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Jin, Mei-Shan,Ha, Cong-Tu,Park, Warn-Gyu Elsevier 2017 INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER - Vol.109 No.-
<P><B>Abstract</B></P> <P>A numerical study on heat transfer effects of cavitating and flashing flows was conducted by employing a compressible homogeneous mixture approach. A dual-time preconditioned method was applied to enhance the efficiency and accuracy of the computations under various flow conditions. A sensitivity analysis of the empirical coefficients used to access the predictive capability of the existing mass transfer models was assessed for cavitating flows in a converging-diverging nozzle. To confirm the use of the calibrated empirical coefficients, computations of the water flows over a cylindrical head form and a Clark-Y hydrofoil were then carried out. The results obtained indicate an overall good agreement with the experimental data. Finally, the thermal effects on the phase change process were confirmed through an examination of a flashing flow along with thermo-fluid flows. The predicted results also show a good agreement with the experimental data. In conclusion, the existing system was shown to be effective in quantitatively predicting the thermal effects of the phase change processes, and can be used to examine the hydro- and thermodynamics of multiphase flows.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A numerical study of cavitating and flashing flows was conducted by employing a compressible homogeneous mixture approach. </LI> <LI> The system dominates pressure-driven vaporization and temperature-driven vaporization together. </LI> <LI> Phase change model’s dependency of model coefficients is assessed. </LI> <LI> The influence of thermal effects on evaporation process is proved by examining a flashing flow. </LI> </UL> </P>
Rafique, Rafia,Baek, Seung Hoon,Phan, Le Minh Tu,Chang, Sung-Jin,Gul, Anam Rana,Park, Tae Jung Elsevier S.A. 2019 Materials Science and Engineering C Vol. No.
<P><B>Abstract</B></P> <P>Using a facile hydrothermal procedure, hydrophilic NaYF<SUB>4</SUB>: Yb<SUP>3+</SUP>/Er<SUP>3+</SUP> nanoparticles (NPs) have been prepared as lanthanide-doped upconversion (UC) materials exhibiting different morphologies, crystal phases and luminescence intensity. The upconversion nanoparticles (UCNP) were characterized by means of electron microscopy and spectroscopy, X-ray diffraction (XRD) and photoluminescence analysis. The molar concentration of reactants and volumes of NaF affect the shapes and uniformity of the synthesized NPs. These parameters also have influence on crystal phase and luminescence intensity of the NPs. Adjusting hydrothermal reaction time and dopant concentration also enable the synthesis of NPs with strong UC luminescence. The as-prepared UCNP showed cellular nontoxicity to HeLa cells, and thus they are capable as promising agents for biological imaging.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fabrication of NaYF<SUB>4</SUB>:Yb<SUP>3+</SUP>/Er<SUP>3+</SUP>, upconversion nanoparticles (UCNPs) </LI> <LI> Molar concentration of NaF and reactants affects shapes and uniformity of nanoparticle. </LI> <LI> Adjusting reaction time and dopant concentration enhance UC luminescence of UCNPs. </LI> <LI> Optimized conditions are promising for <I>in vitro</I> HeLa cell imaging. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Ha Ngoc Minh,Hwang Hoseong,Alam Seemi Tasnim,Nguyen Uyen Tran Tu,Lee Soon Kwang,Park Jin-Soo,Kim Jin-Chul,Kwon Hak Cheol,Kwon Jaeyoung,Kang Kyungsu 한국응용생명화학회 2023 Applied Biological Chemistry (Appl Biol Chem) Vol.66 No.-
The high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infection threatens the effectiveness of current clinical settings. Antimicrobial photodynamic therapy (APDT) is a promising alternative to antibiotics for treating infections due to its low resistance. This study aimed to evaluate the antibacterial properties of APDT with L. fischeri extract (LFE) against MRSA and various skin and oral pathogens in vitro and its photopharmaceutical actions in Caenorhabditis elegans. The antimicrobial activities of APDT with LFE against pathogens were evaluated using plate counting method. The chemical profile was characterized using high-performance liquid chromatography and spectrophotometry. The growth rate assay, lifespan assay, and bacterial attachment on worms were performed to assess the therapeutics effects in C. elegans. The swab method was used for the detection of pathogens on the micropig skin surface. The APDT treatment with L. fischeri extract (LFE, 20 µg/mL) and red light (intensity of 120 W/m2) reduced 4.3–4.9 log (colony forming unit/mL) of Staphylococcus aureus, MRSA, Cutibacterium acnes, Streptococcus mutans; and 2.4 log (CFU/mL) of Candida albicans. Chemical analysis revealed that LFE enriched three active photosensitizers. APDT reduced bacterial populations on worms, recovered growth retardation, and improved lifespan in MRSA-infected C. elegans without causing severe side effects. The surface eradication of MRSA after exposure to LFE with red light was demonstrated on micropig skin. These findings highlight the significance of L. fischeri as a natural resource for the safe phototreatment of MRSA infection in the biomedical and cosmeceutical industries.
방사선 스트레스 반응 방어 유전자의 탐색 및 발현 분석
박누리,하혜정,사미나단 수브라야,최서희,전용삼,진용태,도옥화,쉬프라 쿠마리,이긍주,Park, Nuri,Ha, Hye-Jeong,Subburaj, Saminathan,Choi, Seo-Hee,Jeon, Yongsam,Jin, Yong-Tae,Tu, Luhua,Kumari, Shipra,Lee, Geung-Joo 한국식물생명공학회 2016 식물생명공학회지 Vol.43 No.3
자주달개비는 닭의장풀과의 다년생 식물로, 자주달개비의 수술털은 이온화 방사선에 노출될 경우 분홍색 또는 흰색으로 체세포 돌연변이가 쉽게 일어나 방사선 지표식물로 생물학적인 반응 연구 등에 효과적으로 이용되어 왔다. 본 연구에서는, 자주달개비 BNL 4430을 대상으로 50, 250, 500, 1000 mGy에 해당하는 감마선($^{60}Co$)을 조사한 후 13일차에 있는 샘플을 대상으로 만개한 꽃을 채취하여 RNA를 추출하였다. 추출한 RNA를 바탕으로 Illumina Hi-seq를 이용하여 각 선량에 해당하는 전사체 및 특이발현유전자(Differentially expressed genes, DEGs)를 분석하였다. 전사체는 총 77,326개로, 방사선 비처리구에 비해 2배 이상 상향 발현된 유전자는 50 mGy에서 116개, 250 mGy에서 222개, 500 mGy에서 246개, 1000 mGy에서 308개로 밝혀졌으며, 이 중 각 선량별 특이적으로 반응하는 유전자인 heat shock protein 70 famaily protein, IQ-domain 6, KAR-UP oxidoreductase, zinc transporter 1 precursor를 선발하여 13일차의 RNA 샘플을 대상으로 RT-PCR 및 qRT-PCR을 이용하여 저선량 방사선에 반응하는 유전자를 검정하였다. 검정 결과 DEGs data와 매우 유사한 양상을 보였으며, 선량별로 2.3배에서 최대 96.59배의 높은 발현을 확인하였다. 선발한 유전자는 대부분 세포 내 방어기작과 관련이 되어있는 유전자였으며, 이중 KAR-UP oxidoreductase의 경우 A. thaliana에서 발아와 관련이 있는 유전자로 알려져 있었는데, 이번 연구를 통해 저선량 방사선에 의해서 반응하는 유전자로도 확인이 되었다. 저선량 방사선에 노출된 자주달개비의 유전자 정보를 바탕으로, 저선량의 방사선이 식물체에 미치는 영향과 발현 기작을 연구하는 데에 분자적 수준의 정보를 제공할 수 있게 되었으며, 저선량 방사선의 생물학적 안정성 확보를 위한 감시 보조수단으로 자주달개비가 유용하게 활용될 수 있을 것으로 기대된다. Tradescantia is a perennial plant in the family of Commelinaceae. It is known to be sensitive to radiation. In this study, Tradescantia BNL 4430 was irradiated with gamma radiation at doses of 50 to 1,000 mGy in a phytotron equipped with a $^{60}Co$ radiation source at Korea Atomic Energy Research Institute, Korea. At 13 days after irradiation, we extracted RNA from irradiated floral tissues for RNA-seq. Transcriptome assembly produced a total of 77, 326 unique transcripts. In plantlets exposed to 50, 250, 500, and 1000 mGy, the numbers of up-regulated genes with more than 2-fold of expression compared that in the control were 116, 222, 246, and 308, respectively. Most of the up-regulated genes induced by 50 mGy were heat shock proteins (HSPs) such as HSP 70, indicating that protein misfolding, aggregation, and translocation might have occurred during radiation stress. Similarly, highly up-regulated transcripts of the IQ-domain 6 were induced by 250 mGy, KAR-UP oxidoreductase 1 was induced by 500 mGy, and zinc transporter 1 precursor was induced by 1000 mGy. Reverse transcriptase (RT) PCR and quantitative real time PCR (qRT-PCR) further validated the increased mRNA expression levels of selected genes, consistent with DEG analysis results. However, 2.3 to 97- fold higher expression activities were induced by different doses of radiation based on qRT-PCR results. Results on the transcriptome of Tradescantia in response to radiation might provide unique identifiers to develop in situ monitoring kit for measuring radiation exposure around radiation facilities.
Kang Ye-Won,Sun Tai hui,Kim Ga-Yeong,Jung Ho-Young,Kim Hyun-Jin,Lee Seulki,Park Yu Rang,Tu Jaiden,Lee Jae-Hon,Choi Kwang-Yeon,Cho Chul-Hyun 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.7
In this study, the Search Your Mind (S.Y.M., 心) project aimed to collect prospective digital phenotypic data centered on mood and anxiety symptoms across psychiatric disorders through a smartphone application (app) platform while using both centralized and decentralized research designs: the centralized research design is a hybrid of a general prospective observational study and a digital platform-based study, and it includes face-to-face research such as informed written consent, clinical evaluation, and blood sampling. It also includes digital phenotypic assessment through an application-based platform using wearable devices. Meanwhile, the decentralized research design is a non-face-to-face study in which anonymous participants agree to electronic informed consent forms on the app. It also exclusively uses an application-based platform to acquire individualized digital phenotypic data. We expect to collect clinical, biological, and digital phenotypic data centered on mood and anxiety symptoms, and we propose a possible model of centralized and decentralized research design.
A Review on the Application of Nanotechnology in Food Processing and Packaging
Seong-In Cho,Yong-Rok Kim,Joon Woo Lee,Dae-Sup So,Yong-Jin Cho,Hyun Kwon Suh,Tu San Park,Seoung-Im Oh,Ji-Eun Im 한국산업식품공학회 2010 산업 식품공학 Vol.14 No.4
Currently, nanotechnology is widely applied in various industrial fields and is rapidly emerging as a promising future technology. In food industries, nanotechnology is used to enhance food quality and safety. Numerous cutting-edge studies on the advantages of nanotechnology have been conducted in the fields of food processing, food ingredients and additives, food packaging, and food engineering for optimal health. The market for these areas of research has grown steadily, and is expected to continue to do so. Because of this, R&D for nanotechnology that can be used effectively in food industries is being performed by several companies, as well as in academic research institutions around the world. This review describes the recent global R&D trends that have been in progress for two key areas: food processing and food packaging.