두개안면 부위에 발생한 거대 파젯토이드 섬유성 이형성증의 세포분화 및 증식성에 관한 연구

이상신,송지용,이석근,김철,정진우,한진우,박인우,주재용,박영욱,Lee, Sang-Shin,Song, Chi-Yong,Lee, Suk-Keun,Kim, Cheul,Chung, Jin-Woo,Han, Jin-Woo,Park, In-Woo,Joo, Jae-Yong,Park, Young-Wook 대한치과의사협회 2000 대한치과의사협회지 Vol.38 No.6

기능성 위장관 장애에서 Duloxetine의 효과 : '뇌-장관 축' 모델을 중심으로

이상신,박시성,Lee, Sang-Shin,Park, Si-Sung 한국정신신체의학회 2012 정신신체의학 Vol.20 No.2

기능성 위장관 장애(functional gastrointestinal disorder, FGID)의 생물학적 병태생리는 아직 명확하지 않은 실정이나 최근에 뇌-장관 축(brain-gut axis, BGA) 모델이 각광받고 있다. BGA 모델은 중추신경계(CNS)와 장관신경계(ENS)가 신경계, 신경내분비계, 신경면역계 등으로 밀접하게 연계되어 양방향성으로 항상성을 유지한다는 이론이다. 또한 BGA는 FGID에 대한 항우울제 효과의 이론적 근거를 제공한다. 저자들은 세로토닌 노르에프네프린 재흡수 차단제인 duloxetine이 목 이물감, 우울감을 보이는 환자와 상부 위장관 팽만감, 건강염려증적 불안을 보이는 환자에서 위장관 증상 및 정신의학적 증상에 효과적이었음을 경험하였다. 이에 두 증례보고를 통하여 BGA에 대해서 간략히 검토하고 duloxetine의 효과를 BGA의 측면에서 고찰하였다. 이 두 증례에서 duloxetine의 장관에서 뇌로의 영향(bottom-up regulation)으로는 세로토닌 수용체, 노르에피네프린 수용체 그리고 부신피질자극호르몬방출인자(CRF) 길항효과를 통해서 내장과민성(visceral hypersensitivity) 및 정신의학적 증상을 호전시키고, 뇌에서 장관으로의 영향(top-down regulation)으로는 우울과 불안을 호전시킴으로 위장관 증상에 영향을 미친 것으로 추정해 볼 수 있다. The pathophysiology of functional gastrointestinal disorder(FGID) is not completely understood, but the importance of the 'Brain-Gut Axis(BGA)' model in FGID is being increasingly recognized. The BGA model is a bidirectional, hard-wired and homeostatic relationship between the central nervous system(CNS) and the enteric nervous system(ENS) via neural, neurohormonal and neuroimmunological pathways. In addition, the BGA model would provide a rationale for the use of psychotropics on FGID. The authors experienced two cases in which duloxetine, a serotonin-norepinephrine reuptake inhibitor, was effective in relieving FGID symptoms as well as psychiatric symptoms such as depression and hypochondriacal anxiety. Therefore we discuss the vignettes from the perspective of BGA theory. Duloxetine showed efficacy in these two patients by reducing visceral hypersensivity (bottom-up regulation) and by relieving depression and anxiety(top-down regulation).

정상초음파의 주파수 변화에 따른 C₃H₈-Air 예혼합화염의 전파거동 및 구조변이

이상신,서항석,김정수,Lee, Sang Shin,Seo, Hang Seok,Kim, Jeong Soo 대한기계학회 2014 大韓機械學會論文集B Vol.38 No.2

정상초음파장의 주파수 변이가 프로판/공기 예혼합화염의 전파거동 및 구조변이에 미치는 영향을 규명하기 위해 실험적 연구를 수행하였다. 다양한 당량비 조건에서 슐리렌 기법을 적용한 전파화염 가시화와 연소실 내부압력 측정을 통해 생성물 영역에서의 화염 구조변화 및 전파특성을 관찰하였다. 정상초음파가 존재할 경우 화염선단이 찌그러지고 기연부에서 횡방향 줄무늬가 생성되며, 이러한 구조변이는 정상초음파의 주파수에 종속한다. 또, 전파속도는 정상초음파가 교반하는 경우 증가되며, 화염전파 거동에 미치는 초음파의 영향은 주파수의 증가에 따라 보다 명확해진다는 사실도 확인되었다. The propagation behavior and structural variation of a premixed propane/air flame with frequency change in an ultrasonic standing wave at various equivalence ratios were experimentally investigated using Schlieren photography and pressure measurement. The propagating flame was observed in high-speed Schlieren images, allowing local flame velocities of the moving front to be analyzed in detail. The study reveals that the distorted flame front and horizontal splitting in the burnt zone are due to the ultrasonic standing wave. Vertical locations of the distortion and horizontal stripes are intimately dependent on the frequency of the ultrasonic standing wave. In addition, the propagation velocity of the flame front bounded by the standing wave is greater than that of the flame front without acoustic excitation. As expected, the influence of the ultrasonic standing wave on premixed-flame propagation becomes more prominent as the frequency increases.

헤르페스 감염

이상신(Sang Shin Lee),이석근(Suk Keun Lee) 대한치과의사협회 2010 대한치과의사협회지 Vol.48 No.5

Herpes virus family is highly infectious to patients, their families and dentists. The diagnosis of herpes infection is based on the characteristic clinical appearance and the location of the lesions. Herpes Simplex Virus(HSV) usually acquired through direct contact with infected lesions or body fluids, and the prevalence of HSV infection increases progressively from childhood. Primary infections provoke herpetic gingivostomatis typically affects the tongue, lips, gingival, buccal mucosa and palate. Recurrent infections give rise to vesiculo-ulcerative lesions at vermilion border of lip(herpes labialis). In the form of chickenpox, Varicella Zoster Virus(VZV) usually is infected in childhood. VZV spreads in the affected primary afferent nerve to the skin and produces a vesicular rash and pain. Epstein-Barr Virus(EBV) infects B cells and cause infectious mononucleosis. Latent EBV infection has also been implicated in Burkitt lymphoma, nasopharyngeal carcinoma. Cytomegalovirus(CMV) is associated with immune-compromised patient such as organ transplantation and AIDS patients.

Hybrid Method를 이용한 객체 추출 시스템

이상신(Sang Shin Lee),김중환(Joong Hwan Kim) 한국정보과학회 2000 한국정보과학회 학술발표논문집 Vol.27 No.1B

본 논문에서는 정지영상의 색상을 이용하여 객체의 영역 및 경계선을 추출하고, 각각의 추출된 정보의 장점을 혼합하여 보다 정확한 객체를 추출할 수 있는 Hybrid Method를 제안한다. 그리고 이 방법을 사용하여 추출된 독립영역간의 연관관계(포함, 인접)를 파악하여 사용자가 원하는 객체를 보다 쉽게 추출하는 객체 추출 시스템을 개발한다.

會社의 組織變更에 대한 課稅 小考

이상신(Lee Sang-Shin) 강원대학교 비교법학연구소 2006 江原法學 Vol.22 No.-

Given that taxable events in reorganization are accompanied by transfer of stock, business, and assets and consequent cost, recognition of profit-and-loss transfer is conducted in principle when reorganization occurs. However, in change of an organization, it is difficult to occur particular taxable events because no transfer of assets is performed, identity of juridical personality is admitted, and position of employees is not affected. Due to these reasons, it seems that few controversy has been presented on problems of tax on change of an organization in the USA or Japan. Meanwhile, the revision of the commercial law admits the changes of organizations in limited liability company(LLC) between corporation, introducing LLC. In Japan, these changes are tax-free. When an LLC is changed into a corporation as an organization the responsibility of employees is changed and the assessment of financing is differentiated, which may serve as taxable events. It seems that Korea don't have to follow the tax-free principle of Japan.

物上保證 不動産의 競賣와 讓渡所得稅

이상신(Lee Sang Shin) 강원대학교 비교법학연구소 2006 江原法學 Vol.23 No.-

In case which an immovable mortgaged was sold by official auction for the performance of the suretyship obligation, a surety on things shall have the duty to pay capital gains tax in the absence of legislation to the contrary. Such a result is same in case which exercise of the right of indemnification of is impossible. And such a result is different from Japan which has an legislation. A person who has effected performance on behalf of the obligor may be subrogated to the position of the obligee, A claim which has arisen through the performance by subrogation in corporations tax law is not determined to be bad-debt expenses even if in case which exercise of the right of indemnification of is impossible as well as income tax law. But such a result is cruel to a surety on things if bad-debt expenses is not determined unconditionally. I think that the legislation, which a surety on things shall have the duty to pay capital gains tax after the deduction of the amount due to an impossibility of right of indemnification of exercise in accordance with a law, is needed as well as Japan's income tax law article 64.

정상초음파가 개재하는 프로판/공기 예혼합화염의 슐리렌기법에 의한 가시화

이상신(Sang Shin Lee),김정수(Jeong Soo Kim),이도형(Do Hyong Lee) 한국가시화정보학회 2013 한국가시화정보학회지 Vol.11 No.1

An investigation into the influence of ultrasonic standing wave on the structural behavior of propane/ air premixed flame has been made to get a clue to the combustion reaction acceleration and combustion instability. Visualization technique utilizing the Schlieren photography was employed for the observation of structural variation of the flame reaction zone. Evolutionary characteristics of the flame front were caught by the high-speed Schlieren image, through which local flame velocity of the moving front were analyzed in detail.

파트너십의 법적 성질 및 과세체계에 대한 小考 ― 민법상 조합을 중심으로 ―

이상신 ( Lee Sang Shin ) 서울시립대학교 법학연구소 2009 조세와 법 Vol.2 No.1

2009년부터 파트너십 세제가 도입되어 시행되고 있다. 파트너십 세제는 기업형태의 실질에 따라 법인격이 없더라도 법인세를 과세하거나 또는 법인격이 있더라도 소득세를 과세하는 제3의 과세체계이다. 파트너십의 법적 성질과 과세체계를 우리의 私法상 논의와 연계하여 검토하고자 한 것이 이 글의 목적이다. 파트너십에 대한 법적 성질은 독립실체개념(entity concept)과 집합체개념(aggregate concept)이 혼재된 형태로서 계약관계이면서 數人의 공동사업성을 갖는다는 점에서 민법상 조합이나 투자조합, 합자조합(LP) 모두에 공통점이 있으나, 그에 대한 과세체계는 반드시 법적 성질과 부합하는 것은 아니다. 익명조합원에 대한 파트너십 세제의 적용, 법인조합원의 인정 여부 등은 해석상 私法과 충돌하거나 불명확한 경우라고 할 수 있다. 세법 독자적인 입장에서 파트너십 과세체계를 도입함으로써 “법인격의 존재=법인세 과세”라는 종래의 2분법 사고에 따른 편리성을 희생하였으나 단체의 실질에 맞게 법인이더라도 소득세 과세를 선택할 수 있도록 한 것은 바람직한 것으로 생각한다. 다만 아직 시행 초기이므로 문제점이나 개선방안에 관한 구체적인 연구는 시간이 좀 더 필요할 것이다. The partnership taxation system has been in effect since 2009. It's a third taxation system that levies corporation tax even when there is no corporation entity or income tax despite corporation entity according to the nature of company types. The purpose of this study was to review the legal nature and taxation system of partnership in connection with the discussion of the private law. As for legal nature, partnership consists of an entity and aggregate concept. Partnership under the civil law, investment partnership, and limited partnership all share common characteristics in that they are contract relations and operated by two or more people. However, taxation systems for partnership don't always fit the legal nature. The application of the partnership taxation system by an anonymous partner and the recognition of a corporation partner can conflict with the private law or bear ambiguity in terms of interpretation. The convenience derived from the conventional dual idea that “presence of corporation entity is taxation of corporation tax” was sacrificed by introducing the partnership taxation system in the aspect of tax laws. But it was the right decision to allow organizations to choose income tax even if they're corporations according to their practical nature. Since it's in early days, it will take some time to do specific studies on its problems and improvements.

‘되어보기’ 활동의 교육내용 분석 및 수업 실행 연구

이상신(Lee, Sang-Shin) 학습자중심교과교육학회 2016 학습자중심교과교육연구 Vol.16 No.4

본 연구의 목적은 가상맥락을 활용한 ‘되어보기’ 활동이 핵심 성취기준을 중심으로 수업을 재구성하는 데 견인차 역할을 한다는 가설을 전제로 ‘가상맥락을 활용한 되어보기 활동의 교수학습 모형’을 개발하고 이를 실제 교실수업에 투입함으로써 연구의 타당성과 효율성을 객관적으로 검증함에 있다. 현행 되어보기 활동은 몸 지각활동 이후의 후속 활동이 생략되거나 약화되어 있기 때문에 국어의 표현 및 이해 활동 단계에서 다만 내용 요약 수준의 비슷한 활동 결과물을 생산할 수밖에 없다는 한계 상황에 주목하고 이에 대한 대안으로 ‘체화된 인지(embodied cognition)’에 기반한 ‘감정적 몰입’과 ‘비판적 거리두기’라는 과정 드라마의 원리를 적용하여 인지적 과정을 고려한 ‘되어보기①’과 ‘되어보기②’ 활동 단계를 구안하고 이를 실제 교실수업에 투입한 결과 다음과 같은 시사점을 얻을 수 있었다. 첫째, 가상맥락 속 ‘되어보기①’과 ‘되어보기②’ 활동은 일회성의 역할 수행 학습을 넘어 실질적인 국어활동 학습을 수행하기 위한 총체적 언어학습 방법으로 거듭날 수 있음을 확인할 수 있었다. 둘째, 가상맥락 활용 ‘되어보기①’과 ‘되어보기②’ 활동은 핵심 성취기준 중심 수업 재구성에 중요한 견인차 역할을 함을 확인할 수 있었다. 셋째, ‘되어보기①’과 ‘되어보기②’를 활용한 수업 재구성은 ‘학습내용의 적정화’와 ‘학습경험의 질 함양’에 유의미한 수준의 변화를 주도하는 방법임을 확인할 수 있었다. The purposes of this study were to develop a teaching and learning model for virtual context-based make-believe activities based on a hypothesis that virtual context-based make-believe activities would be the driving force of reconstructing lessons according to the core achievement criteria and test the validity and efficiency of research objectively by applying the model to actual classroom lessons. Since the current make-believe activities had follow-up activities after the body perception ones omitted or weakened, it was inevitable to produce similar activity results at the level of content summary at the stages of text understanding and Korean activities. Recognizing that limitation, the study applied principles of process drama, which are emotional commitment and critical distancing based on embodied cognition, as alternatives to overcome the limitation, devised stages of activities by taking into consideration the cognitive processes of make-believe① and make-believe②, and applied them to actual classroom lessons. Those efforts led to the following implications: first, the activities of make-believe① and make-believe② in a virtual context turned out to be holistic methods for language study for the learning of practical Korean activities beyond the one-time learning of role performance. Secondly, the virtual context-based make-believe① and make-believe② activities played the roles of important driving force in the reconstruction of lessons according to the core achievement criteria. Finally, lesson reconstruction based on make-believe① and make-believe② led changes of significant level to the rationalization of learning content and enhancement of quality of learning experiences.