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수용성 이성분 혼합용매계에서 치환된 벤젠 술폰산 벤질의 가용매 분해 반응
朴炳端,金永基,柳根宇 順天大學校 1987 論文集 Vol.6 No.1
메탄올, 에탄올, 아세토니트릴, 아세톤 및 THF의 수용성 이성분 혼합용매계어서 네가지 벤젠술폰산 벤젠치환체들의 가용매 분해 반응을 35℃에서 연구하였다. 반응속도는 비양성자성 수용성 혼합용매계에서 보다는 양성자성 수용성 혼합용매계에서 빠름을 알 수 있었으며, 이것은 양성자성 혼합용매계에 의한 친전자성 및 친핵성 보조작용이 전이상태를 안정화시키기 때문이라는 것을 알 수 있었다. 가용매분해반응 속도상수를 Grunwald-Winstein 식, 확장된Grunwald-Winstein 식 및 Hammett식으로 해석하였다. 본 반응의 결과로 부터 비양성자성 수용성 혼합용매계서 용매에 의한 친전자성 보조 작용이 크게 나타남을 알 수 있었다. Solvolysis of four benzyl benzensulfonates have been studied in aqueous methanol,ethanlo,acetonitrile,acetone and tetrahydrofuran mixtures at 35℃. The rates were faster in protic solvent-water mixtures than in aprotic solvent-water mixtures. This was considered in the light of transition state stabilization by electrophilic and nucleophilic solvent assistance of protic solvent mixtures. The rates of solvolysis are analyzed in terms of the Grunwald-Winstein equation, extended Grunwald-Winstein equation and Hammett equation. The results showed that strong electrophilic assistance of solvent is operative in the aprotic solvent-water mixtures.
박우철,서상현,강상재,김준근 慶北大學校農業科學技術硏究所 1998 慶北大農學誌 Vol.16 No.-
1996년과 1997년도 2년동안 1월부터 12월까지의 영남지역의 5개소를 선정하여 실험하였다. 본 실험에서 조사한 지역은 낙동강 유로연장 521.1km중 57%에 해당하는 경상북도 유로구간 298.1km로서 상류지역 3개소(안동, 상주, 구미), 중류지역 2개소(왜관, 고령)로 총 5개소에 대해 실시하여 낙동강의 수질오염 특성을 알아보고 낙동강 수질 개선 및 장례에 예상되는 수질악화에 대비한 물 관리의 기초자료로서 활용하고자 본연구를 시도하였으며 그 결과는 아래와 같다. 1. 낙동강의 조사지역 5개소의 pH는 공히 6.5∼8.6 정도를 나타내었다. 2. 용존산소량(DO), 화학적 산소요구량(COD), 생물학적 산소요구량(BOD)은 여름철에 낮아지고 겨울철에 높아지는 현상이 관찰되었다. 3. 부유물질(SS)은 여름철에 급격히 높아지는 현상이 관찰되었다. 4. 총인과 총질소는 조류가 번식하여 부영양화를 일으킬 만큼 높은 수준은 관찰되지 않았으나 상당한 수준의 양이 관찰되었다. 5. NH₄+-N와 NO₃--N는 비교적 높은 수준이 관찰되었다. The purpose of this survey was to investigate the regional and seasonal characteristics of a water system and to obtain basic information of a water system at Andong bridge, Nakdan bridge, Kangjung, Waekwan bridge and Koryung bridge along Nakdong River. We surveyed the water quality in the Nakdong River for 2 years from Jan. 1996 to Dec. 1997. The results summarized were follows; 1) The pH in the Nakdong River on the basic of 2 years average were 6.5-8.6. 2) The DO, the COD and the BOD were low level in summer and high level in winter, respectively. 3) The suspended solids(SS) contents was high especially in summer. 4) The T-P and the T-N contents were higher than the lower level of nitrogen and phosphorous for algae growth and the contents were high especially in winter. 5) The NH₄+-N and NO₃--N were also observed to be quite high.
유산양 유방염에 대한 Chitosan 약침의 치료 효과
황수현,서진석,김덕환,김명철,신상태,전무형,南三郞,김영찬,이우근,표수일 충남대학교 수의과대학 동물의과학연구소 1999 動物醫科學硏究誌 Vol.7 No.-
To improve the therapeutic method for mastitis, treatment effect of chitosan pharmacopuncture was examined in three milking goats(A,B and C). Mastitis was artificially induced in two milking goats(A and B) and one goat(C) was naturally infected case with mastitis. The acupoint used was Yang-Ming and chitosan suspensions(provided from Tottory University, Japan: 30㎎ of chitosan/㎖)were injected to the acupoint with 5㎖/time for 3 days, respectively. As for the change of somatic cells in milk along with chitosan pharmacopuncture, they showed a decreasing tendency after increase on the 3rd day in all udders of B. In addition, as for the change of total leukocyte counts of peripheral blood with chitosan pharmacopuncture, they showed a decreasing tendency after increase on the 3rd day in B and C except A which showed a increasing tendency until on the 7th day. In the change of neutrophil/lymphocyte(N/L) ratio, increasing tendency was seen in A and C but increasing tendency after slight decrease was observed in B. Further, in the change of serum total protein and A/G ratio, serum total protein content was decreased after slightly increase on the 3rd day in A, and they were decreased after increase until on the 7th day in B and C, respectively. As for the change of A/G ratio, different pattern increasing tendency was shown in A, B and C.
최정태,안무업,안희철,최영미,정재봉,서정열,유기철,이삼우,박석현,조준휘,김성환,김아진,송근정 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4
Purpose : This study was conducted to develop field triage, transportation, distribution, and prehospital care at a fire disaster by analyzing the victims of the fore that broke out at a bar in Incheon. Method : We analyzed the cases of the victims of a fire in Incheon in Oct. 1999. We determined the primary care hospital, the arrival time, the burn size, the outcome, and the injury type from the medical records, the concerned organ records, and interviews with concerned persons. Result : The total number of victims was 137: 56 prehospital deaths, 1 hospital death, and 80 survivals. The Pearson correlation coefficient between the burn size and the severity was -0.175. There were 121(89.6%) cases of inhalation injury, 59 (43.7%) cases of flame burns, 66 (48.9%) cases of hypoxic brain damage, and 16 (11.9%) cases involving other types of injury. Conclusion : The causes of death of the fire victims were inhalation injury and hypoxic brain damage due to CO poisoning and other toxic inhalants. We propose the use of a simple triage and rapid treatment(START) system and a reassessment the delayed category in fire disasters.
( Keun Woo Park ),( Chang Jin Seo ),( Dae Young Yun ),( Min Keun Kim ),( Byung Seok Kim ),( Young Seok Han ),( Hoon Kyu Oh ),( Chang Hyeong Lee ) 대한간학회 2015 Clinical and Molecular Hepatology(대한간학회지) Vol.21 No.3
Hepatoblastoma usually occurs in children under the age of 2 years, with very few cases reported in adults. We experienced a case of adult hepatoblastoma in a 36-year-old female with chronic hepatitis B . She had experienced sudden onset abdominal pain. Her serum alpha-fetoprotein level was markedly elevated, and abdominal CT showed a 9-cm mass with internal hemorrhage in the right hepatic lobe with hemoperitoneum, so an emergency hepatic central bisectionectomy was performed. The initial histologic examination revealed that the mass mimicked combined hepatocellular carcinoma and cholangiocarcinoma with spindle-cell metaplasia of the cholangiocarcinoma element. Follow-up abdominal CT performed 3 months later showed a 5.5-cm metastatic mass in the left subphrenic area. Laparoscopic splenectomy with mass excision was performed, and hepatoblastoma was confirmed histologically. A histologic re-examination of previously obtained surgical specimens also confirmed the presence of hepatoblastoma. Metastatic hepatoblastoma was found at multiple sites of the abdomen during follow-up, and so chemotherapy with cisplatin, 5-fluorouracil (5-FU), and vincristine was applied, followed by carboplatin and doxorubicin . Despite surgery and postoperative chemotherapy, she died 12 months after symptom onset. (Clin Mol Hepatol 2015;21:300-308)
Woo, Sang-Keun,Jang, Su Jin,Seo, Min-Jung,Park, Ju Hui,Kim, Byoung Soo,Kim, Eun Jung,Lee, Yong Jin,Lee, Tae Sup,An, Gwang Il,Song, In Ho,Seo, Youngho,Kim, Kwang Il,Kang, Joo Hyun Society of Nuclear Medicine 2019 The Journal of nuclear medicine Vol.60 No.1
<P>The purpose of this study was to develop <SUP>64</SUP>Cu-labeled trastuzumab with improved pharmacokinetics for human epidermal growth factor receptor 2 (HER2). <B>Methods:</B> Trastuzumab was conjugated with SCN-Bn-NOTA and radiolabeled with <SUP>64</SUP>Cu. Serum stability and immunoreactivity of <SUP>64</SUP>Cu-NOTA-trastuzumab were tested. Small-animal PET imaging and biodistribution studies were performed in a HER2-positive breast cancer xenograft model (BT-474). The internal dosimetry for experimental animals was determined using the image-based approach with the Monte Carlo N-particle code. <B>Results:</B> <SUP>64</SUP>Cu-NOTA-trastuzumab was prepared with high radiolabeling yield and radiochemical purity (>98%) and showed high stability in serum and good immunoreactivity. Uptake of <SUP>64</SUP>Cu-NOTA-trastuzumab was highest at 48 h after injection as determined by PET imaging and biodistribution results in BT-474 tumors. The blood radioactivity concentrations of <SUP>64</SUP>Cu-NOTA-trastuzumab decreased biexponentially with time in both mice with and mice without BT-474 tumor xenografts. The calculated absorbed dose of <SUP>64</SUP>Cu-NOTA-trastuzumab was 0.048 mGy/MBq for the heart, 0.079 mGy/MBq for the liver, and 0.047 mGy/MBq for the spleen. <B>Conclusion:</B> <SUP>64</SUP>Cu-NOTA-trastuzumab was effectively targeted to the HER2-expressing tumor in vitro and in vivo, and it exhibited a relatively low absorbed dose due to a short residence time. Therefore, <SUP>64</SUP>Cu-NOTA-trastuzumab could be applied to select the right patients and right timing for HER2 therapy, to monitor the treatment response after HER2-targeted therapy, and to detect distal or metastatic spread.</P>
Seong Woo Cho,Tae Seon Kim,Keun Yook Chung,Makoto Kimura,Yong Weon Seo,Hwa Young Heo,Yong Gu Cho,Hong Sig Kim,Beom Heon Song,Chul Won Lee,Seung Keun Jong,Sun Hee Woo 한국육종학회 2006 한국육종학회지 Vol.38 No.1
Systemic acquired resistance is an important component of the disease resistance repertoire of plants. A novel syntheticchemical, Benzo (1,2,3) thiadiazole-7-carbothioic acid S-methyl ester (BTH), was shown to induce acquired resistance in wheat.BTH prote