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Chlorophenol 化合物과 N-nitrosodimethylamine 同時投與가 흰쥐에 미치는 細胞 遺傳毒性에 關한 硏究
羅悳烈,車喆煥,裵恩相 고려대학교 의과대학 1992 고려대 의대 잡지 Vol.29 No.3
The male ICR were divided into three groups in order to investigate the genotoxicological effects of various chlorophenol compounds in combination with N-nitrosodimethylamine. The first group was the control group and only com oil was adminitered. In the second group the chlorophenol compounds, 2-chlorophenol, 2.4-dichlorophenol. 2.4.6-trichlorophenol and pentachlorophenol were administered alone. The mice were intraperitoneally injected with single doses varying from 50% to 6.25% of LD50 in each group. In the third group, the same procedure was taken and dosage was repeated with an addition of 30mg/kg N-nitrosodimethylamine. Twenty four hours later, the mouse thighbones were removed for microuncleus test. Among the 1,000 of PCE in bone marrow cells the MNPCE was counted and the PCE/NCE ratio were evaluated. The results were as follows: 1) For the second group, the results differed slightly between various compounds : 2-chlorophenol was negative for all the varying doses on the micronucleus test. When the dosage was 50% of LD50, the PCE/NCE ratio in comparison with the control group was remarkably reduced. 2.4-dichlorophenol also tested negative and the PCE/NCE ratio was reduced. But the differences were not statisticaly significant. 2) 2.4.6-trichlorophenol and pentachlorophenol both tested positive when the LD50 was injected. And thd PCE/NCE ratio for pentachlorophenol was particularly reduced when 50% or 25% of the LD50 was injected. 3) In the third group 2-chlorophenol and 2.4-dichlorophenol reacted with an increase of micronuclei only when the LD50 was 50%. Again the PCE/NCE ratio was reduced and 2.4.6-tri-and pentachlorophenol reacted to all levels of dosage with an additive effect, and the increase of micronuclei was particularly remarkable at 50% fo LD50. Pentachlorophenol, at all levels of dosage, showed a reduced PCE/NCE ratio. In conclusion, the chlorophenol, when raised to 50% of LD50 and administered with N-Nitrosodimethylamine, generally showed an increase of micronuclei.
Hyun Kyung Park,Duk Lyul Na,Jae Hong Lee,김종원,기창석 대한의학회 2008 Journal of Korean medical science Vol.23 No.2
Although mutations in three genes, amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2), have been identified as genetic causes of earlyonset Alzheimer s disease (EOAD), there has been a single report on a PSEN1 mutation in Koreans. In the present study, we performed a genetic analysis of six Korean patients with EOAD. Direct sequencing analysis of the APP, PSEN1 and PSEN2 genes revealed two different mutations of the PSEN1 gene (G206S and M233T) and one mutation of the APP gene (V715M) in three patients with age-atonset of 34, 35, and 42 yr, respectively. In addition, two patients with age-at-onset of 55 and 62 yr, respectively, were homozygous for APOE 4 allele. One woman had no genetic alterations. These findings suggest that PSEN1 and APP gene mutations may not be uncommon in Korean patients with EOAD and that genetic analysis should be provided to EOAD patients not only for the identification of their genetic causes but also for the appropriate genetic counseling.
Jung Young Hee,Park Seongbeom,Lee Na Kyung,Han Hyun Jeong,Jang Hyemin,Kim Hee Jin,Seo Sang Won,Na Duk Lyul 대한치매학회 2023 Dementia and Neurocognitive Disorders Vol.22 No.1
Background and Purpose: We investigated the correlation between the deep distribution of white matter hyperintensity (WMH) (dWMH: WMH in deep and corticomedullary areas, with minimal periventricular WMH) and a positive agitated saline contrast echocardiography result. Methods: We retrospectively recruited participants with comprehensive dementia evaluations, an agitated saline study, and brain imaging. The participants were classified into two groups according to WMH-distributions: dWMH and dpWMH (mainly periventricular WMH with or without deep WMH.) We hypothesized that dWMH is more likely associated with embolism, whereas dpWMH is associated with small-vessel diseases. We compared the clinical characteristics, WMH-distributions, and positive rate of agitated saline studies between the two groups. Results: Among 90 participants, 27 and 12 met the dWMH and dpWMH criteria, respectively. The dWMH-group was younger (62.2±7.5 vs. 78.9±7.3, p<0.001) and had a lower prevalence of hypertension (29.6% vs. 75%, p=0.008), diabetes mellitus (3.7% vs. 25%, p=0.043), and hyperlipidemia (33.3% vs. 83.3%, p=0.043) than the dpWMH-group. Regarding deep white matter lesions, the number of small lesions (<3 mm) was higher in the dWMH-group(10.9±9.7) than in the dpWMH-group (3.1±6.4) (p=0.008), and WMH was predominantly distributed in the border-zones and corticomedullary areas. Most importantly, the positive agitated saline study rate was higher in the dWMH-group than in the dpWMH-group (81.5% vs. 33.3%, p=0.003). Conclusions: The dWMH-group with younger participants had fewer cardiovascular risk factors, showed more border-zone-distributions, and had a higher agitated saline test positivity rate than the dpWMH-group, indicating that corticomedullary or deep WMH-distribution with minimal periventricular WMH suggests embolic etiologies.