병사용 진단서 발급을 위해 복강경검사에서 간조직검사를 시행한 젊은 성인 남자의 간침생검 소견 : 새로운 만성간염병리분류를 기준으로 Histologic Grading and Staging of Chronic Hepatitis

전재윤,문영명,박영년,백용한,박찬일,한광협 대한소화기학회 2000 대한소화기학회지 Vol.36 No.2

Background/Aims: This study was designed to assess the etiology and characteristics of chronic liver disease among the young male adults. It was also investigated whether grades of activity and status of fibrosis defined by the new histopathologic classification system of chronic hepatitis are related with alanine aminotransferase (ALT) level and HBeAg status in HBsAg-positive case. Methods: Peritoneoscopic findings, clinical features and histopathologic features of liver were investigated for 140 young men who received liver biopsy for military medical certificate from January 1994 to December 1997. These features were evaluated according to the grade and stage of chronic hepatitis. Results: In Korea, hepatitis B virus was the main cause of chronic hepatitis (87.7%) in young male adults and the infection of hepatitis C virus was rare (1.4%). Among HBsAg-positive cases with normal ALT level, 82.2% of them revealed chronic liver disease, and 48.3% of them showed chronic active hepatitis/cirrhosis in biopsy specimens. The grade of chronic hepatitis showed weak correlation with ALT level and the stage did not. There was no significant difference in the grade and stage of chronic hepatitis according to the serum HBeAg status. Conclusions: The most common cause of chronic liver disease in Korean young male adults was hepatitis B virus, and most (92.6%) of HBsAg-positive cases were proved to have chronic liver diseases histologically, regardless of the serum ALT level. According to new histopathologic classification system of chronic hepatitis, serum ALT level correlated with necroinflammatory activity of chronic hepatitis B, but not with fibrosis in HBsAg-positive cases.

만성 간염의 새로운 등급체계에 따른 만성 B 형 간염의 장기간 추적결과

박병규,이관식,안상훈,전재윤,한광협,문영명,박영년,박찬일 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.3

$quot;목적: 만성 간염은 과거에는 만성 지속성 간염, 만성 소엽성 간염, 만성 활동성 간염으로 분류하였으나 이 분류법의 문제점과 한계점이 제기되어 왔다. 이를 보완하기 위하여 새로운 병리등급이 제시되어 왔고 국내에서는 대한병리학회 소화기병리연구회에서 만성 간염을 간염활성 정도(grade)와 섬유화 진행정도(stage)로 나누고, 간염활성의 등급은 소엽내 활성도와 문맥역/문맥주변부 활성도로 구분하는 새로운 만성 간염의 등급체계를 제시하였다. 본 연구에서는 간조직 검사를 시행받은 만성 B형 간염환자들을 새로운 만성 간염의 등급체계에 따라 재분류하여 장기간 추적결과와 예후인자를 알아보고자 하였다. 대상과 방법: 본 연구는 1984년부터 1996년까지 연세대학교 의과대학 세브란스병원에 내원하여 간조직 검사로 만성 B형 간염으로 확진된 환자들 중 적어도 6개월 이내의 간격으로 2년 이상 추적 관찰이 가능하였던 188명을 대상으로 하였다. 조직검사시의 연령, 성별, 간기능 검사를 알아보고, 추적 관찰 기간동안의 생화학적 간염활성도를 구분하기 위해 혈청 ALT치의 변화에 따라 생화학적 간염활성군과 생화학적 간염비활성군으로 분류하였다. 대상 환자들에서 임상적 또는 조직학적포암종 발생률이 통계적으로 유의하게 높았다(p$lt; 0.01). 대상성 간경변증과 비대상성 간경변증 발생의 독립적인 위험인자는 고령과 추적 관찰 기간동안의 생화학적 간염활성도였고, 간세포암종에서는 고령, 남성 그리고 추적 관찰 기간동안의 생화학적 간염활성도였다(p$lt;0.05). 결론: 새로운 만성 간염의 등급체계는 만성 B형 간염 환자에서 간염의 활성정도를 나타내고, 간경변증으로의 진행을 예측가능하게 한다. 만성 B형 간염 환자에서 추적 관찰 기간동안의 생화학적 간염활성도는 간경변증과 간세포암종 발생의 독립적인 예후인자였다. 그러므로 간염활성을 줄이기 위한 효과적인 치료가 만성 B형 간염 환자에서 간경변증과 간세포암종의 발생을 줄일 수 있을 것으로 기대된다. $quot;Background/Aims: Chronic hepatitis has been divided into chronic persistent hepatitis, chronic lobular hepatitis and chronic active hepatitis. These terms should be discontinued in favor of etiologic terminology. The activity of necro-inflammation and the degree of fibrosis should be evaluated for grading the severity and the stage of the disease. In this study, we sought to evaluate the long-term outcome and prognostic factors of chronic hepatitis B according to the new histological classification of chronic hepatitis proposed by the Korean Study Group for the Pathology of Digestive Diseases. Method: One hundred and eighty-eight patients (mean age, 35.0 years; male/female 3.9:1) with biopsy-proven chronic hepatitis B were retrospectively assessed with a mean follow-up of 80.6 months. The patients were divided into a biochemically-active group and a biochemically-inactive group according to serum alanine aminotransferase (ALT) changes during follow-up periods. The development of compensated cirrhosis and hepatocellular carcinoma were investigated during follow-up periods. As well, the liver biopsy specimens of the patients were reviewed according to the new histological classification of chronic hepatitis (grade of lobular activity and porto-periportal activity, stage of fibrosis). Results: Lobular activity and porto-periportal activity correlated with the serum ALT level at the time of biopsy (p$lt;0.05). The development of compensated cirrhosis correlated with porto-periportal activity and stage of fibrosis (p$lt;0.05). The probability of the development of compensated cirrhosis, decompensated cirrhosis and hepatocellular carcinoma increased significantly in the older age group (≥40 years) and the biochemically-active hepatitis group (p$lt;0.01). The risk factors for the development of compensated cirrhosis and decompensated cirrhosis were old age (≥40 years) and biochemically-active hepatitis during follow-up periods. For hepatocellular carcinoma they were old age (≥40 years), male gender and biochemically-active htitis during follow up periods by multivariate analysis. Conclusions: The present study suggests that the new histological classification of chronic hepatitis indicates hepatitis activity and the prospect for progression to cirrhosis in chronic hepatitis B. The biochemical hepatitis activity during follow-up periods is the independent prognostic factor for the development of cirrhosis and hepatocellular carcinoma in chronic hepatitis B. Therefore, effective treatment to decrease hepatitis activity may reduce the develoment of cirrhosis and hepatocellular carcinoma$quot;.

A Nationwide Survey of Inhalant Allergens Sensitization and Levels of Indoor Major Allergens in Korea

Park, Hye Jung,Lee, Jae-Hyun,Park, Kyung Hee,Ann, Hea Won,Jin, Moo-Nyun,Choi, Soo-Young,Lee, Yong-Won,Hong, Chein-Soo,Park, Jung-Won The Korean Academy of Asthma, Allergy and Clinical 2014 Allergy, Asthma & Immunology Research Vol.6 No.3

<P><B>Purpose</B></P><P>The higher prevalence of respiratory allergic disease may be due to increased exposure to inhalation allergens. We conducted a survey of allergic diseases in autumn and winter with detection of major indoor allergens in major cities in Korea.</P><P><B>Methods</B></P><P>We enrolled 110 subjects from the fourth Korea National Health and Nutrition Examination Survey with stratified, cluster, and systematic sampling procedures. All participants answered a health questionnaire as well as underwent a skin prick test (SPT) and ImmunoCAP for 11 indoor major allergens. We also measured the levels of 5 major allergens (Der f 1, Der p 1, Can f 1, Bla g 1, and Asp f 1) in fine indoor dust from the houses of 60 subjects with a 2-site ELISA.</P><P><B>Results</B></P><P>The prevalence of allergic rhinitis and asthma were 25.5% and 7.3%, respectively. The most common sensitized allergens identified by SPT and ImmunoCAP were <I>Dermatophagoides farinae</I> (40.9%, 36.8%), followed by cockroach (23.6%, 19.5%), mugwort (13.6%, 22.9%), oak (9.1%, 22.9%), Japanese hop (9.1%, 8.6%), and dog dander (8.2%, 6.9%). There was a modest discrepancy between SPT and ImmunoCAP. Der f 1 and Der p 1 were detected in 91.7% and 45.0% of the enrolled houses, respectively. Der f 1 indicated high concentrations in all specific provinces in Korea; however, Der p 1 measured high only in the south. Dog dander allergens were present in 71.7% of houses; however, Bla g 1 was present in only 11.7% of houses and Asp f 1 was not detected in any houses.</P><P><B>Conclusions</B></P><P>The most important inhalant allergens in Korea are house dust mites followed by cockroach, mugwort, oak, Japanese hop, and dog dander in indoor environment, in which The dominant species of house dust mites were different according to region.</P>

Histopathological and immunohistochemical studies of polymorphic reticulosis

Park, Young Nyun,Yang, Woo Ick,Lee, Kwang Gil,Choi, In Joon Yonsei University, College of Medicine 1990 Yonsei medical journal Vol.31 No.3

Hepatocarcinogenesis: imaging-pathologic correlation

Park, Young Nyun,Kim, Myeong-Jin Springer-Verlag 2011 Abdominal imaging Vol.36 No.3

만성 B 형 간염과 신장질환의 조직학적 상관관계

박영수,최창환,안상훈,송건훈,전재윤,한광협,문영명,박영년,정준원,이관식,이현웅,손주혁,정재연 대한간학회 2001 Clinical and Molecular Hepatology(대한간학회지) Vol.7 No.4

Background / Aims : The relationship between HBV infection and nephropathy has been reported with some differences according to the investigators and regions studied. Liver biopsis were not performed in most of the reports. In this study both liver and kidney biopsis were performed. The histologic correlation was analyzed between chronic B viral hepatitis and nephropathy. Methods : From January 1985 ro june and hebaturia. Also, a new histopathologic calssification of chronic hepatitis was applied in the assessment of liver disease. Results : Light microscopy of kidneys showed IgA nephropathy in 7 cases(27%) ; minimal change nephrotic syndrome(MCNS) in 1 case (3.8%); and membranous glomerulonephritis(MGN) in 9 cases(34.6%), membranoproliferative glomerulonephritis (MPGN) in 9 cases (34.6%). Among the cases with a higher hepatitis activity index and fibrosis score, the frequency of MGN and MPGN was higher. The hepatitis activity index of cases with MGN was significantly higher than IgA nephropathy and MPGN (p=0.011, p=0.039). The fibrosis score of cases with MGN and MPGN was significantly higher than IgA nephropathy (p=0.011, p=0.003). The positivity of HBeAg was highest in cases with MGN.Serum C3 level was low in all cases but the serum C4 level was within normal range. Immunofluorescence studies showed granular deposition of Ig G and C3 in the capillary loops in MGN. Conclusion : The frequency of MGN and MPGN was higher when the liver disease was more severe. It was suggested that HBeAg, IgG AND C3 might ci\ontribute to the pathogenesis of MGN in HBsAg positive patients.

Aberrant breast tissue of the perineum : A report on two cases

Park, Young Nyun,Jeong, Hyeon Joo,Lee, Kook Yonsei University, College of Medicine 1990 Yonsei medical journal Vol.31 No.2

Ductular reaction is helpful in defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules

Park, Young Nyun,Kojiro, Masamichi,Di Tommaso, Luca,Dhillon, Amar P.,Kondo, Fukuo,Nakano, Masayuki,Sakamoto, Michiie,Theise, Neil D.,Roncalli, Massimo John Wiley & Sons 2007 Cancer Vol.109 No.5

<B>BACKGROUND.</B><P>Stromal invasion is 1 of the main features used to distinguish high-grade dysplastic nodules (DNs) from well-differentiated hepatocellular carcinomas (HCCs). The authors hypothesized that ductular reaction (DR) takes place around noninvasive hepatocellular nodules but not within the stroma contiguous to invasive HCC.</P><B>METHODS.</B><P>DR/cytokeratin 7 (CK7)-positive patterns were evaluated in 105 resected small hepatic nodules according to the level of invasion. The nodules were classified histologically prior to immunostaining as noninvasive (large regenerative nodules, low-grade DNs, and high-grade DNs), minimally invasive (early HCCs with a vaguely nodular type), and overtly invasive (typical HCCs with a distinctly nodular type) in a review by expert pathologists, the current gold standard. Intranodular DR (inner DR) and DR around the nodule periphery (outer DR) were assessed separately on a semiquantitative scale from 0 to 4+.</P><B>RESULTS.</B><P>DR was 3 or 4+ in the majority of noninvasive nodules (inner DR, 81%; outer DR, 91%), whereas DR was 0 or 1+ in overtly invasive HCCs (inner DR, 96%; outer DR, 81%). Minimally invasive HCCs showed an intermediate DR pattern (2 or 3+ inner DR, 75%; 2+ outer DR, 67%). DR characteristically was absent at the stromal-invasive, leading edge of tumor cells in both minimally invasive HCCs (focal loss of DR/CK7) and overtly invasive HCCs (diffuse loss of DR/CK7). The DR patterns in 41 needle-biopsy samples were similar to the patterns observed in resected nodules.</P><B>CONCLUSIONS.</B><P>DR/CK7 immunostaining may help to identify small foci of invasion and to distinguish noninvasive, high-grade DNs from both minimally invasive and overtly invasive HCCs. Cancer 2007 © 2007 American Cancer Society.</P>

High-Performance Hybrid Buffer Layer Using 1,4,5,8,9,11-Hexaazatriphenylenehexacarbonitrile/Molybdenum Oxide in Inverted Top-Emitting Organic Light-Emitting Diodes

Park, Cheol Hwee,Lee, Hyun Jun,Hwang, Ju Hyun,Kim, Kyu Nyun,Shim, Yong Sub,Jung, Sun-Gyu,Park, Chan Hyuk,Park, Young Wook,Ju, Byeong-Kwon American Chemical Society 2015 ACS APPLIED MATERIALS & INTERFACES Vol.7 No.11

<P>A high-performance 1,4,5,8,9,11-hexaazatriphenylenehexacarbonitrile (HATCN)/molybdenum oxide (MoO3) hybrid buffer layer with high hole-injection efficiency and superior plasma resistance under the sputtering process was developed. The HATCN enhances the hole-injection efficiency, and the MoO3 effectively protects the underlying organic layers from plasma damage during deposition by sputtering. This improves the characteristics of inverted top-emitting organic light-emitting diodes using a top transparent conductive oxide electrode. The device using the hybrid buffer layer showed the highest electroluminescence characteristics among devices with other buffer layers. The high hole-injection efficiency of HATCN was shown by the J-F curve of hole-only devices, and the plasma protection performance of MoO3 was shown by atomic force microscope surface morphology images of the buffer layer film after O-2 plasma treatment.</P>

Pathologic factor

Young Nyun Park 대한외과학회 2010 대한외과학회 학술대회 초록집 Vol.2010 No.11