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Kim Hoyoung,Lim Taehyun,Ha Go Eun,Lee Jee-Young,Kim Jun-Woo,Chang Nienping,Kim Si Hyun,Kim Ki Hun,Lee Jaeick,Cho Yongju,Kim Byeong Wook,Abrahamsson Alva,Kim Sung Hwan,Kim Hyo-Ji,Park Sehan,Lee Sang Ja 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Thus far, attempts to develop drugs that target corticotropin-releasing hormone receptor 1 (CRF1R), a drug target in stress-related therapy, have been unsuccessful. Studies have focused on using high-resolution G protein-coupled receptor (GPCR) structures to develop drugs. X-ray free-electron lasers (XFELs), which prevent radiation damage and provide access to high-resolution compositions, have helped accelerate GPCR structural studies. We elucidated the crystal structure of CRF1R complexed with a BMK-I-152 antagonist at 2.75 Å using fixed-target serial femtosecond crystallography. The results revealed that two unique hydrogen bonds are present in the hydrogen bond network, the stalk region forms an alpha helix and the hydrophobic network contains an antagonist binding site. We then developed two antagonists—BMK-C203 and BMK-C205—and determined the CRF1R/BMK-C203 and CRF1R/BMK-C205 complex structures at 2.6 and 2.2 Å, respectively. BMK-C205 exerted significant antidepressant effects in mice and, thus, may be utilized to effectively identify structure-based drugs against CRF1R.
김세한 ( Sehan Kim ),김내수 ( Naesoo Kim ),김병철 ( Byung Chul Kim ),이재용 ( Jae Yong Lee ),표철식 ( Cheol-Sig Pyo ) 한국정보처리학회 2009 한국정보처리학회 학술대회논문집 Vol.16 No.2
다양한 서비스에서 활용되는 USN 환경에서 각 응용의 기술적 특성에 따른 다양한 계층별 프로토코 기술의 개발이 이루어 지고 있다. 본 논문에서는 무선 센서 네트워크의 다양한 프로토콜 개발에 필수인 분석기에 대한 것으로 무선 상의 여러 채널을 통해 송수신 되는 다양한 프로토콜을 쉽게 분석하는 장치의 구현에 대해 설명한다. XML 을 활용하여 하드웨어 및 소프트웨어의 코드를 바꾸지 않고 사용자 정의에 따른 프로토콜 분석, 시나리오 검증 및 GUI 처리를 가능하게 하여 USN 을 위한 센서 노드들의 성능 측정에 활용하고자 한다.
Kim, In-Wha,Myung, Seung-Jae,Do, Mi Young,Ryu, Yeon-Mi,Kim, Mi Jung,Do, Eun-Ju,Park, Sehan,Yoon, Soon Man,Ye, Byong Duk,Byeon, Jeong-Sik,Yang, Suk-Kyun,Kim, Jin-Ho Blackwell Publishing Asia 2010 Journal of gastroenterology and hepatology Vol.25 No.11
<P>Abstract</P><P>Background and Aim: </P><P>A Western-style diet (WD) is known to play an important role in inflammatory bowel disease and colon carcinogenesis. The purpose of this study was to understand the role of macrophages in WD-induced colitis associated with carcinogenesis.</P><P>Methods: </P><P>Male BALB/c mice were fed a WD or a control diet (CD) for 4 weeks and exposed to azoxymethane (AOM) followed by 2% dextran sulfate sodium (DSS) for 7 days.</P><P>Results: </P><P>The WD increased susceptibility to DSS-induced inflammation and accelerated the infiltration of macrophages. The incidence and multiplicity of colon tumors were higher in mice fed the WD than in those fed the CD (<I>P</I> < 0.05). Levels of prostaglandin-endoperoxide synthase (PTGS) 2 and prostaglandin (PG) E<SUB>2</SUB> in the colon were higher after treatment with AOM and DSS in mice fed the WD than in those fed the CD. In addition, WD consumption increased the DNA binding activity of nuclear factor-kappaB and the serum concentration of tumor necrosis factor (TNF)-&agr;. Mice fed the WD had higher numbers of F4/80-positive cells surrounding cancer cells compared with mice fed the CD. These cells expressed PTGS2, TNF-&agr; and &bgr;-catenin, which are up-regulated by the WD. We also found that the WD increased unphosphorylated &bgr;-catenin accumulation in the cytoplasm and nucleus of colon cancer cells.</P><P>Conclusions: </P><P>A WD increases the susceptibility to DSS-induced inflammation and accelerates the infiltration of macrophages. In turn, this resulted in the development and progression of colon cancer.</P>
서비스수준협정(SLA : Service Level Agreement) 적용에 있어서의 성공요인에 관한 연구
남기찬,김승윤,김세한 서강대학교 경영학연구원 2004 서강경영논총 Vol.14 No.2
This study provides the organizational and environmental factors of the adopting and applying the Service Level Agreement (SLA) by conducting multiple case research. The sampled companies are currently implementing the SLA over I year of usage period. Factors were used to provide the operational contribution for implementing the SLA. The study also provides the effects on IT performance through the SLA. For this, in depth interview was conducted for each sampled company. As a result, if SLA between outsourcer and service provider can be used as an immanence operation tool and actively implemented, SLA will be an strategic tool for various decision making in IT management practice with long term relationship, better shared partnership, and continuous service improvement.