防己황기탕 및 枸杞子가 肥滿白鼠의 體重에 미치는 影響

宋勇善 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1

This study was designed to investigate the effects of Bangkihwangkitang(방기황기탕), Bangkihwangkitang with Lycii frucuts and Lycii fructus on the weight of obese rats. A series of experiments have been conducted in order to measure the effects of the above materials on the weight, organs and serum. The measurements have been performed on ; (1) the weight of liver, spleen, kidneys, adrenal and pituitary; (2) the quantity of total cholesterol, tryglyceride, free fatty acid, total lipid, T_3, T_4, T_3 uptake, free T_3 and free T_4 in serum ; and (3) the quantity of total lipid in feces. The results are : 1. It was significantly proved that Bangkihwangkitang, Bangkihwangkitang with Lycii fructus and Lycii fructus decreased the weight of the obese rats as time passing. 2. It was not shown that Bangkihwangkitang Bangkihwangkitang with Lucii fructus and Lycii fructus had impacts on the weight of liver, spleen, kidneys, adrenal and pituitary. 3. Bangkihwangkitang Bangkihwangkitang with Lucii fructus and Lycii fructus significantly inhibited the increase of the quantity of total cholesterol, tryglyceride, free fatty acid and total lipid in serum. 4. Bangkihwangkitang and Lycii fructus significantly increased the quantity of T_3, T_4, T_3 uptake, free T_3 and free T_4 in serum of obese rats. 5. Bangkihwangkitang with Lycii fructus increased the quantity of T_3, T_4, T_3 uptake, free T_3 and free T_4, in serum of obese rats. The tests of significance proved significant for all these contents except T_3. 6. Bangkihwangkitang, Bangkihwangkitang with Lycii fructus and Lycii fructus did not affect the change of the quantity of total lipid in feces. Based on the results, it is concluded that the clinical application of Bangkihwangkitang, Bangkihwangkitang with Lycii fructus and Lycii fructus can help cure obesity.

上顎洞에 發生한 Aspergillosis의 一例報告

林大銑,宋圭鉉,朴敬浩,朴暎緖,李玩永 中央醫學社 1963 中央醫學 Vol.5 No.4

A case of secondary aspergillosis of the left maxillary sinus following chronic sinusitis in a 42 year old male coal miner specialist is reported. His chief complaints were nasal obstruction and postnasal drip of several years duration. Roentgenogram revealed marked and moderate shadow in the left and right maxillary sinuses respectively. Significant operative findings included almost paper-thin bony walls of the left maxillary sinus, and small amount of yellow greenish purulent material was drained, followed by yellowish brown semisolid tissue on further curettage. The latter specimen was found to be essentially mass of fungi, showing numerous distinctly septate, branching hyphae on the Papanicolaou stain of the direct smears of the cut surface of the specimen, and Hematoxylin-Eosin and Periodic Acid Schiff stains of paraffin sections. Pertinent aspects of clinical and pathological differential diagnosis between aspergillosis - and mucormycosis, are described. Aspergillosis presents usually benign course, with insignificant chief complaints as our case, whereas mucormycosis is most frequently associated with uncontrollable diabetics, and run usually acutely fatal course. There are three main types of ucormycosis-cerebral, pulmonary and intestinal. The characteristic broad nonseptate branching hyphae of mucor, and marked affinity to the blood vessels,, penetrating the tough walls of arteries, with thromboses and infarction, readily differentiate aspergillosis from mucormycosis.

폐암세포에 대한 附子 추출물의 독성 효과

권강범,김은경,문형철,송용선,류도곤 한국전통의학연구소 2006 한국전통의학지 Vol.15 No.1

The aim of this study was to investigate the cytotoxic effect and its mechanism on Radix Aconiti(RA) extract in lung cancer cell lines. RA extract treatment decreased the cell viability in a dose-dependent fashions in lung cancer cells including A549, H460, H23 and H157 cells. Many investigators reported that A549 and H460 cells expressed wild-type p53, but H23 and H157 cells preserved mutated p53. After treatment with RA extract in A549 and H460 cells, we measured the expression of p53 protein levels using Western blot, analysis. In both cells treated with RA extracts, p53 protein expressions were increased in a dose-dependent manner. In our experiments, RA extracts also have cytotoxic effects in H23 and H157, which have mutated p53. Treatment with RA extract decreased bcl-2 protein expressions in both cells. These results suggest that RA extracts have cytotoxic effects via p53 expression increase and bcl-2 inhibitable pathways in A549, H460 cells and H23, H157 cells, respectively.

일부 자동차 공장 근로자들의 職業的 特性과 社會 心理的 Stress의 相關性 硏究

김성삼,홍지우,한현정,최희석,권소희,정해경,김삼태,송용선,이기남 한국전통의학연구소 2004 한국전통의학지 Vol.14 No.1

〈Objective〉 This study were carried out to study to assess the relationship between job characteristics, general characteristics, health behaviors, and psychosocial distress and suggested the preventive oriental medicine approaches in occupational health area. 〈Methods〉 We measured job characteristics(job demand, job control, jop insecurity) by The Karasek's Job Content Questionnaire, health behaviors(smoking, drinking, exercise, coffee), general characteristics at work by a self-administered questionnaire. Psycho social distress was measured by PWI(Psychosocial Well-being Index), a 18-item self- administered instrument. 370 data for research were collected through the process of oriental health examination with questionnaire in workplace. Statistical analysis was done by t test, oneway ANOVA, and hierarchical multiple regression analysis with SPSSWIN (version 10.0) 〈Results〉 Among the 152 respondents, the prevalence of high job strain was 27%(41 persons). The Odds ratio of high job strain was 3.11(95 2.12~4.11), and those of passive group and active group were 2.01(95 0.83~2.76) and 1.80(95 0.83~2.76), respectively. Our results supported the association between psychosocial distress and job strain. 〈Conclusion〉 The odds ratio of high strain isolated group(high strain group+low social support) was 3.59(95 2.05 5.13), but the odds ratio of high strain collective group was 1.32(95 0.23 2.41). Social support at work was modifing factor of the association between psycho social distress and job strain. Therefore we reviewed the evidence that economic depression was associated with psycho social distress in this study, and that the strength of the social support was important in maintain health.

뇌졸중 환자들의 지연도착시간에 관한 요인들

송용선(Yung Sun Song),이수영(Su Young Lee) 한의병리학회 2002 동의생리병리학회지 Vol.16 No.5

Effects of Sobieum(消肥飮) on weight, plasma, and UCP mRNA expressions in zucker rats

Song, Mi-Yeon,Song, Yung-Sun,Chung, Seok-Hee,Lee, Jong-Soo,Kim, Sung-Soo,Shin, Hyun-Dae INSTITUTE OF ORIENTAL MEDICINE KYUNG-HEE UNIVERSIT 2000 JOURNAL OF ORIENTAL MEDICINE Vol.5 No.1

Sobieum(消肥飮) is a herbal formula based on Mahwangbalpyo-tang(麻黃發表湯) which regulates the Taeuimn(太陰人)'s exterior syndrome in Korea's Sasang(四象) constitutional medicine. The present study was aimed to investigate whether the obesity can be improved by the oral adminsitration of Sobieum(消肥飮) extracts. The weight of the whole body, live and adipose tissues, food consumption, uncoupling protein(UCP) mRNA expression, and plasma levels of total-cholesterol, triglyceride, HDL-cholesterol, and leptin were measured in male lean(+/+) and obese(fa/fa) Zucker rats administered Sobieum(消肥飮) extracts(0.125mg/g, twice daily) for 3 weeks. These wee then compared with those of control groups administered physiological saline. Statistical comparisons between the two groups were done by student's t-test. Oral administration of Sobieum(消肥飮) extracts for 3 weeks has been shown to exert anti-obesity and hypolipidemic effects in both lean and obese Zucker rats. The extracts not only reduced weight of body, liver, and adipose tissues but also increased plasma levels of HDL-cholesterol, induced leptin, and up-regulated UCP mRNA expressions in brown adipose tissue which contribute to mitigation of obesity. This study demonstrates that Sobieum(消肥飮) has an effect on the treatment of obesity. Clinical studies are thought to be required.

Anti-Obesity Effects of Egg White Powder in C57BL/6J Mice

Sun hwa Hong,Sang Ho Park,Hong Geun Oh,Yung Ho Chung,Hyun A Lee,Sang Jun Han,Song Hee Lee,Sung Woo Hwang,Won Gyeong Lee,Ok jin Kim 대한수의학회 2012 대한수의학회 학술대회발표집 Vol.2012 No.-

Successful Intravascular Ultrasound Guided Transcatheter Closure of Patent Ductus Arteriosus in Adult using Amplatzer Duct Occluder

Sun Jin Park,Jae Woong Choi,Ji Young Park,Seung Hwan Kim,Jung Hoon Ha,Yoon Kyung Song,Yung Hee Lee,Sung Kee Ryu 조선대학교 의학연구소 2014 The Medical Journal of Chosun University Vol.39 No.3

The patent ductus arteriosus (PDA) is a vascular structure connecting the proximal descending aorta to the roof of the main pulmonary artery, near the origin of the left branch pulmonary artery. Transcatheter closure has become the treatment of choice for most cases of PDA in both children and adults; however, measurement of the exact size and morphology of the shunt in adult cases using only contrast fluoroscopy is difficult. We report on a case of a 49-year-old woman who underwent transcatheter closure of PDA with intravascular ultrasound (IVUS) guideance. In the current case, IVUS is feasible and helpful for measuring the exact size and shape of the PDA.

Poster Session : Activation of JNK, ERK and p38 MAPK by B chain from Korean mistletoe (Viscum Album Coloratum) Lectin

( Sun Mi Her ),( Woong Suk Yang ),( Ki Wook Kim ),( Seung Hoon Yang ),( Seong Kyu Song ),( Yung Choon Yoo ),( Jong Bae Kim ) 생화학분자생물학회 2006 생화학분자생물학회 춘계학술발표논문집 Vol.2006 No.-

성상신경절차단시 주입된 1% Lidocaine 양에 따른 형중 Lidocaine 농도 변화

송선옥(Sun Ok Song),서영호(Yung Ho Suh) 대한통증학회 2001 The Korean Journal of Pain Vol.14 No.1

N/A Background: Sympathetic blocks with local anesthetics are used to differentiate sympathetically- maintained pain (SMP) from sympathetically-independent pain (SIP). However, systemic lidocaine is also used in the management of neuropathic pain. Therefore, there may be possibility of a false positive response in relieving their pain by systemic absorption of lidocaine following a diagnostic sympathetic block in patients with SIP. In this study, we measured the plasma lidocaine concentrations after a stellate ganglion block (SGB) using three volumes of 1% lidocaine. Methods: This prospective, crossover study was performed in 3 patients who experience sudden hearing loss and in 4 volunteers. Each person received SGB three times using three different volumes (6 ml, 12 ml and 16 ml) of 1% lidocaine at one week intervals. SGB was performed using a 23 G butterfly needle via a paratracheal approach by two persons. Two ml of venous blood was obtained from a prepared contra-lateral sided venous route at 1, 3, 5, 7, 10, 20 and 60 min after SGB. Plasma lidocaine level was analyzed by immunoassay. Results: Mean plasma lidocaine concentrations correlated well with the volumes of 1% lidocaine used in SGB; larger volumes showed higher concentrations (P < 0.01). Mean peak plasma concentrations were 1.08 ± 0.18 in 6 ml, 1.90 ± 0.47 in the 12 ml and 2.74 ± 0.67 ㎍/ml in the 16 ml groups (P < 0.01). The mean time to reach peak plasma concentration was not significantly different between the three groups. Conclusions: The peak plasma lidocaine concentrations in SGB using large volume were found to be similar to that of IV lidocaine infusion in the management of neuropathic pain. These data suggest that diagnostic sympathetic block may result in many false positive responses for SMP. Part of its effect may be related to systemic local anesthetic absorption and not to a sympathetic block. Therefore, physicians may be required to use optimal volumes and minimal concentration of local anesthetic in diagnostic sympathetic block procedures and also make a careful assessment of the performance of a permanent sympathetic block.