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Anti-inflammatory activity of AP-SF, a ginsenoside-enriched fraction, from Korean ginseng
Kwang-Soo Baek,Yong Deog Hong,Yong Kim,Nak Yoon Sung,Sungjae Yang,Kyoung Min Lee,Joo Yong Park,Jun Seong Park,Ho Sik Rho,Song Seok Shin,조재열 고려인삼학회 2015 Journal of Ginseng Research Vol.39 No.2
Background: Korean ginseng is an ethnopharmacologically valuable herbal plant with various biologicalproperties including anticancer, antiatherosclerosis, antidiabetic, and anti-inflammatory activities. Sincethere is currently no drug or therapeutic remedy derived from Korean ginseng, we developed a ginsenoside-enriched fraction (AP-SF) for prevention of various inflammatory symptoms. Methods: The anti-inflammatory efficacy of AP-SF was tested under in vitro inflammatory conditionsincluding nitric oxide (NO) production and inflammatory gene expression. The molecular events of inflammatoryresponses were explored by immunoblot analysis. Results: AP-SF led to a significant suppression of NO production compared with a conventional Koreanginseng saponin fraction, induced by both lipopolysaccharide and zymosan A. Interestingly, AP-SFstrongly downregulated the mRNA levels of genes for inducible NO synthase, tumor necrosis factor-a,and cyclooxygenase) without affecting cell viability. In agreement with these observations, AP-SF blockedthe nuclear translocation of c-Jun at 2 h and also reduced phosphorylation of p38, c-Jun N-terminalkinase, and TAK-1, all of which are important for c-Jun translocation. Conclusion: Our results suggest that AP-SF inhibits activation of c-Jun-dependent inflammatory events. Thus, AP-SF may be useful as a novel anti-inflammatory remedy.
Anti-inflammatory activity of AP-SF, a ginsenoside-enriched fraction, from Korean ginseng
Baek, Kwang-Soo,Hong, Yong Deog,Kim, Yong,Sung, Nak Yoon,Yang, Sungjae,Lee, Kyoung Min,Park, Joo Yong,Park, Jun Seong,Rho, Ho Sik,Shin, Song Seok,Cho, Jae Youl The Korean Society of Ginseng 2015 Journal of Ginseng Research Vol.39 No.2
Background: Korean ginseng is an ethnopharmacologically valuable herbal plant with various biological properties including anticancer, antiatherosclerosis, antidiabetic, and anti-inflammatory activities. Since there is currently no drug or therapeutic remedy derived from Korean ginseng, we developed a ginsenoside-enriched fraction (AP-SF) for prevention of various inflammatory symptoms. Methods: The anti-inflammatory efficacy of AP-SF was tested under in vitro inflammatory conditions including nitric oxide (NO) production and inflammatory gene expression. The molecular events of inflammatory responses were explored by immunoblot analysis. Results: AP-SF led to a significant suppression of NO production compared with a conventional Korean ginseng saponin fraction, induced by both lipopolysaccharide and zymosan A. Interestingly, AP-SF strongly downregulated the mRNA levels of genes for inducible NO synthase, tumor necrosis factor-${\alpha}$, and cyclooxygenase) without affecting cell viability. In agreement with these observations, AP-SF blocked the nuclear translocation of c-Jun at 2 h and also reduced phosphorylation of p38, c-Jun N-terminal kinase, and TAK-1, all of which are important for c-Jun translocation. Conclusion: Our results suggest that AP-SF inhibits activation of c-Jun-dependent inflammatory events. Thus, AP-SF may be useful as a novel anti-inflammatory remedy.
Repeated dose 90-day oral toxicity of 20nm, positive charged Zinc Oxide Nanoparticles in SD rats
Nak-Won Seong,Eun-Ho Maeng,Su-Hyun Kim,Jin-Hee Lee,Sung-Sup Shin,Jun-Ho Kim,Taek-Jin Lee,Seon-Ju Kim,Hak-Su Park,Sang-Bum Koh,Eun-Jeong Lee,Yu-Ri Kim,Meyoung-Kon Kim 한국실험동물학회 2013 한국실험동물학회 학술발표대회 논문집 Vol.2013 No.2
Right Gastric Venous Drainage: Angiographic Analysis in 100 Patients
Seong, Nak Jong,Chung, Jin Wook,Kim, Hyo-Cheol,Park, Jae Hyung,Jae, Hwan Jun,An, Sang Bu,Cho, Baik Hwan The Korean Society of Radiology 2012 KOREAN JOURNAL OF RADIOLOGY Vol.13 No.1
<P><B>Objective</B></P><P>To evaluate the pattern of right gastric venous drainage by use of digital subtraction angiography.</P><P><B>Materials and Methods</B></P><P>A series of 100 consecutive patients who underwent right gastric arteriography during transcatheter arterial chemoembolization for hepatocellular carcinoma were included in this study. Angiographic findings were retrospectively analyzed with respect to the presence or absence of the right and aberrant gastric veins, multiplicity of draining veins, aberrant right gastric venous drainage sites, and the termination pattern of aberrant right gastric veins (ARGVs). We also compared the relative size of the right and left gastric veins.</P><P><B>Results</B></P><P>A total of 49 patients collectively had 66 ARGVs. The common drainage sites for the ARGVs included the hepatic segment IV (n = 35) and segment I (n = 15). The termination pattern of ARGV could be classified into 4 different types. The most common type was termination as a superficial parenchymal blush formation in small areas without demonstrable portal branches. A statistically significant difference was found for the dominancy of the right gastric vein in gastric venous drainage between the two groups with or without ARGV (<I>p</I> < 0.05, Fisher's exact test). In the group of patients without ARGV (n = 51), the right gastric vein was equal to (n = 9) or larger than (n = 17) the left gastric vein in 26 patients (26 of 51, 51%).</P><P><B>Conclusion</B></P><P>The incidence of ARGV is higher than expected with four distinct types in its termination pattern. The right gastric vein may play a dominant role in gastric venous drainage.</P>
A 13-week subchronic toxicity study of an <i>Eriobotrya japonica</i> leaf extract in rats
Seong, Nak-Won,Seo, Heung-Sik,Kim, Jun-Ho,Kim, Yong-Jae,Kim, Eun,Lee, Joon-Yeol,Ko, Je-Won,Kim, Jong-Choon Elsevier 2018 Journal of Ethnopharmacology Vol.226 No.-
<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P> <I>Eriobotrya japonica</I> leaf is widely used in traditional medicine, and exhibits various beneficial effects such as anti-inflammatory, antiviral, antioxidant, and antitumor activities. However, limited data are available on the potential adverse effects of <I>E. japonica</I>.</P> <P><B>Aim of the study</B></P> <P>This study investigated the potential subchronic toxicity of an <I>E. japonica</I> leaf extract (EJE) through a 13-week repeated oral dose experiment in Sprague–Dawley rats.</P> <P><B>Materials and methods</B></P> <P>Forty male and 40 female rats were randomly assigned to four experimental groups: three treatment groups receiving 250, 500, and 1000 mg/kg/day of EJE and a vehicle control group receiving sterile distilled water for 13 weeks.</P> <P><B>Results</B></P> <P>Repeated oral administration of EJE for 13 weeks did not cause any treatment-related adverse effects with respect to clinical symptoms, body weight, food and water consumption, urinalysis, ophthalmology, necropsy findings, hematology, serum biochemistry, organ weight, and histopathological examination at any dose tested. Although some changes were observed in clinical symptoms, organ weight, hematology, and histopathology, these findings did not show a dose–response relationship and were within normal historical ranges for control rats.</P> <P><B>Conclusion</B></P> <P>Under the present experimental conditions, the no-observed-adverse-effect level of EJE was > 1000 mg/kg/day in both sexes and no target organs were identified. The results suggest that the EJE is a safe traditional medicine for clinical applications at proper dose.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
여신단(如神丹) 첩부가 만출력 이상에 의한난산을 해소한 임상증례보고
김성준 ( Seong Jun Kim ),최대경 ( Dae Kyoung Choi ),류사현 ( Sa Hyun Yoo ),김양식 ( Yang Sik Kim ),손영주 ( Yeong Joo Sohn ),손낙원 ( Nak Won Sohn ) 대한한방부인과학회 2005 大韓韓方婦人科學會誌 Vol.18 No.4
Objective: This clinical study investigated the effect of Yeosindan on dystocia caused by abnormal expulsive forces. Methods: Yeosindan was applied on the umbilicus of a primipara who had gone through latent phase for 15hrs and was almost expected to undergo C-sec by dystocia. It was sealed with an plaster. Yeosindan was removed immediately after the delivery. Results: 1. 90 minutes after Yeosindan had been applied on the umbilicus of the primipara, the active phase dilatation of uterus was started normally. 2. After 190 minutes from the Yeosindan application, the 2nd stage of labor was finished. 3. In this case, the delivery time, of which average is 344 minutes from the active phase to the second stage of labor, was reduced by 244 minutes. 4. So far, no abnormal condition has been detected in both the neonates and the primiparas.
Ahn, Jun-Ku,Park, Kyoung-Woo,Hur, Sung-Gi,Seong, Nak-Jin,Kim, Chung-Soo,Lee, Jeong-Yong,Yoon, Soon-Gil Royal Society of Chemistry 2010 Journal of materials chemistry Vol.20 No.9
<P>The feasibility of InSbTe (IST) chalcogenide new materials by metalorganic chemical vapor deposition (MOCVD) was demonstrated for PRAM applications. IST-MOCVD at a low temperature of 250 °C resulted in a favorable conformal deposition in the trench structure with a high aspect ratio. The IST films grown at 250 °C showed the highest resistance of approximately 10<SUP>8</SUP> Ω/sq, suggesting the amorphous phase of IST and the films grown at 300 °C include various crystalline phases of IST, In–Sb, and In–Te. MOCVD-IST films exhibited a step-coverage of about 95% in the trench structure with a 5 : 1 aspect ratio (a height of 500 nm and a diameter of 100 nm) and also showed reliable filling of the trench under appropriate deposition conditions. Phase switching between amorphous and crystalline states in the IST films grown on a trench structure at a high-aspect ratio (3.5 : 1) was demonstrated showing functional characteristics for applications in memory devices. The IST-based chalcogenide films used included various crystallized phases of In–Sb–Te, In–Sb and In–Te, which proved to be favorable for multilevel data storage.</P> <P>Graphic Abstract</P><P>The IST films, with completely filled trench structures at 250 °C by metalorganic chemical vapor deposition, showed a good switching behavior and the steps exhibiting the abrupt resistance changes at two different voltages indicate a possibility of the multi-level data storage in IST-PRAM devices. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b922398c'> </P>
요관결석환자에서 발생된 Salmonella typhi 에 의한 Acute Focal Bacterial Nephritis
홍성표,김명재,이태원,김병준,김기중,안우석,이상억,원현상,현용준,성낙천,임천규 대한내과학회 1996 대한내과학회지 Vol.51 No.6
Acute focal bacterial nephritis(AFBN; Acute lobar nephronia) represents a acute, localized, non necrotizing suppurative inflammation of an entire lobule of kidney analogue to segmental involvement of the lung in lobar pneumonia. Renal Abscess, renalcyst and renal cell cancer, which also may appear as a mass, is distinguished radiologically from AFBN by abdominal ultrasonogram, abdominal CT scan, kidney MRI and renal scan. We have experienced a case of a 50-years-old male with acute focal bacterial nephritis by Salmonella typhi with ureteral stone. The patient was treated with chloramphenicol for 3 weeks and discharged, After 5 weeks later, the sonographic examination revealed reduced size of mass at affected kidney. We report this case with review of literatures.