The role of miRNA‑155 in monocrotaline‑induced pulmonary arterial hypertension through c‑Fos/NLRP3/caspase‑1

Shou‑Dong Chai,Zhen‑Kun Li,Rui Liu,Tao Liu,Ming‑Feng Dong,Pei‑Zhe Tang,Jian‑Tang Wang,Sheng‑Jun Ma 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3

Background Nisoldipine can effectively suppress pulmonary arterial smooth muscle cell proliferation and c-Fos expression. Objective To identify the mechanism of the anti-inflammatory effects in monocrotaline-induced pulmonary arterial hypertension (PAH), focusing on the c-Fos/NLRP3/caspase-1 pathway. Results In a mice model of monocrotaline-induced PAH, miRNA-155 expression was increased. In an in vitro model, overexpression of miRNA-155 promoted inflammation and induced c-Fos, NLRP3, and caspase-1 protein expression. The inhibition of c-Fos reduced the effects of miRNA-155 on inflammation in an in vitro model of monocrotaline-induced PAH. The inhibition of NLRP3 reduced the effects of miRNA-155 on inflammation in an in vitro model of monocrotaline-induced PAH. Conclusions miRNA-155 increased inflammation in monocrotaline-induced PAH through c-Fos/NLRP3/caspase-1.

PacCAF: a Grid Portal in Pacific Asia for the CDF Experiment

S. Hou,T. L. Hsieh,P. K. Teng 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.5

We present the PacCAF (Pacific CDF Analysis Farm) computing model for the CDF (Collider Detector at Fermilab) experiment. The PacCAF is a portal for job submission to a pool of computing nodes collected from the LCG (LHC Computing Grid) and the OSG (Open Science Grid) sites in the Pacific Asia region. It has a suit of services for user authentication, software distribution, and network connection to worker nodes. It also provides a web-based online monitoring system for the status of batch jobs and the processes running on worker nodes. The PacCAF architecture is modular and is easy to modify. We discuss the upgrade from being a dedicated local cluster to joining shared resources in a Grid computing environment. We present the PacCAF (Pacific CDF Analysis Farm) computing model for the CDF (Collider Detector at Fermilab) experiment. The PacCAF is a portal for job submission to a pool of computing nodes collected from the LCG (LHC Computing Grid) and the OSG (Open Science Grid) sites in the Pacific Asia region. It has a suit of services for user authentication, software distribution, and network connection to worker nodes. It also provides a web-based online monitoring system for the status of batch jobs and the processes running on worker nodes. The PacCAF architecture is modular and is easy to modify. We discuss the upgrade from being a dedicated local cluster to joining shared resources in a Grid computing environment.

論中國傳統企業效率問題

康 埈 荣,张守鑫 韓國外國語大學校 外國學綜合硏究센터 中國硏究所 2005 中國硏究 Vol.35 No.-

1997~2000년에 발생된 황사에 관한 연구

정용승,김학성,낫짜가도르지 엘,적데어 디,첸 수잰 한국교원대학교 환경과학연구소 2002 환경연구논문집 Vol.- No.7

Joint monitoring of yellow sand (YS) phenomena occurred from 1997 to 2000 was carried out. It was found that the YS in source regions occurred in any time during the year, while the severe dust storms occurred frequently from March to May after the spring thaw. Wind erosion occurred usually with wind greater than about 8 ms^-1 in the source region in any seasons. However, severe YS phenomenon found to occur with wind greater than 15 ms^-1 at least for 3 hours or more. In source regions, YS occurred over 60∼120 days per year. In Korea, YS was found to occur 8∼12 cases per year with 12-22 YS days. It was recorded that maximum concentrations of TSP were 989∼1396 ㎍ m^-3 with PM10 values of 861∼996 ㎍ m^-3 and with the lowest visibility of 1.4∼1.6km. In Mongolia, however, it was observed that the number of dusty days decreased due to the increase in rainy days.

Comparative Analysis of Logistic Regression, Support Vector Machine and Artificial Neural Network for the Differential Diagnosis of Benign and Malignant Solid Breast Tumors by the Use of Three-Dimensional Power Doppler Imaging

Shou-Tung Chen,Yi-Hsuan Hsiao,Yu-Len Huang,Shou-Jen Kuo,Hsin-Shun Tseng,Hwa-Koon Wu,Dar-Ren Chen 대한영상의학회 2009 Korean Journal of Radiology Vol.10 No.5

Objective: Logistic regression analysis (LRA), Support Vector Machine (SVM) and a neural network (NN) are commonly used statistical models in computeraided diagnostic (CAD) systems for breast ultrasonography (US). The aim of this study was to clarify the diagnostic ability of the use of these statistical models for future applications of CAD systems, such as three-dimensional (3D) power Doppler imaging, vascularity evaluation and the differentiation of a solid mass. Materials and Methods: A database that contained 3D power Doppler imaging pairs of non-harmonic and tissue harmonic images for 97 benign and 86 malignant solid tumors was utilized. The virtual organ computer-aided analysis-imaging program was used to analyze the stored volumes of the 183 solid breast tumors. LRA, an SVM and NN were employed in comparative analyses for the characterization of benign and malignant solid breast masses from the database. Results: The values of area under receiver operating characteristic (ROC) curve, referred to as Az values for the use of non-harmonic 3D power Doppler US with LRA, SVM and NN were 0.9341, 0.9185 and 0.9086, respectively. The Az values for the use of harmonic 3D power Doppler US with LRA, SVM and NN were 0.9286, 0.8979 and 0.9009, respectively. The Az values of six ROC curves for the use of LRA, SVM and NN for non-harmonic or harmonic 3D power Doppler imaging were similar. Conclusion: The diagnostic performances of these three models (LRA, SVM and NN) are not different as demonstrated by ROC curve analysis. Depending on user emphasis for the use of ROC curve findings, the use of LRA appears to provide better sensitivity as compared to the other statistical models. Objective: Logistic regression analysis (LRA), Support Vector Machine (SVM) and a neural network (NN) are commonly used statistical models in computeraided diagnostic (CAD) systems for breast ultrasonography (US). The aim of this study was to clarify the diagnostic ability of the use of these statistical models for future applications of CAD systems, such as three-dimensional (3D) power Doppler imaging, vascularity evaluation and the differentiation of a solid mass. Materials and Methods: A database that contained 3D power Doppler imaging pairs of non-harmonic and tissue harmonic images for 97 benign and 86 malignant solid tumors was utilized. The virtual organ computer-aided analysis-imaging program was used to analyze the stored volumes of the 183 solid breast tumors. LRA, an SVM and NN were employed in comparative analyses for the characterization of benign and malignant solid breast masses from the database. Results: The values of area under receiver operating characteristic (ROC) curve, referred to as Az values for the use of non-harmonic 3D power Doppler US with LRA, SVM and NN were 0.9341, 0.9185 and 0.9086, respectively. The Az values for the use of harmonic 3D power Doppler US with LRA, SVM and NN were 0.9286, 0.8979 and 0.9009, respectively. The Az values of six ROC curves for the use of LRA, SVM and NN for non-harmonic or harmonic 3D power Doppler imaging were similar. Conclusion: The diagnostic performances of these three models (LRA, SVM and NN) are not different as demonstrated by ROC curve analysis. Depending on user emphasis for the use of ROC curve findings, the use of LRA appears to provide better sensitivity as compared to the other statistical models.

Inhibition of L-DOPA-Induced Increase in Dopamine Content by (1R,9S)-β-Hydrastine Hydrochloride in PC12 Cells

Shou Yu Yin,Jae Joon Lee,Yu Mi Kim,Chun Mei Jin,Yoo Jung Yang,Min Hee Kang,Myung Koo Lee 한국생약학회 2004 Natural Product Sciences Vol.10 No.3

The effects of BHSH on L-DOPA-induced increase in dopamine content in PC12 cells were investigated. L-DOPA treatment at 20 or 50 mM increased dopamine content after both 24 and 48 h of incubation in PC12 cells. However, the co-treatments of BHSH (10-50 mM) with L-DOPA (20 or 50 mM) significantly inhibited the increase of dopamine content induced by L-DOPA. BHSH treatment at 10-50 mM significantly inhibited basal aromatic L-amino acid decarboxylase (AADC) activity in a concentration-dependent manner at 15 min, and then AADC activity was rapidly recovered to the control level at about 2 h. These results indicate that the inhibition of AADC activity by BHSH was, in part, contributed to the early-stage decrease of dopamine content induced by LDOPA in PC12 cells. Taken together, it is proposed that the short-term inhibition of dopamine biosynthesis by BHSH was mediated by the regulation of tyrosine hydroxylace (TH).

Some Global Convergence Properties of the Levenberg-Marquardt Methods with Line Search

Shou-qiang Du 한국전산응용수학회 2013 Journal of applied mathematics & informatics Vol.31 No.3

In this paper, we consider two kinds of the Levenberg-Marquardt method for solve a system of nonlinear equations. We use line search on every iteration to guarantee that the Levenberg-Marquardt methods are globally convergent. Under mild conditions, we prove that while the descent condition can be satisfied at the iteration of the Levenberg-Marquardt method, the global convergence of the method can be established.

Effects of (1R,9S)-ß-Hydrastine Hydrochloride on Cytotoxicity in PC12 Cells

Shou Yo Yin, Jae Joon Lee, Yu Mi Kim, Chun Mei Jin, Yoo Jung Yang, Myung Koo Lee 충북대학교 약품자원개발연구소 2005 약학논문집 Vol.20 No.-

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Physics Parameters and Design Study for the Beijing Spallation Neutron Source

Shou-Xian Fang,C. Zhang,J. Wei,J.Y. Tang,Q. Qin,S. Wang,S.N. Fu 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.4

The Beijing Spallation Neutron Source (BSNS) will be the next large science facility in China. Based on an 80 MeV linac and a 1.6 GeV rapid cycling synchrotron, the BSNS has a goal to obtain a proton beam power of 100 kW with a repetition rate of 25 Hz in the first phase. An introduction to the conceptual design of the BSNS is given, and the main parameters and key technical features are summarized. The R&D plan is discussed.뒩b

Social Worker Manpower, Community Economic Disadvantage, and Family Violence: Initial Evidence fromTaiwan

Shou-Lu Lee 한국사회복지학회 2014 Asian Social Work and Policy Review Vol.8 No.3

This study is the first to explore the effect of social worker manpower on family violence incidents. In addition, it is the first study to investigate the geography of family violence in Taiwan. Using data from the County-Level Important Indicator Query System, this study performs panel regressions to analyze the determinants of county-level family violence incidents between 2005 and 2011. The empirical results clearly indicate that family violence incidents tend to be higher in counties that suffer economic disadvantage and in which there is an inadequate deployment of social worker manpower. The findings have important implications for combating family violence.