Association of Six Susceptibility Loci with Prostate Cancer in Northern Chinese Men

Zhang, Yu-Rong,Xu, Yong,Yang, Kuo,Liu, Ming,Wei, Dong,Zhang, Yao-Guang,Shi, Xiao-Hong,Wang, Jian-Ye,Yang, Fan,Wang, Xin,Liang, Si-Ying,Zhao, Cheng-Xiao,Wang, Fei,Chen, Xin,Sun, Liang,Zhu, Xiao-Quan,Zh Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Background/Aim: Six prostate cancer (PCa) susceptibility loci were identified in a genome-wide association study (GWAS) in populations of European decent. However, the associations of these 6 single-nucleotide polymorphisms (SNPs) with PCa has remained tobe clarified in men in Northern China. This study aimed to explore the loci associated with PCa risk in a Northern Chinese population. Methods: Blood samples and clinical information of 289 PCa patients and 288 controls from Beijing and Tianjin were collected. All risk SNPs were genotyped using polymerase chain reaction (PCR)-high resolution melting curve technology and gene sequencing. Associations between PCa and clinical covariates (age at diagnosis, prostate-specific antigen [PSA], Gleason score, tumor stage, and level of aggressiveness) and frequencies of alleles and genotypes of these SNPs were analyzed using genetic statistics. Results: Among the candidate SNPs, 11p15 (rs7127900, A) was associated with PCa risk (P = 0.02, odds ratio [OR] = 1.64, 95% confidence interval [CI] = 1.09-2.46). Genotypes showed differences between cases and controls on 11p15 (rs7127900, A), 11q13 (rs7931342, T), and HNF1B (rs4430796, A) (P = 0.03, P = 0.01, and P = 0.04, respectively). The genotype TG on 11q13 (rs7931342, T) was positively associated with an increased Gleason score (P = 0.04, OR = 2.15, 95% CI = 1.02-4.55). Patients carrying TG on 17q24 (rs1859962, G) were negatively associated with an increased body mass index (BMI) (P = 0.03, OR = 0.44, 95% CI = 0.21-0.92) while those with AG on HNF1B (rs4430796, A) were more likely to have PSA increase (P = 0.002). Conclusion: Our study suggests that 11p15 (rs7127900, A) could be a susceptibility locus associated with PCa in Northern Chinese. Genotype TG on 11q13 (rs7931342, T) could be related to an increased Gleason score, AG on HNF1B (rs4430796, A) could be associated with PSA increase, and TG on 17q24 (rs1859962, G) could be negatively associated with an increased BMI in Chinese men with PCa.

Inheritance of Downy Mildew Resistance at Different Developmental Stages in Chinese Cabbage via the Leaf Disk Test

Shengju Zhang,Shuancang Yu,Fenglan Zhang,Longting Si,Yangjun Yu,Xiuyun Zhao,Deshuang Zhang,Weihong Wang 한국원예학회 2012 Horticulture, Environment, and Biotechnology Vol.53 No.5

Downy mildew, caused by Hyaloperonospora parasitica, is a destructive disease of the Chinese cabbage (Brassica rapa ssp. pekinensis). A rapid resistance/susceptibility test for H. parasitica was established by the inoculation of a leaf disk test. Four conditions were tested and the optimal condition was found when the inoculated leaf disk was placed into dark conditions at 16℃ for the first 24 hours after inoculation, followed by 5 days of light at 20℃and 23℃ for 4 hours and 5 hours, respectively, dark at 16℃ and 12℃ for 3 hours and 12 hours, respectively, and a final temperature of 16℃ for 24 hours. There was a good correlation between the resistance levels of leaf disks and the resistance of seedlings or adult plants, which indicated that testing leaf disks should be the preferred methods to predict the resistance of adult plants. Using this method, downy mildew resistance was investigated in a double haploid (DH) population at four developmental stages. The results showed that the genetic pattern, which was deduced from the DH segregation, was relatively similar, but varied slightly during plant development.

两周应国墓地玉器性别差异研究兼论丧葬玉器在社会权力运作中的作用

?思宇(ZHANG SI YU) 글로컬창의산업연구센터 2019 글로컬창의문화연구 Vol.8 No.2

There are obvious gender differences in the jade wares buried in Ying Guo"s tomb. On the whole, ceremonial jade is far more used in men"s tombs than in women"s tombs; women"s tombs use more clothing and decorations than men’s. This article analyzes the differences between the male and female grave owners of Ying Guo"s cemetery during the western and eastern Zhou period(B.C.11c-B.C.3c), combined with the cases of other female nobles in the Central Plains, and analyzes the status of women"s social power outside the ritual system represented by the tripod system. Explore the special role of funeral jade in the actual operation of social power. Unlike the bronze"s clear indication of political identity, the jadeware demonstrates that women are no less powerful than men in real life due to their dual attributes in status hierarchy and decorative items.

Prevalence, Risk Factors, and Psychological Effects of Overactive Bladder in Chinese University Students

Yu Liang,Guo Wei Si,Hui Jie Hu,Zhen Wei Zhang,Cui Ping Song,Qi Feng Dou,Jian Guo Wen 대한배뇨장애요실금학회 2022 International Neurourology Journal Vol.26 No.4

Purpose: The purpose of this study was to investigate the prevalence and risk factors of overactive bladder (OAB) in young adults and to explore the influence of OAB on mental health. Methods: Between October 2019 and January 2020, 14,010 anonymous questionnaires were distributed to freshmen at 2 universities in Henan, China. The students came from all over the country. The questionnaire included general items and information necessary to calculate the overactive bladder symptom score, the Chinese version of the Pittsburgh Sleep Quality Index (PSQI) score, Self-Esteem Scale (SES) score, and Self-Rating Depression Scale (SDS) score. The relationships between the prevalence of OAB and its risk factors were evaluated. Results: The overall prevalence of OAB was 6.0%, with 4.3% of participants characterized as having dry OAB and 1.7% as having wet OAB. The prevalence of mild OAB was 5.5%, and that of moderate OAB was 0.5%; no severe OAB was observed. Higher prevalence rates of OAB were found among women, respondents with constipation, and respondents with primary nocturnal enuresis (PNE) (P <0.05). Compared to healthy controls, the OAB group exhibited a higher mean SDS score (52.12±8.986 vs. 47.71±9.399, P<0.001) and mean PSQI score (5.28±2.486 vs. 4.27±2.431, P<0.001), but a lower mean SES score (27.78±3.599 vs. 29.57±4.109, P<0.001). Conclusions: OAB significantly affects the mental health of young adults. Female sex, constipation, and PNE are risk factors for OAB.

Study on Joint Simulation of Very Fast Transient Overvoltage and Transient Enclosure Voltage in 1000 kV GIS

Zhang Yan-Ze,Chen Xiao-Yue,Si Jun-Jie,He Ze-Yu,Wen Xi-Shan 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.5

Disconnector operation in GIS generates VFTO and TEV, which threaten device insulation and personnel safety. In order to calculate VFTO and TEV more accurately, this paper proposes a VFTO-TEV joint simulation model. Among them, dynamic arc model is used to reflect the dynamic characteristics of high frequency AC arc. In order to reflect the electromagnetic leakage phenomenon caused by the impedance mismatch of high-frequency electromagnetic waves, and the influence of the transient potential difference formed by the transient electromagnetic field on grounding grid on TEV, the geometric structures of high-voltage bushing, grounding pillars and grounding grid are modeled to obtain their respective frequency-dependent admittance matrices, which are converted into corresponding broadband equivalent circuit models by combining vector fitting method and impedance synthesis method. The above modeling method is applied to the 1000 kV GIS test circuit, and the simulation model is built in the ATP-EMTP electromagnetic transient program, and the joint simulation research of VFTO and TEV is carried out. The results show that at each measurement point of the test circuit, the amplitude error of the VFTO obtained by simulation and actual measurement is mostly less than 7%, and the frequency spectrum both contains the main frequency components of 18 MHz and 25 MHz; Compared with the traditional calculation model of obtaining VFTO/TEV using CIGRE model/Petersen's law, the amplitude of VFTO and TEV obtained by joint simulation model is lower and contains richer high-frequency components. In addition, the opening speed of 0.8 m/s also corresponds to the maximum point of the VFTO amplitude of the test circuit. Finally, based on the above modeling method, the effectiveness of adding ferrite beads to suppress VFTO is verified by simulation. © 2017 Elsevier Inc. All rights reserved.

Clinical Efficacy of Bevacizumab Concomitant with Pemetrexed in Patients with Advanced Non-small Cell Lung Cancer

Zhang, Yu-Mei,Li, Yong-Qiang,Liu, Zhi-Hui,Liao, Xiao-Li,Liang, Rong,Lin, Yan,Yuan, Chun-Ling,Liao, Si-Na,Liang, Chao-Yong,Li, Qian,Li, Le-Qun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

Objective: To observe the clinical efficacy of bevacizumab concomitant with pemetrexed in patients with advanced non-small cell lung cancer (NSCLC). Materials and Methods: A total of 72 patients were randomly divided into a combination group (pemetrexed+bevacizumab, n=36) and a pemetrexed group (n=36) and assessed for disease control (CR+PR+SD) after 4-cycles of first-line GP chemotherapy (gemcitabine+cisplatin). Clinical efficacy, progression-free survival time (PFS), overall survival time (OS), overall response rate (ORR), disease control rate (DCR) and rate of adverse responses between two groups were observed and compared. Results: ORR and DCR were 27.8% and 83.4% in combination group, and 16.7% and 69.5% in the pemetrexed group, respectively, but there were no significant differences (P>0.05). PFS in combination group and pemetrexed group were 4.6 months and 3.9 months respectively (P=0.09), whereas OS in the combination group was 14 months, evidently higher than in the pemetrexed group (11 months, P=0.004). Adverse responses in both groups included high blood pressure, bleeding, thrombocytopenia, anemia, elevated transaminase, diarrhea, vomiting and proteinuria, but there were no significant differences (P>0.05). Conclusions: Bevacizumab concomitant with pemetrexed has better clinical efficacy and safety, giving rise to prolonged survival time in patients with advanced NSCLC.

New Insights Into Refractory Chronic Cough and Unexplained Chronic Cough: A 6-Year Ambispective Cohort Study

Zhang Mengru,Morice Alyn H.,Si Fengli,Zhang Li,Chen Qiang,Wang Shengyuan,Zhu Yiqing,Xu Xianghuai,Yu Li,Qiu Zhongmin 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.6

Purpose: Only limited studies have depicted the unique features and management of refractory chronic cough (RCC) and unexplained chronic cough (UCC). These led to the initiation of this study, which reported the demographic characteristics, manifestations, and long-term outcomes on a large series of consecutive RCC/UCC patients, providing a guideline-led real-world clinical experience. Methods: Retrospective baseline information was obtained from Clinical Research Database (January 2016 to May 2021). At least 6 months after the last clinic visit, included subjects were prospectively followed up. Results: Three hundred and sixty-nine RCC and UCC patients (199 females, 53.9%) were analyzed. The median cough duration was 24.0 (12.0–72.0) months. Laryngeal symptoms were reported in 95.9% of the patients. The common triggers for coughing were talking (74.9%), pungent odors (47.3%), eating (45.5%), and cold air (42.8%). RCC was considered in 38.2%, and the remainder of 228 patients had UCC, with an equal sex distribution (P = 0.66). Among the 141 RCCs, 90.8% (128) had refractory reflux cough, which was more responsive to current treatments (P < 0.01). Although most features and test results between RCC and UCC were similar, UCC was more commonly inappropriately treated (P < 0.01). Nineteen (7.7–41.1) months after the final clinic visit, 31.2% still coughed persistently, while 68.8% reported cough improvement or remission. RCC reported more favorable treatment outcomes (including cough improvement, control, and spontaneous remission) than UCC (P < 0.01). Coughs with long duration before the initial cough clinic visit (P < 0.01), frequent urinary incontinence (P < 0.01), and being sensitive to “talking” (P < 0.01) or “cold air” (P < 0.01) were less likely to be solved. Conclusions: The current treatments only improve cough symptoms in two-thirds of patients. Clinical indicators for treatment failure were those coughing for long duration and being sensitive to “talking” or “cold air.”

Synthesis, structure and tribological performance of tungsten disulphide nanocomposites

Si, Ping-Zhan,Choi, Chul-Jin,Lee, Jae-Wook,Geng, Dian-Yu,Zhang, Zhi-Dong Elsevier Sequoia 2007 Materials science & engineering Structural materia Vol.443 No.1-2

<P><B>Abstract</B></P><P>Tungsten disulphide nanocomposites were prepared in large scale by employing the direct reaction between tungsten nanoparticles and sulphur powders. The nanocomposites include a variety of shapes such as isolated WS<SUB>2</SUB> multi-layered sheets, WS<SUB>2</SUB>-coated WO<SUB>3</SUB> nanoparticles, and enclosed fullerene-like WS<SUB>2</SUB> structures. Pin-on-disc wear tests indicate that the addition of a small amount (5wt%) of these nanoparticles to paraffin decreases significantly the wear loss of the pin. Additives of these WS<SUB>2</SUB>/WO<SUB>3</SUB> nanoparticles possess much better tribological performance than micrometer-sized WS<SUB>2</SUB> powders additives do. The surface topography of wear scar of the pins after wear tests with different additives and different loads were studied by scanning electron microscopy. Small (severe) damage of the pin surface was observed for WS<SUB>2</SUB>/WO<SUB>3</SUB> nanoparticles (WS<SUB>2</SUB> micropowders) additives.</P>

Preparation of nano-sized Mg-doped copper silicate materials using coal gangue as the raw material and its characterization for CO2 adsorption

Yu Wu,Zhaojun Wu,Kai Liu,Fu Li,Yujie Pang,Jianbin Zhang,Huayan Si 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.10

This work presents a simple method for the preparation of the Mg-doped nanocomposite copper silicates (Mgx-Cu1x-SiO3) (x=0.25, 0.5, 0.75 and 0.9) using coal gangue waste as the silicon source for CO2 capture at low temperature. The as-prepared Mgx-Cu1x-SiO3 was systemically characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and Brunauer-Emmett-Teller surface area analysis (BET). The results suggest that all Mgx-Cu1x-SiO3 possess large surface areas, micropores and mesoporous structures composed of the agglomerates of small nanoparticles. They exhibit high CO2 adsorption capacity at 298.15 K under 1 bar, and that of Mg0.9-Cu0.1-SiO3 was the highest with the value of 16.73 cm3/g. The Freundlich isotherm model fits the CO2 adsorption isotherm well. Thermodynamic analysis indicates that the CO2 adsorption on Mg0.9-Cu0.1-SiO3 is exothermic (Ho<0), chaotic (So<0), and spontaneous (Go<0). This work highlights the low-temperature adsorption behavior of silicate materials on CO2, which can provide some research basis for the utilization of silica in coal gangue.

Experimental behavior of circular flyash-concrete-filled steel tubular stub columns

Si-Ping Li,Yang Zhang,Guang-Yuan Fu,Chen-Jiang Yu,Bing Chen,She-Xu Zhao 국제구조공학회 2016 Steel and Composite Structures, An International J Vol.22 No.4

The paper presents an experimental study of the structural behavior of circular flyash-concrete-filled steel tubular stub columns under axial compressive loads. In this study, 90% and 100% by weight of the cement in the concrete core was replaced with flyash. Twenty-seven specimens were tested to study the influence of flyash content, wall thickness of the steel tube, and curing age on the ultimate capacity and confinement effect. The experimental results were compared with the design values calculated using AISC-LRFD (1999), ACI (1999), AIJ (1997) and Eurocode 4 (1994). From the experimental study, it was determined that the confinement effect of circular steel tubes filled with high content flyash concrete was better than that of specimens filled with ordinary Portland cement concrete. The 5.88-mm-thick steel tube filled with 100% flyash concrete was equivalent in strength to a steel tube filled with C30 concrete at 28 days.