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Chun, Yoon-Keun,Ha, Joo-hun,Hong-Jung-Woo,Oh, Soo-Myung,Kim, Sung-Soo 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1
Yoon-Keun Chun¹,Joohun Ha□Hong-Jung Woo□, Soo Myung Oh□,Sung Soo Kim□ ¹Department of Molecular Biology, College of Medicine,²Department of Surgery, college of Medicine,³Department of Internal Medicine, College of Oriental Medicine,and ⁴East-Weat Medical Reserch Institute,Kyung Hee University, Seoul, Korea. The HBV DNA Amounts in Serum Have No relationship with ALT level and Hetergeneous Population Coexits in Chronic Hepatitis B Virus Infection. Proceedings of International Symposium on East-West Medicine, Seoul. 212-230, 1999. -Hepatitis B is caused by hepadnavirus. Hepatitis B virus replicates through 3.5kb pregenomic RNA intermediate which is regulated by core promoter. Pathogenesis of hepatitis B virus has been bilieved the result of host immune response. But recently many studies have reported that high level of viral replication caused by mutation in core promoter might result in severs hepatitis. But these studies were performed in vitro, not in vivo. So there is yet debate about which factor, viral of host factor, is more important in pathogenesis of hepatitis B virus. So we measured real viral replication level in 204 chronic hepatitis B patients by quantifying HBV DNA from sera by our novel PCR-based more sensitive method, and compared these results with ALT level measured from same sera, which indicates liver cell damage. Surprisingly there are no significant correlation between HBV DNA quantity and ALT level. Then we cloned core promoter region. In SSCP, we found that many viral mutants coexist in one patient. Base on SSCP result, we chose main viral core promoter type in each patients, which is thought to determine overall viral replication level in this patient. Main type of core promoter region of each 41 patients were directly sequenced. And with these we measured promoter activity by luciferase assay system and compared promoter activity with on another. We found tha there were some differences in promoter activity according to core promoter sequences. And we constructed replication-competent viral constructs with core promoter from 41 patients and Transfected these into HepG2 cell and measured HBV DNA by southern blot. There were also differences in HBV DNA quantity according to core promoter sequences. On these all results we investigated correlation between the effect of HBV core promoter on viral replication in vitro and HBN DNA quantity, ALT level from sera of each patients. We found there is no significant correlation among them. As a result, we concluded that in determining severity chronic hepatitis B patients, host factors of each patient is more important rather than replicative activity of virus itself.
( Yoon Ho Jang ),( Yun Sik Kim ),( Sung Wook Chun ),( Ye Ju Lee ),( Jong Ha Park ),( Eun Shil Kim ),( Sang Keun Shin ) 한국체육학회 2015 국제스포츠과학 학술대회 Vol.2015 No.1
Purpose: This research aimed to explore the effects of a 16-week Otago exercise program as an exercise intervention on functional fitness and Fullerton Advanced Balance scale in elderly women. Method: This research was conducted at N community elderly welfare center in B Metropolitan city, South Korea. A total of 29 subjects were recruited for this research. 14 were assigned to Otago exercise group and 15 were assigned to control group randomly. a 60 minute Otago exercise was applied to them as the intervention 3 times a week for 16 weeks. The Senior fitness test was performed to evaluate upper body and lower body strength, flexibility, dynamic balance & agility, and endurance. Fullerton Advanced Balance scale test was performed to measure static balance ability, dynamic balance ability, coordination ability, and position control ability. Mean and standard deviation were calculated to analyze the research data by using SPSS Version 21.0. Two-way repeated ANOVA was conducted to verify the differences between time and groups, and interaction between time and groups. Statistical significance was set at p<.05. Result: This research showed that there was a statistically significant increase between groups in flexibility for Otago exercise group. Significant interactions between pre-post measurement and groups appeared in upper body and lower body strength, agility and dynamic balance, cardiovascular fitness for Otago exercise group. Significant increase between pre-post measurement among FAB scale items appeared in walk with feet in tandem walk, stand on one leg eyes opened, restore balance after backward disturbance and total score for Otago exercise group. It also showed that Significant interaction was in walk with feet in tandem walk, stand on one leg eyes opened, walking while turning head, restore balance after backward disturbance, and total score for Otago exercise group. Conclusion: Otago exercise program confirmed the effectiveness on functional fitness and Fullerton Balance Advanced scale though it was a kind of low intensity exercise(25%HRR). This program can be used as an effective exercise intervention to enhance balance ability, prevent falls and maintain Quality of life for elderly women living in a community.
Chun, In ,Sung,Kwon, Jung ,Ah,Yoon, Hye ,Ji,Bae, Myung ,Nam,Hong, Jongki,Jung, Ok-Sang WILEY-VCH Verlag 2007 Angewandte Chemie Vol.46 No.26
<B>Graphic Abstract</B> <P>Crosses or chains? The two free pyridyl groups of a dimeric, triethanolamine-triisonicotinate-bridged palladium complex allow the formation of a unique microcross morphology or chain array of microcrystals (see picture), depending on the reaction conditions. These morphologies arise from interactions between microcrystals involving hydrogen bonding of the free pyridyl groups on the microcrystal surface and water molecules. <img src='wiley_img/14337851-2007-46-26-ANIE200701152-content.gif' alt='wiley_img/14337851-2007-46-26-ANIE200701152-content'> </P>