우리나라 일부 광물중 석면섬유의 함유에 대한 조사

백도명,최정근,백남원,Hisanaga, Naomi,Sakai, Kiyoshi 한국산업위생학회 1998 한국산업보건학회지 Vol.8 No.2

A worker employed in a serpentine mine was found developed mesothelioma as the first case of Korea in 1997. Asbestos was known as a causative agent for mesothelioma. Thus, asbestos contamination in mines could be a big health threat to those workers who were unknowingly exposed. However, there was no report that any minerals found in Korea contained asbestos. This study was carried out to find the presence of any asbestiform fibers in minerals which could be obtained in Korean mines. We examined fifteen minerals from 44 mines which were suspected contaminated with asbestiform fibers. Asbestiform analysis was done with high resolution transmission electron microscope(TEM), with energy dispersive X-ray spectroscope(EDX) and X-ray diffraction(XRD) analyses. Among asbestiform fibers, chrysotile was found in chrysotile, serpentine, talc and pyrophylite specimens from 11 mines. Tremolite was found in tremolite and talc specimens from three mines. Mordenite was found in zeolite specimens from two mines. Wallastonite and sepiolite were found in wallastonite and sepiolite specimens respectively. Crocidolite, antigorite and actinolite were found from talc specimens. But no asbestiform fiber contaminants were found in doromite, vermiculite, limestone, marble, gypsum, kaolin, and clary specimens. Thus, these asbestiform fibers such as such as chrysotile, tremolite, mordenite, crocidolite, antigorite and actinolite could be the responsible agents for the health hazards such as mesothelioma and other cancers.

Comparison of Lung Asbestos Fiber Content in Cancer Subjects with Healthy Individuals with no Known History of Occupational Asbestos Exposure in Korea

Han, Jeong Hee,Park, Jung Duck,Sakai, Kiyoshi,Hisanaga, Naomi,Chang, Hee Kyung,Lee, Yong Hwan,Kwon, Il Hoon,Choi, Byung Sun,Chung, Yong Hyun,Kim, Hyeon Yeong,Yang, Jung Sun,Cho, Myung Haing,Yu, Il Je Informa UK (TaylorFrancis) 2009 Journal of toxicology and environmental health. Pa Vol.72 No.21

<P>To evaluate the effects of environmental asbestos exposure on the inducement of lung cancer, pulmonary asbestos and non-asbestos fiber content was determined in 36 normal Korean subjects and 38 lung cancer subjects with no known occupational history of asbestos exposure. Pulmonary asbestos fiber content was measured by transmission electron microscopy (TEM) with energy-dispersive x-ray analysis after applying a low-temperature ashing procedure. Chrysotile fibers were the major fiber type found in the lungs of the Korean subjects. The asbestos fiber concentrations found in the lungs of normal males (25) and females (11) were 0.26 x 10(6) fibers/g of dry lung tissue and 0.16 x 10(6) fibers/g of dry lung tissue, respectively. The asbestos concentrations found in the lungs of cancer subjects were 0.16 x 10(6) fibers/g of dry lung tissue for 32 males and 0.44 x 10(6) fibers/g of dry lung tissue for 6 females. No statistical difference was found in pulmonary asbestos content between the normal and lung cancer subjects, whereas a statistical difference was noted between normal and lung cancer subjects with respect to lung non-asbestos content, indicating a potential role for non-asbestos fibers being associated with lung cancer.</P>

Case Report of Asbestosis

Yong Hwan Lee,Hee Kyung Chung,Kiyoshi Sakai,Naomi Hisanaga,Young Hyun Chung,Jeong Hee Han,Li Je Yu 한국독성학회 2001 Toxicological Research Vol.17 No.3

A patient, 58 years of age, with suspected 0/1 pneumoconiosis since 1993, complained of a dry cough and exertioning dyspnea for 6 months. He had worked in an asbestos company for more than 20 years from 1974. He was subsequently diagnosed with an interstitial lung disease during an annual special health check-up for asbestos workers. A chest X-ray showed an interstitial lung disease and high-resolution computed tomography (HRCT) showed a round opaque asbestosis with chronic hypersensitivity pneumonitis. A pulmonary function test indicated that the patient had a mild restrictive lung disease with FEVI 1.67 liters and 82% FEVI/FVC. The bronchoalveloar larvage fluid included many asbestos bodies, indicating previous exposure to asbestos. Transmission electron microscopy (TEM) using an energy dispersive X-ray analyzer (EDX) revealed many asbestos bodies consisting of mainly crocidolite fibers (6,071×10^6 fibers/g of dry lung). The patient had an unusually high asbestos content of 6,112×10^6 asbestos fibers/g of dry lung.

Case Report of Asbestos Exposure-Related Lung Carcinoma

Hee Kyung Chang,Yong Hwan Lee,Kiyoshi Sakai,Naomi Hisanaga,Yong Hyun Chung,Jeong Hee Han,Il Je Yu 한국독성학회 2002 Toxicological Research Vol.18 No.1

A 61 year-old female patient was hospitalized for lung cancer. Her occupational history indicated that she had worked for an asbestos company for 9 years from 1976. The histopathology of the lung revealed malignant bronchioalveolar adenocarcima (stage Ⅲ) in the lower-left lobe, and a lung sample was found to contain an unusually high level of asbestos, 218.9×10^6 asbestos fibers/g of dry lung tissue. The majority of asbestos fibers found was chrysotile, yet no asbestos body was detected. When compared with Korean male (0.3×10^6 fibers/g of dry lung tissue) and female subjects (0.15×10^6 fibers/g of dry lung tissue) with no known history of occupational asbestos exposure, the apparent cause of the lung cancer in the current patient was occupational exposure to asbestos.

A CASE STUDY OF ASBESTOSIS

정용현,Hee Kyung Chang,Yong Hwan Lee,Kiyoshi Sakai,Naomi Hisanaga,Jeong Hee Han,Yong Mook Lee,Ho Keung Chung,Il Je Yu 환경독성보건학회 1999 한국독성학회 심포지움 및 학술발표회 Vol.- No.-

포항지역 부검 폐조직에서 석면과 비석면 섬유농도에 관한 연구

임현술,김동훈,사카이 기요시,히사나가 나오미,김지용,Lim, Hyun-Sul,Kim, Dong-Hoon,Sakai, Kiyoshi,Hisanaga, Naomi,Kim, Ji-Yong 대한예방의학회 2000 Journal of Preventive Medicine and Public Health Vol.33 No.4

Objectives : To obtain reference values for the pulmonary asbestos and non-asbestos fiber contents of residents in Korea and to compare them with similar results from Japan. Methods : The autopsied lung specimens from 22 deceased people (20 males and 2 females) in Pohang, without any known occupational history of asbestos exposure, were analyzed for incidence of asbestos and non-asbestos fibers by transmission electron microscopy with energy dispersive X-ray analysis after using low temperature ashing procedures. Results : Chrysotite fiber (46.2%) was the major fiber type found in the lungs of the subjects. The asbestos fiber concentrations found in males and females were $0.09\times10^6$ fiberss(g of dry lungs) and $0.30\times10^6$ fibers/(g of dry lungs), respectively, showing a geometric mean concentration $0.09\times10^6$ fibers/(g of dry lung tissue), due to the predominance of males in the sample. The non-asbestos fiber contents in males and females were $4.61\times10^6$ fibers/(g of dry lungs) and $17.79\times10^6$ fibers/(g of dry lungs), respectively, with a geometric mean concentration $5.21\times10^6$ fibers/(g of dry lung tissue). Conclusions : Residents in Pohang had significantly lower levels of both asbestos and non-asbestos fibers than urban residents in Korea. Furthermore, Koreans had significantly lower levels of both asbestos and non-asbestos fibers than Japanese.

Risk Assessment of Baby Powder Exposure through Inhalation

Min Chaul Moon,Jung Duck Park,Byung Soon Choi,So Young Park,Dong Won Kim,Yong Hyun Chung,Naomi Hisanaga,Il Je Yu 한국독성학회 2011 Toxicological Research Vol.27 No.3

This study was conducted to assess the exposure risk through inhalation to baby powder for babies and adults under simulated conditions. Baby powder was applied to a baby doll and the amount of baby powder consumed per application was estimated. The airborne exposure to baby powder during application was then evaluated by sampling the airborne baby powder near the breathing zones of both the baby doll and the person applying the powder (the applicator). The average amount of baby powder consumed was 100 ㎎/application, and the average exposure concentration of airborne baby powder for the applicator and baby doll was 0.00527 ㎎/㎥ (range 0.00157~0.01579 ㎎/㎥) and 0.02207 ㎎/㎥ (range 0.00780~0.04173 ㎎/㎥), respectively. When compared with the Occupational Exposure Limit of 2 ㎎/㎥ set by the Korean Ministry of Labor and the Threshold Limit Value (TLV) of 2 ㎎/㎥ set by the ACGIH (American Conference of Governmental Industrial Hygienists), the exposure concentrations were much lower. Next, the exposure to asbestos-containing baby powder was estimated and the exposure risk was assessed based on the lung asbestos contents in normal humans. As a result, the estimated lung asbestos content resulting from exposure to asbestos-containing baby powder was found to be much lower than that of a normal Korean with no asbestos-related occupational history.

Risk Assessment of Baby Powder Exposure through Inhalation

Moon, Min-Chaul,Park, Jung-Duck,Choi, Byung-Soon,Park, So-Young,Kim, Dong-Won,Chung, Yong-Hyun,Hisanaga, Naomi,Yu, Il-Je Korean Society of ToxicologyKorea Environmental Mu 2011 Toxicological Research Vol.28 No.3

This study was conducted to assess the exposure risk through inhalation to baby powder for babies and adults under simulated conditions. Baby powder was applied to a baby doll and the amount of baby powder consumed per application was estimated. The airborne exposure to baby powder during application was then evaluated by sampling the airborne baby powder near the breathing zones of both the baby doll and the person applying the powder (the applicator). The average amount of baby powder consumed was 100 mg/application, and the average exposure concentration of airborne baby powder for the applicator and baby doll was 0.00527 mg/$m^3$ (range 0.00157~0.01579 mg/$m^3$) and 0.02207 mg/$m^3$ (range 0.00780~0.04173 mg/$m^3$), respectively. When compared with the Occupational Exposure Limit of 2 mg/$m^3$ set by the Korean Ministry of Labor and the Threshold Limit Value (TLV) of 2 mg/$m^3$ set by the ACGIH (American Conference of Governmental Industrial Hygienists), the exposure concentrations were much lower. Next, the exposure to asbestos-containing baby powder was estimated and the exposure risk was assessed based on the lung asbestos contents in normal humans. As a result, the estimated lung asbestos content resulting from exposure to asbestos-containing baby powder was found to be much lower than that of a normal Korean with no asbestos-related occupational history.