Recommending alternative drugs by using generic drug names to minimise side effects

Hwang, Sohee,Kim, Jungrim,Kim, Jeongwoo,Park, Sanghyun Inderscience Enterprises Ltd. 2017 International journal of data mining and bioinform Vol.18 No.4

North Korean Human Rights: Activists and Networks : Andrew Yeo, Danielle Chubb. New York: Cambridge University Press, 2018, 301 pages

Sohee Hwang 숙명여자대학교 아시아여성연구원 2021 OMNES: The Journal of Multicultural Society Vol.11 No.1

Synthesis of the electro-catalyst supported on mesoporous carbon via imprinting method for polymer electrolyte fuel cells

Sohee Hwang,박구곤,임성대,박석희,양태현,김한성,김창수 한국물리학회 2010 Current Applied Physics Vol.10 No.2

The carbon material with tailored mesopore size was explored as an electro-catalyst in polymer electrolyte fuel cells (PEFCs). The mesoporous carbon material possesses unique structural characteristics including non-micropores, specific surface area, pore volume and well-developed interconnected mesoporosity. The good characteristics of the mesoporous carbon make it a large efficient catalyst support for PEFCs. The great mesoporous carbon supported PtRu electro-catalyst has demonstrate an improvement in electro-catalytic activity toward cyclic voltammetry in comparison with commercial Vulcan XC72supported.

ABT-737 ameliorates docetaxel resistance in triple negative breast cancer cell line

Eunjoo Hwang,Seong-Hye Hwang,Jongjin Kim,Jin Hyun Park,Sohee Oh,Young A Kim,Ki-Tae Hwang 대한외과학회 2018 Annals of Surgical Treatment and Research(ASRT) Vol.95 No.5

Purpose: This study aimed to validate the synergistic effect of ABT-737 on docetaxel using MDA-MB-231, a triple negative breast cancer (TNBC) cell line overexpressing B-cell lymphoma-2 (Bcl-2). Methods: Western blot analysis was performed to assess expression levels of Bcl-2 family proteins and caspase-related molecules. Cell viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell cycle distribution was determined by flow cytometry analysis. Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (z-VAD-fmk) was used for pretreatment to assess the role of caspases. Results: Cell viability of MDA-MB-231 after combination treatment with ABT-737 and docetaxel was significantly lower than that after docetaxel or ABT-737 monotherapy based on MTT assay (both P < 0.001), with a combination index of 0.41. The proportion of sub-G1 population after combination treatment was significantly higher than that after docetaxel or ABT-737 monotherapy (P = 0.001, P = 0.003, respectively). Pretreatment with z-VAD-fmk completely restored cell viability of MDA-MB-231 from apoptotic cell death induced by combination therapy (P = 0.001). Although pro-caspase-8 or Bid did not show significant change in expression level, pro-casepase-9 showed significantly decreased expression after combination treatment. Cleaved caspase-3 showed increased expression while poly (ADP-ribose) polymerase cleavage was induced after combination treatment. However, hypoxia-inducible factor 1-alpha and aldehyde dehydrogenase 1 totally lost their expression after combination treatment. Conclusion: Combination of ABT-737 with docetaxel elicits synergistic therapeutic effect on MDA-MB-231, a TNBC cell line overexpressing Bcl-2, mainly by activating the intrinsic pathway of apoptosis. Therefore, adjunct of ABT-737 to docetaxel might be a new therapeutic option to overcome docetaxel resistance of TNBCs overexpressing Bcl-2.

북한 지도자 제거 이후 한반도 불안정성 제고 가능성 고찰 : 해외 참수작전 사례 검토를 중심으로

황소희 ( Hwang Sohee ) 서울대학교 통일평화연구원 2018 통일과 평화 Vol.10 No.1

본 논문은 북핵 문제 해결의 여러 방안 중 하나인 북한 지도부 제거의 결과로 인한 한반도의 불안정성 제고 가능성을 탐색하는 데 목적을 둔다. 참수작전(Decapitation Strike)은 골칫거리로 분류되는 국제정치의 행위자 및 관련 집단을 전면전이 아닌 선별적으로 타격하는(Targeted Killing) 것으로 한반도에서는 북한의 김정은을 대상으로 논의되고 있다. 참수작전의 실행 결과는 반군 및 테러단체를 해산시켜 지역 내 분쟁을 종식시킨 것 외에도 해당지역의 불안정성을 심화시킨 사례도 존재한다. 본 논문은 참수작전이 지역내 안정에 상이한 영향을 미치는 이유에 천착해 해외에서 진행된 참수작전을 분석하여 이것이 지역 안정성에 미치는 요인을 추출해 냈다. 해외에서 실행된 참수작전은 반군단체와 같은 국내 반정부세력, 테러단체 등 초국경행위자, 권위주의체제국가의 지도자를 대상으로 진행되었다. 참수작전의 결과로 지역 안정성에 영향을 미치는 요인을 해당 지역 주민 지지도, 참수대상 추종 세력 포섭 및 제거, 대안리더십으로 추출했으며 이 요인을 한반도 상황에 대입해 예측하였다. 분석 결과 현재 시점에서 북한 지도부 제거는 북한 내부는 물론 한국의 불안정성을 높일 수 있다는 점을 도출하였다. The purpose of this paper is to consider a possibility that the removal of the North Korean leadership will cause and increase instability in the Korean peninsula. A decapitation strike seems to be one of the various measures to settle the nuclear issue of North Korea. The strike is not an all-out war but a targeted-killing of international political actors and related groups classified as troubled. In the Korean peninsula, it has been recently on the agenda for dealing with Kim Jong Eun and its leadership. Decapitation is said to have contributed to dismantling rebellion, terrorist groups and brought the region’s conflicts to an end. It cannot be denied, however, that there is still a possible growth of instability in the region caused by the strike. Based on this possibility, the paper examines some actual cases of overseas decapitation operations. The operations carried out abroad were conducted against the leaders of authoritarian states, rebel organizations, domestic anti-government forces, and terrorist organizations developing into transnational actors. Three factors affecting regional stability have been extracted from the review of the overseas cases; the local residents’ support, the activities of the followers, and the alternative leadership. As a result of the analysis, it is predicted that the removal of the North Korean leadership would increase instability in North Korea as well as in South Korea.

비정부기구정치학으로 분석한 대한민국정부 수립과 교황청

황소희(Sohee Hwang) 경희대학교 인류사회재건연구원 2021 OUGHTOPIA Vol.35 No.3

본 논문은 양차대전 이후 교황청을 중심으로 한 가톨릭 교회의 반공주의와 민주주의 확산을 위한 정치 활동을 대한민국 독립 정부 수립과 외교적 승인 과정을 탐색함으로써 분석하는 데 목적을 지닌다. NGO정치학의 관점에서 1950년 이전 가톨릭 교회가 미국과 연합해 공산주의 확산을 막기 위한 노력을 초대 주한교황사절 패트릭 번(Byrne, J. Patrick) 주교의 인식과 한국에서의 활동을 통해 설명한다. 본 연구는 ‘메리놀외방전교회본부’의 문서고가 소장한 패트릭 번 주교의 서간 모음집을 근거로 작성되었다. 분석 결과 교황청과 가톨릭 교회는 규범의 정치와 국제 가톨릭 네트워크를 동원하는 방법으로 반공주의 외교 활동을 벌였다. 구체적인 사례로 1947년 미군정시기 교황청의 한국 독립국가로 인정, 1948년 5·10 총선거 및 당해 11월 UN 제3차 총회에서 진행된 한국정부 수립 및 외교적 승인과 같은 사례에서 대한민국 초대 번 주교와 가톨릭 교회가 미친 영향력을 추적하여 분석한다. 이는 한국-교황청 관계사를 발굴하는 토대연구의 의미를 지니면서도, 세간에 잘 공개되지 않는 국제관계 내에서 교황청 외교활동의 편린을 살펴볼 수 있는 소재라는 점에서 연구의의를 지닌다. This paper, by exploring how the Republic of Korea government was established and recognized diplomatically after the two World Wars, analyzes the political activities of the Catholic Church centered on the Vatican’s anti-communism and its role in spreading democracy. Adopting an NGO politics perspective, this outlines the Church’s effort to oppose communism through the discernment and actions of bishop Patrick J. Byrne, the first Apostolic Nuncio for Korea, based on Byrne’s letters kept in the Catholic Foreign Mission Society of America(Maryknoll). The Vatican and the Catholic Church acted diplomatically to thwart communism by employing norm-driven politics and mobilizing international Catholic networks. This study traces how Byrne and the Catholic Church affected the Vatican’s approval of the independence of South Korean government in 1947 during the period of U.S. military government, on the May 10 1948 general election on the Korean peninsula, and on the diplomatic accession of the Korean government at the third General Assembly of the UN in 1948. This study contributes to the field in that it is not only foundational because it is focused on exploring the Korea-Vatican relationship but also because it includes an examination of the Vatican’s political activities, which have not been publicly disclosed.

Prognostic Impact of Circumferential Resection Margin in Rectal Cancer Treated with Preoperative Chemoradiotherapy

Hwang, Mi Ri,Park, Ji Won,Park, Sohee,Yoon, Hyekyoung,Kim, Dae Yong,Chang, Hee Jin,Kim, Sun Young,Park, Sung Chan,Choi, Hyo Seong,Oh, Jae Hwan,Jeong, Seung-Yong Springer - Society of Surgical Oncology 2014 Annals of Surgical Oncology Vol.21 No.4

Covalent bonding-assisted nanotransfer lithography for the fabrication of plasmonic nano-optical elements

Hwang, Soon Hyoung,Jeon, Sohee,Kim, Myung Ju,Choi, Dae-Geun,Choi, Jun-Hyuk,Jung, Joo-Yun,Kim, Kwang-Seop,Lee, Jihye,Jeong, Jun Ho,Youn, Jae Ryoun The Royal Society of Chemistry 2017 Nanoscale Vol.9 No.38

<P>Many high-resolution patterning techniques have been developed to realize nano- and microscale applications of electric devices, sensors, and transistors. However, conventional patterning methods based on photo or e-beam lithography are not employed to fabricate optical elements of high aspect ratio and a sub-100 nm scale due to the limit of resolution, high costs and low throughput. In this study, covalent bonding-assisted nanotransfer lithography (CBNL) was proposed to fabricate various structures of high resolution and high aspect ratio at low cost by a robust and fast chemical reaction. The proposed process is based on the formation of covalent bonds between silicon of adhesive layers on a substrate and oxygen of the deposited material on the polymer stamp. The covalent bond is strong enough to detach multiple layers from the stamp for a large area without defects. The obtained nanostructures can be used for direct application or as a hard mask for etching. Two nano-optical applications were demonstrated in this study,<I>i.e.</I>, a meta-surface and a wire-grid polarizer. A perfect absorption meta-surface was generated by transferring subwavelength hole arrays onto a substrate without any post-processing procedures. In addition, a wire-grid polarizer with high aspect ratio (1 : 3) and 50 nm line width was prepared by the nano-transfer of materials, which were used as a hard mask for etching. Therefore, CBNL provides a means of achieving large-area nano-optical elements with a simple roll-to-plate process at low cost.</P>

Plasmonic color filters fabricated via oxide-based nanotransfer printing

Hwang, Soon-Hyoung,Kim, Myung-Ju,Jeon, Sohee,Shin, Bosung,Jeong, Jun-Ho IOP 2018 Nanotechnology Vol.29 No.41

<P>Plasmonic filters have recently become a topic of significant interest because they are suitable for a wide range of applications. However, effective fabrication of plasmonic filters remains a challenge. In this paper, we demonstrate a simple method for fabricating plasmonic color filters based on nanotransfer printing (nTP) , using SiO<SUB>2</SUB> as a hard mask for Al etching. nTP was performed on a 100 nm Al layer deposited on a glass wafer substrate with a 10 nm Al layer and a 20 nm SiO<SUB>2</SUB> layer with a nanohole pattern. The 10 nm Al layer and 20 nm SiO<SUB>2</SUB> layers were previously transferred from a polymer stamp prepared to create patterns of subwavelength-sized holes. The plasmonic filters were ultimately fabricated using the SiO<SUB>2</SUB> layer as a hard mask to selectively etch the Al layer. The optical properties of the fabricated plasmonic filters were evaluated using experimental and simulation tools. In addition, we analyzed the results of nTP on the Al and SiO<SUB>2</SUB> films by varying the temperature, pressure, and SiO<SUB>2</SUB>-film thickness. We believe that this technique is a promising method for fabricating nanostructures and for widening the scope of practical application of plasmonics because of its high efficiency and cost-effectiveness.</P>

Quantification of cation-π interactions in like-charged polyelectrolytes inspired by mussels

Sohee Park,Young Mee Jung,Dong Soo Hwang 한국고분자학회 2016 한국고분자학회 학술대회 연구논문 초록집 Vol.41 No.2