Mirizzi 증후군의 변형된 분류와 치료

김형철,강길호,채만규,김성용,백무준,이문수,박상흠,이문호,김창호,송옥평,조무식,박희주 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Purpose : The Mirizzi syndrome is relatively rare and preoperative diagnosis of this disease is difficult. In 1978, Morelli suggested the subclassification of the Mirizzi syndrome into acute or chronic form. We experienced 5 cases of acute form. We analysed clinical features, preoperative radiologic findings and operative findings of 18 cases including acute forms which were diagnosed as Mirizzi syndrome and should suggest the modified classification of Mirizzi syndrome for choice of appropriate treatment. Method : From January 1995 to December 1998, 18 cases, of which 8 cases were diagnosed at Soonchunhyang University Chunan Hospital, and 10 cases were reported in the Korean Journal were retrospectively analysed with regard to clinical features, preoperative radiologic findings and operative findings. According to the clinical features, whole cases were divided into type Ⅰ(acute form) and type Ⅱ(chronic form) and then each type of cases were subclassified according to preoperative radiologic findings and operative findings. Results : Of 18 cases there were 5 cases in type Ⅰ(27.8%), 13 cases in type Ⅱ(72.2%). Type Ⅱb was most common. Type Ⅰa cases were treated only with cholecystectomy. We applied cholecystectomy, T-tube choledochostomy and patch technique in type Ⅰb and thpe Ⅰc cases. Cholectystectomies including removal of gallstones and internal drainage procedures were done in type Ⅱ chronic forms. Conclusion : The acute form(Type Ⅰ) of Mirizzi syndrome was suggested by Morelli might be subclassified into typeⅠa,Ⅰb and Ⅰc following the presence of the necrotic defect in common hepatic duct. Through the modified classification of Mirizzi syndrome based on clinical feature, preoperative radiologic findings and operative findings, we can choice appropriate treatment.

신규 방사성 항암제 DW-166HC 의 소핵시험

문은이(Eun Yi Moon),이진(Jin Lee),이원용(Won Yong Lee),최청하(Chung Ha Choi),이덕근(Dug Keun Lee),유제만(Jei Man Ryu),정용호(Yong Ho Chung),윤성준(Sung June Yoon),박경배(Kyung Bae Park) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.3

DW-166HC (^(166)Holmium (^(166)Ho)-Chitosan complex) is a new radiopharmaceutic anticancer agent with a broad anti-tumorigenic spectrum, especially against human hepatic cancer. DW-166HC was evaluated for the appearance of micronucleus in polychromatic erythrocytes (PCEs) of mouse bone marrow cells after subcutaneous arid intravenous single administration. Bone marrow cells were prepared at 24 hr and 48 hr after DW-166HC-I (^(165)Ho-Chitosan complex : cold compound) administration and at 24 hr, 72 hr and 2 weeks after DW-166HC (^(166)Ho-Chitosan complex : hot compound) administration. The results showed there was no statistically significant increase of the numbers of PCEs with micronucleus in all DW-166HC-I administered groups compared with a negative control group but there was statistically significant increase of the numbers of PCEs with micronucleus at 24 hr arid 72 hr in all DW-166HC administered groups, which was recovered after 2 weeks from the drug administration. The results also showed the ratio of normochromatic erythrocytes (NCEs) to PCEs of all DW-166HC-I administered groups was not significantly different from that of a negative controi group but there was significant difference of this ratio at 24hr and 72 hr in all DW-166HC administered groups compared with that of negative group, which was also recovered after two weeks from the drug administration. These results suggested that DW-166HC-I may not cause any chromosomal damage but DW-166HC has in vivo mutagenic potential because of its radioactivity.

전기-유압 서어보 기구의 시뮬레이션

박재범,염만오 慶南大學校 附設 工業技術硏究所 1992 硏究論文集 Vol.10 No.-

본 논문은 제어이론을 전기-유압 서어보시스템에 적용시켜 그 응답특성을 구한 것이다. 먼저 시스템의 전달함수를 구하였으며 이 전달함수를 이용하여 유량게인의 변화가 시스템의 응답특성에 미치는 영향을 아날로그식과 디지탈식으로 시물레이션하였다. 그결과 유량게인이 증가하면 시스템의 응답성은 개선되나 과도응답의 오버슈트가 커졌다. 또한 미분보상요소를 시스템의 전달함수에 삽입하여 아날로스식과 디지탈식으로 시뮬레이션한 결과 미보상시보다 시스템의 응답성이 개선되어 짐을 확인하였다. The aim of this study is to apply control theory to the electro-hydraulic servosystem. First the transfer function of the system is derived, and the system is simulated by analog and digital method with the variations of flow gain. With increasing in flow gain, the response of the system is improved, but the overshoot of transient response is increasing. The system response is improved by inserting a compensator element to the transfer function of the system.

Triton WR-1339에 의한 고콜레스테롤증 유발시 해조류 김 추출물의 신장내 콜레스테롤 축적 감소 효과

박인식,안상현,정재만,김진택,김호현 동국대학교 한의학연구소 1998 東國韓醫學硏究所論文集 Vol.7 No.1

본 실험은 김 추출물이 고콜레스테롤증 유발시 발생되는 신장내의 과도한 콜레스테롤 축적에 대한 감소효과의 조사를 위해 ICR 생쥐에 Triton WR-1339(TX) 복강주사로 인위적인 고지혈증을 유발시킨 후 김 추출물(30㎎/㎏)을 복강주사하여 시간의 경과에 따른 신장조직에서의 콜레스테롤을 비롯한 지방입자의 축적양상 변화를 관찰하였다, TX 주사로 고콜레스테롤증 유발시 신장조직 전지역, 즉 사구체, 근위곱슬세관, 원위곱슬세관 그리고 헨레고리에서 콜레스테롤을 비롯한 지방입자의 축적이 증가되는 것으로 나타났다. 그러나 고콜레스테롤증시 나타나는 신장내의 일련의 변화는 김 추출물 처리후 콜레스테롤을 비롯한 지방입자의 축적이 신장조직 전 지역에서 현저하게 감소된 것으로 관찰되었으며, 이러한 감소는 TX 주사후 48시간에서 가장 잘 나타났다. 이상의 결과로 볼 때 해조류 김 추출물은 고콜레스증 유발된 신장내의 과도한 콜레스테롤을 비롯한 지방축적을 감소시키는 항고콜레스테롤증 효과를 하는 것으로 사료된다. Renal tissues of ICR mouse were jntraperitoneally injeced with Porpbyra yezoensis extract(PE) after Triton WR-1339(TX) injection were observed to investigate the cholesterol accumulation decreasing effort of P.E. The renal tissues were obtained at hour 24, 48, and 72 after TX injection that fixed in fromol-calcium solution and were cryocut. The tissue stained black B for lipid and perchloric acid-naphthoquinone mothod for cholesterol. The parietal layer of Bowman's capsule is swelled as cuboidal type at hour 48 after TX injection and the lipid blot and cholesterol particle were noticeably increased in glomerulus and these appeared in convoluted tubule, collecting tubule, and Helen's loop. In PE treated group, the Ipid blot and cholesterol particle were considerably decreased in glomerulus than TX group. As results indicated that the accumulation of lipid including cholesterol caused by TX injection were mitigated in renal tissues by the antihypercholesterolemia effect of PE.

유체전동장치의 설계에 관한 연구

박용호,박진건,염만오 慶南大學校 附設 工業技術硏究所 1994 硏究論文集 Vol.12 No.-

본 연구는 국산화정책의 일환으로 개발된 유체커플링 및 기존커플링(수입품)의 성능을 측정할 수 있는 실험장치를 제작하고 실험데이타를 저장 및 활용할 수 있는 소프트를 개발하여 실험결과를 저장하며 필요에 따라 실험결과를 활용하여 유체커플링의 사용시에 예상되는 문제점을 해결하고 성능개선을 위한 자료를 제공하는데 그 목적을 둔다. 본 연구의 결과는 예상되는 변속유체커플링 및 토크컨버터의 국산화개발에도 응용 가능한 기초적 자료가 되리라 생각한다. The purpose of this research is to construct the experimental test set-ups and establish a series of performance test program for the domestically developed fluid couplings, and to provide a software to store and utilize these experimental data which can be used to improve the performance of the fluid coupling and solve on the job problems confronted in operation. The result of this study can contribute valuable references to the developement of variable speed fluid coupling and torque converter currently pursued by the domestic industry.

다공성 LiTi_2(PO_4)_3 Glass-Ceramics에서 기공 크기 제어에 관한 연구

박만규,강원호 단국대학교 신소재기술연구소 1997 신소재 Vol.7 No.-

다공성 LiTi_2(PO_4)_3 Glass-Ceramics에서 Li_2O 함량을 0∼8 mole ratio로 변화시켜 기공의 크기, 기공율 등을 측정·분석하였고, 최적 조성을 선정한 후 분상 열처리 온도와 시간의 변화에 의해 기공의 크기를 제어하였다. Li_2O 함량이 4 mole ratio일 때 16.85%로 가장 큰 기공율을 나타내었으며, 기공의 평균 직경은 약 0.2㎛였다. 열처리 온도와 시간이 증가함에 따라 기공의 크기도 증가하였고, 약 0.01∼0.2㎛까지 기공 크기의 제어가 가능하였다. The variations of pore size and porosity were examined with the Li_2O content from 0 to 8 mole ratio in the porous LiTi_2(PO_4)_3 glass-ceramics. After selection the optimum composition, pore size was controlled by phase separation time and temperature. The porosity was 16.85% and the mean pore diameter was about 0.2 ㎛ when the Li_2O content was 4 mole ratio. The pore size was extended by increasing the phase separation time and temperature. The pore size was able to be controlled from 0.01 to 0.2㎛.

황, 산소 및 질소 헤테르 고리화합물의 방향족 치환반응성에 관한 분자궤도론적 해석

朴柄珏,金鎬順,徐萬哲 嶺南大學校附設 基礎科學硏究所 1986 基礎科學硏究 Vol.6 No.-

The electrophilic substitution reascivities were invesitigated for sulphur-, oxygen-, and nitrogen-containing aromatic compounds by simple Huckel MO method, separatively. It was found that electrilic reactivity index, S??, for sulphur-containing aromatic compound was related in parallel with the experimental partial rate factor contant, σ+. The reactivities of each position are predicted for the same type of hetero compounds in which N or O atom is substituted for S atom on the basis of observed good parallelism between the S?? and the σ+ for the sulphur-containing aromatic compounds.

긴볼레기말의 항고지혈증 효과에 관한 연구 : Triton WR-1339 주사에 의한 고지혈증 유발 생쥐의 간세포내 지방 축적 감소를 중심으로 Based on the Decreasing Effect of Lipid Accumulation in Hepatocyte of Murine with Hyperlipidemia induced by Triton WR-1339

박인식,안상현,정재만,강윤호,이해풍,서귀문,홍용기,김호현,김진택 동국대학교 한의학연구소 1999 東國韓醫學硏究所論文集 Vol.7 No.2

본 연구는 긴볼레기말 추출물의 항고지혈증 효과를 조사하기 위해 ICR 생쥐에 TritonWR-1339(TX) 복강주사로 인위적인 고지혈증을 유발시킨 후 긴볼레기말 추출물(30㎎/㎏)를 복강주사하여 시간의 경과에 따른 간세포내에서의 지방 축적 변화를 조직화학적으로 관찰하였다. TX 주사후 그물구조의 세포질출 가진 간세포가 간엽 전체에서 관찰되었고, 일부 간소엽에서는 간세포 손상으로 인한 간세포판 소실이 나타났다. 또한 간세포내 지방축척도 증가하여 전체 간소엽의 간세포에서 지방의 과출현을 확인 할 수 있었고, 지방의 크기도 대조군에 비해 증가된 것으로 관찰되었다. 그러나 긴볼레기말 추출물 주사군에서는 그물구조의 세포질을 가진 간세포의 수가 TX 주사군에 비해 감소되었고, 대부분의 간소엽에서 정상적인 간세포판의 배열을 확인할 수 있었다. 간세포내의 지방 축적과 크기도 감소된 경향으로 관찰되었다. 이상의 결과로 볼 때 해조류 긴볼레기말 추출물은 고지혈증이 유발된 생쥐 간세포 내에서의 과도한 지방축적을 감소시키는 항고지혈증 효과를 하는 것으로 사료된다. Hepatic tissues of ICR mouse were intraperitoneally injeced with Colpomenia bullosa(CB) Extract after Triton WR-1339(TX) injection were observed to investigate the antihyperlipermic effect of CB extract for hyperlipidemic hepatic tissue caused by destruction of lipid metabolism. The hepatic tissues were obtained at hour-24, 48, and 72 after TX injection with CB extract treatment. And then these specimen were fixed in 10% neutral buffer solution and were cryocut. The tissue stained by H&E for general morphology and sudan black B for lipid distribution. The increase of hepatocyte having rneshlike cytoplasm were shown in all hepatic lobules after TX injection and the hepatic plates were disappeared in the region of meshlike hepatocyte aggregation, But the hepatocyte having meshlike cytoplasm were disappeared and hapatic plate were rearranged in CB extract injected mouse. The number of blue black colored lipid drop in hepatic cytoplasm of mouse injected with TX were increased and the size of lipid drop were enlarged. But the number of lipid drop in hepatic cytoplasm of mouse treated CB extract were decreased and the size of lipid drop were diminished. As results indicated that the accumulation of lipid drop caused by TX injection were mitigated by the antihyperlipidermic effect of CB extract.

철 환원법에 의한 엣칭용 염화철폐액 처리에서 볼밀에 의한 철의 재생

朴贊友,鄭又元,李萬浩,李尙昱 경북대학교 산업기술연구소 1996 産業技術硏究誌 Vol.24 No.-

We compared the regeneration effects of iron powders with ball-mill treatment at various conditions in the treatment of the waste FeCl_3 solution. And sludges formed during the reaction of Ni^2+ removal were analyzed with X - ray diffractometer and particle size analyzer.

제4형 가족성 고중성지방혈증 임산부에서 발생한 급성 췌장염 1례

박관응,윤채중,김영학,진영기,윤성호,권용은,김태원,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.2

Plasma levels of cholesterol (TC) and triglyceride(TG) physiologically increase during pregnancy. The lipid increment is 23-53% above the pregravidic level for TC and 2- to 3-fold of the prepregnancy level for TG. If the TC and TG are higher than normal values in pregnancy, the patient must be carefully monitored. Acute pancreatitis is the main consequence of hyperlipidemia and occurs either during pregnancy, in the third trimester, or in the puerperium. Mortality is high both for the mother (21%) and the fetus (20%). We report a case of 28 year-old pregnant woman at 29 weeks gestation with hypercholesterolemia (TC = 357 ㎎/dl) and severe hypertriglyceridemia (TG = 1300 ㎎/dl). The patient was admitted to the hospital because of severe epigastric pain, nausea and vomiting. Total serum cholesterol was increased and trigyleride was markedly increased. The electroporesis pattern of serum lipoprotein showed increase in pre-beta lipoprotein fraction, suggesting IV hypertriglyceridemia pattern. According to a review of the literature, the incidence of pancreatitis during pregnancy is 1 in 1000 to 3000 pregnancies. Severe hypertriglyceridemia in pregnancy should be treated with a careful restriction of calories and fat: for preventing acute pancreatitis, hospitalization for intravenous fluid therapy and plasma exchange must be required.