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Seon Yeong Chae,Rowoon Park,홍석원 한국생체재료학회 2022 생체재료학회지 Vol.26 No.3
Background: Astaxanthin (AST) is known as a powerful antioxidant that affects the removal of active oxygen and inhibits the production of lipid peroxide caused by ultraviolet light. However, it is easily decomposed by heat or light during production and storage because of the unsaturated compound nature with a structural double bond. The activity of AST can be reduced and lose its antioxidant capability. Graphene oxide (GO) is an ultrathin nanomaterial produced by oxidizing layered graphite. The chemical combination of AST with GO can improve the dispersion properties to maintain structural stability and antioxidant activity because of the tightly bonded functionalized GO surface. Methods: Layered GO films were used as nanocarriers for the AST molecule, which was produced via flow-enabled self-assembly and subsequent controlled solution deposition of RGD peptide and AST molecules. Synthesis of the GO-AST complex was also carried out for the optimized concentration. The characterization of prepared materials was analyzed through transmission electron microscopy (TEM), scanning electron microscope (SEM), Fourier-transform infrared spectroscopy (FT-IR), atomic force microscope (AFM), and Raman spectroscopy. Antioxidant activity was tested by 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2.2-diphenyl-1-picrylhydrazyl (DPPH) assays. The antibacterial effect and antioxidant effects were monitored for the ultrathin GO/RGD/AST Film. Further, reactive oxygen species (ROS) assay was used to evaluate the anti-inflammatory effects on L-929 fibroblasts. Results: Cotreatment of GO-AST solution demonstrated a high antioxidant combined effect with a high ABTS and DPPH radicals scavenging activity. The GO/RGD/AST film was produced by the self-assembly process exhibited excellent antibacterial effects based on physicochemical damage against E. coli and S. aureus. In addition, the GO/RGD/AST film inhibited H2O2-induced intracellular ROS, suppressed the toxicity of lipopolysaccharide (LPS)-induced cells, and restored it, thereby exhibiting strong antioxidant and anti-inflammatory effects. Conclusion: As GO nanocarrier-assisted AST exerted promising antioxidant and antibacterial reactions, presented a new concept to expand basic research into the field of tissue engineering.
채선영 ( Seon Yeong Chae ),전소영 ( So Young Chun ),박민 ( Min Park ),장유진 ( Yu Jin Jang ),김진래 ( Jin Rae Kim ),오세행 ( Se Heang Oh ),이진호 ( Jin Ho Lee ),송필현 ( Phil Hyun Song ),권태균 ( Tae Gyun Kwon ),김태환 ( Tae Hwan 한국조직공학과 재생의학회 2014 조직공학과 재생의학 Vol.11 No.1s
The innate extracellular matrix (ECM) scaffolds can be a promising scaffold for regeneration of complex organ such as heart, liver and kidney. They possess intact 3-dimentional architecture and biochemical components that allow to access to the organ`s capillary network. In this study we have developed a porcine renal ECM scaffold and analyzed its physical and biochemical characteristics including biocompatibility for human kidney regeneration. A segmented porcine kidney cortex was obtained and treated with 1% (v/v) Triton X-100 (Triton) or sodium dodecyl sulfate (SDS) in a shaking chamber, and rinsed with distilled water. After confirmation of decellularization with H&E stain, the matrix was lyophilized and sterilized. Scanning Electron Microscope (SEM) analysis showed that both scaffolds were preserved with proper architecture including porosity for cell adhesion and composition of the renal ECM. The water uptake ability of the Triton treated scaffold was higher than that of SDS treated one. The maximum compressive strength of Triton was lower than SDS treated scaffolds and that correlates with the results of porosity and water uptake analysis. In ATR-IR analysis, both scaffolds showed a peak at 3445-3446 cm-1 and that indicates the presence of amide II (-NH). Triton treated scaffold demonstrated that there are richer contents of ECM proteins and growth factors compared to SDS treated one. When scaffolds were seeded with primary human kidney cells, Triton treated scaffold showed 2.66 times higher number of adherent cells than SDS treated one at 24 hrs postseeding. On a CCK-8 analysis, the Triton treated scaffold showed significantly higher cell viability and proliferation rate than that of SDS treated one. Both scaffolds had no tumorigenecity for 8 weeks in vivo analysis. In conclusion, we successfully developed porcine renal ECM scaffold and confirmed that there is a great potential of porcine renal ECM scaffold to be used as human kidney regeneration. We also verified that 1% Triton X-100 is more suitable decellularizing agent than SDS regarding structural, biochemical integrity and biocompatibitilty of the scaffold. To support our findings and human application of practical regeneration, we are planning to perform in vivo experiment for kidney regeneration near future.
채영석(Yeong-Seok Chae),김선영(Seon-Yeong Kim),김현승(Hyeon-Seung Kim),문현석(Hyoun-Seok Moon),강인석(Leen-Seok Kang) 한국구매조달학회 2011 한국구매조달학회지 Vol.10 No.2
최근 국내에서 건설사업관리(Construction Management, CM) 계약사례가 점차 증대되고 있다. CM업무의 원활한 수행을 위해 국토해양부 등에서는 CM 업무지침을 공표하고 있으며, 이러한 CM 업무지침은 CM계약 이후의 CM 업무수행지침을 의미한다. 하지만 CM 발주경험이 부족한 발주기관에서는 CM 업무수행지침 외에 CM발주부터 CM 용역계약까지의 업무지침을 필요로 하고 있다. 즉, CM 발주사례가 부족한 기관에서는 CM발주를 위한 기획업무부터 CM업자(Construction Manager, CMr) 선정까지의 업무지침이 실무적으로 도움이 될 수 있다. 따라서 본 연구에서는 기존 CM 발주업무를 조사 및 분석하여 발주기관의 CM 발주단계에 중점을 둔 단계별 업무지침을 표준적인 절차로 구성하며, 이를 프로세스 모형으로 구축하였다. 제시된 업무지침과 모형은 전문가 설문조사로 활용성을 검증하였다. 제시된 업무지침은 CM발주에 경험이 없는 발주기관의 경우에도 CM기획, 입찰, 선정, 계약단계의 단계별 발주업무에 활용이 가능하도록 하여 CM 발주업무의 효율성 제고에 기여할 수 있다. Recently, CM(Construction Management) contracts are gradually increasing. In this trend, the MLTM (Ministry of Land, Transport and Maritime Affairs) announced a CM business guideline. The guideline is focused on businesses after the CM contract. However, contractors that experiences of CM order are not sufficient require a business guideline from CM order to CM contract with a business execution guideline for CM. That is, the guidelines from planning of CM order to selection of CMr(Construction Manager) help the contractors to apply in practice. Therefore, this study develops a business guideline for each stage focusing on a CM order stage of a contractors as a standard process by analyzing existing CM order businesses. Usability of the suggested CM business guideline and its process model is verified by questionnaire of experts. It is expected that the CM business guideline will provide efficiencies in performing an order business of CM by allowing the contractors that the ordering experiences are lack to support order business of each stage, which include planning, bidding, selection and contract of CM business.
채지영 ( Chae Ji Yeong ),윤수인 ( Yun Su In ),배상석 ( Bae Sang Seog ),채희복 ( Chae Hui Bog ),박선미 ( Park Seon Mi ),윤세진 ( Yun Se Jin ),박진우 ( Park Jin U ),배일헌 ( Bae Il Heon ),김석형 ( Kim Seog Hyeong ),송형근 ( Song Hye 대한소화기학회 2004 대한소화기학회지 Vol.43 No.2
Jejunal infarction as a complication of acute pancreatitis is not common and can not be well recognized. This jejunal infarction usually arises from the venous thrombosis rather than arterial thrombosis. Jejunal infarction results in bowel perforation or stenosis according to its extension of injury and progression rate. Pathologic findings of the involved jejunum show a segmental transmural infarction and mesenteric venous thrombotic occlusions. Early diagnosis should be made for better prognosis. We report a patient with jejunal infarction resulting perforation due to acute pancreatitis, in which the initial presenting symptoms were hematemesis and abdominal distention. (Korean J Gastroenterol 2004; 43:120-124)
채지영 ( Chae Ji Yeong ),기주영 ( Gi Ju Yeong ),김민옥 ( Kim Min Og ),유일영 ( Yu Il Yeong ),임정묵 ( Im Jeong Mug ),홍의실 ( Hong Ui Sil ),채희복 ( Chae Hui Bog ),박선미 ( Park Seon Mi ),윤세진 ( Yun Se Jin ) 대한소화기기능성질환·운동학회 2003 Journal of Neurogastroenterology and Motility (JNM Vol.9 No.2
목적: 간경변증은 원인과 관계없이 간 실질조직의 비가역적인 변화와 재생성 결절로 인한 전반적인 섬유화를 특징으로 하는 질병으로 오심, 구토, 트림, 식후 통증, 복부 팽만감 같은 상부위장관 증상들이 있다. 간경변증 환자에서 위배출장애가 관찰된다는 사실이 보고된 바 있으나, 피부 위전도에 대한 연구는 많지 않다. 본 연구에서는 간경변증 환자에서의 피부 위전도를 측정하여 정상인과 차이가 있는지 알아보고 간경변증 환자들 중 복수유무, 저알부민 혈증 여부에 따 Background/Aims: Liver cirrhosis (LC) is characterized by an irreversible change of liver parenchyme, irrespective of origin. It is characterized by esophageal varix bleeding, hepatic encephalopathy, ascites and upper gastrointestinal symptoms. Dysmotilit