싱가포르의 연령주의 : 현황과 사회적 대응 (Ageism in Singapore)

Srinivasan 한국노년학회 2017 한국노년학회 학술발표논문집 Vol.2017 No.국제학술

Dr. Srinivasan Chokkanathan is currently Assistant Professor at the Department of Social Work, National University of Singapore. He graduated from Voorhees College (B.A. in History), from National Institute of Mental Health and Neuro Sciences,India (MPhil in Psychiatric Social Work), from National University of Singapore, Singapore (Ph.D. in Social Work). His primary area of research involves elder mistreatment, ageism, and older adult’ s mental health. He serves as an invited reviewer for numerous journals on Gerontology such as the Journal of Elder Abuse and Neglect, Aging and Mental Health, Aging and Society, and the Journal of Gerontology: Social Sciences. His publications include 15 peer reviewed articles and 13 presentations in International conferences. He recently was the lead editor in a special issue on social care of elderly in the Journal of Asia Pacific Journal of Social Work and Development

Nocardioides soli sp. nov., a bacterium isolated from a mountain soil

Srinivasan, Sathiyaraj,Lee, Sang-Seob,Lee, Jae-Jin,Kim, Myung Kyum Springer-Verlag 2014 Antonie van Leeuwenhoek Vol.106 No.2

Deinococcus humi sp. nov., isolated from soil

Srinivasan, Sathiyaraj,Lee, Jae-Jin,Lim, Sangyong,Joe, Minho,Kim, Myung Kyum Microbiology Society 2012 International journal of systematic and evolutiona Vol.62 No.12

<P>A Gram-staining-positive, strictly aerobic, spherical, non-motile, red-pigmented bacterium, designated strain MK03<SUP>T</SUP>, was isolated from a soil sample collected in South Korea. The taxonomic position of the novel strain was investigated using a polyphasic approach. In phylogenetic analyses based on 16S rRNA gene sequences, strain MK03<SUP>T</SUP> was placed in a clade formed by members of the genus <I>Deinococcus</I> in the family <I>Deinococcaceae</I> and appeared to be most closely related to <I>Deinococcus aerolatus</I> 5516T-9<SUP>T</SUP> (97.4 % sequence similarity), <I>Deinococcus marmoris</I><I/> AA-63<SUP>T</SUP> (97.2 %), <I>Deinococcus radiopugnans</I> ATCC 19172<SUP>T</SUP> (97.2 %) and <I>Deinococcus saxicola</I> AA-1444<SUP>T</SUP> (96.9 %). The genomic DNA G+C content of the novel strain was 64.5 mol%. The chemotaxonomic characteristics of strain MK03<SUP>T</SUP> were typical of members of the genus <I>Deinococcus</I>: MK-8 was identified as the predominant respiratory quinine, the major fatty acids were C16 : 1ω7<I>c</I>, C15 : 1ω6<I>c</I>, C16 : 0 and C15 : 0, ornithine was found to be the diamino acid in the cell-wall peptidoglycan and the novel strain showed resistance to gamma radiation, with a D10 value (i.e. the dose required to reduce the bacterial population by 10-fold) in excess of 9 kGy. In hybridization experiments, only low DNA-DNA relatedness values (11.6-34.5 %) were recorded between the novel strain and its closest relatives in the genus <I>Deinococcus</I>. Based on the phylogenetic, chemotaxonomic, phenotypic and DNA-DNA relatedness data, strain MK03<SUP>T</SUP> represents a novel species of the genus <I>Deinococcus</I>, for which the name <I>Deinococcus humi</I> sp. nov. is proposed. The type strain is MK03<SUP>T</SUP> ( = KCTC 13619<SUP>T</SUP> = JCM 17915<SUP>T</SUP>).</P>

SYNTHESIS AND CHARACTERIZATION OF A HIGHLY CRYSTALLINE NOVEL MESOPOROUS C- AND N-CODOPED TiO2 NANOPHOTOCATALYST

SRINIVASAN ANANDAN,YASURO IKUMA,KATSUYOSHI KAKINUMA,KOICHI NIWA 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2008 NANO Vol.3 No.5

Here we report, for the first time, the synthesis of highly crystalline novel mesoporous carbon/nitrogen (C/N)-codoped TiO2 (MCNT) using ethylene diamine and carbon tetrachloride as the source for nitrogen and carbon, KIT-6 as the template, and titanium tetraisopropoxide as the TiO2 source. The obtained material has been unambiguously characterized by various sophisticated techniques. XRD and TEM analysis revealed that the MCNT material possesses highly crystalline 3D structure with a continuous network of mesoporous channels as well as structure corresponding to TiO2. UV-DRS analysis indicated that light absorption shifted to lower energy and stronger absorption in the visible light region. XPS revealed that C and N were doped effectively and C or N dopants might be present in the chemical environment of Ti–O–N or Ti–O–C. It has been found that the material is highly crystalline and possesses high surface area, pore volume and uniform pore size distribution. Owing to its textural characteristics, it could be useful for various applications, such as photocatalysis, fuel cells, bulky biomolecule adsorption and nanotechnology.

New Classification for Clinically Symptomatic Adjacent Segment Pathology in Cervical Disc Disease

Srinivasan Sreeramulu Uddanapalli 대한척추외과학회 2015 Asian Spine Journal Vol.9 No.6

Study Design: Clinical adjacent segment pathology (CASP) is common after cervical disc surgery. A critical examination of 320 patients operated for cervical disc prolapse revealed that CASP can also occur in patients with congenital and degenerative fusion of cervical spine. This has not been studied in depth and there is a need for a practically applicable classification of CASP. Purpose: To develop a new classification scheme of CASP. Overview of Literature: A review of the literature did not reveal a practically applicable classification incorporating the occurrence of CASP in congenital and degenerative fusion cases. Methods: This was a retrospective analysis of 320 patients operated (509 disc spaces) on for cervical disc prolapse. Cases (n=316) were followed-up for 3–11 years. Random sampling of 220 patients with postoperative magnetic resonance imaging (MRI) in 165 cases was analyzed. Results: Six symptomatic CASP cases required resurgery (1.9%), eight cases involved MRI proven CASP with axial neck pain only and 13 patients were asymptomatic with radiological adjacent segment pathology (RASP). The frequency rate was 8.5% (27/316). Four cases of congenital or degenerative fusion of vertebra developed CASP requiring surgery. CASP is classified as primary or secondary follows. Primary A1 was congenital fusion of vertebra and primary A2 was degenerative fusion of the vertebra. Secondary, which was after cervical disc surgery, comprised B1 (RASP in asymptomatic patients), B2 (CASP in patients with axial neck pain), and B3 (CASP with myeloradiculopathy). B3 was subdivided into single-level CASP (B3a) and multiple-level CASP (B3b). Conclusions: Symptomatic CASP requiring resurgery is infrequent. CASP can occur in patients with congenital and degenerative fusion of the cervical spine. A new classification for CASP along with treatment strategy is proposed. Patients in Primary CASP and B3 CASP require resurgery while others require only observation.

Burkholderia humi sp. nov., Isolated from Peat Soil

Srinivasan, Sathiyaraj,Kim, Jinsoo,Kang, Sang-Rim,Jheong, Weon-Hwa,Lee, Sang-Seob Springer-Verlag 2013 Current microbiology Vol.66 No.3

<P>A Gram-negative, aerobic, short-rod-shaped, non-motile bacterium designated Rs7(T), was isolated from peat soil collected from Russia and was characterized to determine its taxonomic position. 16S rRNA gene sequence analysis revealed that the strain Rs7(T) belongs to the class Betaproteobacteria. The highest degree of sequence similarities were determined to be with Burkholderia tropica Ppe8(T) (98.4 %), Burkholderia unamae MTI-641(T) (97.8 %), Burkholderia bannensis E25(T) (97.7 %), Burkholderia heleia SA41(T) (97.0 %), and Burkholderia sacchari IPT101(T) (97.0 %). Chemotaxonomic data revealed that the strain Rs7(T) possesses ubiquinone Q-8. The polar lipid profile of strain Rs7(T) contained phosphatidylethanolamine, diphosphatidylglycerol, phosphatidylglycerol, and an unknown amino phospholipid. The predominant fatty acids were C(16:0), C(19:0) cyclo ω8c, and C(17:0) cyclo, all of which corroborated the assignment of the strain to the genus Burkholderia. The DNA G+C content was 63.2 mol%. DNA-DNA hybridization experiments showed less than 37.8 % DNA relatedness with closely related type strains, thus confirming separate species status. The results of physiological and biochemical tests allowed phenotypic differentiation of strain Rs7(T) from the members of the genus Burkholderia. Based on these data, Rs7(T) (=KEMC 7302-068(T) = JCM 18069(T)) should be classified as the type strain for a novel Burkholderia species, for which the name Burkholderia humi sp. nov. is proposed.</P>

Pontibacter humi sp. nov., Isolated from Mountain Soil

Srinivasan, Sathiyaraj,Lee, Jae-Jin,Lee, Sang-Seob,Kim, Myung Kyum Springer-Verlag 2014 Current microbiology Vol.69 No.3

Identification of a Novel Keyhole Phenotype in Double-Disk Diffusion Assays of Clindamycin-Resistant Erythromycin-Sensitive Strains of <i>Streptococcus agalactiae</i>

Srinivasan, Usha,Miller, Brady,Debusscher, Joan,Marrs, Carl F.,Zhang, Lixin,Seo, Yong Soo,Oh, Kwan-Young,Kim, Moon Young,Yoon, Hye-Ryung,Ki, Moran,Foxman, Betsy Mary Ann Liebert 2011 Microbial drug resistance Vol.17 No.1

Original Article : Zanamivir Oral Delivery: Enhanced Plasma and Lung Bioavailability in Rats

( Srinivasan Shanmugam ),( Ho Taek Im ),( Young Taek Sohn ),( Kyung Soo Kim ),( Yong Ll Kim ),( Chul Soon Yong ),( Jong Oh Kim ),( Han Gon Choi ),( Jong Soo Woo ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0

The objective of this study was to enhance the oral bioavailability (BA) of zanamivir (ZMR) by increasing its intestinal permeability using permeation enhancers (PE). Four different classes of PEs (Labrasol(®), sodium cholate, sodium caprate, hydroxypropyl β-cyclodextrin) were investigated for their ability to enhance the permeation of ZMR across Caco-2 cell monolayers. The flux and Papp of ZMR in the presence of sodium caprate (SC) was significantly higher than other PEs in comparison to control, and was selected for further investigation. All concentrations of SC (10-200 mM) demonstrated enhanced flux of ZMR in comparison to control. The highest flux (13 folds higher than control) was achieved for the formulation with highest SC concentration (200 mM). The relative BA of ZMR formulation containing SC (PO-SC) in plasma at a dose of 10 mg/kg following oral administration in rats was 317.65% in comparison to control formulation (PO-C). Besides, the AUC0-24 h of ZMR in the lungs following oral administration of PO-SC was 125.22 ± 27.25 ng hr ml(-1) with a Cmax of 156.00 ± 24.00 ng/ml reached at 0.50±0.00 h. But, there was no ZMR detected in the lungs following administration of control formulation (PO-C). The findings of this study indicated that the oral formulation PO-SC containing ZMR and SC was able to enhance the BA of ZMR in plasma to an appropriate amount that would make ZMR available in lungs at a concentration higher (>10 ng/ml) than the IC50 concentration of influenza virus (0.64-7.9 ng/ml) to exert its therapeutic effect.

RESEARCH ARTICLE : Sildenafil vaginal suppositories: preparation, characterization, in vitro and in vivo evaluation

( Srinivasan Shanmugam ),( Young Hun Kim ),( Jeong Hee Park ),( Ho Taek Im ),( Young Taek Sohn ),( Kyeong Soo Kim ),( Yong Ll Kim ),( Chul Soon Yong ),( Jong Oh Kim ),( Han Gon Choi ),( Jong Soo Woo ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0

Aim: The main objective was to investigate the in vitro release profile/kinetics, and in vivo plasma pharmacokinetics (PK) and organ biodistribution (BD) of the prepared sildenafil vaginal suppositories (SVS). Methods: Suppositories containing 25mg of sildenafil were prepared by the cream melting technique using Witepsol H-15 as a suppository base. The suppositories were characterized for weight variation, content uniformity, hardness, disintegration time and crystallinity change. The in vitro dissolution in pH 4.5, and in vivo plasma PK and organ BD of sildenafil from SVS in female Sprague Dawley rats, were also investigated. Results: The mean weight variation, content uniformity, hardness and disintegration time of the prepared SVS were 1.127±0.020g, 98.25±2.50%, 2.5±0.08kg and 9±1.0min, respectively. The release of sildenafil from the SVS was more than 90% at 30min, with a release kinetic of Hixson--Crowell model and non-Fickian diffusion (n=0.464). The plasma PK study demonstrated a significantly lower Cmax (∼10 times) and AUC0-24h (∼13 times) of sildenafil in plasma following intravaginal (IVG) administration of suppositories compared to oral (PO) administration of sildenafil solution. Nevertheless, the organ BD study showed a phenomenally higher Cmax (∼40 times) and AUC0-24h (∼20 times) of sildenafil in uterus following IVG administration of suppositories than PO administration of sildenafil solution. Conclusion: This study demonstrated enhanced sildenafil exposure in the uterus following IVG administration of SVS, which could be used to target the uterus for therapeutic benefits.