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Kwon, Y,Lee, J K,Sung, J K,Lee, J H,Kim, S J,Shin, Y S,Park, K American Scientific Publishers 2009 Journal of Nanoscience and Nanotechnology Vol.9 No.7
<P>The post-heat treated (Y(1-x-y)Gd(x)Eu(y))BO3 (0 < or = x < or = 0.36, 0.06 < or = y < or = 0.13) powders crystallized in a solution of (Y(1-x-y)Gd(x)Eu(y))BO3 with the hexagonal vaterite crystal structure, irrespective of composition. The lattice parameter of the (Y(0.9-x)Gd(x)Eu(0.1))BO3 (0 < or = x < or = 0.36) powders slightly increased with an increase in Gd content. The average powder sizes were sub-micron order and the powders showed relatively uniform size distribution and smooth surface. We obtained improved powder morphologies by adding organic additives such as ethylene glycol and citric acid. For the post-treated (Y(0.9-x)Gd(x)Eu(0.1))BO3, the emission intensity became stronger with increasing Gd content up to x = 0.27. In addition, for the post-treated (Y(0.73-y)Gd(0.27)Eu(y))BO3, the emission intensity gradually increased with Eu content up to y = 0.13. In particular, the emission intensity of the (Y(0.6)Gd)0.27)Eu(0.13))BO3 powders synthesized was higher than that of the commercial (Y,Gd)BO3:Eu3+ product.</P>
Shin, Hong Kyung,Kim, Jeong Hoon,Lee, Do Heui,Cho, Young Hyun,Kwon, Do Hoon,Roh, Sung Woo The Korean Neurosurgical Society 2016 Journal of Korean neurosurgical society Vol.59 No.4
Objective : Brain metastases in gynecologic cancer (ovarian, endometrial, and cervical cancer) patients are rare, and the efficacy of Gamma Knife Radiosurgery (GKRS) to treat these had not been evaluated. We assessed the efficacy of GKRS and prognostic factors for tumor control and survival in brain metastasis from gynecologic cancers. Methods : This retrospective study was approved by the institutional review board. From May 1995 to October 2012, 26 women (mean age 51.3 years, range 27-70 years) with metastatic brain tumors from gynecologic cancer were treated with GKRS. We reviewed their outcomes, radiological responses, and clinical status. Results : In total 24 patients (59 lesions) were available for follow-up imaging. The median follow-up time was 9 months. The mean treated tumor volume at the time of GKRS was $8185mm^3$ (range $10-19500mm^3$), and the median dose delivered to the tumor margin was 25 Gy (range, 10-30 Gy). A local tumor control rate was 89.8% (53 of 59 tumors). The median overall survival was 9.5 months after GKRS (range, 1-102 months). Age-associated multivariate analysis indicated that the Karnofsky performance status (KPS), the recursive partitioning analysis (RPA) classification, and the number of treated lesions were significant prognostic factors for overall survival (HR=0.162, p=0.008, HR=0.107, p=0.038, and HR=2.897, p=0.045, respectively). Conclusion : GKRS is safe and effective for the management of brain metastasis from gynecologic cancers. The clinical status of the patient is important in determining the overall survival time.
Shin, Sung Eun,Li, Hongliang,Kim, Han Sol,Kim, Hye Won,Seo, Mi Seon,Ha, Kwon-Soo,Han, Eun-Taek,Hong, Seok-Ho,Firth, Amy L.,Choi, Il-Whan,Bae, Young Min,Park, Won Sun The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.2
We demonstrated the effect of nortriptyline, a tricyclic antidepressant drug and serotonin reuptake inhibitor, on voltage-dependent $K^+$ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique. Nortriptyline inhibited Kv currents in a concentration-dependent manner, with an apparent $IC_{50}$ value of $2.86{\pm}0.52{\mu}M$ and a Hill coefficient of $0.77{\pm}0.1$. Although application of nortriptyline did not change the activation curve, nortriptyline shifted the inactivation current toward a more negative potential. Application of train pulses (1 or 2 Hz) did not change the nortriptyline-induced Kv channel inhibition, suggesting that the effects of nortiprtyline were not use-dependent. Preincubation with the Kv1.5 and Kv2.1/2.2 inhibitors, DPO-1 and guangxitoxin did not affect nortriptyline inhibition of Kv channels. From these results, we concluded that nortriptyline inhibited Kv channels in a concentration-dependent and state-independent manner independently of serotonin reuptake.
Sang-Chul Na,Min Chul Chun,Gyuyeon Jang,Hyejin Shin,Young-Sun Kwon,Bo Soo Kang,Keundong Lee,Chansoo Yoon,박배호 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.68 No.12
The set process in a unipolar resistance switching Pt/NiO/Pt thin film was conducted in two different ways: the current-biased set process (current sweep mode) and the voltage-biased set process (voltage sweep mode). In the current-biased set process, a compliance current setting was not necessary for continuing stable resistance switching. The resistance of the low resistance state, the reset and the set switching parameters were compared in both modes of the set processes. The distributions of the set parameters were found to be effectively reduced in the current-biased set process. These intriguing properties can be attributed to the prevention of an overshoot current during the set transition.
A 16-Year Single Center Experience of Resected 2029 Pancreatic Ductal Adenocarcinoma
Sang Hyun Shin,Song Cheol Kim,Dae Wook Hwang,Ki Byung Song,Jae Hoon Lee,Bong Jun Kwak,Seong-Ryong Kim,Jaewoo Kwon,Chung Hyeun Ma,Seunghyun Hwang,Kwang-Min Park,Young-Joo Lee 대한외과학회 2016 대한외과학회 학술대회 초록집 Vol.2016 No.11
Kwon, Shin Won,Kim, Chi Heon,Chung, Chun Kee,Park, Tae Hyun,Woo, Su Heon,Lee, Sung-Jae,Yang, Seung Heon The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.6
Objective : In addition to bone bridging inside a cage or graft (intragraft bone bridging, InGBB), extragraft bone bridging (ExGBB) is commonly observed after anterior cervical discectomy and fusion (ACDF) with a stand-alone cage. However, solid bony fusion without the formation of ExGBB might be a desirable condition. We hypothesized that an insufficient contact area for InGBB might be a causative factor for ExGBB. The objective was to determine the minimal area of InGBB by finite element analysis. Methods : A validated 3-dimensional, nonlinear ligamentous cervical segment (C3-7) finite element model was used. This study simulated a single-level ACDF at C5-6 with a cylindroid interbody graft. The variables were the properties of the incorporated interbody graft (cancellous bone [Young's modulus of 100 or 300 MPa] to cortical bone [10000 MPa]) and the contact area between the vertebra and interbody graft (Graft-area, from 10 to $200mm^2$). Interspinous motion between the flexion and extension models of less than 2 mm was considered solid fusion. Results : The minimal Graft-areas for solid fusion were $190mm^2$, $140mm^2$, and $100mm^2$ with graft properties of 100, 300, and 10000 MPa, respectively. The minimal Graft-areas were generally unobtainable with only the formation of InGBB after the use of a commercial stand-alone cage. Conclusion : ExGBB may be formed to compensate for insufficient InGBB. Although various factors may be involved, solid fusion with less formation of ExGBB may be achieved with refinements in biomaterials, such as the use of osteoinductive cage materials; changes in cage design, such as increasing the area of polyetheretherketone or the inside cage area for bone grafts; or surgical techniques, such as the use of plate/screw systems.
Surgical correction of septal deviation after Le Fort I osteotomy
Shin, Young-Min,Lee, Sung-Tak,Kwon, Tae-Geon Korean Association of Maxillofacial Plastic and Re 2016 Maxillofacial Plastic Reconstructive Surgery Vol.38 No.-
Background: The Le Fort I osteotomy is one of the most widely used and useful procedure to correct the dentofacial deformities of the midface. The changes of the maxilla position affect to overlying soft tissue including the nasal structure. Postoperative nasal septum deviation is a rare and unpredicted outcome after the surgery. There are only a few reports reporting the management of this complication. Case Presentation: In our department, three cases of the postoperative nasal septum deviation after the Le Fort I osteotomy had been experienced. Via limited intraoral circumvestibular incision, anterior maxilla, the nasal floor, and the anterior aspect of the septum were exposed. The cartilaginous part of the nasal septum was resected and repositioned to the midline and the anterior nasal spine was recontoured. Alar cinch suture performed again to prevent the sides of nostrils from flaring outwards. After the procedure, nasal septum deviation was corrected and the esthetic outcomes were favorable. Conclusion: Careful extubation, intraoperative management of nasal septum, and meticulous examination of preexisting nasal septum deviation is important to avoid postoperative nasal septum deviation. If it existed after the maxillary osteotomy, septum repositioning technique of the current report can successfully correct the postoperative septal deviation.
Shin Jung Kim,Jin Young Shin,Sung Kwon Ko 고려인삼학회 2016 Journal of Ginseng Research Vol.40 No.1
This study compared the contents of prosapogenin depending on the extracting conditions of Red ginseng to provide basic information for developing Red ginseng-based functional foods. The content of ginsenoside Rg3 reached their maximum value at 24 h of extraction, followed by 36 h and 72 h of extraction at 100℃.