모 제약회사 근로자들의 직업성 천식 유병률과 약제 분말 노출수준

오성수,최용휴,김은아,이영목,장재길,유장진,박승현,김태균,정수영,김규상,강성규 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 제약회사에서 직업상 천식의 유병 규모를 파악하고 작업공정에 대한 작업환경 측정을 통해 제약회사의 약제 분말에 대한 노출수준을 평가하고자 하였다. 방법: 제약회사에서 약제 분말에 노출되는 근로자를 대상으로 천식을 선별하기 위하여 설문조사 및 진찰, 혈액검사, 폐기능 검사 그리고 피부단자시험을 실시하였고, 각 부서별 공정에 따라서 총분진과 항생제 또는 효소제 분말에 대한 작업환경 측정을 실시하였다. 직업상 천식이 의심되는 근로자에 대하여 기관지과민성에 대한 검사(메타콜린을 이용한 비특이 기관지유발시험)와 약제 분말 기관지유발시험을 실시하여 확진하였다. 결과: 설문조사 및 진찰에서 작업 관련 천식 증상이 있는 근로자는 11명(34.4%)이었고, 약제 분말을 이용한 피부단자시험에서 1+ 이상 반응을 보인 근로자 10명(31.2%)이었다. 비특이 기관지유발시험 결과 8명(25.0%)이 양성(PC20 ≤16 mg/ml)이었다. 약제 분말 기관지유발시험을 통해 직업상 천식으로 확진된 근로자는 5명(15.6%)이었다. 작업환경 측정에서 원료를 충진하거나 투입하는 작업 그리고 정립작업에서 약제 분말에 대한 노출이 많았다. 결론: 제약회사에서 직업상 천식은 주로 제조공정 중 약제 분말에 노출된 근로자에서 발생하여, 증상 및 직업성 천식의 유병률이 높았다. 따라서 원료를 충진 또는 투입하는 작업과 정립작업 등 제조과적에서 약제 분말 노출을 줄이기 위한 세심한 주의가 필요하여, 약제 분말을 취급하는 근로자에 대해서는 천식 증상 조사뿐 아니라 정기적으로 피부단자시험, 비특이 기관지유발시험 등을 실시하여야 할 것이다. Objectives: After the investigation of one worker with occupational asthma, we surveyed the preva- lence of occupational asthma and the exposure level of pharmaceutical dust of 32 workers in a pharmaceutical company. Methods: Thirty-two of the 90 employees participated in the survey which consisted of questionnaire, blood sampling, spirometry and skin prick tests with 8 common allergens as well as 9 antibiotics and 2 enzymes. Various indices of the working environment were also measured. Subjects who had a symptom suggestive of work-related asthma or positive skin prick test were further investigated by PC20 methacholine. Nine subjects who had a PC20 result of 16 mg/ml or less (n=7) or had work-related symptoms and positive skin prick test (n=2) were referred to undergo a specific bronchial provocation test to phar- maceutical dust in an academic allergic disease center. Results: Eleven of 32 workers (34.4%) had a work-related symptom suggestive of occupational asthma. Ten (31.2%) showed positive skin prick test. 8 (25.0%) had a PC20 result of 16 mg/ml or less (indicative of significant bronchial hyperresponsiveness), and 5 (15.6%) had a positive result on the specific bronchial provocation test. Exposure levels of stuffing, input of raw materials and screening process were relatively high. Conclusions: This survey showed that pharmaceutical workers have an increased risk of occupational asthma. Although pharmaceutical factories maintain a relatively good working environment, careful control of respiratory tract exposures, especially during stuffing, input or raw materials and screening process, is important to prevent occupational asthma. Pharmaceutical workers need to undergo regular skin prick and methacholine bronchial provocation tests, as well as asthmatic symptom survey, to ensure the early detection and prevention of occupational asthma.

PTFE 이식편을 이용한 대퇴동맥과 슬관절이하 동맥 우회로술의 결과 분석

문성민,손민수,이길연,이상목,고석환,홍성화,윤충,오수명,박호철 대한혈관외과학회 2004 Vascular Specialist International Vol.20 No.1

Crawford Ⅲ형과 Ⅳ형 흉복부 대동맥류 4예 보고

문성민,손민수,이길연,이상목,고석환,홍성화,윤충,오수명,박호철 대한혈관외과학회 2003 Vascular Specialist International Vol.19 No.2

Articles : Catalytic Reduction of NO over Perovskite-Type Catalysts

( Seong Soo Hong ),( Gun Dae Lee ),( Jong Won Park ),( Dae Won Park ),( Kyung Mok Cho ),( Kwang Jung Oh ) 한국화학공학회 1997 Korean Journal of Chemical Engineering Vol.14 No.6

In the present work, we have investigated the reduction of NO by propane over perovskite-type oxides prepared by malic acid method. The catalysts were modified to enhance the activity by substitution of metal into A or B site of perovskite oxides. In addition, the reaction conditions, such as temperature, O₂concentration, and space velocity have been varied to understand their effects on the catalytic performance. In the LaCoO₃type catalyst, the partial substitution of Ba and Sr into A site enhanced the catalytic activity in the reduction of NO. For the La_(0.6_Ba(Sr)_(0.4) Co_(1-x)Fe_xO₃(x=0-1.0) catalyst, the partial substitution of Fe into B site enhanced the conversion of NO, but excess amount of Fe decreased the conversion of NO. The surface area and catalytic activity of perovskite catalysts prepared by malic acid method showed higher values than those of solid reaction method. The conversion of NO increased with increasing O₂concentration and contact time. The introduction of water into reactant feed decreased the catalytic activity but the deactivation was shown to be reversible over La_(0.6)Ba_(0.4) Co_(1-x)Fe_xO₃catalyst.

Distribution of S-alleles among Korean Apples by PCR and Cross-pollination

Seong Heo,Soon-Il Kwon,Jeong-Hwan Hwang,Yong-Uk Shin,Mok-Jong Kim,Bong Ju Park,Sung-Il Oh,Young-Jae Oh,Daeil Kim 한국원예학회 2012 원예과학기술지 Vol.30 No.6

To acquaint correct information about the fertilizability and analyze S-allele based genetic diversity among Korean apples, we investigated self-incompatibility genotypes by PCR and cross-pollination tests in field. As a consequence, S-genotypes of Korean apples were distributed within narrow genetic diversity as S1S3 for ‘Hongro’ and ‘Saenara’; S1S9 for ‘Gamhong’ and ‘Manbok’; S3S5 for ‘Seokwang’; S3S9 for ‘Sunhong’, ‘Seohong’, ‘Chukwang’, and ‘Hwahong’. Coupled with cross-pollination experiments in field, our results provide support for the view that apples are fully compatible when both of their S-loci differ and semi-compatible when they carry one different and one identical S-locus. Furthermore, the results of this study indicate that S-alleles have to be extended to various genotypes for Korean apple breeding.

A Computational Study on the Onset of Oblique Shock-Induced Vortex Breakdown

Seong Mok Moon,Oh Hyun Rho 대한기계학회 1998 KSME/JSME THERMAL and FLUID Engineering Conference Vol.1 No.1

흰쥐의 허리척수분절에서 Vanilloid receptor 1 양성 일차감각 신경섬유의 해부학적 특성에 관한 연구

김성목(Seong Mok Kim),오정민(Jung Min Oh),Juli G. Valtschanoff, 백두진(Doo Jin Baik),황세진(Se Jin Hwang) 대한해부학회 2004 Anatomy & Cell Biology Vol.37 No.3

Capsaicin의 특이적 수용체로서 포유동물의 말초신경에서 capsaicin, 열감각 및 수소이온의 자극에 따른 감각을 수용하는 vanilloid receptor 1 (VR1)는 척수신경절에서 합성되어 말초신경뿐만 아니라 척수로도 이동된다. 본 연구자는 흰쥐의 하부 허리분절 및 상부 엉치척수(L4~S1)에서 VR1의 면역반응과 함께 연접이전부위의 표지물질 및 다양한 일차감각신경의 신경해부학적 표지물질들과 다중면역염색법을 실시하여 VR1양성 일차감각 신경종말의 분류 및 감각 신경종말내 분포양상을 연구하였다. VR1 양성 신경섬유 및 종말은 Rexed lamina I 및 II에서 관찰되었다. L4~L5분절에서 lamina I에 존재하는 VR1 양성민말이집 섬유말단은 소수의 CGRP 및 substance P 양성 신경종말과 공존하였으며 일부종말은 궁둥신경으로부터 주입, 추적된 choleratoxin-B subunit 양성 말이집 섬유종말과도 공존하였고, lamina II에서는 주로 isolectin B4 (IB4)와 공존하였다. 또한 lamina I의 VR1 양성 신경종말은 neurokinin I (NK1) 및 glutatmate 수용체 양성 신경세포 및 가지돌기와 연접을 이루고 있었다. L6~S1분절에서 VR1 양성 신경종말은 뒤가쪽로에 특히 밀집되어 있었으며, lamina I-V 및 내장감각신경의 경로인 medial collateral path (MCP) 및 lateral collateral path (LCP)에서도 관찰되었다. VR1과 substance P는 뒤가쪽로와 LCP의 대부분의 신경섬유와 종말에서 공존하였다. 이상의 소견을 종합할 때 VR1 양성 일차감각 신경섬유는 IB4 양성 및 펩타이드성 일차감각 신경섬유와 부분적으로 중복되는 신경섬유로, 몸통 및 내장성 감각을 전달하는 펩타이드 및 비 펩타이드성 종말을 지니며, 특히 내장감각의 전달에 펩타이드성 VR1 양성 신경종말이 관여하는 것으로 판단된다. Primary afferents sensitive to capsaicin and noxious heat express vanilloid receptor 1(VR1) in both their peripheral and central fibers and terminals. We used multiple immunofluorescence and confocal microscopy to characterize their pattern of termination in rat spinal cord, colocalization of neurochemical markers of primary afferents and other presynaptic receptors. VR1-positive unmyelinated fibers mainly terminate in lamina I, where they co-stain for CGRP, and to a limited extent for SP, and in lamina II, especially its medial half, where they co-stain for IB4. VR1 positive thin myelinated fibers terminate in lamina I and co-stain for the neurochemical tracer CTB, injected in the sciatic nerve. As revealed by simultaneous staining for the synaptic marker synaptophysin, VR1-positive terminals are abundant in lamina I and sparse in lamina II. In L6-S1 spinal cord, VR1-positive fibers and terminals were abundant in Lissauer’s tract, lamina I-V, medial collateral path to lamina X, and lateral collateral path to sacral parasympathetic nucleus. Most of VR1 positive fibers in Lissuer’s tract and LCP are colocalized with SP. In conclusion, it is suggested that VR1 positive fibers in spinal cord are both peptidergic and non-peptidergic, IB4 positive fibers, mediating both somatic and visceral sensations, and that peptidergic VR1 positive fibers are mainly related with visceral sense.

성인염 치주염 치료시 Doxycycline 경구투여의 효과에 관한 임상 및 미생물학적 연구

오목훈(Mok-Hoon Oh),정종평(Choong-Pyoung Chung),손성희(Seong-Heui Son),한수부(Soo-Boo Han),최상묵(Sang-Mook Choi) 大韓微生物學會 1992 大韓微生物學會誌 Vol.27 No.5

경사충격파와 와류간의 상호작용에 관한 수치적 연구

문성목(Seong-Mok Moon),김종암(Chongam Kim),노오현(Oh-Hyun Rho),홍승규(Seung Kyu Hong) 한국항공우주학회 2004 韓國航空宇宙學會誌 Vol.32 No.8

경사충격파와 와류간의 상호작용에 관한 수치적 해석은 경사충격파에 기인한 와류붕괴의 발생에 관한 이론적 모델 및 실험치와 비교하기 위해 수행되었다. 본 연구의 해석을 위해 마하수에 기초한 Roe의 기법 (RoeM)과 2-방정식 난류 모델을 이용하여 3차원 난류 유동장을 효과적으로 계산하였다. 자유류 마하수 2.49에서 와류세기, 축방향속도 성분, 충격파 세 기의 변화에 따른 상호작용의 영향을 연구하였다. 2 방정식 난류모델인 k- ωSST 난류모델과 적절히 모델링된 와류모델을 이용하여 수치연구를 수행함으로써 실험적으로 관찰된 여러 유동장을 정확히 모사할 수 있었다. 경사충격파에 기인한 와류붕괴의 발생에 관한 기준을 결정하기 위한 본 연구결과는 이론적 모델과 실험치와 일치된 결과를 보여주고 있음을 확인하였다. For the prediction on the onset of oblique shock wave-induced vortex breakdown, computational studies on the Oblique Shock wave/Vortex Interaction (OSVI) are conducted and compared with both experimental results and analytic model. A Shock-stable numerical scheme, the Roe scheme with Mach number-based function (RoeM), and a two-equation eddy viscosity-transport approach are used for three-dimensional turbulent flow computations. The computational configuration is identical to available experiment, and we attempt to ascertain the effect of parameters such as a vortex strength, stream wise velocity deficit, and shock strength at a freestream Mach number of 2.49. Numerical simulations using the k- ωSST turbulence model and suitably modeled vortex profiles are able to accurately reproduce many fine features through a direct comparison with experimental observations. The present computational approach to determine the criterion on the onset of oblique shock wave-induced vortex breakdown is found to be in good agreement with both the experimental result and the analytic prediction.

Impacts of Asthma in Patients With Bronchiectasis: Findings From the KMBARC Registry

Moon Seong Mi,Choi Hayoung,Kang Hyung Koo,Lee Sei Won,Sim Yun Su,Park Hye Yun,Kwon Yong-Soo,Kim Sang-Heon,Oh Yeon-Mok,Lee Hyun 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.1

Purpose: Although the coexistence of asthma and bronchiectasis is common, the impacts of asthma on bronchiectastic patients (BE) have not been well evaluated because this issue using bronchiectasis cohorts has been investigated in only a few studies. Methods: In the present study, 598 patients who were prospectively enrolled in the Korean bronchiectasis registry were evaluated. The clinical characteristics between BE with asthma and those without asthma were compared. Results: Asthma was found in 22.4% of BE. BE with asthma had a higher body mass index (BMI) (P = 0.020), more dyspnea (P < 0.001), larger sputum volume (P = 0.015), and lower forced expiratory volume in 1 second (FEV1) (P < 0.001) than those without asthma. BE with asthma had a higher rate of previous pneumonia (P = 0.017) or measles (P = 0.037) than those without asthma. Regarding treatment, BE with asthma used inhaled corticosteroids, long-acting muscarinic antagonists, and leukotriene receptor antagonists more frequently than those without asthma. Although intergroup differences were not observed in disease severity of bronchiectasis (P = 0.230 for Bronchiectasis Severity Index and P = 0.089 for FACED), the Bronchiectasis Health Questionnaire (BHQ) scores indicating the quality of life, were significantly lower in BE with asthma than in those without asthma (61.6 vs. 64.8, P < 0.001). In a multivariable model adjusting for age, sex, body mass index, forced expiratory volume in 1 second %predicted, sputum volume, modified Medical Research Council dyspnea scale ≥ 2, and the number of involved lobes, asthma was associated with lower BHQ scores (β-coefficient = −2.579, P = 0.014). Conclusions: BE with asthma have more respiratory symptoms, worse lung function, and poorer quality of life than those without asthma. A better understanding of the impacts of asthma in BE will guide appropriate management in this population.