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Jeung, H-C,Rha, S Y,Shin, S J,Ahn, J B,Noh, S H,Roh, J K,Chung, H C Nature Publishing Group 2007 The British journal of cancer Vol.97 No.4
<P>Systemic chemotherapy for gastric cancer is often associated with treatment-related toxicity, which is particularly severe in patients with a poor performance status. In this paper, we describe the first study to evaluate S-1 monotherapy as an option for advanced gastric cancer patients who are not candidates for combination chemotherapy due to poor clinical condition. Fifty-two patients with Eastern Cooperative Oncology Group (ECOG) performance scale 2–3, whose general condition had made use of combination chemotherapy impossible, were enrolled. S-1 was administered to 30 patients as second- or third-line therapy. The initial dose of S-1 was 35 mg m<SUP>−2</SUP>, administered b.i.d for 14 days every 3 weeks. With a median follow-up period of 33 weeks, the median progression-free survival, and overall survival were 11 weeks (95% CI, 8–14) and 33 weeks (95% CI, 19–47), respectively. The overall 1-year survival rate was 29% by intent-to-treat analysis. The overall response rate was 12% (95% CI, 3–21), and the percentage of stable disease was 35%, resulting in the disease control rate of 47% (95% CI, 32–60). Significant drug-related toxicity included grade 3 diarrhoea (14%), anorexia (14%), fatigue (10%), neutropenia (10%), and leucopenia (6%). In conclusion, this study indicated the modest activity of S-1 in gastric cancer patients with poor performance status.</P>
Choi, K.Y.,Kim, S.H.,Choi, C.,Jung, M.H.,Wang, X.F.,Chen, X.H.,Noh, J.D.,Lee, S.I. North-Holland 2010 Physica. C, Superconductivity Vol.470 No.suppl1
To clarify the gap structure of the iron-pnictide superconductors, we synthesized optimally doped single crystals of BaFe<SUB>1.8</SUB>Co<SUB>0.2</SUB>As<SUB>2</SUB>, which had a critical temperature, T<SUB>c</SUB>, of 23.6K. The initial M-H curve was used to find the lower critical field, H<SUB>c1</SUB>. The full range of the temperature dependence of H<SUB>c1</SUB> was explained by using a two S-wave gap symmetry. We estimate the two gap as Δ<SUB>1</SUB>(0)=1.64+/-0.2meV for the small gap and Δ<SUB>2</SUB>(0)=6.20+/-0.2meV for the large gap.
Development of the Bio-signal Measurement System for Diagnosis of the Urinary Incontinence
H. K. Min,S. C. Noh,M. K. Park,W. J. Yu,J. H. Park,B. C. Yoo,K. S. Min,H. H. Choi 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7
The diagnosis of the urinary incontinence is decided by medical doctor's subjective conclusion with question, physical test and urodynamic test. Therefore, they can do misdiagnosis and it is limited to objectively support the result of the diagnosis. It is necessary to diagnose exactly because of the treatment pattern have to change according to degree of urinary incontinence. In this study, it is proposed that the development of the bio-signal measurement system which is useful for quantitative index at the diagnosis of urinary incontinence by using to measure contraction pressure of the pelvic floor muscle. The contraction pressure of the pelvic floor muscle was measured by balloon sensor and was changed electrical signal by pressure sensor. Electrical signal was transmitted to PC through the DAQ pad. In PC, GUI was composed to analyze pressure data and to extract the diagnostic parameters. Using the bio-signal measurement system that was proposed in this study, the contraction pressure data were acquired from a normal person and a stress urinary incontinence patient and numeric diagnostic parameters were extracted using developed analysis S/W. After comparing each diagnosis parameters, we can find the difference in differential pressure and pressure reducing rate. With these results, diagnostic parameters were considered that it will be able to use as the index of quantitative urinary incontinence diagnosis.
Yun, S.M.,Woo, S.H.,Oh, S.T.,Hong, S.E.,Choe, T.B.,Ye, S.K.,Kim, E.K.,Seong, M.K.,Kim, H.A.,Noh, W.C.,Lee, J.K.,Jin, H.O.,Lee, Y.H.,Park, I.C. North-Holland 2016 Molecular and cellular endocrinology Vol.422 No.-
Melatonin is implicated in various physiological functions, including anticancer activity. However, the mechanism(s) of its anticancer activity is not well understood. In the present study, we investigated the combined effects of melatonin and arsenic trioxide (ATO) on cell death in human breast cancer cells. Melatonin enhanced the ATO-induced apoptotic cell death via changes in the protein levels of Survivin, Bcl-2, and Bax, thus affecting cytochrome c release from the mitochondria to the cytosol. Interestingly, we found that the cell death induced by co-treatment with melatonin and ATO was mediated by sustained upregulation of Redd1, which was associated with increased production of reactive oxygen species (ROS). Combined treatment with melatonin and ATO induced the phosphorylation of JNK and p38 MAP kinase downstream from Redd1 expression. Rapamycin and S6K1 siRNA enhanced, while activation of mTORC1 by transfection with TSC2 siRNA suppressed the cell death induced by melatonin and ATO treatment. Taken together, our findings suggest that melatonin enhances ATO-induced apoptotic cell death via sustained upregulation of Redd1 expression and inhibition of mTORC1 upstream of the activation of the p38/JNK pathways in human breast cancer cells.
이규승 ( K. S. Lee ),이동훈 ( D. H. Lee ),조용진 ( Y. J. Cho ),정선옥 ( S. O. Chung ),박원엽 ( W. Y. Park ),노광모 ( K. M. Noh ),장영창 ( Y. C. Chang ) 한국농업기계학회 2010 바이오시스템공학 Vol.35 No.6
This study was performed to design and to construct a digital soil cone index(CI) measuring device replacing conventional analog type devices. The device developed in the study consisted of a load cell, a rotary encoder and a motor with a decelerator as its main parts. The cone speed was controlled lower than 3.0 m/s which keeps the standard suggested by the ASABE S313.3 specification. The experiment was conducted in a soil bin system as well as in various fields. The CI data measured by the developed device were compared with those by an existing measurement device(SC900, Spectrum, USA). Based on the experiments at various field conditions, the CI measuring characteristic of the device was quite similar to that of the conventional device within a acceptable R(2) range of more than 0.5(mean=0.76). It was concluded that the digital cone index measuring device was an effective and comprehensive sensor for measuring soil strength.
권영수(Y. S. Kwon),임재영(J. Y. Leem),이철로(C. R. Lee),노삼규(S. K. Noh),유연희(Y. H. Ryu),최정우(J. W. Choe),김성만(S. M. Kim),이욱현(U. H. Lee),류동현(D. H. Ryu),이동한(D. H. Lee),박장환(Jang-Hwan Park) 한국진공학회(ASCT) 1999 Applied Science and Convergence Technology Vol.8 No.4(1)
MBE(Molecular Beam Epitaxy) 방법으로 InAS 양자점의 크기를 달리하여 성장한 lnAs 양자점의 구조적 특성과 분광학적 특성을 조사하였다. 구조적 특성은 AFM(Atomic Force Microscopy)으로 하였으며, 광학적 특성은 PL(Photoluminescence)로 수행하였다. AFM 측정결과 양자점의 밀도는 2 ML에서 최대 값인 1.1×10¹¹/㎠이다. 양자점의 크기가 증가함에 따라 PL 피크는 적색편이를 하고 있었다. 발광피크의 온도의존성을 조사한 결과 온도의 증가에 따라 발광피크는 낮은 에너지로 이동하였으며, 20 K에서 180 K 구간에서는 발광피크의 FWHM(Full Width at Half Maximum) 값은 감소하였으며, 180 K 이상의 온도에서는 온도의 증가에 따라 FWHM도 증가하였다. 한편 Arrehenius-type function으로 구한 활성화 에너지는 InAs 양자점의 크기가 증가함에 따라 증가하였다. We present Photoluminescence (PL) and Atomic Force Microscopy (AFM) image on InAs quantum dots (QDs) having different size which grown by Molecular Beam Epitaxy (MBE). For different size QDs, analysis of the AFM profiles show that the density of QDs was the maximum value (1.1×10¹¹/㎠) at 2.0 ML. In the PL spectra of QDs, it is found that the peak energy decreases with increasing dot size due to the effect of quantum confinement. Temperature dependence of PL intensities show that the PL is quenching and Red shift as the temperature increase. The FWHM range of 20 K~80 K is narrowing with increasing temperature. When temperature is over 180 K, the line-width starts to increase with increasing temperature. At last, temperature dependence of the integrated intensities were fit using the Arrehenius-type function for the activation energy. Fit value of the activation energy was increased with increasing QDs-size.
Kim, J.S.,Han, H.S.,Shin, S.,Han, G.S.,Jung, H.S.,Hong, K.S.,Noh, J.H. Pergamon Press ; Elsevier Science Ltd 2014 International journal of hydrogen energy Vol.39 No.30
The design of photoanode with highly efficient light harvesting and charge collection properties is important in photoelectrochemical (PEC) cell performance for hydrogen production. Here, we report the hierarchical In<SUB>2</SUB>O<SUB>3</SUB>:Sn/TiO<SUB>2</SUB>/CdS heterojunction nanowire array photoanode (ITO/TiO<SUB>2</SUB>/CdS-nanowire array photoanode) as it provides a short travel distance for charge carrier and long light absorption pathway by scattering effect. In addition, optical properties and device performance of the ITO/TiO<SUB>2</SUB>/CdS-nanowire array photoanode were compared with the TiO<SUB>2</SUB> nanoparticle/CdS photoanode. The photocatalytic properties for water splitting were measured in the presence of sacrificial agent such as SO<SUB>3</SUB><SUP>2-</SUP> and S<SUP>2-</SUP> ions. Under illumination (AM 1.5G, 100 mW/cm<SUP>2</SUP>), ITO/TiO<SUB>2</SUB>/CdS-nanowire array photoanode exhibits a photocurrent density of 8.36 mA/cm<SUP>2</SUP> at 0 V versus Ag/AgCl, which is four times higher than the TiO<SUB>2</SUB> nanoparticle/CdS photoanode. The maximum applied bias photon-to-current efficiency for the ITO/TiO<SUB>2</SUB>/CdS-nanowire array and the TiO<SUB>2</SUB> nanoparticle/CdS photoanode were 3.33% and 2.09%, respectively. The improved light harvesting and the charge collection properties due to the increased light absorption pathway and reduced electron travel distance by ITO nanowire lead to enhancement of PEC performance.
Bae, J.S.,Park, S.H.,Jamiyandorj, U.,Kim, K.M.,Noh, S.J.,Kim, J.R.,Park, H.J.,Kwon, K.S.,Jung, S.H.,Park, H.S.,Park, B.H.,Lee, H.,Moon, W.S.,Sylvester, K.G.,Jang, K.Y. American Association of Pathologists and Bacteriol 2016 The American journal of pathology Vol.186 No.12
<P>Recently, the roles of sirtuins (SIRTs) in tumorigenesis have been of interest to oncologists, and protein kinase CK2 alpha 1 (CSNK2A1) has been shown to be involved in tumorigenesis by phosphorylating various proteins, including SIRT1. Therefore, we evaluated the roles of CSNK2A1, SIRT6, and phosphorylated SIRT6 and their relationships in breast carcinoma. Nuclear expression of CSNK2A1 and SIRT6 predicted shorter overall survival and relapse-free survival by multivariate analysis. Inhibition of CSNK2A1 decreased the proliferative and invasive activity of cancer cells. In addition, CSNK2A1 was bound to SIRT6 and phosphorylated SIRT6; evidence for this is provided from immunofluorescence staining, co-immunoprecipitation of CSNK2A1 and SIRT6, a glutathione S-transferase pull-down assay, an in vitro kinase assay, and transfection of mutant CSNK2A1. Knockdown of SIRT6 decreased the proliferation and invasiveness of cancer cells. Overexpression of SIRT6 increased proliferation, but mutation at the Ser338 phosphorylation site of SIRT6 inhibited the proliferation of MCF7 cells. Moreover, both knockdown of SIRT6 and a mutation at the phosphorylation site of SIRT6 decreased expression of matrix metallopeptidase 9, beta-catenin, cyclin D1, and NF-kappa B. Especially, SIRT6 expression was associated with the nuclear localization of B-catenin. This study demonstrates that CSNK2A1 and SIRT6 are indicators of poor prognosis for breast carcinomas and that CSNK2A1-mediated phosphorylation of SIRT6 might be involved in the progression of breast carcinoma.</P>
Concept of an Electron-beam-driven Neutron Generator and the Power Dissipation in the Target
S. J. Noh,K. O. Lee,K. H. Chung 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.3
A preliminary sketch of a concept for an electron-beam-driven neutron generator has been developed. High-intensity photoneutrons (1016 n·s−1) were to be produced from a tungsten targetthrough electromagnetic cascades by using 50-MeV electron beams. The physics study of theelectron-beam-driven neutron generator, as well as the power dissipation in the target, is presented.