Short-duration chemoprophylaxis might reduce incidence of deep vein thrombosis in Asian patients undergoing total knee arthroplasty

Zhang Siyuan,Htet Kway Swar,Tan Xin Yang,Wang Xinyu,Wang Wilson,Chua Weiliang 대한슬관절학회 2020 대한슬관절학회지 Vol.32 No.-

Venous thromboembolism (VTE) is a serious complication that may occur after total knee arthroplasty (TKA), leading to the recommendation of routine chemoprophylaxis by international guidelines. This study aims to determine if short-duration chemoprophylaxis after TKA reduces the incidence of VTE in an Asian population.A retrospective study of 316 patients who underwent unilateral primary TKA between 1 January 2011 and 31 December 2013 was conducted. All patients received mechanical prophylaxis. One hundred seventeen patients (37%) received additional chemoprophylaxis, whereas 199 patients (63%) did not. A Doppler ultrasound (DUS) of both lower limbs was conducted for all patients within 6 days after surgery (median = 3 days) to assess for both proximal and distal DVT. Chemoprophylaxis in the form of enoxaparin (low molecular weight heparin; LMWH), aspirin, or heparin was administered until patients had a normal DUS, for a median duration of 4 days. Patients were followed up clinically for a minimum of 6 months to monitor for delayed or recurrent VTE and at least 2 years for patient-reported outcome measures. Overall, 24 patients (7.59%) developed deep vein thrombosis (DVT): three proximal and 21 distal DVTs. Twenty-three of the 24 patients were asymptomatic. Twenty of 199 patients (10.05%) with only mechanical prophylaxis developed DVT, whereas four of 117 patients (3.42%) with additional chemoprophylaxis developed DVT. Multivariate analysis showed that chemoprophylaxis use was associated with reduced incidence of DVT (odds ratio = 0.19, p value = 0.011). Other factors associated with increased DVT incidence include female gender (odds ratio = 5.45, p value = 0.034), positive history of cancer (odds ratio = 5.14, p value = 0.044), and increased length of stay in hospital (odds ratio = 1.19, p value < 0.001). Our study has shown that despite the low incidence of DVT in Asian patients undergoing TKA, short-duration chemoprophylaxis might be effective in reducing the incidence of DVT. However, most DVTs observed in our study were distal and may be of limited clinical significance. Further studies are needed to investigate the impact of chemoprophylaxis use on the incidence of PE and overall mortality rates among Asian patients.

The construction of the Ni/La2O2CO3 nanorods catalysts with enhanced low-temperature CO2 methanation activities

Hui Yang,Xueying Wen,Siyuan Yin,Yixin Zhang,Cai-e Wu,Liang Xu,Jian Qiu,Xun Hu,Leilei Xu,Mindong Chen 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-

In this work, the La(OH)3 nanorods were successfully synthesized by precisely regulating the parametersof the hydrothermal method. Then, a series of Ni-based CO2 methanation catalysts were fabricated via theincipient-wetness impregnation and deposition–precipitation methods by employing the La(OH)3 nanorodsas the supports. The influences of the support morphology and the preparation method on the metalsupportinteraction, Ni dispersion, and the surface basicity were carefully investigated based on varioustechniques, such as XRD, SEM, H2-TPR, CO2-TPD, XPS, ect. It was found that the rod-shaped La(OH)3 supportedcatalyst prepared by the deposition–precipitation method performed the optimum activity andstability. The reason for this could be derived from the confinement effect of the crystal plane of therod-shaped support, which would promote the formation of the strong metal-support interaction andthe construction of the Ni-La interface with high activity. Furthermore, the online-tandem TG-MS andin-situ DRIFTS technologies were used to investigate the thermal decomposition performance of the catalystprecursors in the calcination process and the reaction intermediates of the CO2 methanation. Therefore, the fundamental roles of support morphology and catalyst preparation method were expectedto direct the advancement of the Ni-based nanostructured catalysts with outstanding low-temperatureperformances.

Particulate Matter 2.5 Causes Deficiency in Barrier Integrity in Human Nasal Epithelial Cells

Mu Xian,Siyuan Ma,Kuiji Wang,Hongfei Lou,Yang Wang,Luo Zhang,Chengshuo Wang,Cezmi A. Akdis 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.1

Purpose: The effect of air pollution-related particulate matter (PM) on epithelial barrier function and tight junction (TJ) expression in human nasal mucosa has not been studied to date. This study therefore aimed to assess the direct impact of PM with an aerodynamic diameter less than 2.5 μm (PM2.5) on the barrier function and TJ molecular expression of human nasal epithelial cells. Methods: Air-liquid interface cultures were established with epithelial cells derived from noninflammatory nasal mucosal tissue collected from patients undergoing paranasal sinus surgery. Confluent cultures were exposed to 50 or 100 μg/mL PM2.5 for up to 72 hours, and assessed for 1) epithelial barrier integrity as measured by transepithelial resistance (TER) and permeability of fluorescein isothiocyanate (FITC) 4 kDa; 2) expression of TJs using real-time quantitative polymerase chain reaction and immunofluorescence staining, and 3) proinflammatory cytokines by luminometric bead array or enzyme-linked immunosorbent assay. Results: Compared to control medium, 50 and/or 100 μg/mL PM2.5-treatment 1) significantly decreased TER and increased FITC permeability, which could not be restored by budesonide pretreatment; 2) significantly decreased the expression of claudin-1 messenger RNA, claudin-1, occludin and ZO-1 protein; and 3) significantly increased production of the cytokines interleukin-8, TIMP metallopeptidase inhibitor 1 and thymic stromal lymphopoietin. Conclusions: Exposure to PM2.5 may lead to loss of barrier function in human nasal epithelium through decreased expression of TJ proteins and increased release of proinflammatory cytokines. These results suggest an important mechanism of susceptibility to rhinitis and rhinosinusitis in highly PM2.5-polluted areas.

Real-time structural health monitoring system based on streaming data

Qilin Zhang,Siyuan Sun,Bin Yang,Roland Wüchner,Licheng Pan,Haitao Zhu 국제구조공학회 2021 Smart Structures and Systems, An International Jou Vol.28 No.2

In this paper, a novel real-time structural health monitoring (SHM) system based on streaming data is proposed. In contrast to a traditional SHM system, the proposed system implements a series of optimizations for data transmission and processing to reduce the latency and better satisfy the real-time requirement. The concept of the watermark in the streaming system is adopted to address the problem of when to trigger the time window calculation under the real-time requirement. Moreover, a well-designed parallel mechanism is used to satisfy the multistage computation requirement in the parallel data stream. A case study in which the proposed system is applied to the Shanghai Tower is presented. The peak picking method is used as an example in the test environment to track the latency of each main operation under different parallelism schemes. The results show that computing in parallel effectively reduces the latency and provides a reference for integrating the random decrement technique (RDT), stochastic subspace identification (SSI), or other more complex but effective algorithms in parallel into the system in the future. The total latency under the test environment from data generation to data transmission to the web server is approximately only 200-400 ms, which indicates the excellent real-time performance of the system.

How are heat waves over Yangtze River valley associated with atmospheric quasi-biweekly oscillation?

Gao, Miaoni,Yang, Jing,Wang, Bin,Zhou, Siyuan,Gong, Daoyi,Kim, Seong-Joong Springer-Verlag 2018 Climate dynamics Vol.51 No.11

The role of exosomal lncRNAs in cancer biology and clinical management

Zhang Wuwen,Wang Qinshi,Yang Yi,Zhou Siyuan,Zhang Ping,Feng Tongbao 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

Exosomes play a vital role in cell–cell communication within the cancer microenvironment. Exosomal long noncoding RNAs (lncRNAs) are important regulators in cancer development and are involved in multiple processes, including cancer cell proliferation, angiogenesis, metastasis, drug resistance, and immunomodulation. Changes in the levels of exosomal lncRNAs often appear with the occurrence and development of cancer. Therefore, exosomal lncRNAs can be used as biomarkers for cancer diagnosis and prognosis. Exosomal lncRNAs can also indicate the treatment response of patients receiving chemotherapy. Moreover, exosomal lncRNAs are potential therapeutic targets for cancer treatment. In this review, we summarize the role of exosomal lncRNAs in cancer biology as well as in clinical management. A more comprehensive and in-depth understanding of the role of exosomal lncRNAs in cancer may help us better understand the mechanism of cancer development and clinically manage cancer patients.

Wind engineering for high-rise buildings: A review

Haitao Zhu,Bin Yang,Qilin Zhang,Licheng Pan,Siyuan Sun 한국풍공학회 2021 Wind and Structures, An International Journal (WAS Vol.32 No.3

As high-rise buildings become more and more slender and flexible, the wind effect has become a major concern to modern buildings. At present, wind engineering for high-rise buildings mainly focuses on the following four issues: wind excitation and response, aerodynamic damping, aerodynamic modifications and proximity effect. Taking these four issues of concern in high-rise buildings as the mainline, this paper summarizes the development history and current research progress of wind engineering for high-rise buildings. Some critical previous work and remarks are listed at the end of each chapter. From the future perspective, the CFD is still the most promising technique for structural wind engineering. The wind load inversion and the introduction of machine learning are two research directions worth exploring.

Multiple Primary Cardiac Malignant Peripheral Nerve Sheath Tumors in the Left Atrium: Case Report

Junfei Li,Qiansu Chen,Shaomei Yu,Siyuan Yang 대한흉부외과학회 2021 Journal of Chest Surgery (J Chest Surg) Vol.54 No.5

Malignant peripheral nerve sheath tumors are rare sarcomas of the heart. Herein, we re- port the case of a 24-year-old man who complained of dyspnea, cough, and upper left back pain. He was found to have multiple primary heart tumors obstructing the right su- perior pulmonary vein in the left atrium, which were diagnosed as malignant peripheral nerve sheath tumors. The patient underwent successful resection of the tumors and im- munohistochemistry was utilized for diagnosis.

Comparative Study on Inclusions in Mg-Nd-Zn-Zr Melt Employing Flux and Fluxless Purification Approach

Hanxue Cao,Hao Jiang,Yanyan Huang,Chengzhi Yang,Siyuan Long 한국정밀공학회 2017 International Journal of Precision Engineering and Vol.18 No.11

Two purification approaches, flux approach (flux shielding and flux refining) and fluxless approach (protective atmospheres and inert gas bubbling), are implemented to remove the inclusions in Mg-Nd-Zn-Zr melt. The purification effects are assessed by studying structural properties, chemical composition and the origin of the inclusions. The amount and the average size of the inclusions raise at first, then decrease during flux (or fluxless) refining process, which include 15 min flux refining (or gas bubbling) and 10 min settling. Both approaches have the effect to protect Mg melt and separate inclusions from the melt, but fluxless approach is not as effective as flux approach in the control of inclusions. Either way, oxides and carbides can be found in magnesium (Mg) melt, and the former are the most predominant non-metallic inclusions. Undissolved zirconium (Zr) particles are observed over the process of both techniques, which is a characteristic of Zr alloying Mg alloys, and these particles are easy to settle due to high density. The emergence of chlorine (Cl) atoms in inclusions implies flux inclusions are formed during flux purification, while sulphur (S) is detected in fluxless purification indicates sulphides or sulphates occur in Mg melt as a result of the usage of fire extinguishing sulfur powder.

Effects of Continuous Straw Returning on Soil Functional Microorganisms and Microbial Communities

Guan Yunpeng,Wu Meikang,Che Songhao,Yuan Shuai,Yang Xue,Li Siyuan,Tian Ping,Wu Lei,Yang Meiying,Wu Zhihai 한국미생물학회 2023 The journal of microbiology Vol.61 No.1

This study examined the changes in soil enzymatic activity, microbial carbon source metabolic diversity, and straw decomposition rates in paddy fields treated with 1, 2, or 3 years of straw returning (SR1–SR3). The soil’s ability to decompose straw and cellulolytic bacteria increased with the number of treatment years (1: 31.9% vs. 2: 43.9% vs. 3: 51.9%, P < 0.05). The numbers of Azotobacter, Nitrobacteria, cellulolytic bacteria, and inorganic phosphate bacteria increased progressively with the numbers of straw returning years. Cellulolytic bacteria and inorganic phosphate bacteria were significantly positively correlated with the decomposition rate (r = 0.783 and r = 0.375, P < 0.05). Based on 16S sequencing results, straw returning improved the microbial diversity of paddy soils by increasing unclassified bacteria and keeping dominant soil microorganism populations unchanged. The relative importance of individual microbial taxa was compared using random forest models. Proteobacteria, ammoniating bacteria, and potassium dissolving bacteria contributed to peroxidase activity. The significant contributors to phosphate monoesterase were Acidobacteriota, Desulfobacterota, ammoniating bacteria, cellulolytic bacteria, and potassium-dissolving bacteria. Proteobacteria, ammoniating bacteria, cellulolytic bacteria, and potassium-dissolving bacteria contributed to urease activity. Desulfobacterota, ammoniating bacteria, cellulolytic bacteria, and potassium-dissolving bacteria contributed to the neutral invertase activity. In conclusion, soil microbial community structure and function were affected within 2 years of straw returning, which was driven by the combined effects of soil organic carbon, available nitrogen, available potassium, and pH. With elapsing straw returning years, soil properties interacted with soil microbial communities, and a healthier soil micro-ecological environment would form.