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LPS Increases 5-LO Expression on Monocytes via an Activation of Akt-Sp1/NF-κB Pathways
Seung Jin Lee,Kyo Won Seo,Chi Dae Kim 대한생리학회-대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.3
5-Lipoxygenase (5-LO) plays a pivotal role in the progression of atherosclerosis. Therefore, this study investigated the molecular mechanisms involved in 5-LO expression on monocytes induced by LPS. Stimulation of THP-1 monocytes with LPS (0∼3 μg/ml) increased 5-LO promoter activity and 5-LO protein expression in a concentration-dependent manner. LPS-induced 5-LO expression was blocked by pharmacological inhibition of the Akt pathway, but not by inhibitors of MAPK pathways including the ERK, JNK, and p38 MAPK pathways. In line with these results, LPS increased the phosphorylation of Akt, suggesting a role for the Akt pathway in LPS-induced 5-LO expression. In a promoter activity assay conducted to identify transcription factors, both Sp1 and NF-κB were found to play central roles in 5-LO expression in LPS-treated monocytes. The LPS-enhanced activities of Sp1 and NF-κB were attenuated by an Akt inhibitor. Moreover, the LPS-enhanced phosphorylation of Akt was significantly attenuated in cells pretreated with an anti-TLR4 antibody. Taken together, 5-LO expression in LPS-stimulated monocytes is regulated at the transcriptional level via TLR4/Akt-mediated activations of Sp1 and NF-κB pathways in monocytes.
Seo, Hwi Won,Suh, Jae Hyun,Kyung, Jong-Soo,Jang, Kyoung Hwa,So, Seung-Ho Korean Society of ToxicologyKorea Environmental Mu 2019 Toxicological Research Vol.35 No.3
As various populations are rapidly becoming an aging society worldwide and interest in health issues has increased, demand for functional foods including herbal products has increased markedly to maintain a healthy state which has led to safety issues about their intake as an inevitable result. The objective of this study was to identify the safety profile of a Korean red ginseng and Salvia plebeia R. Br. extract mixture (KGC-03-PS) which is a valuable ingredient that can be used as a functional food. In the present study, the subacute oral toxicity and bacterial reverse mutagenicity of KGC-03-PS were evaluated. Sprague Dawley rats were administered KGC-03-PS orally for 28 days by gavage. Daily KGC-03-PS dose concentrations were 0, 500, 1,000, or 2,000 mg/kg body weight (bw) per day. Bacterial reverse mutation test with KGC-03-PS dose levels ranging from 312.5 to $5,000{\mu}g/plate$ was carried out by OECD test guideline No. 471. Five bacterial strains (Salmonella typhimurium TA98, TA100, TA1535, TA1537, and Escherichia coli WP2) were tested in the presence or absence of metabolic activation by plate incorporation method. There were no toxicological effects related with test substance in the clinical evaluation of subacute oral toxicity test including clinical signs, body weight, and food consumption. Moreover, no toxicological changes related to KGC-03-PS were observed in the hematological and serum biochemical characteristics as well as in the pathological examinations, which included organ weight measurements and in the gross- or histopathological findings. KGC-03-PS did not induce an increase in the number of revertant colonies in all bacterial strains of the bacterial reverse mutation test. The no-observed-adverse-effect level of KGC-03-PS is greater than 2,000 mg/kg bw/day, and KGC-03-PS did not induce genotoxicity related to bacterial reverse mutations under the conditions used in this study.
CASE REPORT : Single Nodular Pulmonary Amyloidosis: Case Report
( Seung Hyun Lee ),( Young Chun Ko ),( Jong Pil Jeong ),( Chan Woo Park ),( Seok Ho Seo ),( Jong Taek Kim ),( Dae Won Park ),( Cheol Min Bak ),( Seung Ki Moon ),( Shin Hyoung Jo ),( Se Mi Kim ),( Ah L 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Amyloidosis is defined as the presence of extra-cellular deposits of an insoluble fibrillar protein, amyloid. The pulmonary involvement of amyloidosis is usually classified as tracheobronchial, parenchymal nodular, or diffuse alveolar septal. A single nodular lesion can mimic various conditions, including malignancy, pulmonary tuberculosis, and fungal infection. To date, only one case of nodular pulmonary amyloidosis has been reported in Korea, a case involving multiple nodular lesions. Here, we report and discuss the case of a patient having single nodular amyloidosis.
( Seung Suk Seo ),( Chang Wan Kim ),( Sang Won Moon ) 대한슬관절학회 2011 대한슬관절학회지 Vol.23 No.3
Purpose: The purpose of this study is to assess the clinical and radiological results of patients who underwent patellar retention or resurfacing for moderate or severe patellar articular defects during total knee arthroplasty and evaluate the clinical efficacy of patellar resurfacing according to the articular defect of the patella. Materials and Methods: From May 2003 to March 2006, 252 patients (277 cases) underwent total knee arthroplasty by one surgeon. Intraoperatively, we divided these patients into a moderate articular defect group (50-75%: group I) and a severe articular defect group (75-100%: group II) and randomly performed patellar resurfacing. The average age was 67.2 years. There were 234 female and 17 male patients. The average follow-up period was 74.6 months. Clinical outcomes were analyzed using the Knee Society (KS) knee score. Functional score, Hospital for Special Surgery (HSS) score, Feller patellar score and range of motion (ROM). Radiological outcomes were analyzed using the congruence angle, Insall-Salvati ratio and patella tilt angle. Results: The KS knee score and functional score at the last follow-up were 84.4/73.1 in the retention group and 85.2/71.8 in the resurfacing group (p=0.80, p=0.63) in group I. In group II, the values were 82.1/75.1 and 87.0/71.2, respectively (p=0.51, p=0.26). The HSS score and Feller patella score were 86.7/20.3 in the retention group and 84.3/21.7 in the resurfacing group (p=0.31, p=0.29) in group I. In group II, the values were 91.6/21.2 and 85.5/22.1, respectively (p=0.37/p=0.30). The knee ROM (p=0.36/p=0.41), congruence angle (p=0.22/p=0.16), Insall-Salvati ratio (p=0.16/p=0.21) and patella tilt angle (p=0.12/p=0.19) were not statistically different between the two groups. Conclusions: In this study, we could not find any correlations between the degree of patellar articular defect and patellar resurfacing in terms of the clinical and radiological results. Therefore, patellar articular defects is thought to be less meaningful in determining patellar resurfacing.