the metabolism of S-warfarin, which is mainly responsible for its anticoagulant effect. Therefore, it appears that the alteration in the pharmacokinetic parameters of warfarin was due to the inhibitory effect of FPP-3 on the metabolism of R-warfarin. Although there was a significant increase in the plasma concentration, the area under the curve, half life of warfarin, and prothrombin time were not significantly changed. Based on these findings, the pharmacokinetic drug interaction between FPP-3 and warfarin mainly involves R-warfarin and, therefore, this interaction may not be of clinical significance in terms of warfarin-related toxicity.

Design of CPW-Fed Inverted Six Shaped Antenna for IoT Applications

Srinivasan Ashok Kumar,T. Shanmuganantham 한국전기전자재료학회 2020 Transactions on Electrical and Electronic Material Vol.21 No.5

In this paper a novel coplanar waveguide fed antenna with inverted six shaped confi guration having wide band attributes, proposed and designed on a FR4 substrate. The dimensions of the designed antenna are 54 mm × 38 mm. Few rounded corners system is used in this design to improve the bandwidth and gain of proposed antenna. Being a simple antenna, it makes it extremely reasonable for the future generation of Internet of Tings applications. A well-ordered outline process is completed to get an upgraded plan for good impedance matching in the required band. The Reflection coefficients along with the current densities at various phases of the design process are discussed and analyzed to get a decent understanding into the proposed antenna plan. The proposed antenna exhibits stable radiation, having low back lobes and low cross polarization and having greatest gain 6 dBi.

Deinococcus radioresistens sp. nov., a UV and gamma radiation-resistant bacterium isolated from mountain soil.

Srinivasan, Sathiyaraj,Lee, Jae-Jin,Lim, Sang-Yong,Joe, Min-Ho,Im, Seong-Hun,Kim, Myung Kyum N.V. Swets en Zeitlinger 2015 Antonie van Leeuwenhoek Vol.107 No.2

<P>Two Gram-negative, non-motile, short rod-shaped bacterial strains, designated as 8A(T) and 28A, were isolated from Mount Deogyusan, Jeonbuk Province, South Korea. The isolates were analyzed by a polyphasic approach, revealing variations in their phenotypic characters but high DNA-DNA hybridisation values reciprocally, confirming that they belong to the same species. Both the isolates also showed a high resistance to UV compared with Deinococcus radiodurans, and a gamma-radiation resistance similar to other members of the genus Deinococcus. Phylogenetic analysis with the 16S rRNA gene sequences of closely related species indicated their similarities were below 97 %. Chemotaxonomic data showed the most abundant fatty acids to be C16:1??7c and C16:0. The strains can be distinguished from closely related species by the production of esterase (C4) and 관-galactosidase, and by their ability to assimilate L-alanine, L-histidine and N-acetyl-D-glucosamine. Based on the phenotypic, phylogenetic, and chemotaxonomic data, the isolates represent a novel species of the genus Deinococcus, for which the name Deinococcus radioresistens sp. nov. is proposed. The type strain is 8A(T) (KEMB 9004-109(T) = JCM 19777(T)), and a second strain is 28A (KEMB 9004-113 = JCM 19778).</P>

Recent advances in NMR-based structural characterization of αB-crystallin and its potential role in human diseases

Srinivasan Muniyappan,김진해 한국자기공명학회 2019 Journal of the Korean Magnetic Resonance Society Vol.23 No.1

αB-crystallin (αBC) is a member of a small heat-shock protein (sHSP) superfamily and plays a predominant role in cellular protein homeostasis network by rescuing misfolded proteins from irreversible aggregation. αBC assembles into dynamic and polydisperse high molecular weight complexes containing 12 to 48 monomers; this variable stereochemistry of αBC has been linked to quaternary subunit exchange and its chaperone activity. The chaperone activity of αBC poses great potential as therapeutic agents for various neurodegenerative diseases. In this mini-review, we briefly outline the recent advancement in structural characterization of αBCs and its potential role to inhibit protein misfolding and aggregation in various human diseases. In particular, nuclear magnetic resonance (NMR) spectroscopy and its complimentary techniques have contributed much to elucidate highly-dynamic nature of αBCs, among which notable advancements are discussed in detail. We highlight the importance of resolving the structural details of various αBC oligomers, their quaternary dynamics, and structural heterogeneity.

An Efficient Implementation of Mobile Raspberry Pi Hadoop Clusters for Robust and Augmented Computing Performance

Srinivasan, Kathiravan,Chang, Chuan-Yu,Huang, Chao-Hsi,Chang, Min-Hao,Sharma, Anant,Ankur, Avinash Korea Information Processing Society 2018 Journal of information processing systems Vol.14 No.4

Rapid advances in science and technology with exponential development of smart mobile devices, workstations, supercomputers, smart gadgets and network servers has been witnessed over the past few years. The sudden increase in the Internet population and manifold growth in internet speeds has occasioned the generation of an enormous amount of data, now termed 'big data'. Given this scenario, storage of data on local servers or a personal computer is an issue, which can be resolved by utilizing cloud computing. At present, there are several cloud computing service providers available to resolve the big data issues. This paper establishes a framework that builds Hadoop clusters on the new single-board computer (SBC) Mobile Raspberry Pi. Moreover, these clusters offer facilities for storage as well as computing. Besides the fact that the regular data centers require large amounts of energy for operation, they also need cooling equipment and occupy prime real estate. However, this energy consumption scenario and the physical space constraints can be solved by employing a Mobile Raspberry Pi with Hadoop clusters that provides a cost-effective, low-power, high-speed solution along with micro-data center support for big data. Hadoop provides the required modules for the distributed processing of big data by deploying map-reduce programming approaches. In this work, the performance of SBC clusters and a single computer were compared. It can be observed from the experimental data that the SBC clusters exemplify superior performance to a single computer, by around 20%. Furthermore, the cluster processing speed for large volumes of data can be enhanced by escalating the number of SBC nodes. Data storage is accomplished by using a Hadoop Distributed File System (HDFS), which offers more flexibility and greater scalability than a single computer system.

Methane emission from municipal solid waste dumpsites: A case study of Chennai city in India

Srinivasan, Pavithrapriya,Andimuthu, Ramachandran,S.N., Ahamed Ibrahim,Ramachandran, Prasannavenkatesh,Rajkumar, Easwari,Kandasamy, Palanivelu Techno-Press 2020 Advances in environmental research Vol.9 No.2

The indiscriminate growth in global population poses a threat to the world in handling and disposal of Municipal solid waste. Rapid urban growth increases the production, consumption and generation of Municipal solid waste which leads to a drastic change in the environment. The methane produced from the Municipal Solid waste accounts for up to 11% global anthropogenic emissions, which is a major cause for global warming. This study reports the methane emission estimation using IPCC default, TNO, LandGEM, EPER and close flux chamber from open dump yards at Perungudi and Kodungaiyur in Chennai, India. The result reveals that the methane emission using close flux chamber was in the range of 8.8 Gg/yr-11.3 Gg/yr and 6.1Gg/yr to 9.1 Gg/yr at Kodungaiyur and Perungudi dump yard respectively. The per capita waste generation was estimated based on waste generation and population. The waste generation potential was projected using linear regression model for the period 2017-2050. The trend of CH₄ emission in the actual field measurement were increased every year, similarly the emission trend also increased in IPCC default method (mass balance approach), EPER Germany (zero order decay model) where as TNO and Land GEM (first order decay model) were decreased. The present study reveals that Kodungaiyur dump yard is more vulnerable to methane emission compared to Perungudi dump yard and has more potential in waste to energy conversion mechanisms than compare to Perungudi dump yard.

Automated Glaucoma Screening in Retinal Fundus Images

Srinivasan Aruchamy,Partha Bhattacharjee,Goutam Sanyal 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.9

Glaucoma is an eye disease which damages the optic nerve that carries information from the eye to the brain. Glaucoma is the second foremost reason of blindness. An efficient hardware based implementation of glaucoma screening is a significant task in the automated retinal image analysis method. This paper presents an automatic glaucoma screening using a TMS320C6416DSK DSP board. The detection procedure consists of two stages. The first stage comprises of image pre-processing and detection of optic nerve head center using circular Hough Transform .In the second stage, the optic disk diameter is calculated and cup is segmented from disk. The proposition between disk and cup is calculated for abnormal image screening. The implemented technique is tested on a publicly available retinal image data sets and the average accuracy achieved is 97.5%.

Physicochemical Characterization and Skin Permeation of Liposome Formulations Containing Clindamycin Phosphate

Srinivasan Shanmugam,송충길,Santhoshkumar Nagayya-Sriraman,Rengarajan Baskaran,용철순,최한곤,Dae-Duk Kim,우종수,유봉규 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.7

This study was undertaken to evaluate the physicochemical properties and skin permeation of liposome formulations containing clindamycin phosphate (CP), especially when charge was imparted to the liposome. Five different liposome formulations were prepared using Phospholipon 85G (PL) and cholesterol (CH) by conventional lipid film hydration technique. Molar ratio of CH to PL was varied in the range of 0.16-1.0. Charged liposomes were prepared in the same way with addition of 1,2-dioleoyl-3-trimethylammonium-propane chloride salt (DOTAP) and 1,2-dimyristoyl-sn-glycero-3-phosphate monosodium salt (DMPA) as charge carrier lipid for cationic or anionic charge of the liposome, respectively. Fresh full-thickness mice skin was taken and used for skin permeation study using Keshary-Chien diffusion cell with 1.77 ㎠ diffusion area at 37℃. All liposome formulations prepared showed homogeneous size distribution with mean particle size of about 1 μm or less. Among the five liposome formulations prepared, formulation with the molar ratio of 0.5 showed the best result in the physicochemical properties such as polydispersity index, entrapment efficiency, size evolution, and ability of the liposome to retain CP as of entrapped in the vesicles. Charge-impartation of the formulation with cationic charge carrier lipid resulted in additional benefit in terms of inhibition of size evolution, the ability of the liposome to retain CP in the vesicles, and skin permeation. Steady state flux of the drug through the mice skin in the cationic liposome vesicles was 0.75 ± 0.01 μg/㎠h while that in the control (dissolved into mixed alcohol solution) was 0.17 μg/㎠h. One half molar ratio of CH to PL was optimal in terms of physicochemical properties of the liposome formulation containing CP, and incorporation of cationic charge carrier lipid appeared to provide additional benefits for the stability of the liposome formulation and skin permeation of the drug.

Offshore Triceratops Under Impact Forces in Ultra Deep Arctic Waters

Srinivasan Chandrasekaran,R. Nagavinothini 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.2

In the recent years, offshore oil drilling and production is moving towards ultra-deep Arctic region which demands an adaptable structural form. Apart from the environmental loads, offshore structures in Arctic region will also be subjected to impact forces arising due to ship platform collision. Such loads may endanger the safety of the platform due to the combined effect of reduced temperature and impact forces on the material and geometric properties of the structure. Thus, there is a need to understand the behaviour of offshore structures under impact forces in low-temperature conditions. Offshore Triceratops is one of the recent new-generation compliant platforms proved to be suitable for ultra-deepwater applications. The main aim of this study is to assess the response of triceratops under impact forces in Arctic environment numerically. As the buoyant legs of triceratops are susceptible to impact forces arising from ship platform collision, the numerical model of a buoyant leg is developed using Ansys explicit dynamics solver. The impact analyses is then carried out with rectangular box-shaped indenter representing the stem of a ship, under both ambient conditions and Arctic temperature (− 60 °C) and the local response of the platform is studied through force deformation curves and stress contours. In order to study the global response of the platform, the numerical model of triceratops is developed in Ansys Aqwa solver and analysed under the action of impact load time history obtained from explicit analysis of buoyant leg. The impact load on the buoyant leg resulted in the continuous periodic vibration of the platform. Furthermore, parametric studies were also carried out to investigate the effect of indenter velocity, size, and location on the impact response of triceratops under Arctic temperature, and the results are discussed.