Petrogenesis of the late Mesozoic highly fractionated I-type granites in the Luanchuan district: implications for the tectono-magmatic evolution of eastern Qinling

Yunhui Zhang,Huawen Cao,Mo Xu,Shouting Zhang,Li Tang,Shiyan Wang,Qiuming Pei,Guojun Cai,Tong Shen 한국지질과학협의회 2018 Geosciences Journal Vol.22 No.2

Late Mesozoic granites are extensively distributed in the Luanchuan district of eastern Qinling and can be divided into two types: Late Jurassic to Early Cretaceous granites (ore-related plutons) and Late Cretaceous granites (Laojunshan batholith). This study presents new geochemical and zircon U-Pb-Hf isotopic data from the Shibaogou and Yuku plutons to provide robust constraints on the petrogenesis and tectonic significance of the late Mesozoic granites in the Luanchuan district. Zircon U-Pb dating results yielded weighted mean 206Pb/238U ages of 149.1 ± 0.8 Ma and 150.5 ± 0.8 Ma, which were interpreted as the crystallization ages of the Shibaogou and Yuku plutons, respectively. We propose that the late Mesozoic granites contain high concentrations of SiO2 and alkali elements (Na2O + K2O) and feature metaluminous to weakly peraluminous characteristics. Enrichment in light rare earth elements and large ion lithophile elements and depletion in high field strength elements are observed. Mineralogical and geochemical evidence reveal that the late Mesozoic granites are highly fractionated I-type granites with fractional crystallization of feldspar, plagioclase and accessory minerals (e.g., apatite and titanite or magnetite). Based on the Hf composition, we suggest that the parental magmas of the ore-related plutons were derived from remelting of the Taihua and Xiong’er groups with minor contributions of mantle-derived materials and that the Laojunshan batholith was generated by the hybridization of ancient crust- (Kuanping group) and mantle-derived components. Collectively, the above arguments indicates a tectonic transition from compression to post-collisional extension during the late Mesozoic, that was likely triggered by the continental collision of the North China Block and the Yangtze Block, which generated numerous contemporaneous granites and Mo-W-Pb-Zn-Ag-Au poly-metallic deposits.

Larvicidal Activity of Cnidium monnieri Seed Constituents and Four Structurally Related Compounds to Insecticide-Susceptible and -Resistant Culex pipiens pallens

Zhangqian Wang,Jun-Ran Kim,Mo Wang,Young-Joon Ahn 한국응용곤충학회 2011 한국응용곤충학회 학술대회논문집 Vol.2011 No.05

The toxicity of imperatorin (1) and osthol (2) identified in Cnidium monnieri seed and four structurally related compounds to third instar larvae of insecticidesusceptible (KS-CP strain) and field-collected (DJ-CP colony) of Culex pipiens pallens was examined. Results were compared with those of to conventional mosquito larvicide, fenitrothion and temephos. Based on 24-h LC50 values, imperatorin was 1.9, 3.7, 4.2, 12.4, and 15.1 times more toxic than isopimpinellin, isoimperatorin, osthole, xanthotoxin, and bergapten against KS-CP larvae, respectively. Overall, these compounds were less toxic than either fenitrothion or temephos. However, these compounds did not differ in toxicity against larvae from the two Culex strains, even though the DJ-CP larvae exhibited high levels of resistance α-cypermethrin, deltamethrin, chlorpyrifos, fenthion, and chlorfenapyr (resistance ratio, 94-1179). This finding indicates that the isolated compounds and the pyrethroid, organophosphorus, and pyrrole insecticides do not share a common mode of action or elicit cross-resistance.

The effect of Zn(2+) on Pelodiscus sinensis creatine kinase: unfolding and aggregation studies.

Wang, Su-Fang,Lee, Jinhyuk,Wang, Wei,Si, Yue-Xiu,Li, Caiyan,Kim, Tae-Rae,Yang, Jun-Mo,Yin, Shang-Jun,Qian, Guo-Ying Adenine Press 2013 Journal of biomolecular structure & dynamics Vol.31 No.6

<P>We studied the effects of Zn(2+) on creatine kinase from the Chinese soft-shelled turtle, Pelodiscus sinensis (PSCK). Zn(2+) inactivated the activity of PSCK (IC(50)?=?.079??.004?mM) following first-order kinetics consistent with multiple phases. The spectrofluorimetry results showed that Zn(2+) induced significant tertiary structural changes of PSCK with exposure to hydrophobic surfaces and that Zn(2+) directly induced PSCK aggregation. The addition of osmolytes such as glycine, proline, and liquaemin successfully blocked PSCK aggregation, recovering the conformation and activity of PSCK. We measured the ORF gene sequence of PSCK by rapid amplification of cDNA end and simulated the 3D structure of PSCK. The results of molecular dynamics simulations showed that eight Zn(2+) bind to PSCK and one Zn(2+) is predicted to bind in a plausible active site of creatine and ATP. The interaction of Zn(2+) with the active site could mostly block the activity of PSCK. Our study provides important insight into the action of Zn(2+) on PSCK as well as more insights into the PSCK folding and ligand-binding mechanisms, which could provide important insight into the metabolic enzymes of P. sinensis.</P>

Comprehensive analysis of TCR repertoire of COVID-19 patients in different infected stage

Wang Guangyu,Wang Yongsi,Jiang Shaofeng,Fan Wentao,Mo Chune,Gong Weiwei,Chen Hui,He Dan,Huang Jinqing,Ou Minglin,Hou Xianliang 한국유전학회 2022 Genes & Genomics Vol.44 No.7

Background: The current pandemic of coronavirus disease 2019 (COVID-19), transmitted person-to-person by the severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2), poses a threat to global public health. Objective: In this study, we performed the comprehensive analysis of the T cell receptor (TCR) repertoire may contribute to a more in-depth understanding of the pathogenesis of COVID-19. Methods: A comprehensive immunological analysis was performed to explore the features of the TCR repertoire and identified TCR sequences correlated with SARS-CoV-2 viral antigens. Results: we analyzed the COVID-19 patients' TCR repertoires in peripheral blood mononuclear cells (PBMC) which obtained before (baseline), during (acute), and after rehabilitation (convalescent) by ImmunoSEQ-technology, and found that repertoire features of TCRβ-chain (TCRβ) complementary-determining region 3 (CDR3) in COVID-19 patients were remarkable difference, including decreased TCR diversity, abnormal CDR3 length, difference of TRBV/J gene usage and higher TCR sequence overlap. Besides, we identified some COVID-19 disease-associated TCRβ clones, and the abundance of them changed with the progression of the disease. Importantly, these disease-associated TCRβ clones could be used to distinguish COVID-19 patients from healthy controls with high accuracy. Conclusions: We provide a clear understanding of the TCR repertoire of COVID-19 patients, which lays the foundation for better diagnosis and treatment of COVID-19 patients.

Study on the Black Phenotype Mutants of Adult and Pupa of Helicoverpa armigera

Mo Wang,Jianhong Li,Weihua Ma,Lizhen Chen 한국응용곤충학회 2005 한국응용곤충학회 학술대회논문집 Vol.2005 No.05

Larvicidal activity of <i>Cnidium monnieri</i> fruit coumarins and structurally related compounds against insecticide‐susceptible and insecticide‐resistant <i>Culex pipiens pallens</i> and <i>Aedes aegypti</i>

Wang, Zhangqian,Kim, Jun‐,Ran,Wang, Mo,Shu, Shaohua,Ahn, Young‐,Joon John Wiley Sons, Ltd. 2012 Pest Management Science Vol.68 No.7

<P><B>Abstract</B></P><P><B>BACKGROUND:</B> An assessment was made of the toxicity of imperatorin and osthole identified in <I>Cnidium monnieri</I> fruit, 11 related compounds and five insecticides to larvae from insecticide‐susceptible <I>Culex pipiens pallens</I> (KS‐CP strain) and <I>Aedes aegypti</I> and wild <I>C</I>.<I>p</I>. <I>pallens</I> (YS‐CP colony) using a direct‐contact mortality bioassay. Results were compared with those of the conventional larvicide temephos.</P><P><B>RESULTS:</B> Imperatorin (LC<SUB>50</SUB> = 3.14 and 2.88 mg L<SUP>−1</SUP>) was 1.9‐, 3.7‐ and 4.2‐fold and 2.4‐, 4.5‐ and 4.6‐fold more toxic than isopimpinellin, isoimperatorin and osthole against susceptible <I>C. p. pallens</I> and <I>A. aegypti</I> larvae respectively. Overall, all of the compounds were less toxic than temephos (0.011 and 0.019 mg L<SUP>−1</SUP>). The toxicity of these compounds was virtually identical against larvae from the two <I>Culex</I> strains, even though YS‐CP larvae were resistant to fenthion (resistance ratio RR = 390), deltamethrin (RR = 164), cyfluthrin (RR = 14) and temephos (RR = 14). This finding indicates that the coumarins and the insecticides do not share a common mode of action. The structure–activity relationship indicates that the chemical structure and alkoxy substitution and length of the alkoxyl side chain at the C8 position are essential for imparting toxicity.</P><P><B>CONCLUSION:</B> The <I>C. monnieri</I> fruit‐derived coumarins and the related coumarins described merit further study as potential insecticides or lead molecules for the control of insecticide‐resistant mosquito populations. Copyright © 2012 Society of Chemical Industry</P>

Larvicidal activity of <i>Magnolia denudata</i> seed hydrodistillate constituents and related compounds and liquid formulations towards two susceptible and two wild mosquito species

Wang, Zhang‐,qian,Perumalsamy, Haribalan,Wang, Mo,Shu, Shaohua,Ahn, Young‐,Joon John Wiley Sons, Ltd 2016 Pest Management Science Vol.72 No.5

<P><B>Abstract</B></P><P><B>BACKGROUND</B></P><P><I>Anopheles sinensis</I>, <I>Aedes aegypti</I> and <I>Aedes albopictus</I> and <I>Culex pipiens pallens</I> mosquitoes transmit malaria, dengue fever and West Nile virus diseases respectively. This study was conducted to determine the toxicity of 17 constituents from <I>Magnolia denudata</I> seed hydrodistillate (MD‐SHD) and four experimental MD‐SHD liquid formulations (10–50 mg L<SUP>−1</SUP> liquid) to third‐instar larvae from insecticide‐susceptible <I>Cx. p. pallens</I> and <I>Ae. aegypti</I> as well as wild <I>Ae. albopictus</I> and <I>An. sinensis</I>.</P><P><B>RESULTS</B></P><P>2,4‐Di‐<I>tert</I>‐butylphenol was the most toxic constituent (LC<SUB>50</SUB> 1.98–3.90 mg L<SUP>−1</SUP>), followed by linoleic acid (7.19–10.49 mg L<SUP>−1</SUP>), towards larvae of the four mosquito species. High toxicity was also produced by nerolidol, (±)‐limonene, <I>α</I>‐terpinene and <I>γ</I>‐terpinene (LC<SUB>50</SUB> 9.84–36.42 mg L<SUP>−1</SUP>). The toxicity of these compounds was virtually identical towards larvae of the four mosquito species, even though <I>An. sinensis</I> larvae were resistant to deltamethrin and temephos. The MS‐SHD 50 mg L<SUP>−1</SUP> liquid resulted in 92–100% control towards larvae of the four mosquito species, while commercial temephos 200 g L<SUP>−1</SUP> emulsifiable concentrate was almost ineffective towards <I>An. sinensis</I> larvae (30% mortality).</P><P><B>CONCLUSION</B></P><P>Reasonable mosquito control in the aquatic environment can be achieved by MD‐SHD 50 mg L<SUP>−1</SUP> liquid as a potential larvicide. © 2015 Society of Chemical Industry</P>

Genome-Wide Association Analysis to Search for New Loci Associated with Lifelong Premature Ejaculation Risk in Chinese Male Han Population

Wang Fei,Luo Defan,Chen Jianxiang,Pan Cuiqing,Wang Zhongyao,Fu Housheng,Xu Jianbing,Yang Meng,Mo Shaowei,Zhuang Liying,Ye Liefu,Wang Weifu 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.2

Purpose: Genetic factors play an indispensable role in the pathogenesis of lifelong premature ejaculation (LPE). The suscep-tibility genes/SNPs that have been discovered are very limited and can only explain part of the genetic effects of LPE. There-fore, discovering more genetic polymorphisms associated with the occurrence and development of LPE will help reveal the pathogenesis of LPE. Materials Materials and and Methods:Methods: We conducted a genome-wide association study of LPE in 486 Chinese male Han people (cases and controls). We used Gene Titan multi-channel instrument and Axiom Analysis Suite 6.0 software for genotyping. Imputation was performed by IMPUTE2 software and the 1000 Genomes Project (Phase3) was used as reference for haplotype. Finally, logistic regression analysis was performed on all loci that passed the quality control. The odds ratio and 95% confidence in-terval were calculated to determine the association between each SNPs and Chinese male Han population LPE risk. Results:Results: The results showed that a total of 33 genetic variants in 13 genes (LACTBL1 , SSBP3 , ACOT11 , LINC02486 , TMEM154, LINC01098, NONE, HCG27, HLA-C, TNFSF8, TNC, FAM53B, SULF2) have a suggestively significant genome-wide association with LPE risk (p<5×10-6). Conclusions:Conclusions: This study is the first to conduct a GWAS on LPE in Chinese male Han population 33 genetic polymorphisms have a suggestive genome-wide association with LPE risk. This study have provided data supplement for the genetic loci of LPE risk, and laid a scientific foundation for the pathogenesis and the targeted therapy of LPE.

Do the demands of the global forces shape local agenda? An analysis of lifelong learning policies and practice in China

Mo Wang,Dayong Yuan,Maximilian Weidlich 서울대학교 교육연구소 2017 Asia Pacific Education Review Vol.18 No.2

Lifelong learning has become a global phenomenon that has significantly reshaped the conventional foundation of national education systems. Lifelong Learning has experienced an evolution that can be identified in two generations: it first emerged in the 1970s and then quickly gained significance and prevalence by the 1990s. There is general consensus that the rise and spread of the lifelong learning concept in the 1990s was propelled by an intensifying process of globalization, which has also greatly shaped the emphasis and agendas that are captured in the concept. Correspondingly, a dominant albeit disputed trend emerged in literature that portrays lifelong learning as serving the global knowledge economy. Based on a review of the discourse on the global forces that affect lifelong learning, this study explores how lifelong learning policies and practices in China are influenced by globalization. It finds that China has adopted broader agendas of lifelong learning than those required by the global forces. This study serves as a first step towards filling the current research gap: there is a lack of studies exploring lifelong learning policies and practices in East Asia, while most of the existing literature on the topic is focused on Western countries.

현행 중간배당제도의 문제점과 개선방안 -일본법과의 비교고찰을 통하여-

왕순모 ( Wang Sun Mo ) 한국상사판례학회 2003 상사판례연구 Vol.15 No.-

This paper aims to suggest the ways to activate interim dividend through rational analysis by considering differences in the background and spirits of the interim dividend system legislation between Korea and Japan and also disclosing the process of its legislation in Japan. Actually, the Korean corporation law, however, uncritically accepted that of Japan without taking into account the different background and spirits of the Japanese interim dividend system from ours, resulting in difficulty suggesting the ways to activate interim dividend through rational analysis and thereby acknowledging the functional limit of the interim dividend system. The ways to activate interim dividend can be suggested as follows; First, the interim dividend system should be rearranged based on the standpoint of paying the current profit made until the time of interim dividend concerning the legal position of interim dividend which is the most controversial issue. For this matter, a new interim dividend system should be sought for by enforcing the provisional closing at the time of interim dividend and paying interim dividend based on the profit available for dividend calculated at the time of provisional closing. second, the limit amount of the profit available for interim dividend should be readjusted. In the case of the current legal system based on net assets, the legal reserve as a subtractive item or at least profit reserve should be encouraged to be excluded. Third, the responsibility of directors, one of the biggest hindrances in activating the interim dividend on the current legal system, can be solved in a reasonable way by introducing the provisional closing system. Furthermore, to relieve directors of their proving burden or cut off the preposterous scale of interim dividend in advance, a new way of requiring auditors` agreement to the provisional closing should be advised. Fourth, shareholder-protective measures should be prepared which allow to claim the least and just interim dividend, in case that corporations, despite enough profit available for dividend, try to avoid paying interim dividend or are unwilling to do so.