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복합 운동프로그램이 초등학생의 신체구성, 혈중지질 및 체력에 미치는 영향
전종귀,이왕록,박희근,정준현,이영란,신동원,이경숙 충남대학교 체육과학연구소 2006 體育科學硏究誌 Vol.23 No.1
The purpose of the present study was to examine the effects of combined training on the changes of body composition, blood lipid profile and fitness in elementary school students. Thirty subjects participated in the present study. The subjects were divided into two groups either exercise group for 10weeks(15n) or control group for 10weeks(l5n) The results were described as follows; 1) There were significant differences in the body weight and lean body mass after the exercise program between two groups. 2) There were no significant differences in the blood TC, HDL-C, LDL-C, TG concentration after the exercise program between two groups. 3) There were significant differences in the sit-up and flexibility after the exercise group between two groups. In conclusion, it might be thought that the combined training improved the levels of body composition and health-related fitness in elementary subjects.
Gender-dependent hepatic alterations in H-<i>ras</i>12V transgenic mice
Wang, Ai-Guo,Moon, Hyung-Bae,Lee, Mi-Ran,Hwang, Chae Young,Kwon, Ki-Sun,Yu, Seong-Lan,Kim, Yong-Sung,Kim, Mirang,Kim, Jin-Man,Kim, Sang-Keun,Lee, Tae-Hoon,Moon, Eun-Yi,Lee, Dong-Seok,Yu, Dae-Yeul Elsevier 2005 Journal of hepatology Vol.43 No.5
<P><B>Background/Aims</B></P><P>Although it has been proposed that Ras and related signal pathways play important roles in hepatocarcinogenesis, appropriate in vivo models are lacking.</P><P><B>Methods</B></P><P>Two hepatocellular carcinoma lines were established using pronuclear microinjection techniques to create an insertion of the H-<I>ras</I>12V transgene under the control of the albumin enhancer/promoter. The resulting phenotypes and related molecular events were then examined.</P><P><B>Results</B></P><P>Male (but not female) transgenic mice older than 2 months showed hepatic alterations with a high degree of reproducibility, as compared to the wild-type mice. The liver/body-weight ratios were lower for the females than for the males. The transgene-carrying line 28 was investigated extensively with respect to molecular differences between the genders. Male hepatocytes showed higher Ras activity and higher reactive oxygen species (ROS) levels than female hepatocytes. The female hepatocytes showed higher expression levels of p53 and p21<SUP>Waf1/Cip1</SUP>, enhanced cytochrome <I>c</I> release, which correlated with cell cycle arrest, and higher levels of hypodiploid cell formation, as compared to the male hepatocytes.</P><P><B>Conclusions</B></P><P>The gender-related differences in molecular responses to activated Ras may have implications for the prevalence of hepatic alterations in males. Our transgenic mice represent a potentially valuable animal model for future investigations.</P>
Single-Atom Switches and Single-Atom Gaps Using Stretched Metal Nanowires
Wang, Qingling,Liu, Ran,Xiang, Dong,Sun, Mingyu,Zhao, Zhikai,Sun, Lu,Mei, Tingting,Wu, Pengfei,Liu, Haitao,Guo, Xuefeng,Li, Zong-Liang,Lee, Takhee American Chemical Society 2016 ACS NANO Vol.10 No.10
<P>Utilizing individual atoms or molecules as functional units in electronic circuits meets the increasing technical demands for the miniaturization of traditional semiconductor devices. To be of technological interest, these functional devices should be high-yield, consume low amounts of energy, and operate at room temperature. In this study, we developed nanodevices called quantized conductance atomic switches (QCAS) that satisfy these requirements. The QCAS operates by applying a feedback-controlled voltage to a nanoconstriction within a stretched nanowire. We demonstrated that individual metal atoms could be removed from the nanoconstriction and that the removed metal atoms could be refilled into the nanoconstriction, thus yielding a reversible quantized conductance switch. We determined the key parameters for the QCAS between the 'on' and 'off' states at room temperature under a small operating voltage. By controlling the applied bias voltage, the atoms can be further completely removed from the constriction to break the nanowire, generating single-atom nanogaps. These atomic nanogaps are quite stable under a sweeping voltage and can be readjusted with subangstrom accuracy, thus fulfilling the requirement of both reliability and flexibility for the high-yield fabrication of molecular devices.</P>
NURBS Interpolator with Adaptive Smooth Feedrate Scheduling and Minimal Feedrate Fluctuation
Taiyong Wang,Yong-Bin Zhang,Jing-Chuan Dong,Run-Ji Ke,Yan-Yu Ding 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.2
For an effective NURBS interpolator, generating the smooth feedrate profile and minimizing the feedrate fluctuation are two main tasks, which have a great influence on the machining quality. In this paper, a NURBS interpolator is proposed to solve the problem with offline-online two stages, which contain curving splitting, feedrate scheduling, and real-time interpolation modules. At first, in offline module, the limited feedrate of the curve is calculated with consideration of geometric characteristics and dynamic constraints, and the curve is split into several segments according to the key regions. Thus the necessary information is stored. Then the feedrate scheduling algorithm is applied with constant feedrate scheduling method at each segment, where tangential acceleration and jerk are taken into consideration to generate an adaptive smooth S-type feedrate profile. Moreover, in real-time interpolation module, an average feedrate calculation method is proposed to determine the sampling step size. And to minimize the feedrate fluctuation, a double interpolation algorithm based on the cosine theorem is presented, which use the second-order Taylor’s expansion method two times in one interpolation period. Finally, simulations and experiments are conducted to verify the performance of the proposed interpolator.
Sheng-Min Wang,See Hyun Park,Nak-Young Kim,Dong Woo Kang,Hae-Ran Na,Yoo Hyun Um,Seunghoon Han,Sung-Soo Park,Hyun Kook Lim 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.6
Objective Despite a high prevalence of dementia in older adults hospitalized with severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2), or so called COVID-19, research investigating association between preexisting diagnoses of dementia and prognosis of COVID-19 is scarce. We aimed to investigate treatment outcome of patients with dementia after COVID-19. Methods We explored a nationwide cohort with a total of 2,800 subjects older than 50 years who were diagnosed with COVID-19 between January and April 2020. Among them, 223 patients had underlying dementia (dementia group). We matched 1:1 for each dementia- non-dementia group pair yielding 223 patients without dementia (no dementia group) using propensity score matching. Results Mortality rate after COVID-19 was higher in dementia group than in no dementia group (33.6% vs. 20.2%, p=0.002). Dementia group had higher proportion of patients requiring invasive ventilatory support than no dementia group (34.1% vs. 22.0%, p=0.006). Multivariable analysis showed that dementia group had a higher risk of mortality than no dementia group (odds ratio=3.05, p<0.001). We also found that patients in dementia group had a higher risk of needing invasive ventilatory support than those in no dementia group. Conclusion Our results suggest that system including strengthen quarantines are required for patients with dementia during the COVID- 19 pandemic.
Sheng-Min Wang,Kyung-Do Han,Nak-Young Kim,Yoo Hyun Um,Dong Woo Kang,Hae-Ran Na,Chang Uk Lee,Hyun Kook Lim 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.10
Objective Previous studies investigating association of alcohol intake and fracture risk in elderly yielded conflicting results. We first examined the association between alcohol intake and total fracture risk in elderly subjects and further analyzed whether the association varied by fracture locations.Methods This is a nationwide population-based cohort study which included all people aged 66 (n=1,431,539) receiving the National Screening Program during 2009-2014. Time-to-event were defined as duration from study recruitment, the day they received health screening, to the occurrence of fracture.Results Total fracture was significantly lower in mild drinkers [adjusted hazard ratio (aHR)=0.952; 95% confidence interval (95% CI) =0.931-0.973] and higher in heavy drinkers (aHR=1.246; 95% CI=1.201-1.294) than non-drinkers. Risk pattern of alcohol consumption and fracture differed according to affected bones. Similar J-shaped trends were observed for vertebra fractures, but risk of limb fracture showed a linear relationship with alcohol intake. For hip fracture, risk decrement was more pronounced in mild and moderate drinkers, and significant increment was noted only in very severe drinkers [≥60 g/day; (aHR)=1.446; 1.162-1.801].Conclusion Light to moderate drinking generally lowered risk of fractures, but association between alcohol and fracture risk varied depending on the affected bone lesions.
Yin, Binfeng,Wang, Yu,Dong, Mingling,Wu, Jing,Ran, Bei,Xie, Mengxia,Joo, Sang Woo,Chen, Yiping Elsevier 2016 Biosensors & bioelectronics Vol.86 No.-
<P><B>Abstract</B></P> <P>A rapid and multiplexed immunosensor was developed based on a quantum dot (QD)-reverse assaying strategy (RAS) and immuno-magnetic beads (IMBs) for one-step and simultaneous detection of <I>Escherichia coli O157: H7</I> and <I>Salmonella</I>. In a conventional QD-based immunosensor, the fluorescence signal of the “IMBs-target-QD” immunoconjugate is directly used as the assaying readout. However, the fluorescence signal is affected by IMBs due to light scattering and the “IMBs-target-QD” immunoconjugate needs multiple washing and re-suspension steps. To address these problems, we use the surplus QD-antibody conjugate as signal readout in the RAS, which prevents interference from the IMBs, increases the fluorescence signal, and avoids complex operations. Compared with conventional QD-based immunosensor, the sensitivity of QD-RSA immunosensor for detection of <I>Escherichia coli O157: H7</I> has been improved fifty-fold, and whole analysis procedure can be finished within 1h. Therefore, this RSA strategy is promising for improving the performance of QD-based immunosensors and could greatly broaden their applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The immunosensor based on quantum dot-reverse assaying strategy (QD-RAS) was developed. </LI> <LI> The sensitivity of QD-RAS improved 50 times compared to conventional QDs-immunosensor. </LI> <LI> The whole analysis in QD-RAS can be finished in one-step within 1h. </LI> </UL> </P>