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- 저자 : Park Hyewon (검색결과 382 건)
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Deletion of the Serotonin Receptor Type 3A in Mice Leads to Sudden Cardiac Death During Pregnancy.
Park, Hyewon,Oh, Chang-Myung,Park, Junbeom,Park, Hyelim,Cui, Shanyu,Kim, Hyung Suk,Namkung, Jun,Park, Sang-Kyu,Pak, Hui-Nam,Lee, Moon-Hyoung,Kim, Hail,Joung, Boyoung Japanese Circulation Society 2015 CIRCULATION JOURNAL Vol.79 No.8
<P>The serotonin receptor type 3 (Htr3) blocker is associated with QT prolongation and torsades de pointes. However, little is known about effects of Htr3 on the heart arrhythmia.Methods?and?Results:An electrophysiological study Involving knock-out (KO) female mice lacking functional Htr3a (Htr3a(-/-)) and their wild-type littermates during non-pregancy (NP) and late pregnancy (LP) was performed. Htr3a mRNA was present in the wild-type, but not in theHtr3a(-/-)mouse hearts. Serotonin and tryptophan hydroxylase 1 (Tph1), a rate-limiting enzyme of serotonin synthesis in hearts, is increased during pregnancy. The heart weight and size were increased in the pregnant mice regardless of a mutation. The QTc intervals were prolonged after pregnancy in both the wild (NP: 171.216.8 vs. LP: 247.714.3 ms; P<0.001) andHtr3a(-/-)mice (NP: 187.918.7 vs. LP: 275.611.0 ms, P<0.001). Compared with wild-type LP mice,Htr3a(-/-)LP mice had increased spontaneous ventricle tarchycardia (VT; 56% vs. 0%, P=0.002), VT inducibility (66% vs. 25%, P=0.002) and mortality (56% vs. 0%, P=0.002). Pharmacologic administration of serotonin and Htr3 agonists (m-CPBG) decreased the QT interval in wild mice, but not inHtr3a(-/-)mice.</P>
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High Level of Real Urban Air Pollution Promotes Cardiac Arrhythmia in Healthy Mice
Hyewon Park,Sangchul Lim,Seunghoon Lee,문다솜,강지영,김효은,Hyelim Park,Changsoo Kim,Sunho Park,Yeong-Min Lim,Boyoung Joung 대한심장학회 2021 Korean Circulation Journal Vol.51 No.2
Background and Objectives: Ambient particulate matter (PM) in real urban air pollution (RUA) is an environmental health risk factor associated with increased cardiac events. This study investigated the threshold level to induce arrhythmia, as well as arrhythmogenic mechanism of RUA that mainly consisted of PM <2.5 μm in aerodynamic diameter close to ultrafine particles. Methods: RUA was artificially produced by a lately developed pyrolysis based RUA generator. C57BL/6 mice were divided into 4 groups: a control group (control, n=12) and three groups with exposure to RUA with the concentration of 200 µg/m3 (n=12), 400 µg/m3 (n=12), and 800 µg/m3 (n=12). Mice were exposed to RUA at each concentration for 8 hr/day and 5 day/week to mimic ordinary human activity during 3 weeks. Results: The QRS and QTc intervals, as well as intracellular Ca2+ duration, apicobasal action potential duration (APD) gradient, fibrosis, and inflammation of left ventricle of mouse hearts were increased dose-dependently with the increase of RUA concentration, and significantly increased at RUA concentration of 400 µg/m3 compared to control (all p<0.001). In mice exposed to RUA concentration of 800 µg/m3, spontaneous ventricular arrhythmia was observed in 42%, with significant increase of inflammatory markers, phosphorylated Ca2+/calmodulin-dependent protein kinase II (CaMKII), and phospholamban (PLB) compared to control. Conclusions: RUA could induce electrophysiological changes such as APD and QT prolongation, fibrosis, and inflammation dose-dependently, with significant increase of ventricular arrhythmia at the concentration of 400 µg/m3. RUA concentration of 800 µg/m3 increased phosphorylation of CaMKII and PLB.
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( Hyewon Hyewon Park ),( Jung Hee Yang ) 한국패션비즈니스학회 2012 패션 비즈니스 Vol.16 No.3
This study proposed a color scheme that is harmonious with the working environment of industrial sites using Birren`s color harmony theory for color planning. To apply the Birren`s color harmony theory to working clothes, the basic colors were chosen, and six of the eight harmony formulas of Birren excluding achromatic colors (white + grey + black) and solid color harmony (solid colors + white + black) were used to form a palette for each case. For the basic colors, the color chips of four dominant colors (yellow-green, sky-blue, blue, and violet), which were chosen from a field survey for preferences in the first step, and the production of materials in the second step were collected through the PANTONE color chips. The selected color chips were PANTONE 13-0550 TPX, PANTONE 15-4105 TPX, PANTONE 18-3949 TPX, and PANTONE 19-3720 TPX. These color chips were scanned and their RGB values were extracted through Photoshop CS. Then the colors were arranged in accordance with the Birren`s color harmony formulas (Color+Tint+White, Color+Shade+Black, Tint+Tone+Shade, Shade+Tone+Black, Shade+Tone+White, and Tint+Shade+Tone+Gray). In addition, the proposed palette color schemes were applied through Birren`s color harmony formulas using Texpro V 10.1 textile to the schematization of working clothes that were designed in the previous study. Palette formation in line with Birren`s color harmony formulas provided scientific color arrangement results. Visually presenting the color scheme of working clothes will help the color selection of working clothes in tune with the circumstances of industrial sites.
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( Sunji Park ),( Jaehee Lee ),( Ji Eun Park ),( Sun Ha Choi ),( Hyewon Seo ),( Seung Soo Yoo ),( Shin Yup Lee ),( Yu Kyung Kim ),( Seung Ick Cha ),( Jae Yong Park ),( Tae In Park ),( Chang Ho Kim ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background The cause of epithelioid granulomatous inflammation varies widely depending on the affected organ, geographic region, and whether the granulomas morphologically contain necrosis. Compared with other organs, the etiological distribution and morphological patterns of pleural epithelioid granulomas have rarely been investigated. We evaluated the final etiologies and morphological patterns of pleural epithelioid granulomatous inflammation in a country with an intermediate tuberculosis (TB) prevalence. Methods The cases who had granulomatous pleural histology on pleural biopsy, retrospectively were reviewed and their final etiologies were identified. Patient with tuberculous pleurisy (TB-P) were classified into 2 groups according to the presence or absence of microbiological evidence: confirmed and probable TB-P. The clinical, blood, radiological, pleural fluid, and histological data were collected and compared between the confirmed and probable TB-P groups and between the confirmed TB-P and non- TB-P groups. Results Of 83 patients with pleural granulomas, 50 (60.2%) had confirmed TB-P and 29 (34.9%) had probable TB-P. Four patients (4.8%) with non-TB-P were diagnosed. With the exception of microbiological Results, there was no significant difference in patient characteristics and granuloma patterns between the confirmed TB-P and non-TB-P groups, or between patients with confirmed and probable TB-Ps. Additionally, anti-TB treatment outcomes were not significantly different between the confirmed and probable TB-P groups. Conclusions These findings suggest that most pleural granulomatous inflammation (95.2%) was attributable to TB-P in a TB-endemic area and that the granuloma patterns contributed little to the prediction of final diagnosis compared with other organs. However, the clinician should make active effort to find microbiological evidence for differentiation between TB-P and non-TB-P.
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Hyeon Jin Park,Eun-Hye Park,Kyu-Won Jung,Hyun-Joo Kong,Young-Joo Won,Joo Young Lee,Joo Young Lee,Byung-Kiu Park,Hyewon Lee,Hyeon-Seok Eom,Sohee Park 대한혈액학회 2012 Blood Research Vol.47 No.1
Background The nationwide statistical analysis of hematologic malignancies in Korea has not been reported yet. Methods The Korea Central Cancer Registry and the Korean Society of Hematology jointly investigated domestic incidence rates and prevalence of hematologic malignancies occurred between 1999 and 2008, and analyzed survival rates of patients who were diagnosed between 1993 and 2008. Data of hematologic malignancies from 1993 to 2008 were obtained from the Korean National Cancer Incidence Data base. The crude incidence rates, age-specific incidence rates, age-standardized incidence rates, annual percentage change of incidence, and prevalence from 1999-2008 were calculated. Survival rates for patients diagnosed in 1993-2008 were estimated. Results In 2008, a total of 8,006 cases of hematologic malignancies were occurred, which comprised 4.5% of all malignancies. In all genders, non-Hodgkin lymphoma, myeloid leukemia, and multiple myeloma were most frequent diseases. In terms of age, ages between 60 and 69 were most prevalent. From 1999 to 2008, the age-standardized incidence rates increased from 10.2 to 13.7, and the annual percentage change was 3.9%. The 5-year survival rate increased from 38.2% during 1993-1995 to 55.2% during 2004-2008. As of January 2009, number of patients with 10-year prevalence was 33,130, and with 5- to 10-year prevalence was 10,515. Conclusion This is the first nationwide statistical report of hematologic malignancies in Korea. It could be used as the basic information to help investigate epidemiologic characteristics, evaluate progress during the past years, and establish future strategies for hematologic malignancies. Periodic statistical analysis of hematologic malignancies in Korea should be continued.
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Hyewon Lee,Jangwoon Park,Youngguen Choi,Kwangae Park,Moonjin Kim,Heecheon You 대한인간공학회 2013 대한인간공학회 학술대회논문집 Vol.2013 No.5
Objective: 본 연구는 인간공학적 버스 승객석 설계를 위해 기존 버스 승객석들에 대한 주관적 평가 및 형상 분석 결과를 바탕으로 신규 버스 승객석의 형상을 설계하는 방법을 제안하고자 한다. Background: 버스승객석의 형상은 승차자들의 체형에 적합하고 장시간 안락하게 착석할 수 있도록 인간공학적인 설계가 필요하다. Method: 인간공학적 버스 승객석 형상 설계 방법은 4단계(주관적 평가 실험, 버스 승객석의 3D 형상 분석, 선호 profile 특성 분석, 신규 승객석 설계) 절차로 구성된다. 주관적 평가 단계에서는 기존 12종 버스 승객석을 7개 설계 부위별(머리, 흉부, 요추, 등받이 측면, 엉덩이, 허벅지, 좌면 측면 지지부)로 크기 및 형태 측면에서 평가하였다. 3D 형상 분석 단계에서는 기 평가된 버스 승객석들의 3D profile 특성들을 설계 기준선들(centerline, seatback line, seatpan line)을 통해 정량적으로 분석하였다. 선호 profile 특성 분석 단계에서는 주관적 평가 결과를 바탕으로 버스 승객석의 설계 부위별 선호 profile 특성들을 파악하였다. 마지막으로 신규 승객석 설계 단계에서는 파악된 선호 profile 특성들을 조합하여 신규 버스 승객석 형상을 설계하였다. Application: 본 연구는 기존 버스 승객석의 3D 형상을 benchmarking하여 신규 승객석의 형상을 설계하는 방법을 개발하였다. 본 연구에서 제안된 버스 승객석 형상 분석 및 설계 방법은 다양한 인간공학적 시트 설계에 활용 가능할 것으로 기대된다.
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Analyses of physiological wrist tremor with increased muscle activity during bench press exercise
( Hyewon Son ),( Jisu Kim ),( Gyuseog Hong ),( Wonil Park ),( Sungjin Yoon ),( Kiwon Lim ),( Jonghoon Park ) 한국운동영양학회 2019 Physical Activity and Nutrition (Phys Act Nutr) Vol.23 No.1
[Purpose] To date, there have been no studies on the response of wrist tremor to increased muscle activity during exercise. This study aimed to evaluate the wrist tremor response with increasing muscle activity during bench press exercise. [Methods] Triceps muscle activity and wrist tremor response were measured by electromyography and an accelerometer, respectively, during bench press exercise in 11 healthy men without weight-training experience. Subjects performed bench press at 30% repetition maximum (RM), and the rating of perceived exertion (RPE) and lactate concentration were measured before and after exercise. One week later, an equivalent number of bench presses at 30% RM was performed without weight load as a control trial (CT). [Results] RPEs and lactate cincentrations significantly increased after resistance exercise (30% RM) from 7.4 to 14.3 and 1.7 to 4.9, respectively (P<.01), but no Such difference was observed in the CT. Muscle activity linearly increased during the 30% RM exercise, and wrist tremors were shown to linearly decrease. A strong negative correlation was observed between the two cariables (r=-0.88, P<.001) [Conclusion] We found that wrist tremors during resistance exercise, as measured using an accelerometer, can be used to predict muscle activity.
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