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슬라이딩 모드 제어를 이용한 AC서보모터의 원호보간 오차개선에 관한 연구
김은연,이상문,김수진,곽군평 國立 昌原大學校 產業技術硏究院 2004 産技硏論文集 Vol.18 No.-
The objective of this study is aimed at reducing the contour error of AC Servo derives by improving the interpolation error of each axis through sliding mode control system. The errors in machining process by AC Servo motor are due to many elements, such as the delay of the servo drivers, friction and the gain mismatch between x axis and y axis motors and so on. Sliding mode control system is applied to a AC servo drive as a numerical example in this paper. The experiment results which are compared with those of typical PI scheme show the validity of improvement in circular interpolation error of the system.
인간 재조합 인터루긴-32 면역조절작용에 대한 유세포 분석
이광수,김영관,채정일,심정현,김은미,강형식,김수현,윤도영,명평근 충남대학교 생물공학연구소 2006 생물공학연구지 Vol.12 No.-
Xenotransplantation of porcine organs has the potential to overcome the severe shortage of human tissues and organ available for human transplantation. however, it remains various hurdles for clinical xenotransplantation. In pig and mouse xenotransplantation, porcine xenograft evoke a strong cellular rejection response in immunocompetent host and grafts are destroyed within a week. This cellular immune response could involved both T cells and NK cells. A number of groups have shown that human NK cells can recognize and damage porcine endothelial cells. In addition, human T cells can respond to porcine endothelial cells through both direct and indirect mechanisms. Cellular rejection of porcine tissues requires T cells, particularly CD4^(+) cells. A new cytokine recombinant human interleukin-32α,β(IL-32α,β) has a role innate and acquired immune system. In order to investigate the role of recombinant mouse IL-18 and recombinant human IL-32α,β in xenograft rejection, we transplanted the PK(15) cells to C57BL/6 mice with or without intraperitoneal injection of recombinant mouse IL-18 or recombinant human IL-32 α,β. It was analyzed the population of NK cell, T cell and B cell in the C57BL/6 mice transplanted with PK(15) cells and recombinant mouse IL-18 or recombinant human IL-32α,β by flow cytometry analysis. As a result, lymph node and thymus of PK15/IL18, PK15/IL32α and PK15/IL32β injected group were increased to T cell activation population than normal injected groups. CD8^(+) T cells were decreased in lymph node of PK15/IL18, PK15/IL32α and PK15/IL32β injected groups. CD4^(+) T cells were increased in lymph node cell of PK15/IL32α and PK15/IL32β injected group and also, B cell population were increased in lymph node cell and spleen of PK15/IL18, PK15/IL32α and PK15/IL32β injected group. Therefore, we suggest that recombinant mouse IL-18 and recombinant human IL-32α,β suppress xenograft rejection in cellular xenotransplantation.
이광수,김영관,박희진,이재오,명평근 忠南大學校 生命科學硏究院 醫藥品開發硏究所 2006 藥學論文集 Vol.21 No.-
The transplantation of organ, tissues or cells between individuals of different species has been of increasing interest in recent years because the use of animals as organ and tissue donors as a source of transplants would overcome the severe and worsening shortage of human organs available for transplantation. However, There are some major hurdles to the clinical application of xenotransplantation; the immunologic response of the recipient against donor, the physiology of the graft, and the possibility that a xenotransplant might transmit an infection from the source to the recipient. This review describes the unique aspects of the immunological barrier to transplanting organs from non-primates such as pigs into humans, focusing especially on the mechanisms which contribute to immunorecognition, physiology of the rejection and infectious hurdles to xenotransplantation. This communication might be applied to overcoming these hurdles and the possibility that genetic strategies might be used to expand the potential applications of xenotransplantation for the treatment of human disease.
허남칠,김선민,박은령,박평심,김경수,이명렬 조선대학교 기초과학연구소 1998 自然科學硏究 Vol.21 No.1
This study was designed to investigate the free amino acid compositions of salt-fermented fish products in the markets of Chonnam area. The results were as follows : The free amino acid compositions of salt-fermented fish products had varying figures according to the species of raw materials, that is, lysine and leucine were relatively abundant in Myul-chi jeot (salt-fermented anchovy), arginine inSae-woo jeot (salt-fermented small shrimp), glutamic acid inJa-oi jeot (salt-fermented small shrimp). lysine, arginine, alanine and phenylalanine in To-h jeot (salt-fermented trout), etc. Essential amino acid contents were contained 31.02%∼83.46% of total amino acids in all sample, and lysine and leucine were most abundant among essential amino acids. Especially tryptophan was the richest in Cham-jo-gae jeot, phenylalanine in To-ha jeot, Kal-chi-nae-jang jeot and Song-eo jeot in other essential amino acids. because the degree of protein degradation wouldl be influenced on fermentation periods, salt-concentration, fermentation temperature, etc, we expected more systemic research by some varied conditions and the developed analytical techniques on the salt-fermented fish products should be followed.
Reports : Stanniocalcin 2 enhances mesenchymal stem cell survival by suppressing oxidative stress
( Pyung Hwan Kim ),( Sang Su Na ),( Bomnaerin Lee ),( Joo Hyun Kim ),( Je Yoel Cho ) 생화학분자생물학회(구 한국생화학분자생물학회) 2015 BMB Reports Vol.48 No.12
To overcome the disadvantages of stem cell-based cell therapy like low cell survival at the disease site, we used stanniocalcin 2 (STC2), a family of secreted glycoprotein hormones that function to inhibit apoptosis and oxidative damage and to induce proliferation. STC2 gene was transfected into two kinds of stem cells to prolong cell survival and protect the cells from the damage by oxidative stress. The stem cells expressing STC2 exhibited increased cell viability and improved cell survival as well as elevated expression of the pluripotency and self-renewal markers (Oct4 and Nanog) under sub-lethal oxidative conditions. Up-regulation of CDK2 and CDK4 and down-regulation of cell cycle inhibitors p16 and p21 were observed after the delivery of STC2. Furthermore, STC2 transduction activated pAKT and pERK 1/2 signal pathways. Taken together, the STC2 can be used to enhance cell survival and maintain long-term stemness in therapeutic use of stem cells. [BMB Reports 2015; 48(12): 702-707]
Choi Su-La,Choi Yun-Sil,Kim Young-Kwan,Sung Nack-Do,Kho Chang-Won,Park Byong-Chul,Kim Eun-Mi,Lee Jung-Hyung,Kim Kyung-Mee,Kim Min-Yung,Myung Pyung-Keun The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.3
We employed human SK-MEL-28 cells as a model system to identify cellular proteins that accompany N-(4-methyl)phenyl-O-(4-methoxy)phenyl-thionocarbamate (MMTC)-induced apoptosis based on a proteomic approach. Cell viability tests revealed that SK-MEL-28 skin cancer cells underwent more cell death than normal HaCaT cells in a dose-dependent manner after treatment with MMTC. Two-dimensional electrophoresis in conjunction with matrixassisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry analysis or computer matching with a protein database further revealed that the MMTC-induced apoptosis is accompanied by increased levels of caspase-1, checkpoint suppressor-1, caspase-4, NF-kB inhibitor, AP-2, c-Jun-N-terminal kinase, melanoma inhibitor, granzyme K, G1/S specific cyclin D3, cystein rich protein, Ras-related protein Rab-37 or Ras-related protein Rab-13, and reduced levels of EMS (oncogene), ATP synthase, tyrosine-phosphatase, Cdc25c, 14-3-3 protein or specific structure of nuclear receptor. The migration suppressing effect of MMTC on SK-MEL-28 cell was tested. MMTC suppressed the metastasis of SK-MEL-8 cells. It was also identified that MMTC had little angiogenic effect because it did not suppress the proliferation of HUVEC cell line. These results suggest that MMTC is a novel chemotherapeutic and metastatic agents against the SK-MEL-28 human melanoma cell line.